[Clark HA, Snedeker SM. Ochratoxin A: its cancer risk and potential for exposure. J Toxicol Environ Health, part B 2006;9:265-96.10.1080/15287390500195570]Search in Google Scholar
[Miraglia M, Brera C, Pazzaglini B, Grossi S. Assessment of dietary intake of ochratoxin A by the population of EU member states. Directorate general health and consumer protection. Reports on tasks for scientific cooperation. Brussels: European Union; 2002.]Search in Google Scholar
[Delacruz L, Bach PH. The role of ochratoxin A metabolism and biochemistry in animal and human nephrotoxicity. J Biopharm Sci 1990;1:277-304.]Search in Google Scholar
[Gekle M, Sauvant C, Schwerdt G. Ochratoxin A at nanomolar concentrations: a signal modulator in renal cells. Mol Nutr Food Res 2005;49:118-30.10.1002/mnfr.200400062]Search in Google Scholar
[Sauvant C, Holzinger H, Gekle M. The nephrotoxin ochratoxin A induces key parameters of chronic interstitial nephropathy in renal proximal tubular cells. Cell Physiol Biochem 2005;15:125-34.10.1159/000083660]Search in Google Scholar
[Kuiper-Goodman T, Scott PM. Risk assessment of the mycotoxin ochratoxin A. Biomed Environ Sci 1989;2:179-248.]Search in Google Scholar
[Studer-Rohr I, Schlatter J, Dietrich DR. Kinetic parameters and intraindividual fluctuations of ochratoxin A plasma levels in humans. Arch Toxicol 2000;74:499-510.10.1007/s002040000157]Search in Google Scholar
[Stander MA, Nieuwoudt TW, Steyn PS, Shephard GS, Creppy EE, Sewram V. Toxicokinetics of ochratoxin A in vervet monkeys (Cercopithecus aethiops). Arch Toxicol 2001;75:262-9.10.1007/s002040100227]Search in Google Scholar
[Pfohl-Leszkowicz A, Manderville RA. Ochratoxin A: an overview on toxicity and carcinogenicity in animals and humans. Mol Nutr Food Res 2007;51:61-99.10.1002/mnfr.200600137]Search in Google Scholar
[Dahlman A, Dantzler WH, Silbernagl S, Gekle M. Detailed mapping of ochratoxin A reabsorption along the rate nephron in vivo: the nephrotoxin can be reabsorbed in all nephron segments by different mechanisms. J Pharmacol Exp Ther 1998;286:157-62.]Search in Google Scholar
[Pavlović M, Pleština R, Krogh P. Ochratoxin A contamination of foodstuffs in area with Balkan (endemic) nephropathy. Acta Pathol Microbiol Scand B 1979;87:243-6.10.1111/j.1699-0463.1979.tb02433.x]Search in Google Scholar
[Pleština R, Čeović S, Gatenbeck S, Habazin-Novak V, Hult K, Hökby E, Krogh P, Radić B. Human exposure to ochratoxin A in areas of Yugoslavia with endemic nephropathy. J Environ Pathol Toxicol Oncol 1990;10:145-8.]Search in Google Scholar
[Radovanovic Z, Jankovic S, Jevremovic I. Incidence of tumors of urinary organs in a focus of Balkan endemic nephropathy. Kidney Int 1991;40(Suppl 34):S75-6.]Search in Google Scholar
[Radić B, Fuchs R, Peraica M, Lucić A. Ochratoxin A in human sera in the area with endemic nephropathy in Croatia. Toxicol Lett 1997;91:105-9.10.1016/S0378-4274(97)03877-0]Search in Google Scholar
[Simon P. Ochratoxin and kidney disease in the human. J Toxicol 1996;15:239-49.]10.3109/15569549609016446]Search in Google Scholar
[Bach PH, Morin JP, Pfaller W. Nephrotoxicity - what we have learned and what we still need to know! Trends Exp Nephrol 1996;3:4-13.]Search in Google Scholar
[Schilter B, Marin-Kuan M, Delatour T, Nestler S, Mantle P, Cavin C. Ochratoxin A: potential epigenetic mechanisms of toxicity and carcinogenicity. Food Addit Contam 2005;22(Suppl 1):88-93.10.1080/0265203050030931916332626]Search in Google Scholar
[O'Brien E, Dietrich DR. Ochratoxin A: the continuing enigma. Crit Rev Toxicol 2005;35:33-60.10.1080/10408440590905948]Search in Google Scholar
[Ringot D, Chango A, Schneider YJ, Larondelle Y. Toxicokinetics and toxicodynamics of ochratoxin A, an update. Chem Biol Interact 2006;159:18-46.10.1016/j.cbi.2005.10.106]Search in Google Scholar
[Petrik J, Žanić-Grubišić T, Barišić K, Pepeljnjak S, Radić B, Ferenčić Z, Čepelak I. Apoptosis and oxidative stress induced by ochratoxin A in rat kidney. Arch Toxicol 2003;77:685-93.10.1007/s00204-003-0501-8]Search in Google Scholar
[Mally A, Dekant W. DNA adduct formation by ochratoxin A: review of the available evidence. Food Addit Contam 2005;22(Suppl 1):65-74.10.1080/02652030500317544]Search in Google Scholar
[Rahimtula AD, Bèrèziat JC, Bussacchini-Griot V, Bartsch H. Lipid peroxidation as a possible cause of ochratoxin A toxicity. Biochem Pharmacol 1988;37:4469-77.10.1016/0006-2952(88)90662-4]Search in Google Scholar
[Schaaf GJ, Nijmeijer SM, Maas RF, Roestenberg P, de Groene EM, Fink-Gremmels J. The role of oxidative stress in the ochratoxin A-mediated toxicity in proximal tubular cells. Biochim Biophys Acta 2002;1588:149-58.10.1016/S0925-4439(02)00159-X]Search in Google Scholar
[Marin-Kuan M, Nestler S, Verguet C, Bezençon C, Piguet D, Delatour T, Mantle P, Cavin C, Schilter B. MAPK-ERK activation in kidney of male rats chronically fed ochratoxin A at a dose causing a significant incidence of renal carcinoma. Toxicol Appl Pharmacol 2007;224:174-81.10.1016/j.taap.2007.06.014]Search in Google Scholar
[Horvath A, Upham BL, Ganev V, Trosko JE. Determination of the epigenetic effects of ochratoxin in a human kidney and a rat liver epithelial cell line. Toxicon 2002;40:273-82.10.1016/S0041-0101(01)00219-7]Search in Google Scholar
[Gekle M, Schwerdt G, Freudinger R, Mildenberger S, Wilflingseder D, Pollack V, Dander M, Schramek H. Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. J Pharmacol Exp Ther 2000;293:837-44.]Search in Google Scholar
[Schwerdt G, Wilflingseder D, Pollack V, Freudinger R, Mildenberger S, Gekle M. Ochratoxin A-induced stimulation of extracellular signal-regulated kinases 1/2 is associated with Madin-Darby Canine Kidney-C7 cell dedifferentiation J Pharmacol Exp Ther 1997;283:1460-8.]Search in Google Scholar
[Barišić K, Rumora L, Petrik J, Čepelak I, Žanić-Grubišić T. Ochratoxin A induces apoptosis in LLC-PK1 cells via JNK and p38 MAPK activation. Croat Chem Acta 2005;78:385-92.]Search in Google Scholar
[Rumora L, Žanić Grubišić T. MAP kinase signalling cascades in cell proliferation and apoptosis. In: Markotić A, Glavaš-Obrovac Lj, Varljen J, Žanić-Grubišić T, editors. Biochemistry and immunology intersections. Kareala: Research Signpost; 2008. p. 151-71.]Search in Google Scholar
[Raman M, Chen W, Cobb MH. Differential regulation and properties of MAPKs. Oncogene 2007;26:3100-12.10.1038/sj.onc.121039217496909]Search in Google Scholar
[Krishna M, Narang H. The complexity of mitogen-activated protein kinases (MAPKs) made simple. Cell Mol Life Sci 2008;65:3525-44.10.1007/s00018-008-8170-718668205]Search in Google Scholar
[Boutros T, Chevet E, Metrakos P. Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer. Pharmacol Rev 2008;60:261-310.10.1124/pr.107.00106]Search in Google Scholar
[Dickinson RJ, Keyse SM. Diverse physiological functions for dual-specificity MAP kinase phosphatases. J Cell Sci 2006;119:4607-15.10.1242/jcs.03266]Search in Google Scholar
[Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, Westerhoff HV. Control of MAPK signalling: from complexity to what really matters. Oncogene 2005;24:5533-42.10.1038/sj.onc.1208817]Search in Google Scholar
[Hornberg JJ, Bruggeman FJ, Binder B, Geest CR, de Vaate AJ, Lankelma J, Heinrich R, Westerhoff HV. Principles behind the multifarious control of signal transduction. ERK phosphorylation and kinase/phosphatase control. FEBS J 2005;272:244-58.10.1111/j.1432-1033.2004.04404.x]Search in Google Scholar
[Rubinfeld H, Seger R. The ERK cascade: a prototype of MAPK signaling. Mol Biotechnol 2005;31:151-74.10.1385/MB:31:2:151]Search in Google Scholar
[McKay MM, Morrison DK. Integrating signals from RTKs to ERK/MAPK. Oncogene 2007;26:3113-21.10.1038/sj.onc.121039417496910]Search in Google Scholar
[Whitmarsh AJ, Davis RJ. Transcription factor AP-1 regulation by mitogen-activated protein kinase signalling transduction pathways. J Mol Med 1996;74:589-607.10.1007/s0010900500638912180]Search in Google Scholar
[Shaul YD, Seger R. The MEK/ERK cascade: from signalling specificity to diverse functions. Biochim Biophys Acta 2007;1773:1213-26.10.1016/j.bbamcr.2006.10.00517112607]Search in Google Scholar
[Dong C, Davis RJ, Flavell RA. Signaling by the JNK group of MAP kinases. c-jun N-terminal Kinase. J Clin Immunol 2001;21:253-7.10.1023/A:1010975124110]Search in Google Scholar
[Johnson GL, Nakamura K. The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Biochim Biophys Acta 2007;1773:1341-8.10.1016/j.bbamcr.2006.12.009199555917306896]Search in Google Scholar
[Kyriakis JM, Avruch J. Sounding the alarm: protein kinase cascades activated by stress and inflammation. J Biol Chem 1996;271:24313-6.10.1074/jbc.271.40.243138798679]Search in Google Scholar
[Ashwell JD. The many paths to p38 mitogen-activated protein kinase activation in the immune system. Nat Rev Immunol 2006;6:532-40.10.1038/nri186516799472]Search in Google Scholar
[Sridhar SS, Hedley D, Siu LL. Raf kinase as a target for anticancer therapeutics. Mol Cancer Ther 2005;4:677-85.10.1158/1535-7163.MCT-04-029715827342]Search in Google Scholar
[Oka H, Chatani Y, Hoshino R, Ogawa O, Kakehi Y, Terachi T, Okada Y, Kawaichi M, Kohno M, Yoshida O. Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma. Cancer Res 1995;55:4182-7.]Search in Google Scholar
[Teng DH, Perry III WL, Hogan JK, Baumgard M, Bell R, Davis T, Frank D, Frye C, Hattier T, Hu R, Jammulapati S, Janecki T, Laevitt A, Mitvhell JT, Pero P, Sexton D, Schroeder M, Su PH, Swedlund B, Kyriakis JM, Avruch J, Bartel P, Wong AKC, Oliphant A, Thomas A, Skolnick MF, Tavtigian SV. Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor. Cancer Res 1997;57:4177-82.]Search in Google Scholar
[De Bruin EC, Medema JP. Apoptosis and non-apoptotic deaths in cancer development and treatment response. Cancer Treat Rev 2008;34:737-49.10.1016/j.ctrv.2008.07.00118722718]Search in Google Scholar
[Barišić K, Petrik J, Rumora L. Biochemistry of apoptotic cell death. Acta Pharm 2003;53:151-64.]Search in Google Scholar
[Petrik J, Malić A, Barišić K, Rumora L, Kõszegi T, Pepeljnjak S, Žanić-Grubišić T, Čepelak I. Ochratoxin A induces apoptotic and necrotic renal cell death. Croat Chem Acta 2005;78:447-53.]Search in Google Scholar
[Schwerdt G, Freudinger R, Mildenberger S, Silbernagl S, Gekle M. The nephrotoxin ochratoxin A induces apoptosis in cultured human proximal tubule cells. Cell Biol Toxicol 1999;15:405-15.10.1023/A:1007662101880]Search in Google Scholar
[Gekle M, Sauvant C, Schwerdt G, Silbernagl S. Tubulotoxic mechanisms of ochratoxin A. Kidney Blood Press Res 1998;21:277-9.10.1159/0000258779762856]Search in Google Scholar
[Marin-Kuan M, Cavin C, Delatour T, Schilter B. Ochratoxin A carcinogenicity involves a complex network of epigenetic mechanisms. Toxicon 2008;52:195-202.10.1016/j.toxicon.2008.04.16618649906]Search in Google Scholar
[Sugiyama H, Kashihara N, Makino H, Yamasaki Y, Ota A. Apoptosis in glomerular sclerosis. Kidney Int 1996;49:103-11.10.1038/ki.1996.148770955]Search in Google Scholar
[Thomas SE, Andoh TF, Pichler RH, Shankland SJ, Couser WG, Bennett WM, Johnson RJ. Accelerated apoptosis characterizes cyclosporine-associated interstitial fibrosis. Kidney Int 1998;53:897-908.10.1111/j.1523-1755.1998.00835.x9551396]Search in Google Scholar
[Woo D. Apoptosis and loss of renal tissue in polycystic kidney diseases. N Engl J Med 1995;333:18-25.10.1056/NEJM1995070633301047776989]Search in Google Scholar
[Mantle PG, Milijkovic A, Udupa V, Dobrota M. Does apoptosis cause renal atrophy in Balkan endemic nephropathy? Lancet 1998;352:1118-9.10.1016/S0140-6736(05)79758-0]Search in Google Scholar
[Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995;270:1326-31.10.1126/science.270.5240.1326]Search in Google Scholar
[Marshall CJ. Specificity of receptor tyrosine kinase signalling: transient versus sustained extracellular signalregulated kinase activation. Cell 1995;80:179-85.10.1016/0092-8674(95)90401-8]Search in Google Scholar
[Dikic I, Schlessinger J, Lax I. PC12 cells overexpression the insulin receptor undergo insulin-dependent neuronal differentiation. Curr Biol 1994;4:702-8.10.1016/S0960-9822(00)00155-X]Search in Google Scholar
[Traverse S, Seedorf K, Paterson H, Marshall J, Cohen P, Ullrich A. EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr Biol 1994;4:694-701.10.1016/S0960-9822(00)00154-8]Search in Google Scholar
[Chen YR, Meyer CF, Tan TH. Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in γ radiation-induced apoptosis. J Biol Chem 1996;271:631-4.10.1074/jbc.271.2.6318557665]Search in Google Scholar
[Le-Niculescu H, Bonfoco E, Kasuya Y, Claret FX, Green DR, Karin M. Withdrawal of survival factors results in activation of the JNk pathway in neuronal cells leading to Fas ligand induction and cell death. Mol Cell Biol 1999;19:751-63.10.1128/MCB.19.1.751839329858598]Search in Google Scholar
[Xu X, Raber J, Yang D, Su B, Mucke L. Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli. Proc Natl Acad Sci USA 1997;94:12655-60.10.1073/pnas.94.23.12655250739356505]Search in Google Scholar
[Nagai H, Noguchi T, Takeda K, Ichijo H. Pathophysiological roles of ASK1-MAP kinase signalling pathways. J Biochem Mol Biol 2007;40:1-6.]Search in Google Scholar
[Filomeni G, Rotilio G, Ciriolo MR. Disulfide relays and phosphorylative cascades: partners in redox-mediated signalling pathways. Cell Death Differ 2005;12:1555-63.10.1038/sj.cdd.440175416151458]Search in Google Scholar
[Sumbayev VV, Yasinska IM. Regulation of MAP kinasedependent apoptotic pathway: implication of reactive oxygen and nitrogen species. Arch Biochem Biophys 2005;436:406-12.10.1016/j.abb.2005.02.02115797253]Search in Google Scholar
[Matsuzawa A, Ichijo H. Stress-responsive protein kinases in redox-regulated apoptosis signalling. Antioxid Redox Signal 2005;7:472-81.10.1089/ars.2005.7.47215706095]Search in Google Scholar
[Klaunig JE, Kamendulis LM. The role of oxidative stress in carcinogenesis. Annu Rev Pharmacol Toxicol 2004;44:239-67.10.1146/annurev.pharmtox.44.101802.12185114744246]Search in Google Scholar