Optimizing glycerosome formulations via an orthogonal experimental design to enhance transdermal triptolide delivery

1. Y. Fu, Q. Lin and Z. Zhang, Determination of apparent solubility-apparent oil /water partition coefficient and dissociation constant of triptolide and triptolide-glucosamine conjugate, W. China J. Pharm. Sci. 32 (2017) 369–371; https://doi.org/10.13375/j.cnki.wcjps.2017.04.008 (Chinese) Search in Google Scholar

2. X. Song, Y. Zhang and E. Dai, Therapeutic targets of thunder god vine (Tripterygium wilfordii hook) in rheumatoid arthritis (Review), Mol. Med. Rep. 21 (2020) 2303–2310; https://doi.org/10.3892/mmr.2020.1105210.3892/mmr.2020.1105232323812 Search in Google Scholar

3. Z. Yuan, Z. Yuan, M. Hasnat, H. Zhang, P. Liang, L. Sun, Z. Jiang and L. Zhang, A new perspective of triptolide-associated hepatotoxicity: the relevance of NF-κB and NF-κB-mediated cellular FLICE-inhibitory protein, Acta Pharm. Sin. B. 10 (2020) 861–877; https://doi.org/10.1016/j.apsb.2020.02.00910.1016/j.apsb.2020.02.009728015032528833 Search in Google Scholar

4. H. Zhao, Y. Tong, D. Lu and B. Wu, Circadian clock regulates hepatotoxicity of Tripterygium wilfordii through modulation of metabolism, J. Pharm. Pharmacol. (2020); https://doi.org/doi:10.1111/jphp.13299.10.1111/jphp.1329932478421 Search in Google Scholar

5. H. Zeng, X. Zhu, Q. Tian, Y. Yan, L. Zhang, M. Yan, R. Li, X. Li, G. Wang, J. Ma, Y. Su, X. Zhang, L. Ma, Z. Zhang and X. Wu, In vivo antitumor effects of carboxymethyl chitosan-conjugated triptolide after oral administration, Drug Deliv. 27 (2020) 848–854; https://doi.org/10.1080/10717544.2020.177037010.1080/10717544.2020.1770370821644332508161 Search in Google Scholar

6. O. A. Al Hanbali, H. M. S. Khan, M. Sarfraz, M. Arafat, S. Ijaz and A. Hameed, Transdermal patches: Design and current approaches to painless drug delivery, Acta Pharm. 69 (2019) 197–215; https://doi.org/10.2478/acph-2019-001610.2478/acph-2019-001631259729 Search in Google Scholar

7. E. Touitou, Compositions for Applying Active Substances to or Through the Skin, U.S. Pat. 5,540,934 A, 30 Jul 1996. Search in Google Scholar

8. M. L. Manca, M. Zaru, M. Manconi, F. Lai, D. Valenti, C. Sinico and A. M. Fadda, Glycerosomes: a new tool for effective dermal and transdermal drug delivery, Int. J. Pharm. 455 (2013) 66–74; https://doi.org/10.1016/j.ijpharm.2013.07.06010.1016/j.ijpharm.2013.07.06023911913 Search in Google Scholar

9. M. Manconi, G. Petretto, G. D’hallewin, E. Escribano, E. Milia, R. Pinna, A. Palmieri, M. Firoznezhad, J. E. Peris, I. Usach, A. M. Fadda, C. Caddeo and M. L. Manca, Thymus essential oil extraction, characterization and incorporation in phospholipid vesicles for the antioxidant/antibacterial treatment of oral cavity diseases, Colloids Surf. B Biointerfaces. 171 (2018) 115–122; https://doi.org/10.1016/j.colsurfb.2018.07.02110.1016/j.colsurfb.2018.07.02130025373 Search in Google Scholar

10. M. Pleguezuelos-Villa, O. Diez-Sales, M. L. Manca, M. Manconi, A. R. Sauri, E. Escribano-Ferrer and A. Nácher, Mangiferin glycethosomes as a new potential adjuvant for the treatment of psoriasis, Int. J. Pharm. 573 (2020) 118844; https://doi.org/10.1016/j.ijpharm.2019.11884410.1016/j.ijpharm.2019.11884431751638 Search in Google Scholar

11. M. Manconi, M. L. Manca, F. Marongiu, C. Caddeo, I. Castangia, G. L. Petretto, G. Pintore, G. Sarais, G. D’hallewin, M. Zaru, G. Bacchetta and A. M. Fadda, Chemical characterization of Citrus limon var. pompia and incorporation in phospholipid vesicles for skin delivery, Int. J. Pharm. 506 (2016) 449–457; https://doi.org/10.1016/j.ijpharm.2016.04.01410.1016/j.ijpharm.2016.04.01427084291 Search in Google Scholar

12. V. Melis, M. L. Manca, E. Bullita, E. Tamburini, I. Castangia, M. C. Cardia, D. Valenti, A. M. Fadda, J. E. Peris and M. Manconi, Inhalable polymer-glycerosomes as safe and effective carriers for rifampicin delivery to the lungs, Colloids Surf. B Biointerfaces. 143 (2016) 301–308; https://doi.org/10.1016/j.colsurfb.2016.03.04410.1016/j.colsurfb.2016.03.04427022870 Search in Google Scholar

13. H. Liu, M. Shen, D. Zhao, D. Ru, Y. Duan, C. Ding and H. Li, The effect of triptolide-loaded exosomes on the proliferation and apoptosis of human ovarian cancer SKOV3 cells, Biomed. Res. Int. 2019 (2019) 2595801; https://doi.org/10.1155/2019/259580110.1155/2019/2595801655636731240207 Search in Google Scholar

14. X. Niu, D. Zhang, Q. Bian, X. Feng, H. Li, Y. Rao, Y. Shen, F. Geng, A. Yuan, X. Ying and J. Gao, Mechanism investigation of ethosomes transdermal permeation, Int. J. Pharm. 1 (2019) 100027; https://doi.org/10.1016/j.ijpx.2019.10002710.1016/j.ijpx.2019.100027673329131517292 Search in Google Scholar

15. F. J. Leyva-Jiménez, M. L. Manca, M. Manconi, C. Caddeo, J. A. Vázquez, J. Lozano-Sánchez, E. Escribano-Ferrer, D. Arráez-Román and A. Segura-Carretero, Incorporation of lippia citriodora microwave extract into total-green biogelatin-phospholipid vesicles to improve its antioxidant activity, Nanomaterials (Basel). 10 (2020) 765; https://doi.org/10.3390/nano1004076510.3390/nano10040765722174432316238 Search in Google Scholar

16. Y. Suzuki, T. Ogasawara, Y. Tanaka, H. Takeda, T. Sawasaki, M. Mogi, S. Liu and K. Maeyama, Functional G-protein-coupled receptor (GPCR) synthesis: The pharmacological analysis of human histamine H1 receptor (HRH1) synthesized by a wheat germ cell-free protein synthesis system combined with asolectin glycerosomes, Front. Pharmacol. 9 (2018) 38; https://doi.org/10.3389/fphar.2018.0003810.3389/fphar.2018.00038580819529467651 Search in Google Scholar

17. R. Pinna, E. Filigheddu, C. Juliano, A. Palmieri, M. Manconi, G. D’hallewin, G. Petretto, M. Maioli, C. Caddeo, M. L. Manca, G. Solinas, A. Bortone, V. Campanella and E. Milia, Antimicrobial effect of Thymus capitatus and Citrus limon var. pompia as raw extracts and nanovesicles, Pharmaceutics. 11 (2019) 234; https://doi.org/10.3390/pharmaceutics1105023410.3390/pharmaceutics11050234657259531091818 Search in Google Scholar

18. M. Manconi, M. L. Manca, C. Caddeo, G. Sarais, A. Palmieri, G. D’Hallewin and A. M. Fadda, Citrus limon extract loaded in vesicular systems for the protection of oral cavity, Medicines (Basel) 5 (2018) 108; https://doi.org/10.3390/medicines504010810.3390/medicines5040108631344230322189 Search in Google Scholar

19. M. Allaw, M. Manconi, M. Aroffu, F. Marongiu, M. Porceddu, G. Bacchetta, I. Usach, R. A. Rached, H. N. Rajha, R. G. Maroun, J. L. Pedraz, T. B. Lopez-Mendez, A. M. Fadda and M. L. Manca, Extraction, characterization and incorporation of Hypericum scruglii extract in ad hoc formulated phospholipid vesicles designed for the treatment of skin diseases connected with oxidative stress, Pharmaceutics 12 (2020) 1010; https://doi.org/10.3390/pharmaceutics1211101010.3390/pharmaceutics12111010769074833113923 Search in Google Scholar

20. M. Manca, J. Peris, V. Melis, D. Valenti, M. Cardia, D. Lattuada, E. Ferrer, A. Faddaa and M. Manconi, Nanoincorporation of curcumin in polymer-glycerosomes and evaluation of their in vitro-in vivo suitability as pulmonary delivery systems, RSC Adv. 127 (2015) 105149–105159; https://doi.org/10.1039/C5RA24032H10.1039/C5RA24032H Search in Google Scholar

21. C. Caddeo, M. L. Manca, M. Matos, G. Gutierrez, O. Díez-Sales, J. E. Peris, I. Usach, X. Fernàndez-Busquets, A. M. Fadda and M. Manconi, Functional response of novel bioprotective poloxamer-structured vesicles on inflamed skin, Nanomedicine 13 (2017) 1127–1136; https://doi.org/10.1016/j.nano.2016.12.01710.1016/j.nano.2016.12.01728064008 Search in Google Scholar

22. G. Poovi and N. Damodharan, Development of tamoxifen-loaded surface-modified nanostructured lipid carrier using experimental design: in vitro and ex vivo characterization, IET Nanobiotechnol. 14 (2020) 261–274; https://doi.org/10.1049/iet-nbt.2019.027610.1049/iet-nbt.2019.0276867662332463016 Search in Google Scholar

23. Y. T. Zhang, Y. M. Xu, S. J. Zhang, J. H. Zhao, Z. Wang, D. Q. Xu and N. P. Feng, In vivo micro-dialysis for the evaluation of transfersomes as a novel transdermal delivery vehicle for cinnamic acid, Drug Dev. Ind. Pharm. 40 (2014) 301–307; https://doi.org/10.3109/03639045.2012.75688810.3109/03639045.2012.756888 Search in Google Scholar

24. H. F. Salem, R. M. Kharshoum, O. M. Sayed and L. F. Abdel Hakim, Formulation design and optimization of novel soft glycerosomes for enhanced topical delivery of celecoxib and cupferron by Box-Behnken statistical design, Drug Dev. Ind. Pharm. 44 (2018) 1871–1884; https://doi.org/10.1080/03639045.2018.150496310.1080/03639045.2018.1504963 Search in Google Scholar

25. I. A. Naguib, E. A. Abdelaleem, E. S. Hassan, N. W. Ali and M. Gamal, Partial least squares and linear support vector regression chemometric models for analysis of norfloxacin and tinidazole with tinidazole impurity, Spectrochim. Acta A Mol. Biomol. Spectrosc. 239 (2020) 118513; https://doi.org/10.1016/j.saa.2020.11851310.1016/j.saa.2020.118513 Search in Google Scholar

26. M. L. Manca, C. Cencetti, P. Matricardi, I. Castangia, M. Zaru, O. D. Sales, A. Nacher, D. Valenti, A. M. Maccioni, A. M. Fadda and M. Manconi, Glycerosomes: Use of hydrogenated soy phosphatidylcholine mixture and its effect on vesicle features and diclofenac skin penetration, Int. J. Pharm. 511 (2016) 198–204; https://doi.org/10.1016/j.ijpharm.2016.07.00910.1016/j.ijpharm.2016.07.009 Search in Google Scholar

27. E. Touitou, Compositions for Applying Active Substances to or Through the Skin, U.S. Pat. 5,716,638, 10 Feb 1998. Search in Google Scholar

28. M. M. Abdellatif, I. A. Khalil and M. A. F. Khalil, Sertaconazole nitrate loaded nanovesicular systems for targeting skin fungal infection: In-vitro, ex-vivo and in-vivo evaluation, Int. J. Pharm. 527 (2017) 1–11; https://doi.org/10.1016/j.ijpharm.2017.05.02910.1016/j.ijpharm.2017.05.029 Search in Google Scholar

29. B. Godin and E. Touitou, Ethosomes: new prospects in transdermal delivery, Crit. Rev. Ther. Drug Carrier Syst. 20 (2003) 63–102; https://doi.org/10.1615/critrevtherdrugcarriersyst.v20.i1.2010.1615/CritRevTherDrugCarrierSyst.v20.i1.20 Search in Google Scholar

30. J. Vitonyte, M. L. Manca, C. Caddeo, D. Valenti, J. E. Peris, I. Usach, A. Nacher, M. Matos, G. Gutiérrez, G. Orrù, X. Fernàndez-Busquets, A. M. Fadda and M. Manconi, Bifunctional viscous nanovesicles co-loaded with resveratrol and gallic acid for skin protection against microbial and oxidative injuries, Eur. J. Pharm. Biopharm. 114 (2017) 278–287; https://doi.org/10.1016/j.ejpb.2017.02.00410.1016/j.ejpb.2017.02.004 Search in Google Scholar

31. M. J. Naguib, S. Salah, S. A. Abdel Halim and S. M. Badr-Eldin, Investigating the potential of utilizing glycerosomes as a novel vesicular platform for enhancing intranasal delivery of lacidipine, Int. J. Pharm. 582 (2020) 119302; https://doi.org/10.1016/j.ijpharm.2020.11930210.1016/j.ijpharm.2020.119302 Search in Google Scholar

32. K. Zhang, Y. Zhang, Z. Li, N. Li and N. Feng, Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization and evaluation in vitro and in vivo, Int. J. Nanomedicine. 12 (2017) 3521–3532; https://doi.org/10.2147/IJN.S13574910.2147/IJN.S135749 Search in Google Scholar

33. P. Westh, Unilamellar DMPC vesicles in aqueous glycerol: preferential interactions and thermo-chemistry, Biophys. J. 84 (2003) 341–349; https://doi.org/10.1016/S0006-3495(03)74854-110.1016/S0006-3495(03)74854-1 Search in Google Scholar

34. M. L. Manca, I. Castangia, C. Caddeo, D. Pando, E. Escribano, D. Valenti, S. Lampis, M. Zaru, A. M. Fadda and M. Manconi, Improvement of quercetin protective effect against oxidative stress skin damages by incorporation in nanovesicles, Colloids Surf. B Biointerfaces 123 (2014) 566–574; https://doi.org/10.1016/j.colsurfb.2014.09.05910.1016/j.colsurfb.2014.09.05925444664 Search in Google Scholar

35. T. Moolakkadath, M. Aqil, A. Ahad, S. S. Imam, A. Praveen, Y. Sultana and M. Mujeeb, Preparation and optimization of fisetin loaded glycerol based soft nanovesicles by Box-Behnken design, Int. J. Pharm. 578 (2020) 119125; https://doi.org/10.1016/j.ijpharm.2020.11912510.1016/j.ijpharm.2020.11912532036010 Search in Google Scholar

36. M. L. Manca, M. Manconi, M. Zaru, D. Valenti, J. E. Peris, P. Matricardi, A. M. Maccioni and A. M. Fadda, Glycerosomes: Investigation of role of 1,2-dimyristoyl-sn-glycero-3-phosphatidycholine (DMPC) on the assembling and skin delivery performances, Int. J. Pharm. 532 (2017) 401–407; https://doi.org/10.1016/j.ijpharm.2017.09.02610.1016/j.ijpharm.2017.09.02628917990 Search in Google Scholar