1. bookTom 24 (2016): Zeszyt 4 (December 2016)
Informacje o czasopiśmie
License
Format
Czasopismo
eISSN
2284-5623
Pierwsze wydanie
08 Aug 2013
Częstotliwość wydawania
4 razy w roku
Języki
Angielski
access type Otwarty dostęp

Evaluation of Transcription Factor 7 like 2 polymorphisms and haplotypes in risk of Type 2 Diabetes

Data publikacji: 30 Dec 2016
Tom & Zeszyt: Tom 24 (2016) - Zeszyt 4 (December 2016)
Zakres stron: 423 - 430
Otrzymano: 05 Jun 2016
Przyjęty: 09 Oct 2016
Informacje o czasopiśmie
License
Format
Czasopismo
eISSN
2284-5623
Pierwsze wydanie
08 Aug 2013
Częstotliwość wydawania
4 razy w roku
Języki
Angielski
Abstract

Type 2 diabetes (T2D) is a chronic disorder with different genetics and environmental factors. It is one of growing diseases in the world. Previous studies show association between Transcription Factor 7 Like2 (TCF7L2) and T2D. The current study set to evaluate the relation between TCF7L2 polymorphisms and T2D in Southeast Iran. The present case-control study was done on 250 T2D and 250 healthy controls (HCs). For genotyping polymorphisms TCF7L2 (rs11196205) and (rs4132670) Amplification-Refractory Mutation System-Polymers Chain Reaction (ARMS-PCR) was used. The results showed frequency rates of GC and CC genotypes increased in patients compared to controls (31% vs. 6% and 55% vs. 8%, respectively), showing a statistically significant difference (OR=2.67(1.37-5.21), P<0.05 and OR=3.31(1.92-5.71), P< 0.05, respectively). The C allele was associated with an increased risk of T2D, with the frequency of 28% and 11% in patients and controls, respectively (OR=3.11 (2.22-4.37), P< 0.05). Another Polymorphism of this gene TCF7L2 (rs4132670) was not associated with T2D. Furthermore, the haplotype analysis revealed that rs11196205C/rs4132670C and rs11196205C/rs4132670T are risk factors against T2D (OR=2.08 (1.49-2.86, P<0.05 and OR=1.72 (1.06-2.78) P<0.05, respectively). The findings demonstrated that TCF7L2 (rs11196205) genotypes GC, CC, and allele (C) confer risk for susceptibility to T2D.

Keywords

1. Hara K, Shojima N, Hosoe J, Kadowaki T. Genetic architecture of type 2 diabetes. Biochem Biophys Res Commun. 2014;452(2):213-20. DOI: 10.1016/j.bbrc.2014.08.012.10.1016/j.bbrc.2014.08.012Search in Google Scholar

2. Stumvoll M, Goldstein BJ, van Haeften TW. Type 2 diabetes: principles of pathogenesis and therapy. The Lancet. 2005;365(9467):1333-46. DOI: 10.1016/S0140-6736(05)61032-X.10.1016/S0140-6736(05)61032-XSearch in Google Scholar

3. Saravani R, Esmaeeli E, Tamendani MK, Nejad MN. Oxytocin Receptor Gene Polymorphisms in Patients With Diabetes. Gene Cell Tissue. 2015;2(2): e27904. DOI: 10.17795/gct-27904.10.17795/gct-27904Search in Google Scholar

4. Tahrani AA, Piya MK, Kennedy A, Barnett AH. Glycaemic control in type 2 diabetes: targets and new therapies. Pharmacol Ther. 2010;125(2):328-61. DOI: 10.1016/j.pharmthera.2009.11.001.10.1016/j.pharmthera.2009.11.001Search in Google Scholar

5. Nolan CJ, Damm P, Prentki M. Type 2 diabetes across generations: from pathophysiology to prevention and management. The Lancet. 2011;378(9786):169-81. DOI: 10.1016/S0140-6736(11)60614-4.10.1016/S0140-6736(11)60614-4Search in Google Scholar

6. Allahdini M, Kamalidehghan B, Akbari L, Azadfar P, Rahmani A, Ahmadipour F, et al. Prevalence of the rs7903146C> T polymorphism in TCF7L2 gene for prediction of type 2 diabetes risk among Iranians of different ethnicities. Drug Des Devel Ther. 2015;9:5835.Search in Google Scholar

7. Guja C, Gagniuc P, Ionescu-Tîrgovişte C, editors. Genetic factors involved in the pathogenesis of type 2 diabetes. Proc Rom Acad Series B; 2012.Search in Google Scholar

8. Zhou Y, Park S-Y, Su J, Bailey K, Ottosson-Laakso E, Shcherbina L, et al. TCF7L2 is a master regulator of insulin production and processing. Hum Mol Gen. 2014:ddu359.10.1101/003202Search in Google Scholar

9. Mayans S, Lackovic K, Lindgren P, Ruikka K, Ågren Å, Eliasson M, et al. TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden. Eur J Hum Genet. 2007;15(3):342-6. DOI: 10.1038/sj.ejhg.5201773.10.1038/sj.ejhg.520177317245407Search in Google Scholar

10. Klünder-Klünder M, Mejía-Benitez MA, Flores-Huerta S, Burguete-García AI, García-Mena J, Cruz M. rs12255372 variant of TCF7L2 gene is protective for obesity in Mexican children. Arch Med Res. 2011;42(6):495-501. DOI: 10.1016/j.arcmed.2011.05.006.10.1016/j.arcmed.2011.05.00622136959Search in Google Scholar

11. Palmer ND, Lehtinen AB, Langefeld CD, Campbell JK, Haffner SM, Norris JM, et al. Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans. J Clin Endocrinol Metab. 2008;93(1):304-9. DOI: 10.1210/jc.2007-1225.10.1210/jc.2007-1225219075017971425Search in Google Scholar

12. Amoli MM, Amiri P, Tavakkoly-Bazzaz J, Charmchi E, Hafeziyeh J, Keramatipour M, et al. Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population. GENET MOL BIOL. 2010;33(3):449-51. DOI: 10.1590/S1415-47572010005000056.10.1590/S1415-47572010005000056303610821637413Search in Google Scholar

13. Cauchi S, El Achhab Y, Choquet H, Dina C, Krempler F, Weitgasser R, et al. TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis. J Mol Med. 2007;85(7):777-82. DOI: 10.1007/s00109-007-0203-4.10.1007/s00109-007-0203-417476472Search in Google Scholar

14. Barra GB, Dutra LAS, Watanabe SC, Costa PGG, Cruz PSMd, Azevedo MF, et al. Association of the rs7903146 single nucleotide polymorphism at the Transcription Factor 7-like 2 (TCF7L2) locus with type 2 diabetes in Brazilian subjects. Arq Bras Endocrinol Metab. 2012;56(8):479-84. DOI: 10.1590/S0004-27302012000800003.10.1590/S0004-2730201200080000323295285Search in Google Scholar

15. Wegner L, Hussain MS, Pilgaard K, Hansen T, Pedersen O, Vaag A, et al. Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins. J Clin Endocrinol Metab. 2008;93(10):4013-9. DOI: 10.1210/jc.2008-0855.10.1210/jc.2008-085518611970Search in Google Scholar

16. Luo Y, Wang H, Han X, Ren Q, Wang F, Zhang X, et al. Meta-analysis of the association between SNPs in TCF7L2 and type 2 diabetes in East Asian population. Diabetes Res Clin Pract. 2009;85(2):139-46. DOI: 10.1016/j.diabres.2009.04.024.10.1016/j.diabres.2009.04.02419482368Search in Google Scholar

17. Ng MC, Tam CH, Lam VK, So W-Y, Ma RC, Chan JC. Replication and identification of novel variants at TCF7L2 associated with type 2 diabetes in Hong Kong Chinese. J Clin Endocrinol Metab. 2007;92(9):3733-7. DOI: 10.1210/jc.2007-0849.10.1210/jc.2007-084917609304Search in Google Scholar

18. Tangjittipokin W, Chongjarean N, Plengvidhya N, Homsanit M, Yenchitsomanus P-t. Transcription factor 7-like 2 (TCF7L2) variations associated with earlier age-onset of type 2 diabetes in Thai patients. J Genet. 2012;91(2):251-5. DOI: 10.1007/s12041-012-0176-0.10.1007/s12041-012-0176-022942101Search in Google Scholar

19. Qiao H, Zhang X, Zhao X, Zhao Y, Xu L, Sun H, et al. Genetic variants of TCF7L2 are associated with type 2 diabetes in a northeastern Chinese population. Gene. 2012;495(2):115-9. DOI: 10.1016/j.gene.2011.12.055.10.1016/j.gene.2011.12.05522245614Search in Google Scholar

20. Chang Y-C, Chang T-J, Jiang Y-D, Kuo S-S, Lee K-C, Chiu KC, et al. Association study of the genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population. Diabetes. 2007;56(10):2631-7. DOI: 10.2337/db07-0421.10.2337/db07-042117579206Search in Google Scholar

21. Hayashi T, Iwamoto Y, Kaku K, Hirose H, Maeda S. Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population. Diabetologia. 2007;50(5):980-4. DOI: 10.1007/s00125-007-0618-z.10.1007/s00125-007-0618-z17340123Search in Google Scholar

22. Horikoshi M, Hara K, Ito C, Nagai R, Froguel P, Kadowaki T. A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population. Diabetologia. 2007;50(4):747-51. DOI: 10.1007/s00125-006-0588-6.10.1007/s00125-006-0588-617245589Search in Google Scholar

23. Pang D, Smith A, Humphries S. Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes. Nutr Metab Cardiovasc Dis. 2013;23(6):550-6. DOI: 10.1016/j.numecd.2011.12.012.10.1016/j.numecd.2011.12.012377891522402060Search in Google Scholar

24. Karnes JH, Gong Y, Pacanowski MA, McDonough CW, Arwood MJ, Langaee TY, et al. Impact of TCF7L2 single nucleotide polymorphisms on hydrochlorothiazide-induced diabetes. Pharmacogenet Genomics. 2013;23(12):697. DOI: 10.1097/FPC.0000000000000012.10.1097/FPC.0000000000000012389375524128935Search in Google Scholar

Polecane artykuły z Trend MD

Zaplanuj zdalną konferencję ze Sciendo