<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Objective</h3><p>The study was performed to evaluate the novel potential of red rose extract to inhibit SARS-CoV-2 spike protein-Ace2 receptor interaction in vitro.</p></sec>
<sec><h3>Methods</h3><p>ACE2 receptors were His-labelled, and the interaction was studied by chemiluminescence after the addition of anti-His HRP and HRP substrate. The inhibition of SARS-CoV-2 and ACE2 was assessed in a dose-dependent sequence.</p></sec>
<sec><h3>Results</h3><p>The 50% inhibitory concentration was observed at 0.75 percent v/v of the rose extract, and the 90% inhibition was seen at about 1.8 percent v/v. Steam inhalation or nebulization could be simple methods of delivering rose extracts to the lower respiratory tract and pulmonary tissues.</p></sec>
<sec><h3>Conclusion</h3><p>Rose extracts have a potential for inhibition of SARS-CoV-2 and ACE2 receptor in vitro, which could add beneficial effects in Covid-19 treatment. Further tests need to be performed to study their therapeutic benefits in vivo.</p></sec>
</abstract>

ObjectiveThe study was performed to evaluate the novel potential of red rose extract to inhibit SARS-CoV-2 spike protein-Ace2 receptor interaction in vitro.
MethodsACE2 receptors were His-labelled, and the interaction was studied by chemiluminescence after the addition of anti-His HRP and HRP substrate. The inhibition of SARS-CoV-2 and ACE2 was assessed in a dose-dependent sequence.
ResultsThe 50% inhibitory concentration was observed at 0.75 percent v/v of the rose extract, and the 90% inhibition was seen at about 1.8 percent v/v. Steam inhalation or nebulization could be simple methods of delivering rose extracts to the lower respiratory tract and pulmonary tissues.
ConclusionRose extracts have a potential for inhibition of SARS-CoV-2 and ACE2 receptor in vitro, which could add beneficial effects in Covid-19 treatment. Further tests need to be performed to study their therapeutic benefits in vivo.

Rose Exctracts and In-Vitro Inhibition of SARS-CoV-2 Spike: The Ace-2 Interaction

Acta Medica Bulgarica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

ObjectiveThe study was performed to evaluate the novel potential of red rose extract to inhibit SARS-CoV-2 spike protein-Ace2 receptor interaction in...

Rose Exctracts and In-Vitro Inhibition of SARS-CoV-2 Spike: The Ace-2 Interaction

Article Category: Original Articles

Data publikacji: 11 sie 2021

Zakres stron: 41 - 44

Otrzymano: 23 wrz 2020

Przyjęty: 21 lis 2020

DOI: https://doi.org/10.2478/amb-2021-0022

Słowa kluczowe
SARS-Cov-2 Spike protein: ACE2 inhibition, Rose extract, Covid-19

© 2021 M. Arokiaraj et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Rose Exctracts and In-Vitro Inhibition of SARS-CoV-2 Spike: The Ace-2 Interaction

Article Category: Original Articles

Data publikacji: 11 sie 2021

Zakres stron: 41 - 44

Otrzymano: 23 wrz 2020

Przyjęty: 21 lis 2020

DOI: https://doi.org/10.2478/amb-2021-0022

Słowa kluczoweSARS-Cov-2 Spike protein: ACE2 inhibition, Rose extract, Covid-19

© 2021 M. Arokiaraj et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Słowa kluczowe
SARS-Cov-2 Spike protein: ACE2 inhibition, Rose extract, Covid-19