<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Endocannabinoids are lipid metabolites that have paracrine effects. Emerging evidence indicates a role of endocannabinoids and their cognate receptors in synaptic modulation and plasticity at a wide range of synapses throughout the central nervous system. This study aimed to analyze the dynamics of changes in the concentrations of 2 endocannabinoids (anandamide – ANA, and 2-arachidonoylglycerol – 2-AG) and their impact on the carbohydrate-lipid metabolism in patients before kidney transplantation and 7 days, 1, 3, and 6 months after transplantation. Considering the pro-inflammatory action of the compound, an increase in the concentration of 2-AG causes deterioration in kidney function, which, in the case of tests performed after transplantation, is associated with a poor prognosis. In our results, the highest concentration was obtained in the group of patients before transplantation and the lowest after 6 months. In the group of patients after transplantation, ANA and 2-AG were significantly correlated with lipid metabolism parameters, adipocytokines, and inflammatory markers. As both endocannabinoids play a very important role in improving kidney function after transplantation, future studies are needed to examine the potential mechanisms for their action and clinical implication.</p>
</abstract>

Endocannabinoids are lipid metabolites that have paracrine effects. Emerging evidence indicates a role of endocannabinoids and their cognate receptors in synaptic modulation and plasticity at a wide range of synapses throughout the central nervous system. This study aimed to analyze the dynamics of changes in the concentrations of 2 endocannabinoids (anandamide – ANA, and 2-arachidonoylglycerol – 2-AG) and their impact on the carbohydrate-lipid metabolism in patients before kidney transplantation and 7 days, 1, 3, and 6 months after transplantation. Considering the pro-inflammatory action of the compound, an increase in the concentration of 2-AG causes deterioration in kidney function, which, in the case of tests performed after transplantation, is associated with a poor prognosis. In our results, the highest concentration was obtained in the group of patients before transplantation and the lowest after 6 months. In the group of patients after transplantation, ANA and 2-AG were significantly correlated with lipid metabolism parameters, adipocytokines, and inflammatory markers. As both endocannabinoids play a very important role in improving kidney function after transplantation, future studies are needed to examine the potential mechanisms for their action and clinical implication.

Dynamics of changes in the concentrations of anandamide and 2-arachidonoylglycerol and their impact on the carbohydrate-lipid metabolism in patients after kidney transplantation in the follow-up study

Pomeranian Medical University in Szczecin

Department of Laboratory Medicine, Chair of Microbiology, Immunology and Laboratory Medicine

Independent Public Clinical Hospital No. 2 of Pomeranian Medical University in Szczecin

Laboratory of Transfusion Serology with a Blood Bank

Pomeranian Journal of Life Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Endocannabinoids are lipid metabolites that have paracrine effects. Emerging evidence indicates a role of endocannabinoids and their cognate receptors in...

Dynamics of changes in the concentrations of anandamide and 2-arachidonoylglycerol and their impact on the carbohydrate-lipid metabolism in patients after kidney transplantation in the follow-up study

Data publikacji: 20 kwi 2023

Zakres stron: 18 - 22

DOI: https://doi.org/10.21164/pomjlifesci.898

Słowa kluczowe
endocannabinoids, transplantation, anandamide, 2-arachidonoylglycerol

© 2023 Elżbieta Cecerska-Heryć et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Dynamics of changes in the concentrations of anandamide and 2-arachidonoylglycerol and their impact on the carbohydrate-lipid metabolism in patients after kidney transplantation in the follow-up study

Data publikacji: 20 kwi 2023

Zakres stron: 18 - 22

DOI: https://doi.org/10.21164/pomjlifesci.898

Słowa kluczoweendocannabinoids, transplantation, anandamide, 2-arachidonoylglycerol

© 2023 Elżbieta Cecerska-Heryć et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Słowa kluczowe
endocannabinoids, transplantation, anandamide, 2-arachidonoylglycerol