Creutzfeldt-Jakob Disease – A Series of Four Clinical Cases

Creutzfeldt-Jakob Disease (CJD) is a rare, progressive, and fatal degenerative brain disorder caused by prion proteins. The diagnosis of the disease is based on established criteria and biomarkers – cerebrospinal fluid analysis, real-time quaking induced conversion (RT-QulC), magnetic resonance imaging, electroencephalographic findings and brain biopsy. We present a series of four patients with confirmed CJD, followed in our clinical center. We discuss the current diagnostic approach in these patients.