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Investigation of antimicrobial susceptibility, class I, II, and III integrons among clinical isolates of Pseudomonas aeruginosa from hospitalized burn patients in Southern Iran

Rezvan Mirzaei

Rezvan Mirzaei

Department of Microbiology, Falavarjan Branch, Islamic Azad UniversityIsfahan, Iran
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Mirzaei, Rezvan
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Fereshte Ghandehari

Fereshte Ghandehari

Department of Microbiology, Falavarjan Branch, Islamic Azad UniversityIsfahan, Iran
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Ghandehari, Fereshte
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Nazanin Delroshan

Nazanin Delroshan

Department of Microbiology, Falavarjan Branch, Islamic Azad UniversityIsfahan, Iran
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Delroshan, Nazanin
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Laleh Hoveida

Laleh Hoveida

Department of Microbiology, Falavarjan Branch, Islamic Azad UniversityIsfahan, Iran
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Hoveida, Laleh
  
14 mar 2024
Investigation of antimicrobial susceptibility, class I, II, and III integrons among clinical isolates of Pseudomonas aeruginosa from hospitalized burn patients in Southern Iran's Cover Image
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Kategoria artykułu: Original Study
Data publikacji: 14 mar 2024
Zakres stron: 170 - 175
Otrzymano: 10 kwi 2022
Przyjęty: 31 mar 2023
DOI: https://doi.org/10.2478/ahem-2023-0011
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© 2023 Rezvan Mirzaei et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Introduction

Burn infection due to Pseudomonas aeruginosa poses a considerable challenge in terms of graft loss, systemic sepsis, prolonged hospital stays, and even enhanced mortality. The aim of this study was to consider the susceptibility pattern to antibiotics and occurrence of class I, II, and III integrons in P. aeruginosa isolated from hospitalized burn patients.

Materials and Methods

A cross-sectional study was performed on 70 P. aeruginosa isolates obtained from blood, wounds, biopsy, and sputum samples from burn patients between January 2020 and March 2021 from different wards of a teaching hospital in Ahvaz, Iran.

Results

Antimicrobial susceptibility pattern was performed using the disk diffusion method. Also, PCR was carried out for the detection of intI1, intI2 and intI3 genes. Among the 70 P. aeruginosa isolates, 34 (48.6%) isolates were obtained from females and 36 (51.4%) isolates from males. PCR amplification revealed that 51.4% isolates (36/70) had intI1, 30% isolates (21/70) had intI2, and 12.9% isolates (9/70) had both genes. However, the intI3 gene was not detected in any isolates. Furthermore, there is no important association between resistance to antibiotics and the presence of intI genes.

Conclusion

According to our results, there were no statistically significant differences among resistance to antibiotics and the presence of intI and intI1 genes. However, the surveillance of patterns of antibiotic resistance and investigation into the role of integrons in controlling the scattering of antibiotic-resistant genes are recommended.
Język:
Angielski
Częstotliwość wydawania:
1 razy w roku
Dziedziny czasopisma:
Nauki biologiczne, Biologia molekularna, Mikrobiologia i wirusologia, Medycyna, Podstawowe nauki medyczne, Immunologia
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