[1. G. Dannhardt and W. Kiefer, Cyclooxygenase inhibitors-current status and future prospects, Eur. J. Med. Chem. 36 (2001) 109-126; DOI: 10.1016/S0223-5234(01)01197-7.10.1016/S0223-5234(01)01197-7]Search in Google Scholar
[2. Y. Song, D. T. Connor, A. D. Sercel, R. J. Sorenson, R. Doubleday, P. C. Unangst, B. D. Roth, V. G. Beylin, R. B. Gilbertsen, K. Chan, D. J. Schrier, A. Guglietta, D. A. Bornemeier and R. D. Dyer, Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series, J. Med. Chem. 42 (1999) 1161-1169; DOI: 10.1021/jm980570y.10.1021/jm980570y]Search in Google Scholar
[3. S.M. Sondhi, N. Singhal, M. Johar, B. S. Reddy and J. W. Lown, Heterocyclic compounds as inflammation inhibitors, Curr. Med. Chem. 9 (2002) 1045-1074; DOI: 10.2174/0929867023370248.10.2174/0929867023370248]Search in Google Scholar
[4. R. J. Flower, The development of COX2 inhibitors, Nat. Rev. Drug Discov. 2 (2003) 179-191; DOI: 10.1038/nrd1034.10.1038/nrd1034]Search in Google Scholar
[5. O.Moukha-Chafiq,M. L. Taha, H. B. Lazrek, J. J. Vasseur, C. Pannecouque, M. Witvrouw and E. D. Clercq, Synthesis and biological activity of some 4-substituted 1-[1-(2,3-dihydroxy-1-propoxy) methyl-1,2,3-triazol-(4 & 5)-ylmethyl]-1H-pyrazolo[3,4-d]pyrimidines, Farmaco 57 (2002) 27-32; DOI: 10.1016/S0014-827X(01)01152-1.10.1016/S0014-827X(01)01152-1]Search in Google Scholar
[6. S. M. Gomha and H. M. Hassaneen, Synthesis and antimicrobial activity of some new pyrazoles, fused pyrazolo[3,4-d]-pyrimidine and 1,2-dihydroimidazo-[2,1-c][1,2,4]triazin-6-one derivatives, Molecules 16 (2011) 6549-6560; DOI: 10.3390/molecules16086549.10.3390/molecules16086549]Search in Google Scholar
[7. J. M. Quintela, C. Peinado, L. Gonzalez, I. Devesa, M. L. Ferrandiz, M. J. Alcaraz and R. Riguera, 6-Dimethylamino 1H-pyrazolo[3,4-d]pyrimidine derivatives as new inhibitors of inflammatory mediators in intact cells, Bioorg. Med. Chem. 11 (2003) 863-868; DOI: 10.1016/S0968-0896(02)00562-X.10.1016/S0968-0896(02)00562-X]Search in Google Scholar
[8. A. Latrofa, M. Franco, A. Lopedota, A. Rosato, D. Carone and C. Vitali, Structural modifications and antimicrobial activity of N-cycloalkenyl-2-acylalkylidene-2,3-dihydro 1,3 benzothiazoles, Farmaco60 (2005) 291-297; DOI: 10.1016/j.farmac.2005.01.010.10.1016/j.farmac.2005.01.010]Search in Google Scholar
[9. S. Bondock, W. Fadaly and M. A. Metwally, Enaminonitrile in heterocyclic synthesis: Synthesis and antimicrobial evaluation of some new pyrazole, isoxazole and pyrimidine derivatives incorporating a benzothiazole moiety, Eur. J. Med. Chem. 44 (2009) 4813-4818; DOI: 10.1016/j.ejmech. 2009.07.02.]Search in Google Scholar
[10. A. Geronikaki, D. H. Litina and M. Amourgianou, Novel thiazolyl, thiazolinyl and benzothiazolyl Schiff bases as possible lipoxygenase’s inhibitors and anti-inflammatory agents, Farmaco58 (2003) 489-495; DOI: 10.1016/S0014-827X(03)00065-X.10.1016/S0014-827X(03)00065-X]Search in Google Scholar
[11. M. Santagati, M. Modica, A. Santagati, F. Russo, A. Caruso, V. Cutuli, E. Di Pietro and M. Amico- Roxas, Synthesis and pharmacological properties of benzothiazole, 1,3-4-oxadiazole and 1,3,4- -thiadiazole derivatives, Pharmazie 49 (1994) 880-884; DOI: 10.1002/chin.199518135.10.1002/chin.199518135]Search in Google Scholar
[12. A. Gvozdjakova and H. Ivanovicova, Synthesis and properties of 2-hydrazinobenzothiazole derivatives, Chem. Pap. 40 (1986) 797-800.]Search in Google Scholar
[13. A. E. G. Hammam and N. M. Youssif, Synthesis and reactions of 2-mercaptobenzothiazole derivatives of expected biological activity, J. Chem. Eng. Data 27 (1982) 207-208; DOI: 10.1021/je00028a032.10.1021/je00028a032]Search in Google Scholar
[14. L. Boyanova, G. Gergova, R. Nikolov, S. Derejian, E. Lazarova, N. Katsarov, I. Mitov and Z. Krastev, Activity of Bulgarian propolis against 94 Helicobacter pylori strains in vitro by agar-well diffusion, agar dilution and disc diffusion methods, J. Med. Microbiol. 54 (2005) 481-483; DOI: 10.1099/ jmm.0.45880-0.10.1099/jmm.0.45880-0]Search in Google Scholar
[15. Organization for Economic Cooperation and Development, OECD guidelines for Testing of Chemicals. Guideline 423: Acute Oral Toxicity - Acute Toxic Class Method, Adopted; http://www.iccvam. niehs.nih.gov/SuppDocs/FedDocs/OECD/OECD_GL423.pdf, last access: September 28, 2012.]Search in Google Scholar
[16. H. Y. Young, Y. L. Luo, H. Y. Cheng, W. C. Hsieh, J. C. Liao and W. H. Peng, Analgesic and anti-inflammatory activities of [6]-gingerol, J. Ethnopharmacol. 96 (2005) 207-210; DOI: 10.1016/ j.jep.2004.09.009.10.1016/j.jep.2004.09.009]Search in Google Scholar
[17. S. Su, T. Wang, J.A.Duan, W. Zhou, Y.Q.Hua, Y. P. Tang, L. Yu andD.W.Qian, Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha, J. Ethnopharmacol. 134 (2011) 251-258; DOI: 10.1016/j.jep.2010.12.003.10.1016/j.jep.2010.12.003]Search in Google Scholar
[18. C. Cicala, S. Morello, A. Alfieri, V. Vellecco, S. Marzocco and G. Autore, Haemostatic imbalance following carrageenan-induced rat paw oedema, Eur. J. Pharmacol. 577 (2007) 156-161; DOI: 10.1016/ j.ejphar.2007.08.007.10.1016/j.ejphar.2007.08.007]Search in Google Scholar
[19. V. Cioli, S. Putzolu, V. Rossi, P. S. Barcellona and C. Corradino, The role of direct tissue contact in the production of gastro-intestinal ulcers by anti-inflammatory drugs in rats, Toxicol. Appl. Pharmacol. 50 (1979) 283-289; DOI: 10.1016/0041-008X(79)90153-4.10.1016/0041-008X(79)90153-4]Search in Google Scholar
[20. M. Amir, S. A. Javed and H. Kumar, Synthesis and biological evaluation of some 4-(1H-indol- -3-yl)-6-phenyl-1,2,3,4-tetrahydropyrimidin-2-ones/thiones as potent anti-inflammatory agents, Acta Pharm. 58 (2008) 467-477; 10.2478/v10007-008-0028-x.10.2478/v10007-008-0028-x19103580]Search in Google Scholar
[21. A. E. Rashad, M. I. Hegab, R. E. Abdel-Megeida, N. Fathallab and F. M. E. Abdel-Megeid, Synthesis and anti-HSV-1 evaluation of some pyrazoles and fused pyrazolopyrimidines, Eur. J. Med. Chem. 44 (2009) 3285-3292; DOI: 10.1016/j.ejmech.2009.02.012.10.1016/j.ejmech.2009.02.01219285757]Search in Google Scholar
[22. P. M. Brooks and R. O. Day, Nonsteroidal antiinflammatory drugs-differences and similarities, N. Engl. J. Med. 324 (1991) 1716-1725; DOI: 10.1056/NEJM199106133242407.10.1056/NEJM1991061332424072034249]Search in Google Scholar
[23. V. Araujo-Neto, R. R. Bomfim, V. O. B. Oliveira, A. M. P. R. Passos, J. P. R. Oliveira, C. A. Lima, S. S. Mendes, C. S. Estevam and S. M. Thomazzi, Therapeutic benefits of Sideroxylon obtusifolium (Humb. ex Roem. & Schult.) T. D. Penn., Sapotaceae, in experimental models of pain and inflammation, Braz. J. Pharmacogn. 20 (2010) 933-938; DOI: 10.1590/S0102-695X2010005000043.10.1590/S0102-695X2010005000043]Search in Google Scholar