The Value of the “Lab-Score” Method in Identifying Febrile Infants at Risk for Serious Bacterial Infections

1. Baraff LJ. Management of infants and young children with fever without source. Pediatr Ann. 2008;37:673-9.Search in Google Scholar

2. Galetto Lacour A, Zamora SA, Gervaix A. Bedside procalcitonin and C-reactive protein tests in children with fever without localizing signs of infection seen in a referralcenter. Paediatrics. 2003;112:1054-60.10.1542/peds.112.5.1054Search in Google Scholar

3. Craig JC, Williams GJ, Jones M, et al. The accuracy of clinical symptoms and signs for the diagnosis of serious bacterial infection in young febrile children: prospective cohort study of 15 781 febrile illnesses. BMJ. 2010;340:c1594. doi: 10.1136/ bmj.c1594.10.1136/bmj.c1594Search in Google Scholar

4. Van den Bruel A, Haj-Hassan T, Thompson M, Buntinx F, Mant D. Diagnostic value of clinical features at presentation to identify serious infection in children in developed countries: a systematic review. Lancet. 2010;375:834-45.10.1016/S0140-6736(09)62000-6Search in Google Scholar

5. Van den Bruel A, Thompson MJ, Haj-Hassan T, et al. Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review. BMJ. 2011;342:d3082.10.1136/bmj.d308221653621Search in Google Scholar

6. Yo CH, Hsieh PS, Lee SH, et al. Comparison of the test characteristics of procalcitonin to C-reactive protein and leukocytosis for the detection of serious bacterial infections in children presenting with fever without source: a systematic review and meta-analysis. Ann Emerg Med. 2012;60:591-600.10.1016/j.annemergmed.2012.05.02722921165Search in Google Scholar

7. De S, Williams GJ, Hayen A, et al. Value of white cell count in predicting serious bacterial infection in febrile children under 5 years of age. Arch Dis Child. 2014;99:493-9.10.1136/archdischild-2013-30475424406804Search in Google Scholar

8. Galetto Lacour A, Gervaix A, Zamora SA, et al. Procalcitonin, IL-6, IL-8, IL-1 receptor antagonist and C-reactive protein as identificators of serious bacterial infections in children with fever without localising signs. Eur J Pediatr. 2001;160:95-100.10.1007/s00431000068111271398Search in Google Scholar

9. Andreola B, Bressan S, Callegaro S, Liverani A, Plebani M, Da Dalt L. Procalcitonin and C-reactive protein as diagnostic markers of severe bacterial infections in febrile infants and children in the emergency department. Pediatr Infect Dis J. 2007;26:672-7.10.1097/INF.0b013e31806215e317848876Search in Google Scholar

10. Pratt A, Attia MW. Duration of fever and markers of serious bacterial infections in young febrile children. Pediatr Int. 2007;49:31-5.10.1111/j.1442-200X.2007.02316.x17250502Search in Google Scholar

11. Maniaci V, Dauber A, Weiss S, Nylen E, Becker KL, Bachur R. Procalcitonin in young febrile infants for the detectin of serious bacterial infections. Pediatrics. 2008;122:701-10.10.1542/peds.2007-350318829791Search in Google Scholar

12. Olaciregui I, Hernandez U, Munoz JA, Emparanza JI, Landa JJ. Markers that predict serious bacterial infection in infants under 3 months of age presenting with fever of unknown origin. Arch Dis Child. 2009;94:501-5.10.1136/adc.2008.14653019158133Search in Google Scholar

13. Manzano S, Bailey B, Gervaix A, Cousineau J, Delvin E, Girodias JB. Markers for bacterial infection in children with fever without source. Arch Dis Child. 2011;96:440-6.10.1136/adc.2010.20376021278424Search in Google Scholar

14. Mahajan P, Grzybrowski M, Chen X, et al. Procalcitonin as a marker of serious bacterial infections in febrile children younger than 3 years old. Acad Emerg Med. 2014;21:171-9.10.1111/acem.1231624673673Search in Google Scholar

15. Nijman RG, Vergouwe Y, Thompson M, et al. Clinical prediction model to aid emergency doctors managing febrile children at risk of serious bacterial infections: diagnostic study. BMJ. 2013:346:f1706.10.1136/bmj.f1706361418623550046Search in Google Scholar

16. Galetto-Lacour A, Zamora SA, Gervaix A. A score identifying serious bacterial infections in children with fever without source. Pediatr Infect Dis. 2008;27:654-6.10.1097/INF.0b013e318168d2b418536624Search in Google Scholar

17. Galetto-Lacour A, Zamora SA, Andreola B, et al. Validation of a laboratory index score for the identification of severe bacterial infection in children with fever without source. Arch Dis Child. 2010;95:968-73.10.1136/adc.2009.17680020515973Search in Google Scholar

18. Bressan S, Gomez B, Mintegi S, et al. Diagnostic performance of the “Lab-score” in predicting severe and invasive bacterial infections in well-appearing young febrile infants. Pediatr Infect Dis J. 2012;31:1239-44.Search in Google Scholar

19. Nijman RG, Moll HA, Smit FJ, et al. C-reactive Protein, Procalcitonin and the“Lab-score” for Detecting Serious Bacterial Infections in Febrile Children at the Emergency Department: A Prospective Observational Study. Pediatr Infect Dis J. 2014;33:273-9.10.1097/INF.000000000000046625093971Search in Google Scholar

20. Herz AM, Greenhow TL, Alcantara J, et al. Changing epidemiology of outpatient bacteraemia in 3 - to 36 -months -old children after the introduction of the heptavalent-conjugated pneumococcal vaccine. Pediatr Infect Dis J. 2006;25:293-300.10.1097/01.inf.0000207485.39112.bf16567979Search in Google Scholar

21. NICE Clinical Guideline 47. Feverish illness in children: assessment and initial management in children younger than 5 years. National Collaborating Center for Women's and Child Health; 2007.Search in Google Scholar

22. Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003;31:1250-6.10.1097/01.CCM.0000050454.01978.3B12682500Search in Google Scholar

23. Thayyil S, Shenoy M, Hamaluba M, Gupta A, Frater J, Verber IG. Is procalcitonin useful in early diagnosis of serious bacterial infections in children? Acta Pediatrica. 2005;94:155-8.Search in Google Scholar

24. Shaw KN, Gorelick M, McGowan KL, Yakscoe NM, Schwartz JS. Prevalence of urinary tract infection in febrile young children in the emergency department. Pediatrics. 1998;102:e16.10.1542/peds.102.2.e169685461Search in Google Scholar

25. Mintegi S, Benito J, Pijoan JI, et al. Occult pneumonia in infants with high fever without source: a prospective multicenter study. Pediatr Emerg Care 2010;26:470-4.10.1097/PEC.0b013e3181e582e420577140Search in Google Scholar

26. Dandona P, Nix D, Wilson MF, et al. Procalcitonin increase after endotoxin injection in normal subjects. J Clin Endocrinol Metab. 1994;79:1605-8.Search in Google Scholar

27. Gendrel D, Bohuon C. Procalcitonin as a marker of bacterial infection. Pediatr Infect Dis J. 2000;19:679-8.10.1097/00006454-200008000-0000110959733Search in Google Scholar

28. Gras-Le Guen C, Delmas C, Launay E, et al. Contribution of procalcitonin to occult bacteraemia detection in children. Scand J Infect Dis. 2007;39:1063-6.10.1080/0036554060090475317366034Search in Google Scholar

29. Bressan S, Andreola B, Cattelan F, et al. Predicting severe bacterial infections in well-appearing febrile neonates: laboratory markers accuracy and duration of fever. Pediatr Infect Dis J. 2008;27:227-32.Search in Google Scholar