<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Humans are exposed to chemicals and PM (particulate matter), including ultrafine particles (nanoparticles), mainly through inhalation. This creates a risk to their health. Another effect to exposure is expression of cytokines and their role in lung inflammation and morphpathogenesis. We conducted a pilot project based on testing of realistic exposure scenarios by describing morphological changes of the respiratory tract in Wistar rats (male) during a 30-day exposure in office where there was high intensity of printing activities. Tracheal tissue of experimental animals had increasing concentrations of inflammatory interleukin IL-1 and decreasing concentrations of IL-6 and TNF-α. The lungs of the experimental animals tended to show focal infiltration of inflammatory cells, vascular plethora, focal and/or diffuse localisation of lymphatic nodules, and also vascular sclerosis and focal emphysema. The results suggested potential dangerous and adverse effect of poor indoor air quality (particles, including nanoparticles, and chemical compounds) on respiratory tract tissue of rats.</p></abstract>

Humans are exposed to chemicals and PM (particulate matter), including ultrafine particles (nanoparticles), mainly through inhalation. This creates a risk to their health. Another effect to exposure is expression of cytokines and their role in lung inflammation and morphpathogenesis. We conducted a pilot project based on testing of realistic exposure scenarios by describing morphological changes of the respiratory tract in Wistar rats (male) during a 30-day exposure in office where there was high intensity of printing activities. Tracheal tissue of experimental animals had increasing concentrations of inflammatory interleukin IL-1 and decreasing concentrations of IL-6 and TNF-α. The lungs of the experimental animals tended to show focal infiltration of inflammatory cells, vascular plethora, focal and/or diffuse localisation of lymphatic nodules, and also vascular sclerosis and focal emphysema. The results suggested potential dangerous and adverse effect of poor indoor air quality (particles, including nanoparticles, and chemical compounds) on respiratory tract tissue of rats.

Evaluation of Histological Findings of Airways of Rats Exposed to Highly Polluted Indoor Air in Offices

Institute of Occupational Safety and Environmental Health, Rīga Stradiņš University, Dzirciema iela 16, Rīga, LV-1007,

Institute of Anatomy and Anthropology, Rīga Stradiņš University, Dzirciema iela 16, Rīga, LV-1007,

Laboratory of Biochemistry, Rīga Stradiņš University, Dzirciema iela 16, Rīga, LV-1007,

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Humans are exposed to chemicals and PM (particulate matter), including ultrafine particles (nanoparticles), mainly through inhalation. This creates a risk to...

Evaluation of Histological Findings of Airways of Rats Exposed to Highly Polluted Indoor Air in Offices

Data publikacji: 30 lis 2016

Zakres stron: 341 - 344

Otrzymano: 21 wrz 2016

DOI: https://doi.org/10.1515/prolas-2016-0052

Słowa kluczowe
indoor air quality, rats’ trachea tissue, rats’ lung tissue, IL6, IL1, TNF-α

© 2016 Žanna Martinsone et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Evaluation of Histological Findings of Airways of Rats Exposed to Highly Polluted Indoor Air in Offices

Data publikacji: 30 lis 2016

Zakres stron: 341 - 344

Otrzymano: 21 wrz 2016

DOI: https://doi.org/10.1515/prolas-2016-0052

Słowa kluczoweindoor air quality, rats’ trachea tissue, rats’ lung tissue, IL6, IL1, TNF-α

© 2016 Žanna Martinsone et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Słowa kluczowe
indoor air quality, rats’ trachea tissue, rats’ lung tissue, IL6, IL1, TNF-α