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Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin 2015; 65: 5-29. 10.3322/caac.2125425559415SiegelRLMillerKDJemalA.Cancer statistics2015CA Cancer J Clin20156552910.3322/caac.21254Open DOISearch in Google Scholar
Kleeff J, Friess H, Buchler MW. Neoadjuvant therapy for pancreatic cancer. Br J Surg 2007; 94: 261-2. 10.1002/bjs.573717315287KleeffJFriessHBuchlerMW.Neoadjuvant therapy for pancreatic cancerBr J Surg200794261210.1002/bjs.5737Open DOISearch in Google Scholar
Gillen S, Schuster T, Meyer Zum Buschenfelde C, Friess H, Kleeff J. Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages. PLoS Med 2010; 7: e1000267. 10.1371/journal.pmed.100026720422030GillenSSchusterTMeyer Zum BuschenfeldeCFriessHKleeffJ.Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentagesPLoS Med20107e100026710.1371/journal.pmed.1000267Open DOISearch in Google Scholar
Naumann P, Habermehl D, Welzel T, Debus J, Combs SE. Outcome after neoadjuvant chemoradiation and correlation with nutritional status in patients with locally advanced pancreatic cancer. Strahlenther Onkol 2013; 189: 745-52. 10.1007/s00066-013-0393-323896631NaumannPHabermehlDWelzelTDebusJCombsSE.Outcome after neoadjuvant chemoradiation and correlation with nutritional status in patients with locally advanced pancreatic cancerStrahlenther Onkol20131897455210.1007/s00066-013-0393-3Open DOISearch in Google Scholar
Han QB, Li ML, Li SH, Mou YK, Lin ZW, Sun HD. Ent-kaurane diterpenoids from Isodon rubescens var. lushanensis. Chem Pharm Bull (Tokyo) 2003; 51: 790-3.1284358310.1248/cpb.51.790HanQBLiMLLiSHMouYKLinZWSunHD.Ent-kaurane diterpenoids from Isodon rubescens var. lushanensisChem Pharm Bull (Tokyo)2003517903Search in Google Scholar
Owona BA, Schluesener HJ. Molecular insight in the multifunctional effects of oridonin. Drugs R D 2015; 15: 233-44. 10.1007/s40268-015-0102-z26290464OwonaBASchluesenerHJ.Molecular insight in the multifunctional effects of oridoninDrugs R D2015152334410.1007/s40268-015-0102-zOpen DOISearch in Google Scholar
Tian W, Chen SY. Recent advances in the molecular basis of anti-neoplastic mechanisms of oridonin. Chin J Integr Med 2013; 19: 315-20. 10.1007/s11655-013-1437-323546635TianWChenSY.Recent advances in the molecular basis of anti-neoplastic mechanisms of oridoninChin J Integr Med2013193152010.1007/s11655-013-1437-3Open DOISearch in Google Scholar
Bai N, He K, Zhou Z, Tsai ML, Zhang L, Quan Z, et al. Ent-kaurane diterpenoids from Rabdosia rubescens and their cytotoxic effects on human cancer cell lines. Planta Med 2010; 76: 140-5. 10.1055/s-0029-118600219653147BaiNHeKZhouZTsaiMLZhangLQuanZEnt-kaurane diterpenoids from Rabdosia rubescens and their cytotoxic effects on human cancer cell linesPlanta Med201076140510.1055/s-0029-1186002Open DOISearch in Google Scholar
Xu B, Shen W, Liu X, Zhang T, Ren J, Fan Y, et al. Oridonin inhibits BxPC-3 cell growth through cell apoptosis. Acta Biochim Biophys Sin (Shanghai) 2015; 47: 164-73. 10.1093/abbs/gmu13425651847XuBShenWLiuXZhangTRenJFanYOridonin inhibits BxPC-3 cell growth through cell apoptosisActa Biochim Biophys Sin (Shanghai)2015471647310.1093/abbs/gmu134Open DOISearch in Google Scholar
Qi X, Zhang D, Xu X, Feng F, Ren G, Chu Q, et al. Oridonin nanosuspension was more effective than free oridonin on G2/M cell cycle arrest and apoptosis in the human pancreatic cancer PANC-1 cell line. Int J Nanomedicine 2012; 7: 1793-804. 10.2147/IJN.S2948322619528QiXZhangDXuXFengFRenGChuQOridonin nanosuspension was more effective than free oridonin on G2/M cell cycle arrest and apoptosis in the human pancreatic cancer PANC-1 cell lineInt J Nanomedicine20127179380410.2147/IJN.S29483Open DOISearch in Google Scholar
Bu HQ, Liu DL, Wei WT, Chen L, Huang H, Li Y, et al. Oridonin induces apoptosis in SW1990 pancreatic cancer cells via p53- and caspase-dependent induction of p38 MAPK. Oncol Rep 2014; 31: 975-82. 10.3892/or.2013.288824297112BuHQLiuDLWeiWTChenLHuangHLiYOridonin induces apoptosis in SW1990 pancreatic cancer cells via p53- and caspase-dependent induction of p38 MAPKOncol Rep2014319758210.3892/or.2013.2888Open DOISearch in Google Scholar
Bu HQ, Luo J, Chen H, Zhang JH, Li HH, Guo HC, et al. Oridonin enhances antitumor activity of gemcitabine in pancreatic cancer through MAPK-p38 signaling pathway. Int J Oncol 2012; 41: 949-58. 10.3892/ijo.2012.151922710877BuHQLuoJChenHZhangJHLiHHGuoHCOridonin enhances antitumor activity of gemcitabine in pancreatic cancer through MAPK-p38 signaling pathwayInt J Oncol2012419495810.3892/ijo.2012.1519Open DOISearch in Google Scholar
Ikezoe T, Yang Y, Bandobashi K, Saito T, Takemoto S, Machida H, et al. Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways. Mol Cancer Ther 2005; 4: 578-86. 10.1158/1535-7163.MCT-04-027715827331IkezoeTYangYBandobashiKSaitoTTakemotoSMachidaHOridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathwaysMol Cancer Ther200545788610.1158/1535-7163.MCT-04-0277Open DOISearch in Google Scholar
Liu JJ, Huang RW, Lin DJ, Peng J, Zhang M, Pan X, et al. Ponicidin, an entkaurane diterpenoid derived from a constituent of the herbal supplement PC-SPES, Rabdosia rubescens, induces apoptosis by activation of caspase-3 and mitochondrial events in lung cancer cells in vitro. Cancer Invest 2006; 24: 136-48. 10.1080/07357900500524371LiuJJHuangRWLinDJPengJZhangMPanXPonicidin, an entkaurane diterpenoid derived from a constituent of the herbal supplement PC-SPES, Rabdosia rubescens, induces apoptosis by activation of caspase-3 and mitochondrial events in lung cancer cells in vitroCancer Invest2006241364810.1080/07357900500524371Open DOISearch in Google Scholar
Liu JJ, Zhang Y, Guang WB, Yang HZ, Lin DJ, Xiao RZ. Ponicidin inhibits monocytic leukemia cell growth by induction of apoptosis. Int J Mol Sci 2008; 9: 2265-77. 10.3390/ijms911226519330074LiuJJZhangYGuangWBYangHZLinDJXiaoRZ.Ponicidin inhibits monocytic leukemia cell growth by induction of apoptosisInt J Mol Sci2008922657710.3390/ijms9112265Open DOISearch in Google Scholar
Zhang JF, Liu PQ, Chen GH, Lu MQ, Cai CJ, Yang Y, et al. Ponicidin inhibits cell growth on hepatocellular carcinoma cells by induction of apoptosis. Dig Liver Dis 2007; 39: 160-6. 10.1016/j.dld.2006.09.01117049940ZhangJFLiuPQChenGHLuMQCaiCJYangYPonicidin inhibits cell growth on hepatocellular carcinoma cells by induction of apoptosisDig Liver Dis200739160610.1016/j.dld.2006.09.011Open DOISearch in Google Scholar
Liu YF, Lu YM, Qu GQ, Liu Y, Chen WX, Liao XH, et al. Ponicidin induces apoptosis via JAK2 and STAT3 signaling pathways in gastric carcinoma. Int J Mol Sci 2015; 16: 1576-89. 10.3390/ijms1601157625588213LiuYFLuYMQuGQLiuYChenWXLiaoXHPonicidin induces apoptosis via JAK2 and STAT3 signaling pathways in gastric carcinomaInt J Mol Sci20151615768910.3390/ijms16011576Open DOISearch in Google Scholar
Murayama C, Nagao Y, Sano S, Ochiai M, Fuji K, Fujita E, et al. Effect of oridonin, a Rabdosia diterpenoid, on radiosensitization with misonidazole. Experientia 1987; 43: 1221-3.10.1007/BF019455333691743MurayamaCNagaoYSanoSOchiaiMFujiKFujitaEEffect of oridonin, a Rabdosia diterpenoid, on radiosensitization with misonidazoleExperientia19874312213Open DOISearch in Google Scholar
Zhou GB, Kang H, Wang L, Gao L, Liu P, Xie J, et al. Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo. Blood 2007; 109: 3441-50. 10.1182/blood-2006-06-032250ZhouGBKangHWangLGaoLLiuPXieJOridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivoBlood200710934415010.1182/blood-2006-06-032250Open DOISearch in Google Scholar
Denekamp J, Waites T, Fowler JF. Predicting realistic RBE values for clinically relevant radiotherapy schedules. Int J Radiat Biol 1997; 71: 681-94.924618310.1080/095530097143699DenekampJWaitesTFowlerJF.Predicting realistic RBE values for clinically relevant radiotherapy schedulesInt J Radiat Biol19977168194Search in Google Scholar
Steel GG, Peckham MJ. Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity. Int J Radiat Oncol Biol Phys 1979; 5: 85-91.10.1016/0360-3016(79)90044-0422420SteelGGPeckhamMJ.Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivityInt J Radiat Oncol Biol Phys197958591Open DOISearch in Google Scholar
Morgan MA, Lawrence TS. Molecular pathways: overcoming radiation resistance by targeting DNA damage response pathways. Clin Cancer Res 2015; 21: 2898-904. 10.1158/1078-0432.CCR-13-322926133775MorganMALawrenceTS.Molecular pathways: overcoming radiation resistance by targeting DNA damage response pathwaysClin Cancer Res201521289890410.1158/1078-0432.CCR-13-3229Open DOISearch in Google Scholar
Hsieh TC, Wijeratne EK, Liang JY, Gunatilaka AL, Wu JM. Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens. Biochem Biophys Res Commun 2005; 337: 224-31. 10.1016/j.bbrc.2005.09.04016176802HsiehTCWijeratneEKLiangJYGunatilakaALWuJM.Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescensBiochem Biophys Res Commun20053372243110.1016/j.bbrc.2005.09.040Open DOISearch in Google Scholar
Roos WP, Kaina B. DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis. Cancer Lett 2013; 332: 237-48. 10.1016/j.canlet.2012.01.00722261329RoosWPKainaB.DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosisCancer Lett20133322374810.1016/j.canlet.2012.01.007Open DOISearch in Google Scholar
MacPhail SH, Banath JP, Yu TY, Chu EH, Lambur H, Olive PL. Expression of phosphorylated histone H2AX in cultured cell lines following exposure to X-rays. Int J Radiat Biol 2003; 79: 351-8.1294324310.1080/0955300032000093128MacPhailSHBanathJPYuTYChuEHLamburHOlivePL.Expression of phosphorylated histone H2AX in cultured cell lines following exposure to X-raysInt J Radiat Biol2003793518Search in Google Scholar
Sedelnikova OA, Rogakou EP, Panyutin IG, Bonner WM. Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody. Radiat Res 2002; 158: 486-92.1223681610.1667/0033-7587(2002)158[0486:QDOIID]2.0.CO;2SedelnikovaOARogakouEPPanyutinIGBonnerWM.Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibodyRadiat Res200215848692Search in Google Scholar
Zhang T, Tan Y, Zhao R, Liu Z. DNA damage induced by oridonin involves cell cycle arrest at G2/M phase in human MCF-7 cells. Contemp Oncol (Pozn) 2013; 17: 38-44. 10.5114/wo.2013.3377223788960ZhangTTanYZhaoRLiuZ.DNA damage induced by oridonin involves cell cycle arrest at G2/M phase in human MCF-7 cellsContemp Oncol (Pozn)201317384410.5114/wo.2013.33772Open DOISearch in Google Scholar
Li YH, Wang X, Pan Y, Lee DH, Chowdhury D, Kimmelman AC. Inhibition of non-homologous end joining repair impairs pancreatic cancer growth and enhances radiation response. PLoS One 2012; 7: e39588. 10.1371/journal.pone.003958822724027LiYHWangXPanYLeeDHChowdhuryDKimmelmanAC.Inhibition of non-homologous end joining repair impairs pancreatic cancer growth and enhances radiation responsePLoS One20127e3958810.1371/journal.pone.0039588Open DOISearch in Google Scholar
Wang SQ, Wang C, Chang LM, Zhou KR, Wang JW, Ke Y, et al. Geridonin and paclitaxel act synergistically to inhibit the proliferation of gastric cancer cells through ROS-mediated regulation of the PTEN/PI3K/Akt pathway. Oncotarget 2016; 7: 72990-3002. 10.18632/oncotarget.1216627659528WangSQWangCChangLMZhouKRWangJWKeYGeridonin and paclitaxel act synergistically to inhibit the proliferation of gastric cancer cells through ROS-mediated regulation of the PTEN/PI3K/Akt pathwayOncotarget2016772990300210.18632/oncotarget.12166Open DOISearch in Google Scholar
Cao S, Xia M, Mao Y, Zhang Q, Donkor PO, Qiu F, et al. Combined oridonin with cetuximab treatment shows synergistic anticancer effects on laryngeal squamous cell carcinoma: involvement of inhibition of EGFR and activation of reactive oxygen species-mediated JNK pathway. Int J Oncol 2016; 49: 2075-87. 10.3892/ijo.2016.369627667173CaoSXiaMMaoYZhangQDonkorPOQiuFCombined oridonin with cetuximab treatment shows synergistic anticancer effects on laryngeal squamous cell carcinoma: involvement of inhibition of EGFR and activation of reactive oxygen species-mediated JNK pathwayInt J Oncol20164920758710.3892/ijo.2016.3696Open DOISearch in Google Scholar
