<abstract xmlns="http://www.w3.org/1999/xhtml"><p><italic>Cymbopogon citratus</italic> (DC) Stapf., commonly known as lemongrass, possesses strong antioxidant and cardiotonic properties. Lemongrass water extract contains several polyphenolic compounds including gallic acid, isoquercetin, quercetin, rutin, catechin and tannic acid. Rutin, isoquercetin catechin and quercetin are the flavonoids most abundantly found in the extract. The extract significantly decreased total cholesterol, low-density lipoprotein and atherogenic index in rats after treatment (<italic>p</italic> &lt; 0.05). Expression of genes and protein of sterol regulatory element binding protein-1c (SREBP1c) and HMG-CoA reductase (HMGR) was also lowered significantly in treated groups (<italic>p</italic> &lt; 0.05). Moreover, serum antioxidant capacity increased in treated rats in comparison with untreated ones (<italic>p</italic> &lt; 0.05) and was associated with decreased serum lipid peroxidation.</p></abstract>

Cymbopogon citratus (DC) Stapf., commonly known as lemongrass, possesses strong antioxidant and cardiotonic properties. Lemongrass water extract contains several polyphenolic compounds including gallic acid, isoquercetin, quercetin, rutin, catechin and tannic acid. Rutin, isoquercetin catechin and quercetin are the flavonoids most abundantly found in the extract. The extract significantly decreased total cholesterol, low-density lipoprotein and atherogenic index in rats after treatment (p < 0.05). Expression of genes and protein of sterol regulatory element binding protein-1c (SREBP1c) and HMG-CoA reductase (HMGR) was also lowered significantly in treated groups (p < 0.05). Moreover, serum antioxidant capacity increased in treated rats in comparison with untreated ones (p < 0.05) and was associated with decreased serum lipid peroxidation.

Effect of lemongrass water extract supplementation on atherogenic index and antioxidant status in rats

Department of Preclinical Science, Faculty of Medicine

School of Preclinical Science, Institute of Science

Department of Pharmacology, Faculty of Medicine

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Cymbopogon citratus (DC) Stapf., commonly known as lemongrass, possesses strong antioxidant and cardiotonic properties. Lemongrass water extract contains...

Effect of lemongrass water extract supplementation on atherogenic index and antioxidant status in rats

Data publikacji: 26 kwi 2018

Zakres stron: 185 - 197

Przyjęty: 08 sty 2018

DOI: https://doi.org/10.2478/acph-2018-0015

Słowa kluczowe
lipid profile, antioxidant, SREBP1c, HMG-CoA reductase

© 2018 Nuntiya Somparn et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Effect of lemongrass water extract supplementation on atherogenic index and antioxidant status in rats

Data publikacji: 26 kwi 2018

Zakres stron: 185 - 197

Przyjęty: 08 sty 2018

DOI: https://doi.org/10.2478/acph-2018-0015

Słowa kluczowelipid profile, antioxidant, SREBP1c, HMG-CoA reductase

© 2018 Nuntiya Somparn et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Słowa kluczowe
lipid profile, antioxidant, SREBP1c, HMG-CoA reductase