<abstract xmlns="http://www.w3.org/1999/xhtml">The H blood group system, ISBT symbol H (018), consists of a single antigen (H) defined by a terminal fucose residue found on red blood cells and in secretions formed by the action of α-1,2-fucosyltransferases 1 (α2FucT1) and 2 (α2FucT2), respectively. Mutant alleles of the corresponding <italic>FUT1</italic> and <italic>FUT2</italic> genes result in either a H– phenotype (Bombay phenotype, Oh) or a weak H phenotype (para-Bombay, H+w). In addition, the <italic>FUT2</italic> gene is the molecular basis of the secretor (Se) status, and homozygosity or compound heterozygosity for null alleles is associated with the nonsecretor (se) status. H– individuals have natural anti-H (mostly IgM), which can cause severe hemolytic transfusion reactions with intravascular hemolysis. <italic><bold>Immunohematology</bold></italic><bold>2016;32:112–118.</bold></abstract>

The H blood group system, ISBT symbol H (018), consists of a single antigen (H) defined by a terminal fucose residue found on red blood cells and in secretions formed by the action of α-1,2-fucosyltransferases 1 (α2FucT1) and 2 (α2FucT2), respectively. Mutant alleles of the corresponding FUT1 and FUT2 genes result in either a H– phenotype (Bombay phenotype, Oh) or a weak H phenotype (para-Bombay, H+w). In addition, the FUT2 gene is the molecular basis of the secretor (Se) status, and homozygosity or compound heterozygosity for null alleles is associated with the nonsecretor (se) status. H– individuals have natural anti-H (mostly IgM), which can cause severe hemolytic transfusion reactions with intravascular hemolysis. Immunohematology2016;32:112–118.

The H blood group system

Immunohematology

{"article-title":"The H blood group system"}

The H blood group system, ISBT symbol H (018), consists of a single antigen (H) defined by a terminal fucose residue found on red blood cells and in secretions...

The H blood group system

Article Category: Review

Data publikacji: 09 paź 2019

Zakres stron: 112 - 118

DOI: https://doi.org/10.21307/immunohematology-2019-056

Słowa kluczowe
H antigen, Bombay phenotype, O,

© 2016 E.A. Scharberg et al., published by Sciendo

The H blood group system

Article Category: Review

Data publikacji: 09 paź 2019

Zakres stron: 112 - 118

DOI: https://doi.org/10.21307/immunohematology-2019-056

Słowa kluczoweH antigen, Bombay phenotype, O,

© 2016 E.A. Scharberg et al., published by Sciendo

Słowa kluczowe
H antigen, Bombay phenotype, O,