<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Atopic dermatitis (AD), or eczema, is a common skin disease that is often associated with other atopic disorders, such as allergic rhinitis and asthma. The disease can develop both in infancy and adulthood, and characterizes with recurrent episodes impairing the quality of life. The review аnalyzes the genetical, immunological, and environmental factors in the pathogenesis of AD. The role of the skin barrier function is also considered in regard of the main hypotheses for AD development. Further elucidation of the mechanisms involved in the pathogenesis of AD could give interesting and useful clues for therapeutic protocols and prophylactic approaches.</p>
</abstract>

Atopic dermatitis (AD), or eczema, is a common skin disease that is often associated with other atopic disorders, such as allergic rhinitis and asthma. The disease can develop both in infancy and adulthood, and characterizes with recurrent episodes impairing the quality of life. The review аnalyzes the genetical, immunological, and environmental factors in the pathogenesis of AD. The role of the skin barrier function is also considered in regard of the main hypotheses for AD development. Further elucidation of the mechanisms involved in the pathogenesis of AD could give interesting and useful clues for therapeutic protocols and prophylactic approaches.

Insights Into Atopic Dermatitis – From Pathogenesis to Therapy

Department of Physiology and Pathophysiology

Medical Faculty, Medical University – Sofia

Department of Pharmacology and Toxicology, Medical Faculty

Acta Medica Bulgarica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Insights Into Atopic Dermatitis \u2013 From Pathogenesis to Therapy"}

Atopic dermatitis (AD), or eczema, is a common skin disease that is often associated with other atopic disorders, such as allergic rhinitis and asthma. The...

Insights Into Atopic Dermatitis – From Pathogenesis to Therapy

Data publikacji: 14 maj 2023

Zakres stron: 73 - 80

Otrzymano: 02 lis 2022

Przyjęty: 28 gru 2022

DOI: https://doi.org/10.2478/amb-2023-0022

Słowa kluczowe
atopic dermatitis, pathogenesis, genetics, environment, skin barrier

© 2023 K. Papadakis et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Insights Into Atopic Dermatitis – From Pathogenesis to Therapy

Data publikacji: 14 maj 2023

Zakres stron: 73 - 80

Otrzymano: 02 lis 2022

Przyjęty: 28 gru 2022

DOI: https://doi.org/10.2478/amb-2023-0022

Słowa kluczoweatopic dermatitis, pathogenesis, genetics, environment, skin barrier

© 2023 K. Papadakis et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Słowa kluczowe
atopic dermatitis, pathogenesis, genetics, environment, skin barrier