Risk factors of transient tachypnea of the newborn developing into pulmonary hypertension of the newborn: a case-control study
, , oraz | 01 sie 2023
O artykule
Article Category: Brief communication (original)
Data publikacji: 01 sie 2023
Zakres stron: 310 - 315
DOI: https://doi.org/10.2478/abm-2022-0034
Słowa kluczowe
© 2023 Gunlawadee Maneenil et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Baseline demographic and clinical characteristics
| Cesarean section | 22 (95.7) | 51 (86.4) |
| Gestational diabetes | 3 (13) | 4 (6.8) |
| Maternal asthma | 1 (4.3) | 1 (1.7) |
| PIH | 0 (0) | 9 (15.3) |
| GA (weeks) | 36.5 ± 1.5 | 36 ± 2.3 |
| Male | 12 (52.2) | 34 (57.6) |
| Birth weight (g) | 2825 ± 517 | 2668 ± 727 |
| Apgar score at 1 min | 8 (8–8.5) | 8 (6–8) |
| Apgar score at 5 min | 9 (9–9) | 9 (8–9) |
| PPV | 2 (8.7) | 20 (33.9) |
| Creatinine – 24 h (mg/dL) | 0.6 ± 0.1 | 0.7 ± 0.2 |
| Creatinine – 48 h (mg/dL) | 0.7 ± 0.2 | 0.7 ± 0.2 |
| RR (breaths/min) | 72 (69–80) | 66 (63–73) |
| SpO2 (%) | 88 (85–91.5) | 90 (89–95) |
| MAP (cmH2O) | 8 (7.7–9) | 7 (7–8) |
| OI | 6.5 (4.2–14.3) | 3.1 (2.1–5.1) |
| pH | 7.3 (7.2–7.3) | 7.3 (7.3–7.4) |
| PCO2 | 42.9 ± 10.5 | 38.1 ± 10.2 |
| PaO2 | 62 (50.5–115) | 93 (65–132) |
Univariate and multivariate analyses of the factors between infants diagnosed with TTN-PPHN (n = 23) and infants with severe TTN (n = 59)
| Received PPV, no vs. yes | 5.38 | 1.15–25.29 | 0.01 | 9.96 | 2.1–47.29 | <0.001 |
| RR ≥70 breaths/min | 4.43 | 1.52–12.9 | 0.004 | |||
| SpO2≤90% | 3.21 | 1.18–8.72 | 0.02 | |||
| MAP ≥8 cmH2O | 3.90 | 1.34–11.35 | 0.009 | 29.22 | 4.46–191.23 | <0.001 |
| OI ≥10 | 11.57 | 2.76–48.49 | <0.001 | |||
| PaO2≤60 mmHg | 5.61 | 1.85–17.0 | 0.002 | |||
| PCO2≥45 mmHg | 3.06 | 1.12–8.32 | 0.03 | |||
Comparison of neontal outcomes between infants diagnosed with TTN-PPHN and infants with severe TTN
| Pneumothorax | 4 (17.4) | 2 (3.4) | 0.04 |
| VAP | 5 (21.7) | 2 (3.4) | 0.01 |
| Inotropic 2 agents | 21 (91.3) | 12 (20.3) | <0.001 |
| Ventilator days | 7 (5–11.5) | 2 (1–3) | <0.001 |
| Oxygen days | 10 (9–16) | 3 (2–5.5) | <0.001 |
| LOS (d) | 15 (12.2–18.8) | 8 (6–11) | <0.001 |
| Hospital cost (US$) | 311.4 ±97.9 | 160.3 ±57.5 | <0.001 |