<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The aim of this study was to investigate the role of serum cytokines in the diagnosis of acute appendicitis (AA) and acute mesenteric lymphadenitis (AML). Data were collected prospectively on 7 to 18 year old children (October 2010 - October 2013): 31 patients with AA, 26 patients with AML, and 17 patients with elective non-inflammatory surgical disease were selected as controls. Serum levels of IL-10, IL-12(p70), IL-1β, IL-4, IL-6, IL-8, IL-17, MCP-1, EGF, TNF-α were measured. Patients with AA had significantly increased serum levels of IL-6(1) (z = -3.72; p = 0.0002) and IL-10(1) (z = -2.81; p = 0.005) compared to AML before any treatment. The consecutive measurements of MCP-1 in serum demonstrated a significant difference within 72 hours in the AA group (Wilks’ Lambda test 0.80; F(2;29) = 3.5; p = 0.04) and also in the AML group (Wilks’ Lambda test 0.70; F(2;24) = 5.0; p = 0.01). The increased values of IL-6 and IL-10 were the most reliable cytokines one hour before surgical intervention for patients with AA. MCP-1 values changed significantly within 72 hours after patient hospitalisation but did not differ between the groups, and could not be a helpful serum biomarker in distinguishing patients with AA and AML. </p></abstract>

The aim of this study was to investigate the role of serum cytokines in the diagnosis of acute appendicitis (AA) and acute mesenteric lymphadenitis (AML). Data were collected prospectively on 7 to 18 year old children (October 2010 - October 2013): 31 patients with AA, 26 patients with AML, and 17 patients with elective non-inflammatory surgical disease were selected as controls. Serum levels of IL-10, IL-12(p70), IL-1β, IL-4, IL-6, IL-8, IL-17, MCP-1, EGF, TNF-α were measured. Patients with AA had significantly increased serum levels of IL-6(1) (z = -3.72; p = 0.0002) and IL-10(1) (z = -2.81; p = 0.005) compared to AML before any treatment. The consecutive measurements of MCP-1 in serum demonstrated a significant difference within 72 hours in the AA group (Wilks’ Lambda test 0.80; F(2;29) = 3.5; p = 0.04) and also in the AML group (Wilks’ Lambda test 0.70; F(2;24) = 5.0; p = 0.01). The increased values of IL-6 and IL-10 were the most reliable cytokines one hour before surgical intervention for patients with AA. MCP-1 values changed significantly within 72 hours after patient hospitalisation but did not differ between the groups, and could not be a helpful serum biomarker in distinguishing patients with AA and AML.

Different Cytokine Profiles in Children with Acute Appendicitis and Acute Mesenteric Lymphadenitis / Atðíirîga Citokînu Grupas Seruma Iekaisuma Mediatoru Izpausme Akûta Apendicîta Un Akûta Mezenteriâla Limfadenîta Gadîjumâ Bçrniem

Department of Paediatric Surgery, Children’s University Hospital, Vienîbas gatve 45, Rîga, LV-1004, LATVIA

Department of Paediatric Surgery, Rîga Stradiòð University, Vienîbas gatve 45, Rîga, LV-1004, LATVIA

Department of Physiology and Biochemistry, Rîga Stradiòð University, Dzirciema iela 16, Rîga, LV-1007, LATVIA

Department of Research, Statistics and Health Promotion, Centre for Disease Prevention and Control of Latvia, Duntes iela 22, LV-1005, Rîga, LATVIA

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The aim of this study was to investigate the role of serum cytokines in the diagnosis of acute appendicitis (AA) and acute mesenteric lymphadenitis (AML). Data...

Different Cytokine Profiles in Children with Acute Appendicitis and Acute Mesenteric Lymphadenitis / Atðíirîga Citokînu Grupas Seruma Iekaisuma Mediatoru Izpausme Akûta Apendicîta Un Akûta Mezenteriâla Limfadenîta Gadîjumâ Bçrniem

Data publikacji: 19 lut 2016

Zakres stron: 283 - 289

Otrzymano: 20 sty 2015

DOI: https://doi.org/10.1515/prolas-2015-0044

Słowa kluczowe
appendicitis, mesenteric lymphadenitis, cytokines, diagnosis

© by Astra Zviedre

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Different Cytokine Profiles in Children with Acute Appendicitis and Acute Mesenteric Lymphadenitis / Atðíirîga Citokînu Grupas Seruma Iekaisuma Mediatoru Izpausme Akûta Apendicîta Un Akûta Mezenteriâla Limfadenîta Gadîjumâ Bçrniem

Data publikacji: 19 lut 2016

Zakres stron: 283 - 289

Otrzymano: 20 sty 2015

DOI: https://doi.org/10.1515/prolas-2015-0044

Słowa kluczoweappendicitis, mesenteric lymphadenitis, cytokines, diagnosis

© by Astra Zviedre

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Słowa kluczowe
appendicitis, mesenteric lymphadenitis, cytokines, diagnosis