The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology

1. W. Sneader, Drug Discovery. A History, John Wiley & Sons, Chichester 2005.10.1002/0470015535Search in Google Scholar

2. D. T. Courtwright, Forces of Habit – Drugs and the Making of the Modern World, Harvard University Press, Cambridge (MA) 2002.10.4159/9780674029903Search in Google Scholar

3. M. Hanada, Case Studies in Modern Drug Discovery and Development, John Wiley & Sons, Hoboken (NJ) 2012.Search in Google Scholar

4. D. A. Dias, S. Urban and U. Roessner, A historical overview of natural products in drug discovery, Metabolites2 (2012) 303–336; https://doi.org/10.3390/metabo202030310.3390/metabo2020303390120624957513Search in Google Scholar

5. M. Friedman, Chemistry, nutrition, and health-promoting properties of Hericium erinaceus (Lion’s mane) mushroom fruiting bodies and mycelia and their bioactive compounds, J. Agric. Food Chem. 63 (2015) 7108–7123; https://doi.org/10.1021/acs.jafc.5b0291410.1021/acs.jafc.5b0291426244378Search in Google Scholar

6. X. He, X. Wang, J. Fang, Y. Chang, N. Ning, H. Guo, L. Huang, X. Huang and Z. Zhao, Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion’s mane) mushroom: A review, Int. J. Biol. Macromol. 97 (2017) 228–237; https://doi.org/10.1016/j.ijbiomac.2017.01.04010.1016/j.ijbiomac.2017.01.04028087447Search in Google Scholar

7. G. Wang, X. Zhang, S. E. Maier, L. Zhang and R. J. Maier, In vitro and in vivo inhibition of Helicobacter pylori by ethanolic extracts of Lion’s mane medicinal mushroom, Hericium erinaceus (Agaricomycetes), Int. J. Med. Mushrooms21 (2019) 1–11; https://doi.org/10.1615/IntJMedMush-rooms.201802948710.1615/IntJMedMushrooms.2018029487Search in Google Scholar

8. M. Qin, Y. Geng, Z. Lu, H. Xu, J. S. Shi, X. Xu and Z. H. Xu, Antiinflammatory effects of ethanol extract of Lion’s mane medicinal mushroom, Hericium erinaceus (Agaricomycetes), in mice with ulcerative colitis, Int. J. Med. Mushrooms18 (2016) 227–234; https://doi.org/10.1615/IntJMedMush-rooms.v18.i3.5010.1615/IntJMedMushrooms.v18.i3.50Search in Google Scholar

9. M. Wang, T. Konishi, Y. Gao, D. Xu and Q. Gao, Anti-gastric ulcer activity of polysaccharide fraction isolated from mycelium culture of Lion’s mane medicinal mushroom, Hericium erinaceus (higher Basidiomycetes), Int. J. Med. Mushrooms17 (2015) 1055–1060; https://doi.org/10.1615/intjmedmushrooms.v17.i11.5010.1615/IntJMedMushrooms.v17.i11.50Search in Google Scholar

10. W. Li, W. Zhou, E. J. Kim, S. H. Shim, H. K. Kang and Y. H. Kim, Isolation and identification of aromatic compounds in Lion’s Mane Mushroom and their anticancer activities, Food Chem. 170 (2015) 336–342; https://doi.org/10.1016/j.foodchem.2014.08.07810.1016/j.foodchem.2014.08.07825306354Search in Google Scholar

11. S. P. Kim, M. Y. Kang, Y. H. Choi, J. H. Kim, S. H. Nam and M. Friedman, Mechanism of Hericium erinaceus (yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells, Food Funct.2 (2011) 348–356; https://doi.org/10.1039/c1fo10030k10.1039/c1fo10030k21779573Search in Google Scholar

12. M. Wang, Y. Zhang, X. Xiao, D. Xu, Y. Gao and Q. Gao, A polysaccharide isolated from mycelia of the Lion’s mane medicinal mushroom Hericium erinaceus (Agaricomycetes) induced apoptosis in precancerous human gastric cells, Int. J. Med. Mushrooms19 (2017) 1053–1060; https://doi.org/10.1615/IntJMedMushrooms.201702497510.1615/IntJMedMushrooms.201702497529431066Search in Google Scholar

13. X. Zan, F. Cui, Y. Li, Y. Yang, D. Wu, W. Sun and L. Ping, Hericium erinaceus polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest and apoptosis, Int. J. Biol. Macromol. 76 (2015) 242–253; https://doi.org/10.1016/j.ijbiomac.2015.01.06010.1016/j.ijbiomac.2015.01.06025703932Search in Google Scholar

14. Y. Li, G. Zhang, T. B. Ng and H. Wang, A novel lectin with antiproliferative and HIV-1 reverse transcriptase inhibitory activities from dried fruiting bodies of the monkey head mushroom Hericium erinaceum, J. Biomed. Biotechnol.2010 (2010) Article ID 716515 (9 pages); https://doi.org/10.1155/2010/71651510.1155/2010/716515Search in Google Scholar

15. S. S. Han, C. K. Cho, Y. W. Lee and H. S. Yoo, Antimetastatic and immunomodulating effect of water extracts from various mushrooms, J. Acupunct. Meridian Stud.2 (2009) 218–227; https://doi.org/10.1016/S2005-2901(09)60058-310.1016/S2005-2901(09)60058-3Search in Google Scholar

16. X. Sheng, J. Yan, Y. Meng, Y. Kang, Z Han, G. Tai, Y. Zhou and H. Cheng, Immunomodulatory effects of Hericium erinaceus derived polysaccharides are mediated by intestinal immunology, Food Funct.8 (2017) 1020–1027; https://doi.org/10.1039/c7fo00071e10.1039/C7FO00071E28266682Search in Google Scholar

17. I.-C. Li, L.-Y. Lee, T.-T. Tzeng, W.-P. Chen, Y.-P. Chen, Y.-J. Shiao and C.-C. Chen, Neurohealth properties of Hericium erinaceus mycelia enriched with erinacines, Behav. Neurol.2018 (2018) 5802634 (10 pages); https://doi.org/10.1155/2018/580263410.1155/2018/5802634598723929951133Search in Google Scholar

18. P. Rossi, V. Cesaroni, F. Brandalise, A. Occhinegro, D. Ratto, F. Perrucci, V. Lanaia, C. Girometta, G. Orrù and E. Savino, Dietary supplementation of Lion’s mane medicinal mushroom, Hericium erinaceus (Agaricomycetes), and spatial memory in wild-type mice, Int. J. Med. Mushrooms20 (2018) 485–494; https://doi.org/10.1615/IntJMedMushrooms.201802624110.1615/IntJMedMushrooms.201802624129953363Search in Google Scholar

19. P. S. Liu, S. H. Chueh, C. C. Chen, L. Y. Lee and L. Y. Shiu, Lion’s mane medicinal mushroom, Hericium erinaceus (Agaricomycetes), modulates purinoceptor-coupled calcium signaling and murine nociceptive behavior, Int. J. Med. Mushrooms19 (2017) 499–507; https://doi.org/10.1615/IntJMedMushrooms.v19.i6.2010.1615/IntJMedMushrooms.v19.i6.2029199560Search in Google Scholar

20. C.-C. Zhang, X. Yin, C.-Y. Cao, J. Wei, Q. Zhang and J.-M. Gao, Chemical constituents from Hericium erinaceus and their ability to stimulate NGF-mediated neurite outgrowth on PC12 cells, Bioorg. Med. Chem. Lett.25 (2015) 5078–5082; https://doi.org/10.1016/j.bmcl.2015.10.01610.1016/j.bmcl.2015.10.01626481911Search in Google Scholar

21. K. Mori, S. Inatomi, K. Ouchi, Y. Azumi and T. Tuchida, Improving effects of the mushroom yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial, Phytother. Res.23 (2009) 367–372; https://doi.org/10.1002/ptr.263410.1002/ptr.263418844328Search in Google Scholar

22. M. Nagano, K. Shimizu, R. Kondo, C. Hayashi, D. Sato, K. Kitagawa and K. Ohnuki, Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake, Biomed. Res.31 (2010) 231–237; https://doi.org/10.2220/biomedres.31.23110.2220/biomedres.31.23120834180Search in Google Scholar

23. A. Blagodatski, M. Yatsunskaya, V. Mikhailova, V. Tiasto, A. Kagansky and V. L. Katanaev, Medicinal mushrooms as an attractive new source of natural compounds for future cancer therapy, Oncotarget9 (2018) 29259–29274; https://doi.org/10.18632/oncotarget.2566010.18632/oncotarget.25660604437230018750Search in Google Scholar

24. L. J. Standish, C. A. Wenner, E. S. Sweet, C. Bridge, A. Nelson, M. Martzen, J. Novack and C. Torkelson, Trametes versicolor mushroom immune therapy in breast cancer, J. Soc. Integr. Oncol.6 (2008) 122–128.Search in Google Scholar

25. K. Oba, S. Teramukai, M. Kobayashi, T. Matsui, Y. Kodera and J. Sakamoto, Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curative resections of gastric cancer, Cancer Immunol. Immunother.56 (2007) 905–911; https://doi.org/10.1007/s00262-006-0248-110.1007/s00262-006-0248-117106715Search in Google Scholar

26. J. Sakamoto, S. Morita, K. Oba, T. Matsui, M. Kobayashi, H. Nakazato and Y. Ohashi, Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curatively resected colorectal cancer: a meta-analysis of centrally randomized controlled clinical trials, Cancer Immunol. Immunother. 55 (2006) 404–411; https://doi.org/10.1007/s00262-005-0054-110.1007/s00262-005-0054-116133112Search in Google Scholar

27. K. Sugimachi, K. Inokuchi and H. Matsuura, Hormone conditioned cancer chemotherapy for recurrent breast cancer prolongs survival, Jpn. J. Surg.14 (1984) 217–221.10.1007/BF024695716748393Search in Google Scholar

28. Y. Iino, T. Yokoe, M. Maemura, J. Horiguchi, H. Takei, S. Ohwada and Y. Morishita, Immunochemotherapies versus chemotherapy as adjuvant treatment after curative resection of operable breast cancer, Anticancer Res. 15 (1995) 2907–2911.Search in Google Scholar

29. L. Zhong, P. Yan, W. C. Lam, L. Yao and Z. Bian, Coriolus versicolor and Ganoderma lucidum related natural products as an adjunct therapy for cancers: A systematic review and meta-analysis of randomized controlled trials, Front. Pharmacol. 10 (2019) 703 (14 pages); https://doi.org/10.3389/fphar.2019.0070310.3389/fphar.2019.00703661631031333449Search in Google Scholar

30. H. Lu, Y. Yang, E. Gad, C. Inatsuka, C. A. Wenner, M. L. Disis and L. J. Standish, TLR2 agonist PSK activates human NK cells and enhances the antitumor effect of HER2-targeted monoclonal antibody therapy, Clin. Cancer Res. 17 (2011) 6742–6753; https://doi.org/10.1158/1078-0432.CCR-11-114210.1158/1078-0432.CCR-11-1142320698721918170Search in Google Scholar

31. H. Lu, Y. Yang, E. Gad, C. A. Wenner, A. Chang, E. R. Larson, Y. Dang, M. Martzen, L. J. Standish and M. L. Disis, Polysaccharide krestin is a novel TLR2 agonist that mediates inhibition of tumor growth via stimulation of CD8 T cells and NK cells, Clin. Cancer Res. 17 (2011) 67–76; https://doi.org/10.1158/1078-0432.CCR-10-176310.1158/1078-0432.CCR-10-1763301724121068144Search in Google Scholar

32. K. Quayle, C. Coy, L. Standish and H. Lu, The TLR2 agonist in polysaccharide-K is a structurally distinct lipid which acts synergistically with the protein-bound β-glucan, J. Nat. Med. 69 (2015) 198–208; https://doi.org/10.1007/s11418-014-0879-z10.1007/s11418-014-0879-z25510899Search in Google Scholar

33. Z. Wang, B. Dong, Z. Feng, S. Yu and Y. Bao, A study on immunomodulatory mechanism of polysaccharopeptide mediated by TLR4 signaling pathway, BMC Immunol. 16 (2015) Article ID 34 (9 pages); https://doi.org/10.1186/s12865-015-0100-510.1186/s12865-015-0100-5445099426032186Search in Google Scholar

34. H. Dou, Y. Chang and L. Zhang, Coriolus versicolor polysaccharopeptide as an immunotherapeutic in China, Prog. Mol. Biol. Transl. Sci. 163 (2019) 361–381; https://doi.org/10.1016/bs.pmbts.2019.03.00110.1016/bs.pmbts.2019.03.00131030754Search in Google Scholar

35. Y. Chang, M. Zhang, Y. Jiang, Y. Liu, H. Luo, C. Hao, P. Zeng and L. Zhang, Preclinical and clinical studies of Coriolus versicolor polysaccharopeptide as an immunotherapeutic in China, Discov. Med. 23 (2017) 207–219.Search in Google Scholar

36. F. Hong, R.. Hansen, J. Yan D. Allendorf, J. Baran, G. Ostroff and G. Ross, Beta-glucan functions as an adjuvant for monoclonal antibody immunotherapy by recruiting tumoricidal granulocytes as killer cells, Cancer Res. 63 (2003) 9023–9031; https://cancerres.aacrjournals.org/content/63/24/9023.longSearch in Google Scholar

37. S. Modak, G. Koehne, A. Vickers, R. O’Reilly and N.-K. V. Cheung, Rituximab therapy of lymphoma is enhanced by orally administered (1®3),(1®4)-D-β-glucan, Leuk. Res. 29 (2005) 679–683; https://doi.org/10.1016/j.leukres.2004.10.00810.1016/j.leukres.2004.10.00815863209Search in Google Scholar

38. M. Thomas, P. Sadjadian, J. Kollmeier, J. Lowe, P. Mattson, J. R. Trout, M. Gargano, M. L. Patchen, R. Walsh, M. Beliveau, J. F. Marier, N. Bose, K. Gorden and F. Schneller III, A randomized, open-label, multicenter, phase II study evaluating the efficacy and safety of BTH1677 (1,3-1,6 beta glucan; Imprime PGG) in combination with cetuximab and chemotherapy in patients with advanced non-small cell lung cancer, Invest. New Drugs35 (2017) 345–358; https://doi.org/10.1007/s10637-017-0450-310.1007/s10637-017-0450-3541830728303530Search in Google Scholar

39. N. H. Segal, P. Gada, N. Senzer, M. Gargano, M. Patchen and L. Saltz, A phase II efficacy and safety, open-label, multicenter study of imprime PGG injection in combination with cetuximab in patients with stage IV KRAS-mutant colorectal cancer, Clin. Colorectal Cancer15 (2016) 222–227; https://doi.org/10.1016/j.clcc.2016.02.01310.1016/j.clcc.2016.02.013562151926975418Search in Google Scholar

40. H. Asai, H. Iijima, K. Matsunaga, Y. Oguchi, H. Katsuno and K. Maeda, Protein-bound polysaccharide K augments IL-2 production from murine mesenteric lymph node CD4+ T cells by modulating T cell receptor signaling, Cancer Immunol. Immunother.57 (2008) 1647–1655; https://doi.org/10.1007/s00262-008-0498-110.1007/s00262-008-0498-118343922Search in Google Scholar

41. A. L. Engel, G. C. Sun, E. Gad, L. R. Rastetter, K. Strobe, Y. Yang, Y. Dang, M. L. Disis and H. Lu, Protein-bound polysaccharide activates dendritic cells and enhances OVA-specific T cell response as vaccine adjuvant, Immunobiology218 (2013) 1468–1476; https://doi.org/10.1016/j.imbio.2013.05.00110.1016/j.imbio.2013.05.001378351923735481Search in Google Scholar

42. M. Kato, K. Hirose, M. Hakozaki, M. Ohno, Y. Saito, R. Izutani, J. Noguchi, Y. Hori, S. Okumoto, D. Kuroda, H. Nomura, S. Nishimatsu and H. Ohoyanagi, Induction of gene expression for immunomodulating cytokines in peripheral blood mononuclear cells in response to orally administered PSK, an immunomodulating protein-bound polysaccharide, Cancer Immunol. Immunother.40 (1995) 152–156.10.1007/BF015173467728773Search in Google Scholar

43. C. B. Lau, C. Y. Ho, C. F. Kim, K. N. Leung, K. P. Fung, T. F. Tse, H. H. Chan and M. S. Chow, Cytotoxic activities of Coriolus versicolor (yunzhi) extract on human leukemia and lymphoma cells by induction of apoptosis, Life Sci.75 (2004) 797–808; https://doi.org/10.1016/j.lfs.2004.04.00110.1016/j.lfs.2004.04.00115183073Search in Google Scholar

44. C. Inatsuka, Y. Yang, E. Gad, L. Rastetter, M. L. Disis and H. Lu, Gamma delta T cells are activated by polysaccharide K (PSK) and contribute to the anti-tumor effect of PSK, Cancer Immunol. Immunother.62 (2013) 1335–1345; https://doi.org/10.1007/s00262-013-1436-410.1007/s00262-013-1436-4372762923685781Search in Google Scholar

45. C. J. Torkelson, E. Sweet, M. R. Martzen, M. Sasagawa, C. A. Wenner, J. Gay, A. Putiri and L. J. Standish, Phase 1 clinical trial of Trametes versicolor in women with breast cancer, ISRN Oncol. 2012 (2012) 251632 (7 pages); https://doi.org/10.5402/2012/25163210.5402/2012/251632336947722701186Search in Google Scholar

46. B. K. Sekhon, D. M. Sze, W. K. Chan, K. Fan, G. Q. Li, D. E. Moore and R. H. Roubin, PSP activates monocytes in resting human peripheral blood mononuclear cells: immunomodulatory implications for cancer treatment, Food Chem. 138 (2013) 2201–2209; https://doi.org/10.1016/j.food-chem.2012.11.00910.1016/j.foodchem.2012.11.009Search in Google Scholar

47. C. A. Wenner, M. R. Martzen, H. Lu, M. R. Verneris, H. Wang and J. W. Slaton, Polysaccharide-K augments docetaxel-induced tumor suppression and antitumor immune response in an immunocompetent murine model of human prostate cancer, Int. J. Oncol. 40 (2012) 905–913; https://doi.org/10.3892/ijo.2011.129210.3892/ijo.2011.1292358455522159900Search in Google Scholar

48. Q. Y. Hu, H. Wang, W. M. Shen, X. R. Chen and M. Zou, Promoting effects of polysaccharide of Polysticius versicolor (L) FR. in C57BL/6J mice bearing melanoma B16, Chin. J. Antibiot. 6 (1988) 425–431.Search in Google Scholar

49. S. Xu, Y. H. Song, H. Li and H. B. Cai, Curative effect observation on advanced colorectal cancer by the treatment with PSP combined with XELOX regimen, Acta Univ. Med. Nanjing12 (2008) 1616–1618.Search in Google Scholar

50. H. Fritz, D. A. Kennedy, M. Ishii, D. Fergusson, R. Fernandes, K. Cooley and D. Seely, Polysaccharide K and Coriolus versicolor extracts for lung cancer: A systematic review, Integr. Cancer Ther. 14 (2015) 201–211; https://doi.org/10.1177/153473541557288310.1177/153473541557288325784670Search in Google Scholar

51. A. Knežević, M. Stajić, I. Sofrenić, T. Stanojković, I. Milovanović, V. Tešević and J. Vukojević, Antioxidative, antifungal, cytotoxic and antineurodegenerative activity of selected Trametes species from Serbia, PLoS ONE13 (2018) e0203064 (18 pages); https://doi.org/10.1371/journal.pone.020306410.1371/journal.pone.0203064611837330169542Search in Google Scholar

52. L. Janjušević, B. Pejin, S. Kaišarević, S. Gorjanović, F. Pastor, K. Tešanović and M. Karaman, Trametes versicolor ethanol extract, a promising candidate for health-promoting food supplement, Nat. Prod. Res. 32 (2018) 963–967; https://doi.org/10.1080/14786419.2017.136648410.1080/14786419.2017.136648428817965Search in Google Scholar

53. C. Y. Ho, C. F. Kim, K. N. Leung, K. P. Fung, T. F. Tse, H. Chan and C. B. Lau, Differential anti-tumor activity of coriolus versicolor (yunzhi) extract through p53- and/or Bcl-2-dependent apoptotic pathway in human breast cancer cells, Cancer Biol. Ther. 4 (2005) 638–644; https://doi.org/10.4161/cbt.4.6.172110.4161/cbt.4.6.172115908782Search in Google Scholar

54. D. Roca-Lema, O. Martinez-Iglesias, C. Fernández de Ana Portela, A. Rodríguez-Blanco, M. Valladares-Ayerbes, A. Díaz-Díaz, A. Casas-Pais, C. Prego and A. Figueroa, In vitro anti-proliferative and anti-invasive effect of polysaccharide-rich extracts from Trametes versicolor and Grifola frondosa in colon cancer cells, Int. J. Med. Sci.16 (2019) 231–240; https://doi.org/10.7150/ijms.2881110.7150/ijms.28811636752230745803Search in Google Scholar

55. T.-C. Hsieh, J. Kunicki, Z. Darzynkiewicz and J. M. Wu, Effects of extracts of Coriolus versicolor (I’m-Yunity™) on cell-cycle progression and expression of interleukins-1β, -6, and -8 in promyelocytic HL-60 leukemic cells and mitogenically stimulated and nonstimulated human lymphocytes, J. Altern. Complement. Med. 8 (2002) 591–602; https://doi.org/10.1089/10755530232082510110.1089/10755530232082510112470440Search in Google Scholar

56. N. Hirahara, M. Fujioka, T. Edamatsu, A. Fujieda, F. Sekine, T. Wada and T. Tanaka, Protein-bound polysaccharide-K (PSK) induces apoptosis and inhibits proliferation of promyelomonocytic leukemia HL-60 cells, Anticancer Res. 31 (2011) 2733–2738.Search in Google Scholar

57. T. S. Hattori, N. Komatsu, S. Shichijo and K. Itoh, Protein-bound polysaccharide K induced apoptosis of the human Burkitt lymphoma cell line, Namalwa, Biomed. Pharmacother. 58 (2004) 226–230; https://doi.org/10.1016/j.biopha.2004.02.00410.1016/j.biopha.2004.02.00415183847Search in Google Scholar

58. C. Iguchi, Y. Nio, H. Takeda, K. Yamasawa, N. Hirahara, T. Toga, M. Itakura and K. Tamura, Plant polysaccharide PSK: cytostatic effects on growth and invasion; modulating effect on the expression of HLA and adhesion molecules on human gastric and colonic tumor cell surface, Anticancer Res. 21 (2001) 1007–1013.Search in Google Scholar

59. S. F. Yang, T. F. Zhuang, Y. M. Si, K. Y. Qi and J. Zhao, Coriolus versicolor mushroom polysaccha-rides exert immunoregulatory effects on mouse B cells via membrane Ig and TLR-4 to activate the MAPK and NF-κB signaling pathways, Mol. Immunol. 64 (2015) 144–151; https://doi.org/10.1016/j.molimm.2014.11.00710.1016/j.molimm.2014.11.00725480394Search in Google Scholar

60. H. Zhang, T. Morisaki, C. Nakahara, H. Matsunaga, N. Sato, F. Nagumo, J. Tadano and M. Katano, PSK-mediated NF-kappaB inhibition augments docetaxel-induced apoptosis in human pancreatic cancer cells NOR-P1, Oncogene22 (2003) 2088–2096; https://doi.org/10.1038/sj.onc.120631010.1038/sj.onc.120631012687011Search in Google Scholar

61. E. Jiménez-Medina, E. Berruguilla, I. Romero, I. Algarra, A. Collado, F. Garrido and A. Garcia-Lora, The immunomodulator PSK induces in vitro cytotoxic activity in tumor cell lines via arrest of cell cycle and induction of apoptosis, BMC Cancer8 (2008) Article ID 78 (10 pages); https://doi.org/10.1186/1471-2407-8-7810.1186/1471-2407-8-78229147118366723Search in Google Scholar