[Agrawal A., Murphy R.F., Agrawal D.K. (2007). DNA methylation in breast and colorectal cancers. Mod. Pathol., 20: 711–721.10.1038/modpathol.380082217464311]Search in Google Scholar
[Altamura G., Strazzullo M., Corteggio A., Francioso R., Roperto F., D ‘ Esposto M., Borzacchiello G. (2012). O(6)-methylguanine-DNA methyltransferase in equine sarcoids: molecular and epigenetic analysis. BMC Vet. Res., 8: 218.10.1186/1746-6148-8-218351246423140380]Search in Google Scholar
[Bogaert L., van Heerden M., de Cock H.E.V., Martens A., Chiers K. (2011). Molecular and immunohistochemical distinction of equine sarcoid from schwannoma. Vet. Pathol., 48: 737–741.10.1177/030098581037707020634412]Search in Google Scholar
[Bonazzi V.F., Nancarrow D.J., Stark M.S., Moser R.J., Boyle G.M., Aoude L.G., Schmidt C., Hayward N.K. (2011). Cross-platform array screening identifies COL1A2, THBS1, TNFRSF10D and UCHL1 as genes frequently silenced by methylation in melanoma. PLoS One, 6:e26121.10.1371/journal.pone.0026121319759122028813]Search in Google Scholar
[Boultwood J., Wainscoat J.S. (2007). Gene silencing by DNA methylation in haematological malignancies. Brit. J. Haematol., 138: 3–11.10.1111/j.1365-2141.2007.06604.x17489980]Search in Google Scholar
[Broström H. (1995). Equine sarcoids. A clinical and epidemiological study in relation to equine leucocyte antigens (ELA). Acta Vet. Scan., 36: 223–236.10.1186/BF0354769180954137484549]Search in Google Scholar
[Carvalho A.L., Jeronimo C., Kim M.M., Henrique R., Zhang Z., Hoque M.O., Chang S., Brait M., Nayak C.S., Jiang W.W., Claybourne Q., Tokumaru Y., Lee J., Goldenberg D., Garrett-Mayer E., Goodman S., Moon C.S., Koch W., Wes-tra W.H., Sidransky D., Califano J.A. (2008). Evaluation of promoter hypermethylation detection in body fluids as a screening/diagnosis tool for head and neck squamous cell carcinoma. Clin. Cancer Res., 14: 97–107.10.1158/1078-0432.CCR-07-072218172258]Search in Google Scholar
[Chambers G., Ellsmore V.A., O ‘ Brien P.M., Reid S.W.J., Love S., Campo M.S., Nasir L. (2003). The association of bovine papillomavirus with equine sarcoids. J. Gen. Virol., 84: 1055–1062.10.1099/vir.0.18947-012692268]Search in Google Scholar
[Chan M.W., Chan L.W., Tang N.L., Lo K.W., Tong J.H., Chan A.W., Cheung H.Y., Wong W.S., Chan P.S., Lai F.M., To K.F. (2003). Frequent hypermethylation of promoter region of RASSF1A in tumor tissues and voided urine of urinary bladder cancer patients. Int. J. Cancer., 104: 611–616.10.1002/ijc.1097112594816]Search in Google Scholar
[Chen K., Sawhney R., Khan M., Benninger M.S., Hou Z., Sethi S., Stephen J.K., Worsham M.J. (2007). Methylation of multiple genes as diagnostic and therapeutic markers in primary head and neck squamous cell carcinoma. Arch. Otolaryngol. Head Neck Surg., 133: 1131–1138.10.1001/archotol.133.11.113118025318]Search in Google Scholar
[Christiansen D.H., Andersen M.K., Pedersen-Bjergaard J. (2003). Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia. Leukemia, 17: 1813–1819.10.1038/sj.leu.240305412970781]Search in Google Scholar
[Das P.M., Singal R. (2004). DNA methylation and cancer. J. Clin. Oncol., 22: 4632–4642.10.1200/JCO.2004.07.15115542813]Search in Google Scholar
[Djos A., Martinsson T., Kogner P., Carén H. (2012). The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma. Mol. Cancer, 11: 40.10.1186/1476-4598-11-40349326622695170]Search in Google Scholar
[Epperson E.D., Castleman W.L. (2017). Bovine papillomavirus DNA and S100 profiles in sarcoids and other cutaneous spindle cell tumors in horses. Vet. Pathol., 54: 44–52.10.1177/030098581665316927312364]Search in Google Scholar
[Esteller M. (2005). Aberrant DNA methylation as a cancer-inducing mechanism. Annu. Rev. Pharmacol. Toxicol., 45: 629–656.10.1146/annurev.pharmtox.45.120403.09583215822191]Search in Google Scholar
[Evron E., Umbricht C.B., Korz D., Raman V., Loeb D.M., Niranjan B., Buluwe-la L., Weitzman S.A., Marks J., Sukumar S. (2001). Loss of cyclin D2 expression in the majority of breast cancers is associated with promoter hypermethylation. Cancer Res., 61: 2782–2787.]Search in Google Scholar
[Fendri A., Masmoudi A., Khabir A., Sellami-Boudawara T., Daoud J., Frik-ha M., Ghorbel A., Gargouri A., Mokdad-Gargouri R. (2009). Inactivation of RASS-F1A, RARβeta2 and DAP-kinase by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma. Cancer Biol. Ther., 8: 444–451.10.4161/cbt.8.5.768619221469]Search in Google Scholar
[Furuta J., Umebayashi Y., Miyamoto K., Kikuchi K., Otsuka F., Sugimura T., Ushijima T. (2004). Promoter methylation profiling of 30 genes in human malignant melanoma. Cancer Sci., 95: 962–968.10.1111/j.1349-7006.2004.tb03184.x15596045]Search in Google Scholar
[Gonzalez-Gomez P., Bello M.J., Alonso M.E., Amiñoso C., Lopez-Marin I., De Campos J.M., Isla A., Gutierrez M., Rey J.A. (2004). Promoter methylation status of multiple genes in brain metastases of solid tumors. Int. J. Mol. Med., 13: 93–98.10.3892/ijmm.13.1.93]Search in Google Scholar
[Guo H., Carlson J.A., Slominski A. (2012). Role of TRPM in melanocytes and melanoma. Exp. Dermatol., 21: 650–654.10.1111/j.1600-0625.2012.01565.x342276122897572]Search in Google Scholar
[Hoon D.S., Spugnardi M., Kuo C., Huang S.K., Morton D.L., Taback B. (2004). Profiling epigenetic inactivation of tumor suppressor genes in tumors and plasma from cutaneous melanoma patients. Oncogene, 23: 4014–4022.10.1038/sj.onc.1207505285646915064737]Search in Google Scholar
[Leakey T., Zielinski J., Siegfried R.N., Siegel E.R., Fan C.Y., Cooney C.A. (2008). A simple algorithm for quantifying DNA methylation levels on multiple independent CpG sites in bisulfite genomic sequencing electropherograms. Nucleic Acids Res., 36: e64.10.1093/nar/gkn210244181018480118]Search in Google Scholar
[Lee M.G., Kim H.Y., Byun D.S., Lee S.J., Lee C.H., Kim J.I., Chang S.G., Chi S.G. (2001). Frequent epigenetic inactivation of RASSF1A in human bladder carcinoma. Cancer Res., 61: 6688–6692.]Search in Google Scholar
[Li Q., Ahuja N., Burger P.C., Issa J.P. (1999). Methylation and silencing of the Thrombospondin-1 promoter in human cancer. Oncogene, 18: 3284–3289.10.1038/sj.onc.120266310359534]Search in Google Scholar
[Lindner D.J., Wu Y., Haney R., Jacobs B.S., Fruehauf J.P., Tuthill R., Borden E.C. (2013). Thrombospondin-1 expression in melanoma is blocked by methylation and targeted reversal by 5-Aza-deoxycytidine suppresses angiogenesis. Matrix Biol., 32: 123–132.10.1016/j.matbio.2012.11.010361507123202046]Search in Google Scholar
[Lunardi M., de Alcântara B.K., Otonel R.A., Rodrigues W.B., Alfieri A.F., Alfieri A.A. (2013). Bovine papillomavirus type 13 DNA in equine sarcoids. J. Clin. Microbiol., 51: 2167–2171.10.1128/JCM.00371-13369770723637294]Search in Google Scholar
[Maruya S., Issa J.P., Weber R.S., Rosenthal D.I., Haviland J.C., Lotan R., El-Naggar A.K. (2004). Differential methylation status of tumor-associated genes in head and neck squamous carcinoma: incidence and potential implications. Clin. Cancer Res., 10: 3825–3830.10.1158/1078-0432.CCR-03-037015173091]Search in Google Scholar
[Maruyama R., Toyooka S., Toyooka K.O., Harada K., Virmani A.K., Zochbauer-Muller S., Farinas A.J., Vakar-Lopez F., Minna J.D., Sagalowsky A., Czer-niak B., Gazdar A.F. (2001). Aberrant promoter methylation profile of bladder cancer and its relationship to clinicopathological features. Cancer Res., 61: 8659–8663.]Search in Google Scholar
[Melnikov A., Shrestha S., Yi Q., Replogle C., Borgia J., Bonomi P., Liptay M., Ugolini D., Neri M., Verri C., Sozzi G., Levenson V. (2014). Non-small cell lung cancer can be detected and its subtypes differentiated by a blood test of methylation in cell-free DNA from plasma. JSM Biomar., 1: 1003.]Search in Google Scholar
[Ogi K., Toyota M., Ohe-Toyota M., Tanaka N., Noguchi M., Sonoda T., Koha-ma G., Tokino T. (2002). Aberrant methylation of multiple genes and clinicopathological features in oral squamous cell carcinoma. Clin. Cancer Res., 8: 3164–3171.]Search in Google Scholar
[Oshimo Y., Nakayama H., Ito R., Kitadai Y., Yoshida K., Chayama K., Yasui W. (2003). Promoter methylation of cyclin D2 gene in gastric carcinoma. Int. J. Oncol., 23: 1663–1670.10.3892/ijo.23.6.1663]Search in Google Scholar
[R Development Core Team (2011). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, URL http://www.R-project.org/]Search in Google Scholar
[Rohde C., Zhang Y., Reinhardt R., Jeltsch A. (2010). BISMA – fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences. BMC Bioinformatics, 11: 230.10.1186/1471-2105-11-230287769120459626]Search in Google Scholar
[Spugnardi M., Tommasi S., Dammann R., Pfeifer G.P., Hoon D.S. (2003). Epigenetic inactivation of RAS association domain family protein 1 (RASSF1A) in malignant cutaneous melanoma. Cancer Res., 63: 1639–1643.]Search in Google Scholar
[Strazzullo M., Corteggio A., Altamura G., Francioso R., Roperto F., D ‘ Esposi-to M., Borzacchiello G. (2012). Molecular and epigenetic analysis of the fragile histidine triad tumour suppressor gene in equine sarcoids. BMC Vet. Res., 8: 30.10.1186/1746-6148-8-30336146422424615]Search in Google Scholar
[Virmani A.K., Rathi A., Sathyanarayana U.G., Padar A., Huang C.X., Cunnig-ham H.T., Farinas A.J., Milchgrub S., Euhus D.M., Gilcrease M., Herman J., Minna J.D., Gazdar A. F. (2001). Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter 1A in breast and lung carcinomas. Clin. Cancer Res., 7: 1998–2004.]Search in Google Scholar