Current insights in CSF leaks: a literature review of mechanisms, pathophysiology and treatment options

1. Mantur M., Łukaszewicz-Zając M., Mroczko B., Kulakowska A., Ganslandt O., Kemona H., Szmitkowski M., Drozdowski W., Zimmermann R., Kornhuber J., Lewczuk P. - Cerebrospinal fluid leakage--reliable diagnostic methods. Clin Chim Acta., 2011;412(11-12):837-840. doi: 10.1016/j. cca.2011.02.017. Epub 2011 Feb 17.Search in Google Scholar

2. Nuss D.W., Constantino P.D. - Diagnosis and management of cerebrospinal fluid leaks: highlights of the instructional courses of the American Academy of Otolaryngology - Head Neck Surgery. Otolaryngol Head Neck Surg., 1995;8:79-95.Search in Google Scholar

3. Schlosser R.J., Bolger W.E. - Nasal cerebrospinal fluid leaks: critical review and surgical considerations. Laryngoscope, 2004;114(2):255-265.10.1097/00005537-200402000-0001514755200Search in Google Scholar

4. Lieberman S.M., Chen S., Jethanamest D., Casiano R.R. - Spontaneous CSF rhinorrhea: prevalence of multiple simultaneous skull base defects. Am J Rhinol Allergy., 2015;29(1):77-81. doi: 10.2500/ajra.2015.29.4121.Search in Google Scholar

5. Lemonnier L.A., Tessema B., Kuperan A.B., Jourdy D.N., Telischi F.F., Morcos J.J., Casiano R.R. - Managing cerebrospinal fluid rhinorrhea after lateral skull base surgery via endoscopic endonasal eustachian tube closure. Am J Rhinol Allergy., 2015;29(3):207-210. doi: 10.2500/ajra.2015.29.4146.Search in Google Scholar

6. Eljamel M.S., Foy P.M. - Post-traumatic CSF fistulae, the case for surgical repair. Br J Neurosurg., 1990;4(6):479-483.Search in Google Scholar

7. Woodworth B.A., Schlosser R.J., Faust R.A., Bolger W.E. - Evolutions in the management of congenital intranasal skull base defects. Arch Otolaryngol Head Neck Surg., 2004;130(11):1283-1288.Search in Google Scholar

8. Woodworth B.A., Prince A., Chiu A.G., Cohen N.A., Schlosser R.J., Bolger W.E., Kennedy D.W., Palmer J.N. - Spontaneous CSF leaks: a paradigm for definitive repair and management of intracranial hypertension. Otolaryngol Head Neck Surg., 2008;138(6):715-720. doi: 10.1016/j.otohns.2008.02.010.Search in Google Scholar

9. Park J.I., Strelzow V., Friedman W.H. - Current management of cerebro- spinal fluid rhinorrhea. Laryngoscope, 2009;93(10):1294-1300.10.1002/lary.1983.93.10.12946621228Search in Google Scholar

10. Kerr J.T., Chu F.W.K., Bayles S.W. - Cerebrospinal fluid rhinorrhea: diagnosis and management. Otolaryngol Clin North Am., 2005;38(4):597-611.Search in Google Scholar

11. Meco C., Oberascher G. - Comprehensive algorithm for skull base dural lesion and cerebrospinal fluid fistula diagnosis. Laryngoscope, 2004;114(6):991-999.10.1097/00005537-200406000-0000715179201Search in Google Scholar

12. Mokri B., Atkinson J.L., Piepgras D.G. - Absent headache despite CSF volume depletion (intracranial hypotension). Neurology, 2000;55(11):1722-1724.10.1212/WNL.55.11.1722Search in Google Scholar

13. Mokri B., Hunter S.F., Atkinson J.L.D., Piepgras D.G. - Orthostatic headaches caused by CSF leak but with normal CSF pressures. Neurology, 1998;51:786-790.10.1212/WNL.51.3.7869748027Search in Google Scholar

14. Mathias T., Levy J., Fatakia A., McCoul E.D. - Contemporary approach to the diagnosis and management of cerebrospinal fluid rhinorrhea. Ochsner J., 2016;16(2):136-142.Search in Google Scholar

15. Bernal-Sprekelsen M., Alobid I., Mullol J., Trobat F., Tomas-Barberan M. - Closure of cerebrospinal fluid leaks prevents ascending bacterial meningitis. Rhinology, 2005;43(4):277-281.Search in Google Scholar

16. Cassano M., Felippu A. - Endoscopic treatment of cerebrospinal fluid leaks with the use of lower turbinate grafts: a retrospective review of 125 cases. Rhinology, 2009;47(4):362-368. doi: 10.4193/Rhin08.175.Search in Google Scholar

17. Scholsem M., Scholtes F., Collignon F., Robe P., Dubuisson A., Kaschten B., Lenelle J., Martin D. -Surgical management of anterior cranial base fractures with cerebrospinal fluid fistulae: a single-institution experience. Neurosurgery, 2008;62(2):463-469;discussion 469-471. doi: 10.1227/01.neu.0000316014.97926.82.Search in Google Scholar

18. Yilmazlar S., Arslan E., Kocaeli H., Dogan S., Aksoy K., Korfali E., Doygun M. - Cerebrospinal fluid leakage complicating skull base fractures: analysis of 81 cases. Neurosurg Rev., 2006;29(1):64-71. Epub 2005 Jun 4.10.1007/s10143-005-0396-315937689Search in Google Scholar

19. Bolger W.E., Kennedy D.W. - Nasal endoscopy in the outpatient clinic. Otolaryngol Clin North Am., 1992;25(4):791-802.Search in Google Scholar

20. Dula D.J., Fales W. - The 'ring sign': is it a reliable indicator for cerebral spinal fluid? Ann Emerg Med., 1993;22(4):718-720.Search in Google Scholar

21. Warnecke A., Averbeck T., Wurster U., Harmening M., Lenarz T., Stöver T. - Diagnostic relevance of beta2-transferrin for the detection of cerebrospinal fluid fistulas. Arch Otolaryngol Head Neck Surg., 2004;130(10):1178-1184.Search in Google Scholar

22. Meco C., Arrer E., Oberascher G. - Efficacy of cerebrospinal fluid fistula repair: sensitive quality control using the beta-trace protein test. Am J Rhinol., 2007;21(6):729-736.Search in Google Scholar

23. Meco C., Oberascher G., Arrer E., Moser G., Albegger K. - Betatrace protein test: new guidelines for the reliable diagnosis of cerebrospinal fluid fistula. Otolaryngol Head Neck Surg., 2003;129(5):508-517.Search in Google Scholar

24. Schnabel C., Di Martino E., Gilsbach J.M., Riediger D., Gressner A.M., Kunz D. - Comparison of beta2-transferrin and beta-trace protein for detection of cerebrospinal fluid in nasal and ear fluids. Clin Chem., 2004;50(3):661-663.Search in Google Scholar

25. Chan D.T., Poon W.S., IP C.P., Chiu P.W., Goh K.Y. - How useful is glucose detection in diagnosing cerebrospinal fluid leak? The rational use of CT and Beta-2 transferrin assay in detection of cerebrospinal fluid fistula. Asian J Surg., 2004;27(1):39-42.Search in Google Scholar

26. Kosoy J., Trieff N.M., Winkelmann P., Bailey B.J. - Glucose in nasal secretions. Diagnostic significance. Arch Otolaryngol., 1972;95(3):225-229.Search in Google Scholar

27. Lund V.J., Savy L., Lloyd G., Howard D. - Optimum imaging and diagnosis of cerebrospinal fluid rhinorrhoea. J Laryngol Otol., 2000;114(2):988-992.Search in Google Scholar

28. Naidich T.P., Moran C.J. - Precise anatomic localization of a traumatic sphenethmoidal cerebrospinal fluid rhinorrhea by metrizamide CT cisterography. J Neurosurg., 1980;53(2):222-228.Search in Google Scholar

29. El Gammal T., Brooks B.S. - MR cisternography: initial experience in 41 cases. AJNR Am J Neuroradiol., 1994;15(9):1647-1656.Search in Google Scholar

30. Eljamel M.S., Pidgeon C.N., Toland J., Phillips J.B., O’Dwyer A.A. - MRI cisternography, and the localization of CSF fistulae. Br J Neurosurg., 1994;8(4):433-437.Search in Google Scholar

31. Jeon T.J., Lee J.D., Lee B.I., Kim D.I., Yoo H.S. - Radionuclide cisternography in spontaneous intracranial hypotension with simultaneous leaks at the cervicothoracic and lumbar levels. Clin Nucl Med., 2001;26(2):114-116.Search in Google Scholar

32. Horikoshi T., Ikegawa H., Uchida M., Takahashi T., Watanabe A., Umeda T. - Tracer clearance in radionuclide cisternography in patients with spontaneous intracranial hypotension. Cephalalgia, 2006;26(8):1010-1015.10.1111/j.1468-2982.2006.01152.x16886938Search in Google Scholar

33. Liu H.S., Chen Y.T., Wang D., Liang H., Wang Y., Wang S.J., Wang Y., Chen G.Q., Zuo H.C. - The use of topical intranasal fluorescein in endoscopic endonasal repair of cerebrospinal fluid rhinorrhea. Surg Neurol., 2009;72(4):341-345; discussion 346. doi: 10.1016/j.surneu.2009.03.034. Epub 2009 Jul 15.Search in Google Scholar

34. Jones N.S., Becker D.G. - Advances in the management of CSF leaks. New techniques will improve the management of unilateral clear nasal discharge. BMJ, 2001;322:122-123.10.1136/bmj.322.7279.122111940111159556Search in Google Scholar

35. Albert B., Leibrock L.G. - Neurological approaches to cerebrospinal fluid rhinorrhea. Ear Nose Throat J., 2005;71:300-305.Search in Google Scholar

36. Ratilal B.O., Costa J., Pappamikail L., Sampaio C. - Antibiotic prophylaxis for preventing meningitis in patients with basilar skull fractures. Cochrane Database Syst Rev., 2015;28(4):CD004884. doi: 10.1002/14651858.pub4.Search in Google Scholar

37. Gosal J.S., Gurmey T., Kursa G.K., Salunke P., Gupta S.K. - Is acetazolamide really useful in the management of traumatic cerebrospinal fluid rhinorrhea? Neurol India., 2015;63(2):197-201. doi: 10.4103/0028-3886.156280.Search in Google Scholar

38. Carrion E., Hertzog J.H., Medlock M.D., Hauser G.J., Dalton H.J. - Use of acetazolamide to decrease cerebrospinal fluid production in chronically ventilated patients with ventriculopleural shunts. Arch Dis Child., 2001;84(1):68-71.Search in Google Scholar

39. Caballero N., Bhalla V., Stankiewicz J.A., Welch K.C. - Effect of lumbar drain placement on recurrence of cerebrospinal rhinorrhea after endoscopic repair. Int Forum Allergy Rhinol., 2012;2(3):222-226. doi: 10.1002/ alrt.21023. Epub 2012 Feb 16.Search in Google Scholar

40. Albu S., Florian I.S., Bolboaca S.D. - The benefit of early lumbar drain insertion in reducing the length of CSF leak in traumatic rhinorrhea. Clin Neurol Neurosurg., 2016;142:43-47. doi: 10.1016/j.clineuro.2016.01.016. Epub 2016 Jan 13.Search in Google Scholar

41. Friedman J.A., Ebersold M.J., Quast L.M. - Post-traumatic cerebrospinal fluid leakage. World J Surg., 2001;25(8):1062-1066.Search in Google Scholar

42. Tosun F., Gonul E., Yetiser S., Gerek M. - Analysis of different surgical approaches for the treatment of cerebrospinal fluid rhinorrhea. Minim Invasive Neurosurg., 2005;48(6):355-360.Search in Google Scholar

43. Dodson E.E., Gross C.W., Swerdloff J.L., Gustafson L.M. - Transnasal endoscopic repair of cerebrospinal fluid rhinorrhea and skull base defects: a review of twenty-nine cases. Otolaryngol Head Neck Surg., 1994;111(5):600-605.Search in Google Scholar

44. Hegazy H.M., Carrau R.L., Snyderman C.H., Kassam A., Zweig J. -Transnasal endoscopic repair of cerebrospinal fluid rhinorrhea: a metaanalysis. Laryngoscope, 2000;110(7):1166-1172.10.1097/00005537-200007000-0001910892690Search in Google Scholar

45. Lee T.J., Huang C.C., Chuang C.C., Huang S.F. - Transnasal endoscopic repair of cerebrospinal fluid rhinorrhea and skull base defect: ten-year experience. Laryngoscope, 2004;114(8):1475-1481.10.1097/00005537-200408000-0002915280729Search in Google Scholar

46. Lopatin A.S., Kapitanov D.N., Potapov A.A. - Endonasal endoscopic repair of spontaneous cerebrospinal fluid leaks. Arch Otolaryngol Head Neck Surg., 2003;129(8):859-863.Search in Google Scholar

47. Marshall A.H., Jones N.S., Robertson I.J.A. - CSF rhinorrhoea: the place of endoscopic sinus surgery. Br J Neurosurg., 2001;15(1):8-12.Search in Google Scholar

48. Spetzler R.F., Zabramski J.M. - Cerebrospinal fluid fistulae: their management and repair. In: Youmans J.R., editor. - Youmans Neurological Surgery. 3rd ed. Philadelphia (PA): WB Saunders Company, 1990;p.2269-2289.Search in Google Scholar

49. Elmorsy S.M., Khafagy Y.W. - Endoscopic management of spontaneous CSF rhinorrhea with septal graft and middle turbinate rotational flap technique: a review of 31 cases. Ear Nose Throat J., 2014;93(6):E14-E19.Search in Google Scholar

50. Landeiro J.A., Flores M.S., Lazaro B.C.R., Melo M.H. - Surgical management of cerebrospinal fluid rhinorrhea under endoscopic control. Arq Neuro-Psiquiatr., 2004;62(3b):827-831.10.1590/S0004-282X2004000500016Search in Google Scholar

51. Adams A.S., Francis D.O., Russell P.T. - Outcomes of outpatient endoscopic repair of cerebrospinal fluid rhinorrhea. Int Forum AllergyRhinol., 2016;6(11):1126-1130. doi: 10.1002/alr.21810. Epub 2016 Sep 14.Search in Google Scholar