Neuroprotective effects of arbutin against oxygen and glucose deprivation-induced oxidative stress and neuroinflammation in rat cortical neurons

1. Z. Yang, C. Weian, H. Susu and W. Hanmin, Protective effects of mangiferin on cerebral ischemiareperfusion injury and its mechanisms, Eur. J. Pharmacol. 771 (2015) 145–151; https://doi.org/10.1016/j.ejphar.2015.12.00310.1016/j.ejphar.2015.12.00326656757 Search in Google Scholar

2. R. H. Lee, M. H. Lee, C. Y. Wu, A. Couto e Silva, H. E. Possoit, T. H. Hsieh, A. Minagar and H. W. Lin, Cerebral ischemia and neuroregeneration, Neural Regen. Res. 13 (2018) 373–385; https://doi.org/10.4103/1673-5374.22871110.4103/1673-5374.228711590049029623912 Search in Google Scholar

3. W. Li and S. Yang, Targeting oxidative stress for the treatment of ischemic stroke: Upstream and downstream therapeutic strategies, Brain Circ. 2 (2016) 153–163; https://doi.org/10.4103/2394-8108.19527910.4103/2394-8108.195279612622430276293 Search in Google Scholar

4. R. L. Jayaraj, S. Azimullah, R. Beiram, F. Y. Jalal and G. A. Rosenberg, Neuroinflammation: friend and foe for ischemic stroke, J. Neuroinflammation 16 (2019) Article ID 142 (24 pages); https://doi.org/10.1186/s12974-019-1516-210.1186/s12974-019-1516-2661768431291966 Search in Google Scholar

5. D. Lin, L. Wang, S. Yan, Q. Zhang, J. H. Zhang and A. Shao, The role of oxidative stress in common risk factors and mechanisms of cardio-cerebrovascular ischemia and depression, Oxid. Med. Cell. Longev. 2019 (2019) Article ID 2491927 (13 pages); https://doi.org/10.1155/2019/249192710.1155/2019/2491927704448032148646 Search in Google Scholar

6. O. A. Harari and J. K. Liao, NF-κB and innate immunity in ischemic stroke, Ann. N. Y. Acad. Sci. 1207 (2010) 32–40; https://doi.org/10.1111/j.1749-6632.2010.05735.x10.1111/j.1749-6632.2010.05735.x380709720955423 Search in Google Scholar

7. M. Kawabori and M. A. Yenari, Inflammatory responses in brain ischemia, Curr. Med. Chem. 22 (2015) 1258–1277; https://doi.org/10.2174/092986732266615020915403610.2174/0929867322666150209154036556803925666795 Search in Google Scholar

8. T. Shichita, M. Ito and A. Yoshimura, Post-ischemic inflammation regulates neural damage and protection, Front. Cell. Neurosci. 8 (2014) Article ID 319 (8 pages); https://doi.org/10.3389/fncel.2014.0031910.3389/fncel.2014.00319419654725352781 Search in Google Scholar

9. C. Pop, L. Vlase and M. Tamas, Natural resources containing arbutin. Determination of arbutin in the leaves of Bergenia crassifolia (L.) Fritsch. acclimated in Romania, Not. Bot. Hortic. Agrobot. Cluj-Napoca 37 (2009) 129–132; https://doi.org/10.15835/nbha3713108 Search in Google Scholar

10. F. Yousefi, S. Mahjoub, M. Pouramir and F. Khadir, Hypoglycemic activity of Pyrus biossieriana Buhse leaf extract and arbutin: Inhibitory effects on alpha amylase and alpha glucosidase, Casp. J. Int. Med. 4 (2013) 763–767. Search in Google Scholar

11. F. Khadir, M. Pouramir, S. G. Joorsaraee, F. Feizi, H. Sorkhi and F. Yousefi, The effect of arbutin on lipid peroxidation and antioxidant capacity in the serum of cyclosporine-treated rats, Casp. J. Int. Med. 6 (2015) 196–200. Search in Google Scholar

12. M. E. Shahaboddin, M. Pouramir, A. A. Moghadamnia, H. Parsian, M. Lakzaei and H.Mir, Pyrus biossieriana Buhse leaf extract: An antioxidant, antihyperglycaemic and antihyperlipidemic agent, Food Chem. 126 (2011) 1730–1733; https://doi.org/10.1016/j.foodchem.2010.12.06910.1016/j.foodchem.2010.12.06925213951 Search in Google Scholar

13. B. E. Myagmar, E. Shinno, T. Ichiba and Y. Aniya, Antioxidant activity of medicinal herb Rhodococcum vitis-idaea on galactosamine-induced liver injury in rats, Phytomedicine 11 (2004) 416–423; https://doi.org/10.1016/j.phymed.2003.04.00310.1016/j.phymed.2003.04.00315330497 Search in Google Scholar

14. S. R. Ahmadian, M. Ghasemi-Kasman, M. Pouramir and F. Sadeghi, Arbutin attenuates cognitive impairment and inflammatory response in pentylenetetrazol-induced kindling model of epilepsy, Neuropharmacology 146 (2019) 117–127; https://doi.org/10.1016/j.neuropharm.2018.11.03810.1016/j.neuropharm.2018.11.03830503994 Search in Google Scholar

15. H. J. Lee and K. W. Kim, Anti–inflammatory effects of arbutin in lipopolysaccharide-stimulated BV2 microglial cells, Inflamm. Res. 61 (2012) 817–825; https://doi.org/10.1007/s00011-012-0474-210.1007/s00011-012-0474-222487852 Search in Google Scholar

16. M. Dadgar, M. Pouramir, Z. Dastan, M. Ghasemi-Kasman, M. Ashrafpour, A. A. Moghadamnia, S. Khafri and M. Pourghasem, Arbutin attenuates behavioral impairment and oxidative stress in an animal model of Parkinson’s disease, Avicenna J. Phytomed. 8 (2018) 533–542. Search in Google Scholar

17. Y. Ding, D. Kong, T. Zhou, N.-D. Yang, C. Xin, J. Xu, Q. Wang, H. Zhang, Q. Wu, X. Lu, K. Lim, B. Ma, C. Zhang, L. Li and W. Huang, α-Arbutin protects against Parkinson’s disease-associated mitochondrial dysfunction in vitro and in vivo, Neuromol. Med. 22 (2019) 56–67; https://doi.org/10.1007/s12017-019-08562-610.1007/s12017-019-08562-631401719 Search in Google Scholar

18. Z. Dastan, M. Pouramir, M. Ghasemi-Kasman, Z. Ghasemzadeh, M. Dadgar, M. Gol, M. Ashraf-pour, M. Pourghasem, A. A. Moghadamnia and S. Khafri, Arbutin reduces cognitive deficit and oxidative stress in animal model of Alzheimer’s disease, Int. J. Neurosci. 129 (2019) 1145–1153; https://doi.org/10.1080/00207454.2019.163837610.1080/00207454.2019.163837631251091 Search in Google Scholar

19. J. X. Wu, L. Y. Zhang, Y. L. Chen, S. S. Yu, Y. Zhao and J. Zhao, Curcumin pretreatment and post-treatment both improve the antioxidative ability of neurons with oxygen-glucose deprivation, Neural. Regen. Res. 10 (2015) 481–489; https://doi.org/10.4103/1673-5374.15370010.4103/1673-5374.153700439611425878600 Search in Google Scholar

20. J. Ye and Y. Zhang, Curcumin protects against intracellular amyloid toxicity in rat primary neurons, Int. J. Clin. Exp. Med. 5 (2012) 44–49. Search in Google Scholar

21. L. Wang, L. Zhang, Z. B. Chen, J. Y. Wu, X. Zhang and Y. Xu, Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1, Eur. J. Pharmacol. 609 (2009) 40–44; https://doi.org/10.1016/j.ejphar.2009.03.03310.1016/j.ejphar.2009.03.03319303870 Search in Google Scholar

22. J. Xiang, Y. P. Tang, Z. Y. Zhou, P. Wu, Z. Wang, M. Mori and D. F. Cai, Apocynum venetum leaf extract protects rat cortical neurons from injury induced by oxygen and glucose deprivation in vitro, Can. J. Physiol. Pharmacol. 88 (2010) 907–917; https://doi.org/10.1139/y10-06910.1139/Y10-069 Search in Google Scholar

23. W. Zhao, S. Wang, T. Qin and W. Wang, Arbutin attenuates hydrogen peroxide-induced oxidative injury through regulation of microRNA-29a in retinal ganglion cells, Biomed. Pharmacother. 112 (2019) Article ID 108729; https://doi.org/10.1016/j.biopha.2019.10872910.1016/j.biopha.2019.10872930970524 Search in Google Scholar

24. D. Gao, T. Huang, X. Jiang, S. Hu, L. Zhang and Z. Fei, Resveratrol protects primary cortical neuron cultures from transient oxygen-glucose deprivation by inhibiting MMP-9, Mol. Med. Rep. 9 (2014) 2197–2204; https://doi.org/10.3892/mmr.2014.208610.3892/mmr.2014.208624682241 Search in Google Scholar

25. J. Wu, Q. Li, X. Wang, S. Yu, L. Li, X. Wu, Y. Chen, J. Zhao and Y. Zhao, Neuroprotection by curcumin in ischemic brain injury involves the Akt/Nrf2 pathway, PLoS ONE 8 (2013) e59843 (9 pages); https://doi.org/10.1371/journal.pone.005984310.1371/journal.pone.0059843361087923555802 Search in Google Scholar

26. R. AlJohri, M. AlOkail and S. H. Haq, Neuroprotective role of vitamin D in primary neuronal cortical culture, eNeurologicalSci 14 (2018) 43–48; https://doi.org/10.1016/j.ensci.2018.12.00410.1016/j.ensci.2018.12.004631286030619951 Search in Google Scholar

27. J. Chen-Roetling, L. Chen and R. F. Regan, Minocycline attenuates iron neurotoxicity in cortical cell cultures, Biochem. Biophys. Res. Commun. 386 (2009) 322–326; https://doi.org/10.1016/j.bbrc.2009.06.02610.1016/j.bbrc.2009.06.026278294419523448 Search in Google Scholar

28. P. B. Godkar, R. K. Gordon, A. Ravindran and B. P. Doctor, Celastrus paniculatus seed oil and organic extracts attenuate hydrogen peroxide- and glutamate-induced injury in embryonic rat fore-brain neuronal cells, Phytomedicine 13 (2006) 29–36; https://doi.org/10.1016/j.phymed.2003.11.01110.1016/j.phymed.2003.11.01116360930 Search in Google Scholar

29. M. G. Ryou and R. T. Mallet, An in vitro oxygen-glucose deprivation model for studying ischemiareperfusion injury of neuronal cells, Methods Mol. Biol. 1717 (2018) 229–235; https://doi.org/10.1007/978-1-4939-7526-6_1810.1007/978-1-4939-7526-6_1829468596 Search in Google Scholar

30. T. S. Anthonymuthu, E. M. Kenny and H. Bayır, Therapies targeting lipid peroxidation in traumatic brain injury, Brain Res. 1640 (2016) 57–76; https://doi.org/10.1016/j.brainres.2016.02.00610.1016/j.brainres.2016.02.006487011926872597 Search in Google Scholar

31. A. Nurmi, P. J. Lindsberg, M. Koistinaho, W. Zhang, E. Juettler, M. L. Karjalainen-Lindsberg, F. Weih, N. Frank, M. Schwaninger and J. Koistinaho, Nuclear factor-kappaB contributes to infarction after permanent focal ischemia, Stroke 35 (2004) 987–991; https://doi.org/10.1161/01.STR.0000120732.45951.2610.1161/01.STR.0000120732.45951.2614988572 Search in Google Scholar