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Greenlee RT, Murray T, Bolden S, Wingo PA. Cancer statistics, 2000. CA Cancer J Clin. 2000; 50:7–33.GreenleeRTMurrayTBoldenSWingoPACancer statistics, 2000CA Cancer J Clin20005073310.3322/canjclin.50.1.710735013Search in Google Scholar
Woodman CB, Collins SI, Young LS. The natural history of cervical HPV infection: unresolved issues. Nat Rev Cancer. 2007; 7:11–22.WoodmanCBCollinsSIYoungLSThe natural history of cervical HPV infection: unresolved issuesNat Rev Cancer20077112210.1038/nrc205017186016Search in Google Scholar
Bhattacharjee R, Das SS, Biswal SS, Nath A, Das D, Basu A, et al. Mechanistic role of HPV-associated early proteins in cervical cancer: molecular pathways and targeted therapeutic strategies. Crit Rev Oncol Hematol. 2022; 174:103675. doi: 10.1016/j.critrevonc.2022.103675BhattacharjeeRDasSSBiswalSSNathADasDBasuAMechanistic role of HPV-associated early proteins in cervical cancer: molecular pathways and targeted therapeutic strategiesCrit Rev Oncol Hematol202217410367510.1016/j.critrevonc.2022.10367535381343Open DOISearch in Google Scholar
Zhu H, Zhu H, Tian M, Wang D, He J, Xu T. DNA methylation and hydroxymethylation in cervical cancer: diagnosis, prognosis and treatment. Front Genet. 2020; 11:347. doi: 10.3389/fgene.2020.00347ZhuHZhuHTianMWangDHeJXuTDNA methylation and hydroxymethylation in cervical cancer: diagnosis, prognosis and treatmentFront Genet20201134710.3389/fgene.2020.00347716086532328088Open DOISearch in Google Scholar
Rius M, Lyko F. Epigenetic cancer therapy: rationales, targets and drugs. Oncogene. 2012; 31:4257–65.RiusMLykoFEpigenetic cancer therapy: rationales, targets and drugsOncogene20123142576510.1038/onc.2011.60122179827Search in Google Scholar
Christensen BC, Marsit CJ. Epigenomics in environmental health. Front Genet. 2011; 2:84. doi: 10.3389/fgene.2011.00084ChristensenBCMarsitCJEpigenomics in environmental healthFront Genet201128410.3389/fgene.2011.00084326863622303378Open DOISearch in Google Scholar
Dey P. Epigenetic changes in tumor microenvironment. Indian J Cancer. 2011; 48:507–12.DeyPEpigenetic changes in tumor microenvironmentIndian J Cancer2011485071210.4103/0019-509X.9224622293269Search in Google Scholar
Goeppert B, Konermann C, Schmidt CR, Bogatyrova O, Geiselhart L, Ernst C, et al. Global alterations of DNA methylation in cholangiocarcinoma target the Wnt signaling pathway. Hepatology. 2014; 59:544–54.GoeppertBKonermannCSchmidtCRBogatyrovaOGeiselhartLErnstCGlobal alterations of DNA methylation in cholangiocarcinoma target the Wnt signaling pathwayHepatology2014595445410.1002/hep.2672124002901Search in Google Scholar
Murata H, Tsuji S, Tsujii M, Sakaguchi Y, Fu HY, Kawano S, Hori M. Promoter hypermethylation silences cyclooxygenase-2 (Cox-2) and regulates growth of human hepatocellular carcinoma cells. Lab Invest. 2004; 84:1050–9.MurataHTsujiSTsujiiMSakaguchiYFuHYKawanoSHoriMPromoter hypermethylation silences cyclooxygenase-2 (Cox-2) and regulates growth of human hepatocellular carcinoma cellsLab Invest2004841050910.1038/labinvest.370011815156159Search in Google Scholar
Schagdarsurengin U, Wilkens L, Steinemann D, Flemming P, Kreipe HH, Pfeifer GP, et al. Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma. Oncogene. 2003; 22:1866–71.SchagdarsurenginUWilkensLSteinemannDFlemmingPKreipeHHPfeiferGPFrequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinomaOncogene20032218667110.1038/sj.onc.120633812660822Search in Google Scholar
King TD, Suto MJ, Li Y. The Wnt/β-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancer. J Cell Biochem. 2012; 113:13–8.KingTDSutoMJLiYThe Wnt/β-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancerJ Cell Biochem201211313810.1002/jcb.2335021898546Search in Google Scholar
Wang C, Yue Y, Shao B, Qiu Z, Mu J, Tang J, et al. Dickkopf-related protein 2 is epigenetically inactivated and suppresses colorectal cancer growth and tumor metastasis by antagonizing Wnt/β-catenin signaling. Cell Physiol Biochem. 2017; 41:1709–24.WangCYueYShaoBQiuZMuJTangJDickkopf-related protein 2 is epigenetically inactivated and suppresses colorectal cancer growth and tumor metastasis by antagonizing Wnt/β-catenin signalingCell Physiol Biochem20174117092410.1159/00047186128365691Search in Google Scholar
Hirata H, Hinoda Y, Nakajima K, Kawamoto K, Kikuno N, Kawakami K, et al. Wnt antagonist gene DKK2 is epigenetically silenced and inhibits renal cancer progression through apoptotic and cell cycle pathways. Clin Cancer Res. 2009; 15:5678–87.HirataHHinodaYNakajimaKKawamotoKKikunoNKawakamiKWnt antagonist gene DKK2 is epigenetically silenced and inhibits renal cancer progression through apoptotic and cell cycle pathwaysClin Cancer Res20091556788710.1158/1078-0432.CCR-09-055819755393Search in Google Scholar
He Y-H, Su R-J, Zheng J. Detection of DKK-1 gene methylation in exfoliated cells of cervical squamous cell carcinoma and its relationship with high risk HPV infection. Arch Gynecol Obstet. 2021; 304:743–50.HeY-HSuR-JZhengJDetection of DKK-1 gene methylation in exfoliated cells of cervical squamous cell carcinoma and its relationship with high risk HPV infectionArch Gynecol Obstet20213047435010.1007/s00404-021-05982-333547934Search in Google Scholar
Dobre M, Salvi A, Pelisenco IA, Vasilescu F, De Petro G, Herlea V, Milanesi E. Crosstalk between DNA methylation and gene mutations in colorectal cancer. Front Oncol. 2021; 11:697409. doi: 10.3389/fonc.2021.697409DobreMSalviAPelisencoIAVasilescuFDe PetroGHerleaVMilanesiECrosstalk between DNA methylation and gene mutations in colorectal cancerFront Oncol20211169740910.3389/fonc.2021.697409828195534277443Open DOISearch in Google Scholar
Sugai T, Yoshida M, Eizuka M, Uesugii N, Habano W, Otsuka K, et al. Analysis of the DNA methylation level of cancer-related genes in colorectal cancer and the surrounding normal mucosa. Clin Epigenetics. 2017; 9:55. doi: 10.1186/s13148-017-0352-4SugaiTYoshidaMEizukaMUesugiiNHabanoWOtsukaKAnalysis of the DNA methylation level of cancer-related genes in colorectal cancer and the surrounding normal mucosaClin Epigenetics201795510.1186/s13148-017-0352-4543759528533824Open DOISearch in Google Scholar
Uren A, Wolf V, Sun YF, Azari A, Rubin JS, Toretsky JA. Wnt/Frizzled signaling in Ewing sarcoma. Pediatr Blood Cancer. 2004; 43:243–9.UrenAWolfVSunYFAzariARubinJSToretskyJAWnt/Frizzled signaling in Ewing sarcomaPediatr Blood Cancer200443243910.1002/pbc.2012415266408Search in Google Scholar
Mu J, Hui T, Shao B, Li L, Du Z, Lu L, et al. Dickkopf-related protein 2 induces G0/G1 arrest and apoptosis through suppressing Wnt/beta-catenin signaling and is frequently methylated in breast cancer. Oncotarget. 2017; 8:39443–59.MuJHuiTShaoBLiLDuZLuLDickkopf-related protein 2 induces G0/G1 arrest and apoptosis through suppressing Wnt/beta-catenin signaling and is frequently methylated in breast cancerOncotarget20178394435910.18632/oncotarget.17055550362428467796Search in Google Scholar
Chandrashekar DS, Karthikeyan SK, Korla PK, Patel H, Shovon AR, Athar M, et al. UALCAN: an update to the integrated cancer data analysis platform. Neoplasia. 2022; 25:18–27.ChandrashekarDSKarthikeyanSKKorlaPKPatelHShovonARAtharMUALCAN: an update to the integrated cancer data analysis platformNeoplasia202225182710.1016/j.neo.2022.01.001878819935078134Search in Google Scholar
Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Rodriguez IP, Chakravarthi BVSK, Varambally S. UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 2017; 19:649–58.ChandrashekarDSBashelBBalasubramanyaSAHCreightonCJRodriguezIPChakravarthiBVSKVaramballySUALCAN: a portal for facilitating tumor subgroup gene expression and survival analysesNeoplasia2017196495810.1016/j.neo.2017.05.002551609128732212Search in Google Scholar
McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M, Clark GM; Statistics Subcommittee of The NCI-EORTC Working Group on Cancer Diagnostics. REporting recommendations for tumor MARKer prognostic studies (REMARK). Breast Cancer Res Treat. 2006; 100:229–35.McShaneLMAltmanDGSauerbreiWTaubeSEGionMClarkGMStatistics Subcommittee of The NCI-EORTC Working Group on Cancer DiagnosticsREporting recommendations for tumor MARKer prognostic studies (REMARK)Breast Cancer Res Treat20061002293510.1007/s10549-006-9242-816932852Search in Google Scholar
Wang K-H, Lin C-J, Liu C-J, Liu D-W, Huang R-L, Ding D-C, et al. Global methylation silencing of clustered proto-cadherin genes in cervical cancer: serving as diagnostic markers comparable to HPV. Cancer Med. 2015; 4:43–55.WangK-HLinC-JLiuC-JLiuD-WHuangR-LDingD-CGlobal methylation silencing of clustered proto-cadherin genes in cervical cancer: serving as diagnostic markers comparable to HPVCancer Med20154435510.1002/cam4.335431211725418975Search in Google Scholar
Costello JF, Frühwald MC, Smiraglia DJ, Rush LJ, Robertson GP, Gao X, et al. Aberrant CpG-island methylation has non-random and tumour-type–specific patterns. Nat Genet. 2000; 24:132–8.CostelloJFFrühwaldMCSmiragliaDJRushLJRobertsonGPGaoXAberrant CpG-island methylation has non-random and tumour-type–specific patternsNat Genet200024132810.1038/7278510655057Search in Google Scholar
Silva TD, Vidigal VM, Felipe AV, DE Lima JM, Neto RA, Saad SS, Forones NM. DNA methylation as an epigenetic biomarker in colorectal cancer. Oncol Lett. 2013; 6:1687–92.SilvaTDVidigalVMFelipeAVDE LimaJMNetoRASaadSSForonesNMDNA methylation as an epigenetic biomarker in colorectal cancerOncol Lett2013616879210.3892/ol.2013.1606383419924260063Search in Google Scholar
Zhu J, Zhang S, Gu L, Di W. Epigenetic silencing of DKK2 and Wnt signal pathway components in human ovarian carcinoma. Carcinogenesis. 2012; 33:2334–43.ZhuJZhangSGuLDiWEpigenetic silencing of DKK2 and Wnt signal pathway components in human ovarian carcinomaCarcinogenesis20123323344310.1093/carcin/bgs27822964660Search in Google Scholar
Sato H, Suzuki H, Toyota M, Nojima M, Maruyama R, Sasaki S, et al. Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors. Carcinogenesis. 2007; 28:2459–66.SatoHSuzukiHToyotaMNojimaMMaruyamaRSasakiSFrequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumorsCarcinogenesis20072824596610.1093/carcin/bgm17817675336Search in Google Scholar
Jung IL, Kang HJ, Kim KC, Kim IG. Knockdown of the Dickkopf 3 gene induces apoptosis in a lung adenocarcinoma. Int J Mol Med. 2010; 26:33–8.JungILKangHJKimKCKimIGKnockdown of the Dickkopf 3 gene induces apoptosis in a lung adenocarcinomaInt J Mol Med201026338Search in Google Scholar
Shao Y-C, Nie X-C, Song G-Q, Wei Y, Xia P, Xu X-Y. Prognostic value of DKK2 from the Dickkopf family in human breast cancer. Int J Oncol. 2018; 53:2555–65.ShaoY-CNieX-CSongG-QWeiYXiaPXuX-YPrognostic value of DKK2 from the Dickkopf family in human breast cancerInt J Oncol20185325556510.3892/ijo.2018.4588620315730320375Search in Google Scholar
Nikolaidis C, Nena E, Panagopoulou M, Balgkouranidou I, Karaglani M, Chatzaki E, et al. PAX1 methylation as an auxiliary biomarker for cervical cancer screening: a meta-analysis. Cancer Epidemiol. 2015; 39:682–6.NikolaidisCNenaEPanagopoulouMBalgkouranidouIKaraglaniMChatzakiEPAX1 methylation as an auxiliary biomarker for cervical cancer screening: a meta-analysisCancer Epidemiol201539682610.1016/j.canep.2015.07.00826234429Search in Google Scholar
Wang H, Duan X-L, Qi X-L, Meng L, Xu Y-S, Wu T, Dai P-G. Concurrent hypermethylation of SFRP2 and DKK2 activates the Wnt/β-catenin pathway and is associated with poor prognosis in patients with gastric cancer. Mol Cells. 2017; 40:45–53.WangHDuanX-LQiX-LMengLXuY-SWuTDaiP-GConcurrent hypermethylation of SFRP2 and DKK2 activates the Wnt/β-catenin pathway and is associated with poor prognosis in patients with gastric cancerMol Cells201740455310.14348/molcells.2017.2245530388828152305Search in Google Scholar