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Serum TSH level in obese children and its correlations with atherogenic lipid indicators and carotid intima media thickness

Małgorzata Rumińska
Małgorzata Rumińska
, 
Ewelina Witkowska-Sędek
Ewelina Witkowska-Sędek
, 
Anna Majcher
Anna Majcher
, 
Michał Brzewski
Michał Brzewski
, 
Monika Krawczyk
Monika Krawczyk
 oraz 
Beata Pyrżak
Beata Pyrżak
   | 31 sty 2019
Journal of Ultrasonography's Cover Image
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Article Category: original-paper
Data publikacji: 31 sty 2019
Zakres stron: 296 - 301
Otrzymano: 25 cze 2018
Przyjęty: 31 gru 2018
DOI: https://doi.org/10.15557/jou.2018.0043
Słowa kluczowe
© 2018 Ewelina Witkowska-Sędek et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1.

Measurement of intima-media thickness (IMT) at the far wall of a common carotid artery about 1 cm from the bifurcation
Measurement of intima-media thickness (IMT) at the far wall of a common carotid artery about 1 cm from the bifurcation

Fig. 2.

Increased thickness of carotid intima-media in a 12 years old girl from the obese group
Increased thickness of carotid intima-media in a 12 years old girl from the obese group

The comparison of lipid profiles, atherogenic lipid indicates and carotid intima-media thickness in the non-obese children and the obese children divided according to the value of TSH level

Variable Non-obese children (n = 38) Obese children
Total (n = 110) TSH ≤4 μIU/ml (n = 104) TSH >4 μIU/ml (n = 5)
TC (mg/dl) 156.77 ± 23.85 177.47 ± 29.52*** 176.4 ± 29.18 196.0 ± 31.79
HDL-C (mg/dl) 54 (33–92) 42 (25–92)*** 42 (25–92) 49.5 (30–58)
LDL-C (mg/dl) 84.26 ± 25.64 106.31 ± 27.19*** 105.58 ± 27.01 119.0 ± 29.66
TG (mg/dl) 73 (23–167) 124 (39–458)*** 123 (39–458) 162.5 (106–219)
TG/HDL-C 1.29 (0.33–4.28) 2,99 (0.53–14.31)*** 2.99 (0.53–14.31) 3.75 (2.0–6,1)
LDL C/HDL C 1.56 (0.09–3.03) 2.47 (0.7–6.76)*** 2.44 (0.7–6.76) 2.64 (1,71–5.0)
TC/HDL-C 2.94 (1.36–4.87) 4.16 (2.0–10.32)*** 4.16 (2.0–10.32) 4.29 (3.29–7.23)
IMT 0.58 (0.25–0.73) 0.6 (0.22–1.4) 0.6 (0.22–1.4) 0.65 (0.5–0.7)

Multivariate regression analysis of intima-media thickness (dependent variable)

Independent variables B SE p-value 95% CI
MODEL 1
Age (years) 0.008 0.007 0.258 −0.006−0.021
Sex (male = 1/female = 2) −0.052 0.036 0.153 −0.124−0.019
SDS BMI 0,.047 0.041 0.259 −0.034−0.127
TSH (μIU/ml) 0.041 0.020 0.041 0.003−0.080
MODEL 2
Age (years) 0.008 0.007 0.282 −0.006−0.022
Sex (male = 1/female = 2) −0.052 0.038 0.0170 −0.126−0.022
SDS BMI 0.049 0.043 0.255 −0.035−0.134
TC (mg/dl) 0.000 0.002 0.844 −0.004−0.004
LDL-C (mg/dl) 0.000 0.002 0.838 −0.005−0.004
TG (mg/dl) 0.000 0.000 0.878 −0.001−0.001
TSH (μIU/ml) 0.040 0.021 0.058 −0.001−0.081
eISSN:
2451-070X
Język:
Angielski
Częstotliwość wydawania:
4 razy w roku
Dziedziny czasopisma:
Medicine, Basic Medical Science, other
Kanał RSS czasopisma