Otwarty dostęp

Scoulerine promotes cytotoxicity and attenuates stemness in ovarian cancer by targeting PI3K/AKT/mTOR axis


Zacytuj

Y. Zhang, G. Luo, M. Li, P. Guo, Y. Xiao, H. Ji and Y. Hao, Global patterns and trends in ovarian cancer incidence: age, period and birth cohort analysis, BMC Cancer 19(1) (2019) Article ID 984 (14 pages); https://doi.org/10.1186/s12885-019-6139-6Search in Google Scholar

B. M. Reid, J. B. Permuth and T. A. Sellers, Epidemiology of ovarian cancer: a review, Cancer Biol. Med. 14(1) (2017) 9–32; https://doi.org/10.20892/j.issn.2095-3941.2016.0084Search in Google Scholar

M. A. Amaya Padilla, M. Binju, G. Wan, Y. S. Rahmanto, P. Kaur and Y. Yu, Relationship between ovarian cancer stem cells, epithelial mesenchymal transition and tumour recurrence, Cancer Drug Resist. 2(4) (2019) 1127–1135; https://doi.org/10.20517/cdr.2019.76Search in Google Scholar

K. Ushijima, Treatment for recurrent ovarian cancer at first relapse, J. Oncol. 2010 (2010) 1–7; https://doi.org/10.1155/2010/497429Search in Google Scholar

H. Acloque, M. S. Adams, K. Fishwick, M. Bronner-Fraser and M. A. Nieto, Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease, J. Clin. Invest. 119(6) (2009) 1438–1449; https://doi.org/10.1172/JCI38019Search in Google Scholar

F. Guo, B. C. Parker Kerrigan, D. Yang, L. Hu, I. Shmulevich, A. K. Sood, F. Xue and W. Zhang, Post-transcriptional regulatory network of epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions, J. Hematol. Oncol. 7 (2014) Article ID 19 (11 pages); https://doi.org/10.1186/1756-8722-7-19Search in Google Scholar

M. Zeisbergand, E. G. Neilson, Biomarkers for epithelial-mesenchymal transitions, J. Clin. Invest. 119(6) (2009) 1429–1437; https://doi.org/10.1172/JCI36183Search in Google Scholar

M. Scimeca, C. Antonacci, D. Colombo, R. Bonfiglio, O. C. Buonomo and E. Bonanno, Emerging prognostic markers related to mesenchymal characteristics of poorly differentiated breast cancers, Tumour Biol. 37(4) (2016) 5427–5435; https://doi.org/10.1007/s13277-015-4361-7Search in Google Scholar

K. D. Steffensen, A. B. Alvero, Y. Yang, M. Waldstrom, P. Hui, J. C. Holmberg, D. A. Silasi, A. Jakobsen, T. Rutherford and G. Mor, Prevalence of epithelial ovarian cancer stem cells correlates with recurrence in early-stage ovarian cancer, J. Oncol. 2011 (2011) Article ID 620523 (13 pages); https://doi.org/10.1155/2011/620523Search in Google Scholar

Z. Pieterse, M. A. Amaya-Padilla, T. Singomat, M. Binju, B. D. Madjid, Y. Yu and P. Kaur, Ovarian cancer stem cells and their role in drug resistance, Int. J. Biochem. Cell Biol. 106 (2019) 117–126; https://doi.org/10.1016/j.biocel.2018.11.012Search in Google Scholar

P. Liu, H. Cheng, T. M. Roberts and J. J. Zhao, Targeting the phosphoinositide 3-kinase pathway in cancer, Nat. Rev. Drug Discov. 8 (2009) 627–44; https://doi.org/10.1038/nrd2926Search in Google Scholar

C. Gewinner, Z. C. Wang, A. Richardson, J. Teruya-Feldstein, D. Etemadmoghadam, D. Bowtell, J. Barretina, W. M. Lin, L. Rameh, L. Salmena, P. P. Pandolfi and L. C. Cantley, Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling, Cancer Cell 16(2) (2009) 115–125; https://doi.org/10.1016/j.ccr.2009.06.006Search in Google Scholar

X. Tan, S. Chen, J. Wu, J. Lin, C. Pan, X. Ying, Z. Pan, L. Qiu, R. Liu, R. Geng and W. Huang, PI3K/AKT-mediated upregulation of WDR5 promotes colorectal cancer metastasis by directly targeting ZNF407, Cell Death Dis. 8(3) (2017) Article ID e2686 (12 pages); https://doi.org/10.1038/cddis.2017.111Search in Google Scholar

S. D. Westfalland, M. K. Skinner, Inhibition of phosphatidylinositol 3-kinase sensitizes ovarian cancer cells to carboplatin and allows adjunct chemotherapy treatment, Mol. Cancer Ther. 4(11) (2005) 1764–177; https://doi.org/10.1158/1535-7163.mct-05-0192Search in Google Scholar

H. J. Choi, J. H. Heo, J. Y. Park, J. Y. Jeong, H. J. Cho, K. S. Park, S. H. Kim, Y. W. Moon, J. S. Kim and H. J. An, A novel PI3K/mTOR dual inhibitor, CMG002, overcomes the chemoresistance in ovarian cancer, Gynecol. Oncol. 153(1) (2019) 135–148; https://doi.org/10.1016/j.ygyno.2019.01.012Search in Google Scholar

D. K. Armstrong, B. Bundy, L. Wenzel, H. Q. Huang, R. Baergen, S. Lele, L. J. Copeland, J. L. Walker and R. A. Burger, Intraperitoneal cisplatin and paclitaxel in ovarian cancer, N. Engl. J. Med. 354(1) (2006) 34–43; https://doi.org/10.1056/NEJMoa052985Search in Google Scholar

M. Cristea, E. Han, L. Salmon and R. J. Morgan, Review: Practical considerations in ovarian cancer chemotherapy, Ther. Adv. Med. Oncol. 2(3) (2010) 175–187; https://doi.org/10.1177/1758834010361333Search in Google Scholar

D. Jelovac and D. K. Armstrong, Recent progress in the diagnosis and treatment of ovarian cancer, CA Cancer J. Clin. 61(3) (2011) 183–203; https://doi.org/10.3322/caac.20113Search in Google Scholar

D. Cella, A. Peterman, S. Hudgens, K. Webster and M. A. Socinski, Measuring the side effects of taxane therapy in oncology: the functional assesment of cancer therapy-taxane (FACT-taxane), Cancer 98(4) (2003) 822–831; https://doi.org/10.1002/cncr.11578Search in Google Scholar

F. Steger, M. G. Hautmann and O. Kolbl, 5-FU-induced cardiac toxicity--an underestimated problem in radiooncology?, Radiat. Oncol. 7 (2012) Article ID 212 (4 pages); https://doi.org/10.1186/1748-717X-7-212Search in Google Scholar

J. H. Schrittwieser, V. Resch, S. Wallner, W. D. Lienhart, J. H. Sattler, J. Resch, P. Macheroux and W. Kroutil, Biocatalytic organic synthesis of optically pure (S)-scoulerine and berbine and benzylisoquinoline alkaloids, J. Org. Chem. 76(16) (2011) 6703–6714; https://doi.org/10.1021/jo201056fSearch in Google Scholar

K. Habartova, R. Havelek, M. Seifrtova, K. Kralovec, L. Cahlikova, J. Chlebek, E. Cermakova, N. Mazankova, J. Marikova, J. Kunes, L. Novakova and M. Rezacova, Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells, Sci. Rep. 8(1) (2018) Article ID 4829 (14 pages); https://doi.org/10.1038/s41598-018-22862-0Search in Google Scholar

J. Tian, J. Mo, L. Xu, R. Zhang, Y. Qiao, B. Liu, L. Jiang, S. Ma and G. Shi, Scoulerine promotes cell viability reduction and apoptosis by activating ROS-dependent endoplasmic reticulum stress in colorectal cancer cells, Chem. Biol. Interact. 327 (2020) Article ID 109184; https://doi.org/10.1016/j.cbi.2020.109184Search in Google Scholar

J. Roche, The epithelial-to-mesenchymal transition in cancer, Cancers (Basel) 10(2) (2018) Article ID 52 (4 pages); https://doi.org/10.3390/cancers10020052Search in Google Scholar

D. Ribatti, R. Tamma and T. Annese, Epithelial-mesenchymal transition in cancer: A historical overview, Transl. Oncol. 13(6) (2020) Article ID 100773 (9 pages); https://doi.org/10.1016/j.tranon.2020.100773Search in Google Scholar

Z. Yu, T. G. Pestell, M. P. Lisanti and R. G. Pestell, Cancer stem cells, Int. J. Biochem. Cell Biol. 44(2) (2012) 2144–2151; https://doi.org/10.1016/j.biocel.2012.08.022Search in Google Scholar

S. Floor, W. C. van Staveren, D. Larsimont, J. E. Dumont and C. Maenhaut, Cancer cells in epithelial--to-mesenchymal transition and tumor-propagating-cancer stem cells: distinct, overlapping or same populations, Oncogene 30(46) (2011) 4609–4621; https://doi.org/10.1038/onc.2011.184Search in Google Scholar

P. Wangchuk, T. Sastraruji, M. Taweechotipatr, P. A. Keller and S. G. Pyne, Anti-inflammatory, antibacterial and anti-acetylcholinesterase activities of two isoquinoline alkaloids-scoulerine and cheilanthifoline, Nat. Prod. Commun. 11(12) (2016) 1801–1804; https://doi.org/10.1177/1934578X1601101207Search in Google Scholar

P. Wangchuk, P. A. Keller, S. G. Pyne, A. C. Willis and S. Kamchonwongpaisan, Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia, J. Ethnopharmacol. 143(1) (2012) 310–313; https://doi.org/10.1016/j.jep.2012.06.037Search in Google Scholar

X. Cheng, D. Wang, L. Jiang and D. Yang, DNA topoisomerase I inhibitory alkaloids from Corydalis saxicola, Chem. Biodivers. 5(7) (2008) 1335–1344; https://doi.org/10.1002/cbdv.200890121Search in Google Scholar

A. Das, A. Bhattacharya, S. Chakrabarty, A. Ganguli and G. Chakrabarti, Smokeless tobacco extract (STE)-induced toxicity in mammalian cells is mediated by the disruption of cellular microtubule network: a key mechanism of cytotoxicity, PLoS One 8(7) (2013) Article ID e68224 (12 pages); https://doi.org/10.1371/journal.pone.0068224Search in Google Scholar

N. A. Franken, H. M. Rodermond, J. Stap, J. Haveman and C. van Bree, Clonogenic assay of cells in vitro, Nat. Protoc. 1(5) (2006) 2315–2319; https://doi.org/10.1038/nprot.2006.339Search in Google Scholar

J. Pijuan, C. Barcelo, D. F. Moreno, O. Maiques, P. Siso, R. M. Marti, A. Macia and A. Panosa. In vitro cell migration, invasion and adhesion assays: From cell imaging to data analysis, Front. Cell Dev. Biol. 7 (2019) Article ID 107 (16 pages); https://doi.org/10.3389/fcell.2019.00107Search in Google Scholar

I. Haque, A. Ghosh, S. Acup, S. Banerjee, K. Dhar, A. Ray, S. Sarkar, S. Kambhampati and S. K. Banerjee, Leptin-induced ER-alpha-positive breast cancer cell viability and migration is mediated by suppressing CCN5-signaling via activating JAK/AKT/STAT-pathway, BMC Cancer 18(1) (2018) Article ID 99 (14 6Search in Google Scholar

A. Das, S. Chakrabarty, D. Choudhury and G. Chakrabarti, 1,4-Benzoquinone (PBQ) induced toxicity in lung epithelial cells is mediated by the disruption of the microtubule network and activation of caspase-3, Chem. Res. Toxicol. 23(6) (2010) 1054–1066; https://doi.org/10.1021/tx1000442Search in Google Scholar

L. R. Menezes, C. O. Costa, A. C. Rodrigues, F. R. Santo, A. Nepel, L. M. Dutra, F. M. Silva, M. B. Soares, A. Barison, E. V. Costa and D. P. Bezerra, Cytotoxic alkaloids from the stem of Xylopia laevigata, Molecules 21(7) 2016 Article ID 890 (10 pages); https://doi.org/10.3390/molecules21070890Search in Google Scholar

R. Y. Huang, P. Guilford and J. P. Thiery, Early events in cell adhesion and polarity during epithelialmesenchymal transition, J. Cell Sci. 125(Pt 19) (2012) 4417–4422; https://doi.org/10.1242/jcs.099697Search in Google Scholar

H. Xu, Y. Tian, X. Yuan, H. Wu, Q. Liu, R. G. Pestell and K. Wu, The role of CD44 in epithelial-mesenchymal transition and cancer development, Onco Targets Ther. 8 (2015) 3783–3792; https://doi.org/10.2147/OTT.S95470Search in Google Scholar

Z. Zou, T. Tao, H. Li and X. Zhou, mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges, Cell Biosci. 10 (2020) Article ID 31 (11 pages); https://doi.org/10.1186/s13578-020-00396-1Search in Google Scholar

eISSN:
1846-9558
Język:
Angielski
Częstotliwość wydawania:
4 razy w roku
Dziedziny czasopisma:
Pharmacy, other