Can colistin susceptibility results determined in multidrug resistant Gram-negative bacteria be used for polymyxin B?
, , , , oraz | 14 lis 2023
Article Category: Original Study
Data publikacji: 14 lis 2023
Zakres stron: 125 - 132
Otrzymano: 31 sty 2023
Przyjęty: 17 sie 2023
DOI: https://doi.org/10.2478/ahem-2023-0017
Słowa kluczowe
© 2023 Rıza Adaleti et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Introduction
The present study aimed to compare the MIC values of colistin and polymyxin B in fermentative and non-fermentative Gram-negative bacteria and to examine whether the susceptibility results determined with colistin can be used for polymyxin B.
Materials and Methods
A total of 268 strains of
Results
Of the 268 strains, 40.7% were found to be colistin resistant and 34% polymyxin B resistant. Essential agreement (EA) and categorical agreement (CA) ratios for all isolates were found to be 81.3% and 85.1%, respectively. Identical MIC values were found for colistin and polymyxin B in 104 isolates (38.8%), and this rate was 31.1% and 48.7% in Enterobacterales and non-fermentative bacteria, respectively. Colistin resistance rates were 25.4% for
Conclusion
According to the results of the study, it was concluded that the MIC values of colistin and polymyxin B antibiotics in all bacteria were not compatible with each other. Colistin susceptibility results cannot be used for treatment with polymyxin B, despite CLSI's recommendation.