The role of the hepatic metabolisation for the interaction between valproic acid and carbapenem antibiotics

González C., Villena R.:Interacción entre meropenem y ácido valproica: A propósito de dos casos pediátricos. Revista chilena de infectológia, 2012, 29: 353–356.10.4067/S0716-1018201200030001823096479Search in Google Scholar

Keränen T., Kuusisto H.:Concomitant treatment with imipenem causes a rapid and extensive decrease in the plasma concentrations of valproic acid. Journal of Epileptology, 2016, 24: 63–66.10.1515/joepi-2016-0006Search in Google Scholar

Mancl E.E., Gidal B.E.:The effect of carbapenem antibiotics on plasma concentrations of valproic acid. The Annals of Pharmacotherapy, 2009, 43: 2082–2087.10.1345/aph.1M29619934386Search in Google Scholar

Rösche J., Pohley I., Jung S.-U., Benecke R.:Meropenem and valproic acid – a combination with a high risk of severe interaction. Aktuelle Neurologie, 2014, 41: 162–166.10.1055/s-0034-1370964Search in Google Scholar

Spriet I., Goyens J., Meersseman W., Wilmer A., Willems L., Van Paesschen W.:Interaction between valproate and meropenem: a retrospective study. The Annals of Pharmacotherapy, 2007, 41: 1130–1136.10.1345/aph.1K07917609232Search in Google Scholar

Spriet I., Willems L.:No interaction between valproate and meropenem in a cirrhotic patient. The Annals of Pharmacotherapy, 2011, 45: 1167.10.1345/aph.1Q16521811003Search in Google Scholar