<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Cell therapy for the ischemic injured heart has been largely investigated in the last two decades, and most of the small cohort and randomized clinical studies, as well as meta-analyses led to the conclusion that cell-based human regenerative therapy is safe and effective in term of reducing adverse clinical outcomes and increasing left ventricular performance. Both the in vitro and in vivo rodent animal models of ischemic heart failure using bone marrow-derived mononuclear cells promised marvelous success in regeneration of the heart suffering from ischemic burden. However, in certain patient groups, stem cell studies failed to reach the primary endpoint, showing no effect of this regenerative therapy. This brief overview addresses the contradictory results between human cardiac regenerative studies and the very positive rodent experiments.</p></abstract>

Cell therapy for the ischemic injured heart has been largely investigated in the last two decades, and most of the small cohort and randomized clinical studies, as well as meta-analyses led to the conclusion that cell-based human regenerative therapy is safe and effective in term of reducing adverse clinical outcomes and increasing left ventricular performance. Both the in vitro and in vivo rodent animal models of ischemic heart failure using bone marrow-derived mononuclear cells promised marvelous success in regeneration of the heart suffering from ischemic burden. However, in certain patient groups, stem cell studies failed to reach the primary endpoint, showing no effect of this regenerative therapy. This brief overview addresses the contradictory results between human cardiac regenerative studies and the very positive rodent experiments.

Cardiac Stem Cell-based Regenerative Therapy for the Ischemic Injured Heart — a Short Update 2017

Journal of Cardiovascular Emergencies

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Cell therapy for the ischemic injured heart has been largely investigated in the last two decades, and most of the small cohort and randomized clinical...

Cardiac Stem Cell-based Regenerative Therapy for the Ischemic Injured Heart — a Short Update 2017

Data publikacji: 11 lip 2017

Zakres stron: 81 - 83

Otrzymano: 25 maj 2017

Przyjęty: 02 cze 2017

DOI: https://doi.org/10.1515/jce-2017-0009

Słowa kluczowe
stem cells, ischemic heart diseases, cardiac regeneration

© 2017 Mariann Gyöngyösi et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Cardiac Stem Cell-based Regenerative Therapy for the Ischemic Injured Heart — a Short Update 2017

Data publikacji: 11 lip 2017

Zakres stron: 81 - 83

Otrzymano: 25 maj 2017

Przyjęty: 02 cze 2017

DOI: https://doi.org/10.1515/jce-2017-0009

Słowa kluczowestem cells, ischemic heart diseases, cardiac regeneration

© 2017 Mariann Gyöngyösi et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Słowa kluczowe
stem cells, ischemic heart diseases, cardiac regeneration