In vitro and in vivo evaluation of electrochemotherapy with trans-platinum analogue trans-[PtCl₂(3-Hmpy)₂]

1Emens LA, Middleton G. The interplay of immunotherapy and chemotherapy: harnessing potential synergies. Cancer Immunol Res 2015; 3: 436-443. 10.1158/2326-6066.CIR-15-0064EmensLAMiddletonG. The interplay of immunotherapy and chemotherapy: harnessing potential synergies Cancer Immunol Res 2015 3 436 443 10.1158/2326-6066.CIR-15-0064Open DOISearch in Google Scholar

2Riaz N, Sherman E, Koutcher L, Shapiro L, Katabi N, Zhang ZG, et al. Concurrent chemoradiotherapy with cisplatin versus cetuximab for squamous cell carcinoma of the head and neck. Am J Clin Oncol-Canc 2016; 39: 27-31. 10.1097/COC.0000000000000006RiazNShermanEKoutcherLShapiroLKatabiNZhangZG Concurrent chemoradiotherapy with cisplatin versus cetuximab for squamous cell carcinoma of the head and neck Am J Clin Oncol-Canc 2016 39 27 31 10.1097/COC.0000000000000006Open DOISearch in Google Scholar

3Izgi K, Iskender B, Sakalar C, Arslanhan A, Yuksek EH, Hizar E, et al. Effects of epirubicin and cisplatin against 4T1 breast cancer cells are enhanced by myrtucommulone-A. Anticancer Agents Med Chem 2016. [Epub ahead of print]. 10.2174/1871520616666160404110543IzgiKIskenderBSakalarCArslanhanAYuksekEHHizarE Effects of epirubicin and cisplatin against 4T1 breast cancer cells are enhanced by myrtucommulone-A Anticancer Agents Med Chem 2016 [Epub ahead of print] 10.2174/1871520616666160404110543Open DOISearch in Google Scholar

4Amable L. Cisplatin resistance and opportunities for precision medicine. Pharmacol Res 2016; 106: 27-36. 10.1016/j.phrs.2016.01.001AmableL. Cisplatin resistance and opportunities for precision medicine Pharmacol Res 2016 106 27 36 10.1016/j.phrs.2016.01.001Open DOISearch in Google Scholar

5Galluzzi L, Vitale I, Michels J, Brenner C, Szabadkai G, Harel-Bellan A, et al. Systems biology of cisplatin resistance: past, present and future. Cell Death Dis 2014; 5: e1257. 10.1038/cddis.2013.428GalluzziLVitaleIMichelsJBrennerCSzabadkaiGHarel-BellanA Systems biology of cisplatin resistance: past, present and future Cell Death Dis 2014 5 e1257 10.1038/cddis.2013.428Open DOISearch in Google Scholar

6Burger H, Zoumaro-Djayoon A, Boersma AWM, Helleman J, Berns EMJJ, Mathijssen RHJ, et al. Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2). Brit J Pharmacol 2010; 159: 898-908. 10.1111/j.1476-5381.2009.00569.BurgerH Zoumaro-DjayoonABoersmaAWMHellemanJBernsEMJJMathijssenRHJ Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2) Brit J Pharmacol 2010 159 898 908 10.1111/j.1476-5381.2009.00569Open DOISearch in Google Scholar

7Ciarimboli G. Membrane transporters as mediators of cisplatin side-effects. Anticancer Res 2014; 34: 547-50.CiarimboliG. Membrane transporters as mediators of cisplatin side-effects Anticancer Res 2014 34 547 50Search in Google Scholar

8Larson CA, Blair BG, Safaei R, Howell SB. The role of the mammalian copper transporter 1 in the cellular accumulation of platinum-based drugs. Mol Pharmacol 2009; 75: 324-30. 10.1124/mol.108.052381LarsonCABlairBGSafaeiRHowellSB. The role of the mammalian copper transporter 1 in the cellular accumulation of platinum-based drugs Mol Pharmacol 2009 75 324 30 10.1124/mol.108.052381Open DOISearch in Google Scholar

9Icsel C, Yilmaz VT, Ari F, Ulukaya E, Harrison WTA. trans-Dichloridopalladium (II) and platinum (II) complexes with 2-(hydroxymethyl)pyridine and 2-(2-hydroxyethyl)pyridine: synthesis, structural characterization, DNA binding and in vitro cytotoxicity studies. Eur J Med Chem 2013; 60: 386-94. 10.1016/j.ejmech.2012.12.002IcselCYilmazVTAriFUlukayaEHarrisonWTA. trans-Dichloridopalladium (II) and platinum (II) complexes with 2-(hydroxymethyl)pyridine and 2-(2-hydroxyethyl)pyridine: synthesis, structural characterization, DNA binding and in vitro cytotoxicity studies Eur J Med Chem 2013 60 386 94 10.1016/j.ejmech.2012.12.002Open DOISearch in Google Scholar

10Kasparkova J, Marini V, Najajreh Y, Gibson D, Brabec V. DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine, or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell lines. Biochemistry 2003; 42: 6321-32. 10.1021/bi0342315KasparkovaJMariniVNajajrehYGibsonDBrabecV. DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine, or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell lines Biochemistry 2003 42 6321 32 10.1021/bi0342315Open DOISearch in Google Scholar

11Martinez A, Lorenzo J, Prieto MJ, Font-Bardia M, Solans X, Aviles FX, et al. Influence of the position of substituents in the cytotoxic activity of trans platinum complexes with hydroxymethyl pyridines. Bioorg Med Chem 2007; 15: 969-79. 10.1016/j.bmc.2006.10.031MartinezALorenzoJPrietoMJ Font-BardiaMSolansXAvilesFX Influence of the position of substituents in the cytotoxic activity of trans platinum complexes with hydroxymethyl pyridines Bioorg Med Chem 2007 15 969 79 10.1016/j.bmc.2006.10.031Open DOISearch in Google Scholar

12Najajreh Y, Perez JM, Navarro-Ranninger C, Gibson D. Novel soluble cationic trans-diaminedichloroplatinum (II) complexes that are active against cisplatin resistant ovarian cancer cell lines. J Med Chem 2002; 45: 5189-95.NajajrehYPerezJM Navarro-RanningerCGibsonD. Novel soluble cationic trans-diaminedichloroplatinum (II) complexes that are active against cisplatin resistant ovarian cancer cell lines J Med Chem 2002 45 5189 95Search in Google Scholar

13Quiroga AG. Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA. J Inorg Biochem 2012; 114: 106-12. 10.1016/j.jinorgbio.2012.06.002QuirogaAG. Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA J Inorg Biochem 2012 114 106 12 10.1016/j.jinorgbio.2012.06.002Open DOISearch in Google Scholar

14Ramos-Lima FJ, Moneo V, Quiroga AG, Carnero A, Navarro-Ranninger C. The role of p53 in the cellular toxicity by active trans-platinum complexes containing isopropylamine and hydroxymethylpyridine. Eur J Med Chem 2010; 45: 134-41. 10.1016/j.ejmech.2009.09.035Ramos-LimaFJMoneoVQuirogaAGCarneroA Navarro-RanningerC. The role of p53 in the cellular toxicity by active trans-platinum complexes containing isopropylamine and hydroxymethylpyridine Eur J Med Chem 2010 45 134 41 10.1016/j.ejmech.2009.09.035Open DOISearch in Google Scholar

15Coluccia M, Natile G. Trans-platinum complexes in cancer therapy. Anticancer Agents Med Chem 2007; 7: 111-23.ColucciaMNatileG. Trans-platinum complexes in cancer therapy Anticancer Agents Med Chem 2007 7 111 23Search in Google Scholar

16Johnstone TC, Suntharalingam K, Lippard SJ. The next generation of platinum drugs: targeted Pt (II) agents, nanoparticle delivery, and Pt (IV) prodrugs. Chem Rev 2016; 116: 3436-86. 10.1021/acs.chemrev.5b0059JohnstoneTCSuntharalingamKLippardSJ. The next generation of platinum drugs: targeted Pt (II) agents, nanoparticle delivery, and Pt (IV) prodrugs Chem Rev 2016 116 3436 86 10.1021/acs.chemrev.5b0059Open DOISearch in Google Scholar

17Shahsavar F, Bozorgmehr M, Mirzadegan E, Abedi A, Lighvan ZM, Mohammadi F, et al. A novel platinum-based compound with preferential cytotoxic activity against a panel of cancer cell lines. Anticancer Agents Med Chem 2016; 16: 393-403.ShahsavarFBozorgmehrMMirzadeganEAbediALighvanZMMohammadiF A novel platinum-based compound with preferential cytotoxic activity against a panel of cancer cell lines Anticancer Agents Med Chem 2016 16 393 403Search in Google Scholar

18Ari F, Aztopal N, Icsel C, Yilmaz VT, Guney E, Buyukgungor O, et al. Synthesis, structural characterization and cell death-inducing effect of novel palladium (II) and platinum (II) saccharinate complexes with 2-(hydroxymethyl) pyridine and 2-(2-hydroxyethyl) pyridine on cancer cells in vitro. Bioorg Med Chem 2013; 21: 6427-34. 10.1016/j.bmc.2013.08.050AriFAztopalNIcselCYilmazVTGuneyEBuyukgungorO Synthesis, structural characterization and cell death-inducing effect of novel palladium (II) and platinum (II) saccharinate complexes with 2-(hydroxymethyl) pyridine and 2-(2-hydroxyethyl) pyridine on cancer cells in vitro Bioorg Med Chem 2013 21 6427 34 10.1016/j.bmc.2013.08.050Open DOISearch in Google Scholar

19Cemazar M, Pipan Z, Grabner S, Bukovec N, Sersa G. Cytotoxicity of different platinum (II) analogues to human tumour cell lines in vitro and murine tumour in vivo alone or combined with electroporation. Anticancer Res 2006; 26: 1997-2002.CemazarMPipanZGrabnerSBukovecNSersaG. Cytotoxicity of different platinum (II) analogues to human tumour cell lines in vitro and murine tumour in vivo alone or combined with electroporation Anticancer Res 2006 26 1997 2002Search in Google Scholar

20Grabner S, Cemazar M, Bukovec N, Sersa G. Syntheses and cytotoxicity of Pt (II) complexes with acyclovir. Acta Chim Slov 2006; 53: 153-8.GrabnerSCemazarMBukovecNSersaG. Syntheses and cytotoxicity of Pt (II) complexes with acyclovir Acta Chim Slov 2006 53 153 8Search in Google Scholar

21Grabner S, Modec B, Bukovec N, Bukovec P, Cemazar M, Kranjc S, et al. Cytotoxic trans-platinum (II) complex with 3-hydroxymethylpyridine: synthesis, X-ray structure and biological activity evaluation. J Inorg Biochem 2016; 161: 40-51. 10.1016/j.jinorgbio.2016.04.031GrabnerSModecBBukovecNBukovecPCemazarMKranjcS Cytotoxic trans-platinum (II) complex with 3-hydroxymethylpyridine: synthesis, X-ray structure and biological activity evaluation J Inorg Biochem 2016 161 40 51 10.1016/j.jinorgbio.2016.04.031Open DOISearch in Google Scholar

22Tiwari G, Tiwari R, Sriwastawa B, Bhati L, Pandey S, Pandey P, et al. Drug delivery systems: an updated review. Int J Pharm Investig 2012; 2: 2-11. 10.4103/2230-973X.96920TiwariGTiwariRSriwastawaBBhatiLPandeySPandeyP Drug delivery systems: an updated review Int J Pharm Investig 2012 2 2 11 10.4103/2230-973X.96920Open DOISearch in Google Scholar

23Kaur H, Desai SD, Kumar V, Rathi P, Singh J. Heterocyclic drug-polymer conjugates for cancer targeted drug delivery. Anticancer Agents Med Chem 2016; 16: 1355-77.KaurHDesaiSDKumarVRathiPSinghJ. Heterocyclic drug-polymer conjugates for cancer targeted drug delivery Anticancer Agents Med Chem 2016 16 1355 77Search in Google Scholar

24Neumann E, Schaeferridder M, Wang Y, Hofschneider PH. Gene-transfer into mouse lyoma cells by electroporation in high electric-fields. EMBO J 1982; 1: 841-5.NeumannESchaeferridderMWangYHofschneiderPH. Gene-transfer into mouse lyoma cells by electroporation in high electric-fields EMBO J 1982 1 841 5Search in Google Scholar

25Cemazar M, Miklavcic D, Mir LM, Belchradek J, Bonnay M, Fourcault D, et al. Electrochemotherapy of tumours resistant to cisplatin: a study in a murine tumour model. Eur J Cancer 2001; 37: 1166-72. 10.1016/S09598049(01)00091-0CemazarMMiklavcicDMirLMBelchradekJBonnayMFourcaultD Electrochemotherapy of tumours resistant to cisplatin: a study in a murine tumour model Eur J Cancer 2001 37 1166 72 10.1016/S09598049(01)00091-0Open DOISearch in Google Scholar

26Kranjc S, Cemazar M, Grosel A, Pipan Z, Sersa G. Effect of electroporation on radiosensitization with cisplatin in two cell lines with different chemo- and radiosensitivity. Radiol Oncol 2003; 37: 101-7.KranjcSCemazarMGroselAPipanZSersaG. Effect of electroporation on radiosensitization with cisplatin in two cell lines with different chemo- and radiosensitivity Radiol Oncol 2003 37 101 7Search in Google Scholar

27Kranjc S; Cemazar M, Grosel A, Scancar J, Sersa G. Electroporation of LPB sarcoma cells in vitro and tumors in vivo increases the radiosensitizing effect of cisplatin. Anticancer Res 2003; 23: 275-81.KranjcS CemazarMGroselAScancarJSersaG. Electroporation of LPB sarcoma cells in vitro and tumors in vivo increases the radiosensitizing effect of cisplatin Anticancer Res 2003 23 275 81Search in Google Scholar

28Sersa G, Cemazar M, Miklavcic D. Antitumor effectiveness of electrochemotherapy with cis-diamminedichloroplatinum (II) in mice. Cancer Res 1995; 55: 3450-5.SersaGCemazarMMiklavcicD. Antitumor effectiveness of electrochemotherapy with cis-diamminedichloroplatinum (II) in mice Cancer Res 1995 55 3450 5Search in Google Scholar

29Cemazar M, Miklavcic D, Scancar J, Dolzan V, Golouh R, Sersa G. Increased platinum accumulation in SA-1 tumour cells after in vivo electrochemotherapy with cisplatin. Brit J Cancer 1999; 79: 1386-91.CemazarMMiklavcicDScancarJDolzanVGolouhRSersaG. Increased platinum accumulation in SA-1 tumour cells after in vivo electrochemotherapy with cisplatin Brit J Cancer 1999 79 1386 91Search in Google Scholar

30Cemazar M, Tamzali Y, Sersa G, Tozon N, Mir L.M, Miklavcic D, et al. Electrochemotherapy in veterinary oncology. J Vet Intern Med 2008; 22: 826-31. 10.1111/j.1939-1676.2008.0117.xCemazarMTamzaliYSersaGTozonNMirL.MMiklavcicD Electrochemotherapy in veterinary oncology J Vet Intern Med 2008 22 826 31 10.1111/j.1939-1676.2008.0117.xOpen DOISearch in Google Scholar

31Maglietti F, Tellado M, Olaiz N, Michinski S, Marshal, G. Combined local and systemic bleomycin administration in electrochemotherapy to reduce the number of treatment sessions. Radiol Oncol 2016; 50: 58-63. 10.1515/raon-2016-0015MagliettiFTelladoMOlaizNMichinskiSMarshalG. Combined local and systemic bleomycin administration in electrochemotherapy to reduce the number of treatment sessions Radiol Oncol 2016 50 58 63 10.1515/raon-2016-0015Open DOISearch in Google Scholar

32Mali B, Jarm T, Snoj M, Sersa G, Miklavcic D. Antitumor effectiveness of electrochemotherapy: a systematic review and meta-analysis. Eur J Surg Oncol 2013; 39: 4-16. 10.1016/j.ejso.2012.08.016MaliBJarmTSnojMSersaGMiklavcicD. Antitumor effectiveness of electrochemotherapy: a systematic review and meta-analysis Eur J Surg Oncol 2013 39 4 16 10.1016/j.ejso.2012.08.016Open DOISearch in Google Scholar

33Yarmush ML, Golberg A, Sersa G, Kotnik T, Miklavcic D. Electroporation-based technologies for medicine: principles, applications, and challenges. Annu Rev Biomed Eng 2014; 16: 295-320. 10.1146/annurev-bioeng-071813-1046221YarmushMLGolbergASersaGKotnikTMiklavcicD. Electroporation-based technologies for medicine: principles, applications, and challenges Annu Rev Biomed Eng 2014 16 295 320 10.1146/annurev-bioeng-071813-104622Open DOISearch in Google Scholar

34Cemazar M, Milacic R, Miklavcic D, Dolzan V, Sersa G. Intratumoral cisplatin administration in electrochemotherapy: antitumor effectiveness, sequence dependence and platinum content. Anticancer Drugs 1998; 9: 525-30.CemazarMMilacicRMiklavcicDDolzanVSersaG. Intratumoral cisplatin administration in electrochemotherapy: antitumor effectiveness sequence dependence and platinum content Anticancer Drugs 1998 9 525 30Search in Google Scholar

35Sersa G, Teissie J, Cemazar M, Signori E, Kamensek U, Marshall Get al. Electrochemotherapy of tumors as in situ vaccination boosted by immunogene electrotransfer. Cancer Immunol Immunother 2015; 64: 1315-27. 10.1007/s00262-015-1724-2SersaGTeissieJCemazarMSignoriEKamensekUMarshallG Electrochemotherapy of tumors as in situ vaccination boosted by immunogene electrotransfer Cancer Immunol Immunother 2015 64 1315 27 10.1007/s00262-015-1724-2Open DOISearch in Google Scholar

36Markelc B, Sersa G, Cemazar M. Differential mechanisms associated with vascular disrupting action of electrochemotherapy: intravital microscopy on the level of single normal and tumor blood vessels. PloS One, 2013; 8: e59557. 10.1371/journal.pone.0059557MarkelcBSersaGCemazarM. Differential mechanisms associated with vascular disrupting action of electrochemotherapy: intravital microscopy on the level of single normal and tumor blood vessels PloS One 2013 8 e59557 10.1371/journal.pone.0059557Open DOISearch in Google Scholar

37Belehradek JJ, Barski G, Thonier M. Evolution of cell-mediated antitumor immunity in mice bearing a syngeneic chemically induced tumor. Influence of tumor growth, surgical removal and treatment with irradiated tumor cells. Int J Cancer 1972; 9: 461-9.BelehradekJJBarskiGThonierM. Evolution of cell-mediated antitumor immunity in mice bearing a syngeneic chemically induced tumor. Influence of tumor growth surgical removal and treatment with irradiated tumor cells Int J Cancer 1972 9 461 9Search in Google Scholar

38Sedlar A, Dolinsek T, Markelc B, Prosen L, Kranjc S, Bosnjak M, et al. Potentiation of electrochemotherapy by intramuscular IL-12 gene electrotransfer in murine sarcoma and carcinoma with different immunogenicity. Radiol Oncol 2012; 46: 302-11. 10.2478/v10019-012-0044-9SedlarADolinsekTMarkelcBProsenLKranjcSBosnjakM Potentiation of electrochemotherapy by intramuscular IL-12 gene electrotransfer in murine sarcoma and carcinoma with different immunogenicity Radiol Oncol 2012 46 302 11 10.2478/v10019-012-0044-9Open DOISearch in Google Scholar

39Hollis L.S, Amundsen AR, Stern EW. Chemical and biological properties of a new series of cis-diammineplatinum (II) antitumor agents containing three nitrogen donors: cis-[Pt(NH₃)₂(N-donor)Cl]⁺. J Med Chem 1989; 32: 128-36.HollisL.SAmundsenARSternEW. Chemical and biological properties of a new series of cis-diammineplatinum (II) antitumor agents containing three nitrogen donors: cis-[Pt(NH₃)₂(N-donor)Cl]⁺ J Med Chem 1989 32 128 36Search in Google Scholar

40Leng M, Locker D, Giraud-Panis MJ, Schwartz A, Intini FP, Natile G, et al. Replacement of an NH₃ by an iminoether in transplatin makes an antitumor drug from an inactive compound. Mol Pharmacol 2000; 58: 1525-35.LengMLockerD Giraud-PanisMJSchwartzAIntiniFPNatileG Replacement of an NH₃ by an iminoether in transplatin makes an antitumor drug from an inactive compound Mol Pharmacol 2000 58 1525 35Search in Google Scholar

41Perez JM, Kelland LR, Montero EI, Boxall FE, Fuertes MA, Alonso C, et al. Antitumor and cellular pharmacological properties of a novel platinum (IV) complex: trans-[PtCl₂(OH)₂(dimethylamine) (isopropylamine)]. Mol Pharmacol 2003; 63: 933-44.PerezJMKellandLRMonteroEIBoxallFEFuertesMAAlonsoC Antitumor and cellular pharmacological properties of a novel platinum (IV) complex: trans-[PtCl₂(OH)₂(dimethylamine) (isopropylamine)] Mol Pharmacol 2003 63 933 44Search in Google Scholar

42Cemazar M, Miklavcic D, Vodovnik L, Jarm T, Rudolf Z, Stabuc B, et al. Improved therapeutic effect of electrochemotherapy with cisplatin by intratumoral drug administration and changing of electrode orientation for electropermeabilization on EAT tumor model in mice. Radiol Oncol 1995; 29: 121-7.CemazarMMiklavcicDVodovnikLJarmTRudolfZStabucB Improved therapeutic effect of electrochemotherapy with cisplatin by intratumoral drug administration and changing of electrode orientation for electropermeabilization on EAT tumor model in mice Radiol Oncol 1995 29 121 7Search in Google Scholar

43Baharuddin P, Satar, N, Fakiruddin KS, Zakaria N, Lim MN, Yusoff NM, et al. Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines. Oncol Rep 2016; 35: 13-25. 10.3892/or.2015.4371BaharuddinP SatarN FakiruddinKSZakariaNLimMNYusoffNM Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines Oncol Rep 2016 35 13 25 10.3892/or.2015.4371Open DOISearch in Google Scholar

44Lee JH, Chae JW, Kim JK, Kim HJ, Chung JY, Kim YH. Inhibition of cisplatin-resistance by RNA interference targeting metallothionein using reducible oligo-peptoplex. J Control Release 2015; 215: 82-90. 10.1016/j.jconrel.2015.07.015LeeJHChaeJWKimJKKimHJChungJYKimYH. Inhibition of cisplatin-resistance by RNA interference targeting metallothionein using reducible oligo-peptoplex J Control Release 2015 215 82 90 10.1016/j.jconrel.2015.07.015Open DOISearch in Google Scholar

45Chong SX, Au-Yeung SC, To KK. Monofunctional platinum (PtII) compounds - shifting the paradigm in designing new pt-based anticancer agents. Curr Med Chem 2016; 23: 1268-85. 10.2174/0929867323666160311114509ChongSX Au-YeungSCToKK. Monofunctional platinum (PtII) compounds - shifting the paradigm in designing new pt-based anticancer agents Curr Med Chem 2016 23 1268 85 10.2174/0929867323666160311114509Open DOISearch in Google Scholar

46Igarashi K, Yamamoto N, Hayashi K, Takeuchi A, Miwa S, Odani A, et al. Effectiveness of two novel anionic and cationic platinum complexes in the treatment of osteosarcoma. Anticancer Agents Med Chem 2015; 15: 390-9.IgarashiKYamamotoNHayashiKTakeuchiAMiwaSOdaniA Effectiveness of two novel anionic and cationic platinum complexes in the treatment of osteosarcoma Anticancer Agents Med Chem 2015 15 390 9Search in Google Scholar

47Hudej R, Miklavcic D, Cemazar M, Todorovic V, Sersa G, Bergamo A, et al. Modulation of activity of known cytotoxic ruthenium (III) compound (KP418) with hampered transmembrane transport in electrochemotherapy in vitro and in vivo. J Membrane Biol 2014; 247: 1239-51. 10.1007/s00232-014-9696-2HudejRMiklavcicDCemazarMTodorovicVSersaGBergamoA Modulation of activity of known cytotoxic ruthenium (III) compound (KP418) with hampered transmembrane transport in electrochemotherapy in vitro and in vivo J Membrane Biol 2014 247 1239 51 10.1007/s00232-014-9696-2Open DOISearch in Google Scholar

48Hudej R, Turel I, Kanduser M, Scancar J, Kranjc S, Sersa G, et al. The Influence of electroporation on cytotoxicity of anticancer ruthenium (III) complex KP1339 in vitro and in vivo, Anticancer Res, 2010, 30 2055-63.HudejRTurelIKanduserMScancarJKranjcSSersaG The Influence of electroporation on cytotoxicity of anticancer ruthenium (III) complex KP1339 in vitro and in vivo Anticancer Res 2010 30 2055 63Search in Google Scholar

49Calvet CY, Famin D, Andre FM, Mir LM. Electrochemotherapy with bleomycin induces hallmarks of immunogenic cell death in murine colon cancer cells. Oncoimmunology 2014; 3: e28131. 10.4161/onci.28131CalvetCYFaminDAndreFMMirLM. Electrochemotherapy with bleomycin induces hallmarks of immunogenic cell death in murine colon cancer cells Oncoimmunology 2014 3 e28131 10.4161/onci.28131Open DOISearch in Google Scholar

50Cemazar M, Golzio M, Sersa G, Escoffre JM, Coer A, Vidic S, et al. Hyaluronidase and collagenase increase the transfection efficiency of gene electrotransfer in various murine tumors. Hum Gene Ther 2012; 23: 128-37. 10.1089/hum.2011.073CemazarMGolzioMSersaGEscoffreJMCoerAVidicS Hyaluronidase and collagenase increase the transfection efficiency of gene electrotransfer in various murine tumors Hum Gene Ther 2012 23 128 37 10.1089/hum.2011.073Open DOISearch in Google Scholar

51Bartel C, Bytzek AK, Scaffidi-Domianello YY, Grabmann G, Jakupec MA, Hartinger CG, et al. Cellular accumulation and DNA interaction studies of cytotoxic trans-platinum anticancer compounds. J Biol Inorg Chem 2012; 17: 465-74. 10.1007/s00775-011-0869-5BartelCBytzekAK Scaffidi-DomianelloYYGrabmannGJakupecMAHartingerCG Cellular accumulation and DNA interaction studies of cytotoxic trans-platinum anticancer compounds J Biol Inorg Chem 2012 17 465 74 10.1007/s00775-011-0869-5Open DOISearch in Google Scholar

52Khazanov E, Barenholz Y, Gibson D, Najajreh Y. Novel apoptosis-inducing trans-platinum piperidine derivatives: synthesis and biological characterization. J Med Chem 2002; 45: 5196-204.KhazanovEBarenholzYGibsonDNajajrehY. Novel apoptosis-inducing trans-platinum piperidine derivatives: synthesis and biological characterization J Med Chem 2002 45 5196 204Search in Google Scholar

53Halamikova A, Heringova P, Kasparkova J, Intini FP, Natile G, Nemirovski A, et al. Cytotoxicity, mutagenicity, cellular uptake, DNA and glutathione interactions of lipophilic trans-platinum complexes tethered to 1-adamantylamine. J Inorg Biochem 2008; 102: 1077-89. 10.1016/j.jinorgbio.2007.12.015HalamikovaAHeringovaPKasparkovaJIntiniFPNatileGNemirovskiA Cytotoxicity, mutagenicity, cellular uptake DNA and glutathione interactions of lipophilic trans-platinum complexes tethered to 1-adamantylamine J Inorg Biochem 2008 102 1077 89 10.1016/j.jinorgbio.2007.12.015Open DOISearch in Google Scholar

54Chowdhury MA, Huq F, Abdullah A, Beale P, Fisher K. Synthesis, characterization and binding with DNA of four planaramineplatinum (II) complexes of the forms: trans-PtL₂Cl₂ and [PtL₃Cl]Cl, where L = 3-hydroxypyridine, 4-hydroxypyridine and imidazo(1,2-alpha)pyridine. J Inorg Biochem 2005; 99: 1098-112.ChowdhuryMAHuqFAbdullahABealePFisherK. Synthesis, characterization and binding with DNA of four planaramineplatinum (II) complexes of the forms: trans-PtL₂Cl₂ and [PtL₃Cl]Cl, where L = 3-hydroxypyridine, 4-hydroxypyridine and imidazo(1,2-alpha)pyridine J Inorg Biochem 2005 99 1098 112Search in Google Scholar

55Novakova O, Kasparkova J, Malina J, Natile G, Brabec V. DNA-protein crosslinking by trans-[PtCl₂(E-iminoether)₂]. A concept for activation of the trans geometry in platinum antitumor complexes. Nucleic Acids Res 2003; 31: 6450-60.NovakovaOKasparkovaJMalinaJNatileGBrabecV. DNA-protein crosslinking by trans-[PtCl₂(E-iminoether)₂]. A concept for activation of the trans geometry in platinum antitumor complexes Nucleic Acids Res 2003 31 6450 60Search in Google Scholar

56Richards AD, Rodger A. Synthetic metallomolecules as agents for the control of DNA structure. Chem Soc Rev 2007; 36: 471-83.RichardsADRodgerA. Synthetic metallomolecules as agents for the control of DNA structure Chem Soc Rev 2007 36 471 83Search in Google Scholar

57Martincic A, Cemazar M, Sersa G, Kovac V, Milacic R, Scancar J. A novel method for speciation of Pt in human serum incubated with cisplatin, oxaliplatin and carboplatin by conjoint liquid chromatography on monolithic disks with UV and ICP-MS detection. Talanta 2013; 116: 141-8. 10.1016/j.talanta.2013.05.01MartincicACemazarMSersaGKovacVMilacicRScancarJ. A novel method for speciation of Pt in human serum incubated with cisplatin oxaliplatin and carboplatin by conjoint liquid chromatography on monolithic disks with UV and ICP-MS detection Talanta 2013 116 141 8 10.1016/j.talanta.2013.05.01Open DOISearch in Google Scholar

58Martincic A, Milacic R, Cemazar M, Sersa G, Scancar J. The use of CIM-DEAE monolithic chromatography coupled to ICP-MS to study the distribution of cisplatin in human serum. Anal Methods 2012; 4: 780-90. 10.1016/j.chroma.2014.10.054MartincicAMilacicRCemazarMSersaGScancarJ. The use of CIM-DEAE monolithic chromatography coupled to ICP-MS to study the distribution of cisplatin in human serum Anal Methods 2012 4 780 90 10.1016/j.chroma.2014.10.054Open DOISearch in Google Scholar