<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Objective</h3>
<p>This study aims to develop semisolid pharmaceutical forms for the topical administration of mometasone furoate.</p>
</sec>
<sec><h3>Methods</h3>
<p>Two creams (O1 and O2) and four hydroxypropyl methylcellulose-based hydrogels were prepared (H3-H6). Two different sorts of hydroxypropyl methylcellulose were used in concentrations of 15 and 20%. Consistency, spreadability, viscosity, and pH were measured. In vitro drug release was determined by a vertical, Franz diffusion cell. Mathematical models were applied for a better understanding of release phenomena.</p>
</sec>
<sec><h3>Results</h3>
<p>O1 and O2 presented lower values for penetration depth and spreadability. Hydrogel viscosity is influenced by the type and concentration of the gel-forming agent. Viscosity decreases in the order H6, H5, H4, and H3. pH varies between 4.6 to 5.92, fulfilling the requirements of European Pharmacopiea. Creams showed 5.49 and 6.59% of mometasone released after 6 hours. The lowest viscosity hydrogel presented the best dissolution of 40.11% mometasone after 6 hours.</p>
</sec>
<sec><h3>Conclusions</h3>
<p>H3 hydrogel releases the highest amount of mometasone furoate after 6 hours. The release is best described by the Korsmeyer-Peppas model explained by water diffusion and polymeric chain relaxation happen during the swelling of the polymer.</p>
</sec>
</abstract>

Objective
This study aims to develop semisolid pharmaceutical forms for the topical administration of mometasone furoate.

Methods
Two creams (O1 and O2) and four hydroxypropyl methylcellulose-based hydrogels were prepared (H3-H6). Two different sorts of hydroxypropyl methylcellulose were used in concentrations of 15 and 20%. Consistency, spreadability, viscosity, and pH were measured. In vitro drug release was determined by a vertical, Franz diffusion cell. Mathematical models were applied for a better understanding of release phenomena.

Results
O1 and O2 presented lower values for penetration depth and spreadability. Hydrogel viscosity is influenced by the type and concentration of the gel-forming agent. Viscosity decreases in the order H6, H5, H4, and H3. pH varies between 4.6 to 5.92, fulfilling the requirements of European Pharmacopiea. Creams showed 5.49 and 6.59% of mometasone released after 6 hours. The lowest viscosity hydrogel presented the best dissolution of 40.11% mometasone after 6 hours.

Conclusions
H3 hydrogel releases the highest amount of mometasone furoate after 6 hours. The release is best described by the Korsmeyer-Peppas model explained by water diffusion and polymeric chain relaxation happen during the swelling of the polymer.

Development of semisolid pharmaceutical forms with mometasone furoate

Pharmaceutical Technology and Cosmetology Department, Faculty of Pharmacy

George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures

Department of Industrial Pharmacy and Management, Faculty of Pharmacy

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution 4.0 International License.

{"article-title":"Development of semisolid pharmaceutical forms with mometasone furoate"}

Objective
This study aims to develop semisolid pharmaceutical forms for the topical administration of mometasone furoate.

Methods
Two creams (O1 and O2) and...

Development of semisolid pharmaceutical forms with mometasone furoate

Data publikacji: 28 gru 2023

Zakres stron: 280 - 284

Otrzymano: 21 paź 2023

Przyjęty: 06 lis 2023

DOI: https://doi.org/10.2478/amma-2023-0045

Słowa kluczowe
mometasone furoate, hydrogel, diffusion, dermal administration

© 2023 Emőke Margit Rédai et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Development of semisolid pharmaceutical forms with mometasone furoate

Data publikacji: 28 gru 2023

Zakres stron: 280 - 284

Otrzymano: 21 paź 2023

Przyjęty: 06 lis 2023

DOI: https://doi.org/10.2478/amma-2023-0045

Słowa kluczowemometasone furoate, hydrogel, diffusion, dermal administration

© 2023 Emőke Margit Rédai et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Słowa kluczowe
mometasone furoate, hydrogel, diffusion, dermal administration