[1. Reich DS, Lucchinetti CF Calabresi PA,2018. Multiple Sclerosis. N. Engl. J. Med 2018; 378: 169–180.]Search in Google Scholar
[2. Walton C, King R, Rechtman L et al. Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition. Mult Scler 2020;26(14):1816-1821.10.1177/1352458520970841]Search in Google Scholar
[3. Maier S, Bălaşa R, Buruian M, Maier A, Bajko Z. Depression in multiple sclerosis – Review. Romanian Journal of Neurology/Revista Romana de Neurologie 2015; XIV: 22-29.10.37897/RJN.2015.1.4]Search in Google Scholar
[4. Cerqueira AC, Andrade PS, Godoy-Barreiros JM, Silva ACO, Nardi AE. Risk factors for suicide in multiple sclerosis: a case-control study. J Bras Psiquiatr 2015;64(4):303-6.10.1590/0047-2085000000093]Search in Google Scholar
[5. Abreu P, Mendonça MT, Guimaraes J, Sa MJ. Esclerose múltipla: epidemiologia, fisiopatologia e diagnostico diferencial. Sinapse 2012;12(2):5e14.]Search in Google Scholar
[6. Hatch MN, Schaumburg CS, Lane TE, Keirstead HS. Endogenous remyelination is induced by transplant rejection in a viral model of multiple sclerosis. J Neuroimmunol 2009;212(1):74e81.10.1016/j.jneuroim.2009.05.002]Search in Google Scholar
[7. Atlas of MS, 3rd Edition. The Multiple Sclerosis International Federation (MSIF), London, September 2020. Available at https://www.msif.org/wp-content/uploads/2020/10/Atlas-3rd-Edition-Epidemiology-report-EN-updated-30-9-20.pdf Accessed October 2, 2021.]Search in Google Scholar
[8. Smets I, Van Deun L, Bohyn C et al. Belgian Study Group for Multiple Sclerosis. Corticosteroids in the management of acute multiple sclerosis exacerbations. Acta Neurol Belg 2017;117(3):623-633.10.1007/s13760-017-0772-0]Search in Google Scholar
[9. Horta-Hernández AM, Esaclera-Izquierdo B, Yusta-Izquierdo A et al. High-dose oral methylprednisolone for the treatment of multiple sclerosis relapses: cost-minimisation analysis and patient’s satisfaction. Eur J Hosp Pharm 2019;26(5):280-284.10.1136/ejhpharm-2018-001499]Search in Google Scholar
[10. Callegari I, Derfuss T, Galli E. Update on treatment in multiple sclerosis. Presse Med. 2021;50(2):104068. doi: 10.1016/j.lpm.2021.104068.10.1016/j.lpm.2021.104068]Search in Google Scholar
[11. Derfuss T, Mehling M, Papadopoulou A, Bar-Or A, Cohen JA, Kappos L. Advances in oral immunomodulating therapies in relapsing multiple sclerosis. Lancet Neurol 2020;19:336–47.10.1016/S1474-4422(19)30391-6]Search in Google Scholar
[12. van Pesch V, Sindic CJ, Ferna´ndez O. Effectiveness and safety of natalizumab in real-world clinical practice: review of observational studies. Clin Neurol Neurosurg 2016;149:55–63.10.1016/j.clineuro.2016.07.00127475049]Search in Google Scholar
[13. Butzkueven H, Kappos L, Wiendl H, et al. Tysabri Observational Program (TOP) Investigators. Long-term safety and effectiveness of natalizumab treatment in clinical practice: 10 years of real-world data from the Tysabri Observational Program (TOP). J Neurol Neurosurg Psychiatry 2020;91(6):660-668.10.1136/jnnp-2019-322326727920132234967]Search in Google Scholar
[14. Montalban X, Hauser SL, Kappos L, et al. Ocrelizumab versus placebo in primary progressive multiple sclerosis. N Engl J Med 2017;376:209–20.10.1056/NEJMoa160646828002688]Search in Google Scholar
[15. Baker D, Herrod SS, Alvarez-Gonzalez C, Giovannoni G, Schmierer K. Interpreting lymphocyte reconstitution data from the pivotal phase 3 trials of alemtuzumab. JAMA Neurol 2017;74:961–9.10.1001/jamaneurol.2017.0676571032328604916]Search in Google Scholar
[16. Fabis-Pedrini MJ, Carroll WM, Kermode AG. Efficacy and safety of mitoxantrone use in aggressive multiple sclerosis (P3.414). Neurology 2018;90(15):P3.414.]Search in Google Scholar
[17. Cohen JA, Baldassari LE, Atkins HL, et al. Autologous hematopoietic cell transplantation for treatment-refractory relapsing multiple sclerosis: position statement from the American Society for Blood and Marrow Transplantation. Biol Blood Marrow Transplant 2019;25:845–54.10.1016/j.bbmt.2019.02.01430794930]Search in Google Scholar
[18. Bullis JR, Boettcher H, Sauer-Zavala S, Farchione TJ, Barlow DH. What is an emotional disorder? A transdiagnostic mechanistic definition with implications for assessment, treatment, and prevention. Clin Psychol Sci Pract. 2019;26:e12278.10.1111/cpsp.12278]Search in Google Scholar
[19. Feinstein A, Magalhaes S, Richard JF, Audet B, Moore C. The link between multiple sclerosis and depression. Nat Rev Neurol 2014;10(9):507-517.10.1038/nrneurol.2014.13925112509]Search in Google Scholar
[20. Butler E, Matcham F, Chalder T. A systematic review of anxiety amongst people with multiple sclerosis. Mult. Scler. Relat. Disord 2016;10 :145–168.]Search in Google Scholar
[21. Boeschoten RE, Braamse AMJ, Beekman ATF, et al. Prevalence of depression and anxiety in Multiple Sclerosis: A systematic review and meta-analysis. J Neurol Sci 2017;372:331-341.10.1016/j.jns.2016.11.06728017241]Search in Google Scholar
[22. Possa MF, Minacapelli E, Canale S, Comi G, Martinelli V, Falautano M. The first year after diagnosis: psychological impact on people with multiple sclerosis. Psychol Health Med 2017;22:1063-1071.10.1080/13548506.2016.127404328058855]Search in Google Scholar
[23. Pujol J, Bello J, Deus J, Martí-Vilalta JL, Capdevila A. Lesions in the left arcuate fasciculus region and depressive symptoms in multiple sclerosis. Neurology 1997;49:1105-1110.10.1212/WNL.49.4.11059339697]Search in Google Scholar
[24. Bakshi R, Czarnecki D, Shaikh ZA, et al. Brain MRI lesions and atrophy are related to depression in multiple sclerosis. Neuroreport 2000;11:1153-1158.10.1097/00001756-200004270-0000310817583]Search in Google Scholar
[25. Gobbi C, Rocca MA, Riccitelli G, et al. Influence of the topography of brain damage on depression and fatigue in patients with multiple sclerosis. Mult Scler 2014;20:192-201.10.1177/135245851349368423812284]Search in Google Scholar
[26. Stuke H, Hanken K, Hirsch J, et al. Cross-sectional and longitudinal relationships between depressive symptoms and brain atrophy in MS patients. Front Hum Neurosci 2016;10:622.10.3389/fnhum.2016.00622515969728018194]Search in Google Scholar
[27. Minden SL, Feinstein A, Kalb RC, et al. Evidence-based guideline: assessment and management of psychiatric disorders in individuals with MS: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology 2014;82:174-181.10.1212/WNL.0000000000000013389743424376275]Search in Google Scholar
[28. Brenner P, Piehl F. Fatigue and depression in multiple sclerosis: pharmacological and non-pharmacological interventions. Acta Neurol Scand 2016;134:47-54.10.1111/ane.1264827580906]Search in Google Scholar
[29. Patten SB, Metz LM. Interferon beta1a and depression in secondary progressive MS: data from the SPECTRIMS Trial. Neurology 2002;59:744-746.10.1212/WNL.59.5.744]Search in Google Scholar
[30. Patti F, Amato MP, Trojano M, et al. Quality of life, depression and fatigue in mildly disabled patients with relapsing-remitting multiple sclerosis receiving subcutaneous interferon beta-1a: 3-year results from the COGIMUS (COGnitive Impairment in MUltiple Sclerosis) study. Mult Scler 2011;17:991-1001.10.1177/135245851140194321502310]Search in Google Scholar
[31. Zephir H, De Seze J, Stojkovic T, et al. Multiple sclerosis and depression: influence of interferon beta therapy. Mult Scler 2003;9(3):284-288.10.1191/1352458503ms915oa12814176]Search in Google Scholar
[32. Drago A, Crisafulli C, Sidoti A, Serretti A. The molecular interaction between the glutamatergic, noradrenergic, dopaminergic and serotoninergic systems informs a detailed genetic perspective on depressive phenotypes. Prog Neurobiol. 2011;94:418-60.10.1016/j.pneurobio.2011.05.00921723912]Search in Google Scholar
[33. Bechtholt-Gompf AJ, Walther HV, Adams MA, Carlezon WA, Öngür D, Cohen BM. Blockade of astrocytic glutamate uptake in rats induces signs of anhedonia and impaired spatial memory. Neuropsychopharmacology. 2010;35:2049–2059. doi: 10.1038/npp.2010.74.10.1038/npp.2010.74305529920531459]Search in Google Scholar
[34. Maier S, Buruian M, Maier A, et al. The determinants of depression in a Romanian cohort of multiple sclerosis patients. Acta Neurol Belg 2016;116:135–143.10.1007/s13760-015-0547-426442687]Search in Google Scholar
[35. Tauil CB, Grippe TC, Dias RM, et al. Suicidal ideation, anxiety, and depression in patients with multiple sclerosis. Arq Neuropsiquiatr 2018;76(5):296-301.10.1590/0004-282x2018003629898075]Search in Google Scholar
[36. McGuigan C, Hutchinson M. Unrecognised symptoms of depression in a community–based population with multiple sclerosis. J. Neurol 2006; 253 (2): 219–223.10.1007/s00415-005-0963-016177840]Search in Google Scholar
[37. Güner MC, Yazarb MS, Meterelliyozb KS. Cognitive predictors of depression and anxiety in individuals with newly diagnosed Multiple Sclerosis. Eur. J. Psychiat 2020;34(4):202-210.]Search in Google Scholar
[38. Coughlin SS, Sher L. Suicidal behavior and neurological illnesses. J Depress Anxiety 2013; 9(1):12443.]Search in Google Scholar
[39. Gill S, Santo J, Ph.D., Blair M, Morro SA. Depressive Symptoms Are Associated With MoreNegative Functional Outcomes Than Anxiety Symptoms in Persons With Multiple Sclerosis. J Neuropsychiatry Clin Neurosci 2019; 31:37–42.10.1176/appi.neuropsych.1801001130187820]Search in Google Scholar
[40. Hanna M, Strober LB. Anxiety and depression in Multiple Sclerosis (MS): Antecedents, consequences, and differential impact on well-being and quality of life. Mult Scler Relat Disord 2020;44:102261.10.1016/j.msard.2020.102261771908632585615]Search in Google Scholar
[41. Suh Y, Motl RW and Mohr DC. Physical activity, disability, and mood in the early stage of multiple sclerosis. Disabil Health J 2010; 3(2): 93–98.10.1016/j.dhjo.2009.09.00221122774]Search in Google Scholar
[42. Ayache SS, Chalah MA. Fatigue in multiple sclerosis – insights into evaluation and management? Neurophysiol Clin 2017;2017 (47):139–71.]Search in Google Scholar
[43. Ayache SS, Chalah MA, Kümpfel T, Padberg F, Lefaucheur JP, Palm U. Multiple sclerosis fatigue, its neural correlates, and its modulation with tDCS. Fortschr Neurol Psychiatr 2017;85:260–9.]Search in Google Scholar
[44. Herring TE, Alschuler KN, Knowles LM, et al. Differences in correlates of fatigue between relapsing and progressive forms of multiple sclerosis, Mult Scler Relat Disord 54:103109.10.1016/j.msard.2021.10310934237561]Search in Google Scholar
[45. Greeke EE, Chua AS, Healy BC, Rintell DJ, Chitnis T, Glanz BI. Depression and fatigue in patients with multiple sclerosis. J Neurol Sci. 2017 Sep 15;380:236-241.10.1016/j.jns.2017.07.04728870578]Search in Google Scholar
[46. Poddaa J, Ponzioa M, Uccellia MM, et al. Predictors of clinically significant anxiety in people with multiple sclerosis: A one-year follow-up study. Mult Scler Relat Disord 2020;45:102417.10.1016/j.msard.2020.10241732736214]Search in Google Scholar
[47. Korostil M, Feinstein A. Anxiety disorders and their clinical correlates in multiple sclerosis patients. Mult Scler 2007;13:67-72.10.1177/135245850607116117294613]Search in Google Scholar
[48. Wallis O, Bol Y, Köhler S, van Heugten C. Anxiety in multiple sclerosis is related to depressive symptoms and cognitive complaints. Acta Neurol Scand 2020;141(3):212-218.10.1111/ane.1319131693750]Search in Google Scholar
[49. Brenner P, Burkill S, Jokinen J, Hillert J, Bahmanyar S, Montgomery S. Multiple sclerosis and risk of attempted and completed suicide-a cohort study. Eur J Neurol. 2016 Aug;23(8):1329-36. doi: 10.1111/ene.13029.10.1111/ene.1302927120108]Search in Google Scholar
[50. Romaniuc A, Bălaşa R, Ştirbu N, et al. The Main Determinants for Suicidal Ideation in a Romanian Cohort of Multiple Sclerosis Patients. Behav Neurol. 2020;2594702.10.1155/2020/2594702720151132399081]Search in Google Scholar
[51. Feinstein A. An examination of suicidal intent in patients with multiple sclerosis. Neurology 2002;59:674-678.10.1212/WNL.59.5.674]Search in Google Scholar
[52. Lewis VM, Williams K, KoKo C, Woolmore J, Jones C, Powell T. Disability, depression and suicide ideation in people with multiple sclerosis. J Affect Disord 2017;208:662-669.10.1016/j.jad.2016.08.03827866709]Search in Google Scholar
[53. Shen Q, Lu H, Xie D, Wang H, Zhao Q, Xu Y. Association between suicide and multiple sclerosis: An updated meta-analysis. Mult Scler Relat Disord 2019;34:83-90.10.1016/j.msard.2019.06.01231233959]Search in Google Scholar
[54. Silveira C, Guedes R, Maia D, Curral R, Coelho R. Neuropsychiatric Symptoms of Multiple Sclerosis: State of the Art. Psychiatry Investig 2019;16(12):877-888.10.30773/pi.2019.0106693313931805761]Search in Google Scholar
[55. Stamoula E, Siafis S, Dardalas I, et al. Antidepressants on Multiple Sclerosis: A Review of In Vitro and In Vivo Models. Front Immunol 2021;12:677879.10.3389/fimmu.2021.677879817321034093579]Search in Google Scholar
[56. Fiest KM, Walker JR, Bernstein CN, et al. Systematic review and meta-analysis of interventions for depression and anxiety in persons with multiple sclerosis. Mult Scler Relat Disord 2016;18:96–104.10.1016/j.msard.2015.10.00426856938]Search in Google Scholar
[57. Politte LC, Huffman JC, Stern TA. Neuropsychiatric manifestations of multiple sclerosis. Prim Care Companion J Clin Psychiatry 2008;10(4):318-324.10.4088/PCC.v10n0408252823818787677]Search in Google Scholar
[58. Campbell N, Boustani M, Limbil T, et al. The cognitive impact of anticholinergics: a clinical review. Clin Interv Aging 2009;4:225-33.]Search in Google Scholar
[59. Gray SL, Anderson ML, Dublin S, et al. Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study. JAMA Intern Med 2015;175(3):401-7.10.1001/jamainternmed.2014.7663435875925621434]Search in Google Scholar
[60. Cuijpers P, Berking M, Andersson G, Quigley L, Kleiboer A, Dobson KS. A meta-analysis of cognitive-behavioural therapy for adult depression, alone and in comparison with other treatments. Can J Psychiatry 2013;58(7):376-85.10.1177/07067437130580070223870719]Search in Google Scholar
[61. Kiropoulos L, Kilpatrick T, Kalincik T, et al. Comparison of the effectiveness of a tailored cognitive behavioural therapy with a supportive listening intervention for depression in those newly diagnosed with multiple sclerosis (the ACTION-MS trial): protocol of an assessor-blinded, active comparator, randomised controlled trial. Trials 2020; 21(1):100.10.1186/s13063-019-4018-8697186731959224]Search in Google Scholar
[62. Beck AT, Rush AJ, Shaw BE, Emery G. Cognitive therapy of depression. New York: Guilford Press, 1979.]Search in Google Scholar
[63. Ghielen I, Rutten S, Boeschoten RE, et al. The effects of cognitive behavioral and mindfulness-based therapies on psychological distress in patients with multiple sclerosis, Parkinson’s disease and Huntington’s disease: Two meta-analyses. J Psychosom Res 2019;122:43-51.10.1016/j.jpsychores.2019.05.00131126411]Search in Google Scholar
[64. Hind D, Cotter J, Thake A, et al. Cognitive behavioural therapy for the treatment of depression in people with multiple sclerosis: a systematic review and meta-analysis. BMC Psychiatry 2014; 14:5.10.1186/1471-244X-14-5389056524406031]Search in Google Scholar
[65. Ratajska A, Zurawski J, Healy B, Glanz BI. Computerized Cognitive Behavioral Therapy for Treatment of Depression in Multiple Sclerosis: A Narrative Review of Current Findings and Future Directions. Int J MS Care 2019;21(3):113-123.10.7224/1537-2073.2017-094655299131191176]Search in Google Scholar
[66. Huguet A, Rao S, McGrath PJ, Wozney L, Wheaton M, Conrod J, Rozario S. A Systematic Review of Cognitive Behavioral Therapy and Behavioral Activation Apps for Depression. PLoS One 2016; 11(5):e0154248.10.1371/journal.pone.0154248485292027135410]Search in Google Scholar
[67. Hayter AL, Salkovskis PM, Silber E, Morris RG. The impact of health anxiety in patients with relapsing remitting multiple sclerosis: Misperception, misattribution and quality of life. Br J Clin Psychol 2016;55(4):371-386.10.1111/bjc.1210626806805]Search in Google Scholar
[68. Chalah MA, Ayache SS. Cognitive behavioral therapies and multiple sclerosis fatigue: A review of literature. J Clin Neurosci 2018;52:1-4.10.1016/j.jocn.2018.03.02429609859]Search in Google Scholar
[69. van den Akker LE, Beckerman H, Collette EH, et al. TREFAMS-ACE Study Group. Cognitive behavioral therapy positively affects fatigue in patients with multiple sclerosis: Results of a randomized controlled trial. Mult Scler 2017;23(11):1542-1553.10.1177/135245851770936128528567]Search in Google Scholar
[70. Gromisch ES, Kerns RD, Beauvais J. Pain-related illness intrusiveness is associated with lower activity engagement among persons with multiple sclerosis. Mult Scler Relat Disord 2020;38:101882.10.1016/j.msard.2019.10188231812040]Search in Google Scholar
[71. Abbasi S, Alimohammadi N, Pahlavanzadeh S. Effectiveness of cognitive behavioral therapy on the quality of sleep in women with multiple sclerosis: a randomized controlled trial study. Int J Community Based Nurs Midwifery 2016;4:320–8.]Search in Google Scholar
[72. Calandri E, Graziano F, Borghi M, Bonino S. Improving the quality of life and psychological well-being of recently diagnosed multiple sclerosis patients: preliminary evaluation of a group-based cognitive behavioral intervention. Disabil Rehabil 2016;1–8.10.1080/09638288.2016.119843027385055]Search in Google Scholar
[73. Mohr DC, Cox D, Merluzzi N. Self-Injection Anxiety Training: a treatment for patients unable to self-inject injectable medications. Mult. Scler 2005;11(2):182-185.10.1191/1352458505ms1146oa15794392]Search in Google Scholar
[74. Topcu G, Griffiths H, Bale C, et al. Psychosocial adjustment to multiple sclerosis diagnosis: A meta-review of systematic reviews. Clin Psychol Rev 2020; 82: 101923,10.1016/j.cpr.2020.10192332992071]Search in Google Scholar
[75. Hofmann SG, Hayes SC. The Future of Intervention Science: Process-Based Therapy. Clin Psychol Sci. 2019;7(1):37-50.10.1177/2167702618772296635052030713811]Search in Google Scholar
[76. David D, Schnur J, Belloiu, A. Another Search for the “Hot” Cognitions: Appraisal, Irrational Beliefs, Attributions, and Their Relation to Emotion. J Ration Emot Cogn Behav Ther 2002; 20(2): 93–131.10.1023/A:1019876601693]Search in Google Scholar
[77. Ellis A. Changing rational-emotive therapy (RET) to rational emotive behavior therapy (REBT). J Ration Emot Cogn Behav Ther 1995;13(2): 85–89.10.1007/BF02354453]Search in Google Scholar
[78. David D, Cotet C, Matu S, Mogoase C, Stefan S. 50 years of rational emotive and cognitive-behavioral therapy: A systematic review and meta-analysis. J. Clin. Psychol 2018; 74(3): 304–318.]Search in Google Scholar
[79. Popa CO, Predatu R. The effect of an integrative CBT/REBT intervention in improving emotional functioning and emotional stability in Romanian medical students. J Evid-Base Psychot 2019;19(1):59-72.10.24193/jebp.2019.1.4]Search in Google Scholar
[80. Maggio MG, Cuzzola MF, Latella D, et al. How personality traits affect functional outcomes in patients with multiple sclerosis: A scoping review on a poorly understood topic. Mult Scler Relat Disord 2020;46.10.1016/j.msard.2020.10256033049463]Search in Google Scholar