Otwarty dostęp

Environmental exposure to glyphosate does not inhibit human acetylcholinesterase and butyrylcholinesterase

Dora Kolić

Dora Kolić

Institute for Medical Research and Occupational Health, Division of ToxicologyZagreb, Croatia
Wyszukaj tego autora
Sciendo|Google Scholar
Kolić, Dora
, 
Vesna Pehar

Vesna Pehar

Dr Franjo Tuđman Croatian Defence AcademyZagreb, Croatia
Wyszukaj tego autora
Sciendo|Google Scholar
Pehar, Vesna
 oraz 
Zrinka Kovarik

Zrinka Kovarik

  • Institute for Medical Research and Occupational Health, Division of ToxicologyZagreb, Croatia
  • University of Zagreb Faculty of ScienceZagreb, Croatia
Profil Orcid
Wyszukaj tego autora
Sciendo|Google Scholar
Kovarik, Zrinka
  
29 mar 2024
Environmental exposure to glyphosate does not inhibit human acetylcholinesterase and butyrylcholinesterase's Cover Image
O artykule
Poprzedni artykuł
Następny artykuł
Zacytuj
Pobierz okładkę
Kategoria artykułu: Original article
Data publikacji: 29 mar 2024
Zakres stron: 76 - 80
Otrzymano: 01 sty 2024
Przyjęty: 01 mar 2024
DOI: https://doi.org/10.2478/aiht-2024-75-3822
Słowa kluczowe
© 2024 Dora Kolić et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

Figure 1

Chemical structure of glyphosate
Chemical structure of glyphosate

Figure 2

Glyphosate inhibition profiles for human AChE and BChE shown as the dissociation constant of the enzyme-inhibitor complex (Ki, upper panels) and IC50 values (lower panels) determined in the presence of substrate acetylthiocholine (ATCh) over a range of glyphosate concentrations (c). The same dataset was used to determine both kinetic profiles. Inhibition was evaluated from four experiments measured at 25 °C
Glyphosate inhibition profiles for human AChE and BChE shown as the dissociation constant of the enzyme-inhibitor complex (Ki, upper panels) and IC50 values (lower panels) determined in the presence of substrate acetylthiocholine (ATCh) over a range of glyphosate concentrations (c). The same dataset was used to determine both kinetic profiles. Inhibition was evaluated from four experiments measured at 25 °C

Dissociation constants (Ki) of glyphosate for human AChE and BChE and approximated IC50 values

Enzyme Ki (mmol/L) Approx. IC50 (mmol/L)
AChE 28.4±2.7 25.1
BChE 19.3±1.8 20.0
Języki:
Angielski, Croatian, Slovenian
Częstotliwość wydawania:
4 razy w roku
Dziedziny czasopisma:
Medycyna, Podstawowe nauki medyczne, Podstawowe nauki medyczne, inne
Kanał RSS czasopisma