<abstract xmlns="http://www.w3.org/1999/xhtml">Multidrug-resistant organisms (MDROs) are becoming an increasing problem in hospitals. It is believed that screening patients for the incidence of MDROs prior to hospital admission not only allows for the proper management of infection following medical procedures, but can also potentially reduce the transmission of these bacteria to other patients.The aim of this study was to assess the carriers of selected MDROs in the gastrointestinal tract among patients with advanced ovarian cancer admitted to the hospital for cytoreductive surgery and to estimate the possible relationship between rectal colonization with these organisms and nosocomial infections.From December 2013 to May 2014, we evaluated the colonization with VRE (vancomycin-resistant <italic>Enterococcus</italic>), <italic>E. coli</italic> KPC+ (class A carbapenemase producing <italic>Escherichia coli</italic>), <italic>E. coli</italic> MBL+ (class B carbapenemase, metallo-ß lactamase producing <italic>Escherichia coli</italic>), and <italic>E. coli</italic> ESBL+ (extended-spectrum ß-lactamase producing <italic>Escherichia coli</italic>) in 42 patients. The patients were divided into two subgroups corresponding to the extent of their surgery: the first subgroup consisted of patients with large bowel resection (n=18) and the second subgroup of patients without resection (n=24). A rectal swab was taken within 24 hours of admission. Perioperative infectious complications were analyzed for the first 90 days following surgery with regard to the type of infection and the occurrence of examined MDROs.In our study, 2.4 % of all patients (23.8/1,000 hospitalizations) were colonized with ESBL - producing <italic>Escherichia coli</italic>: 0.0 % in the first subgroup and 4.2% in the second subgroup, respectively. We did not identify any patients who were colonized with VRE, <italic>E. coli</italic> MBL+, or <italic>E. coli</italic> KPC+. Surgical site infections were seen in 8 (19.1%) out of 42 patients. We were, therefore, unable to confirm a relationship between MDROs colonizing the large bowel and the etiological agents of perioperative infections. However, despite the lack of identification of MDROs as etiological agents of postoperative infection, the risk of serious infectious complications, combined with the changing epidemiological situation, means that microbiological monitoring should be performed in patients with ovarian cancer before and after cytoreductive surgery.</abstract>

Multidrug-resistant organisms (MDROs) are becoming an increasing problem in hospitals. It is believed that screening patients for the incidence of MDROs prior to hospital admission not only allows for the proper management of infection following medical procedures, but can also potentially reduce the transmission of these bacteria to other patients.The aim of this study was to assess the carriers of selected MDROs in the gastrointestinal tract among patients with advanced ovarian cancer admitted to the hospital for cytoreductive surgery and to estimate the possible relationship between rectal colonization with these organisms and nosocomial infections.From December 2013 to May 2014, we evaluated the colonization with VRE (vancomycin-resistant Enterococcus), E. coli KPC+ (class A carbapenemase producing Escherichia coli), E. coli MBL+ (class B carbapenemase, metallo-ß lactamase producing Escherichia coli), and E. coli ESBL+ (extended-spectrum ß-lactamase producing Escherichia coli) in 42 patients. The patients were divided into two subgroups corresponding to the extent of their surgery: the first subgroup consisted of patients with large bowel resection (n=18) and the second subgroup of patients without resection (n=24). A rectal swab was taken within 24 hours of admission. Perioperative infectious complications were analyzed for the first 90 days following surgery with regard to the type of infection and the occurrence of examined MDROs.In our study, 2.4 % of all patients (23.8/1,000 hospitalizations) were colonized with ESBL - producing Escherichia coli: 0.0 % in the first subgroup and 4.2% in the second subgroup, respectively. We did not identify any patients who were colonized with VRE, E. coli MBL+, or E. coli KPC+. Surgical site infections were seen in 8 (19.1%) out of 42 patients. We were, therefore, unable to confirm a relationship between MDROs colonizing the large bowel and the etiological agents of perioperative infections. However, despite the lack of identification of MDROs as etiological agents of postoperative infection, the risk of serious infectious complications, combined with the changing epidemiological situation, means that microbiological monitoring should be performed in patients with ovarian cancer before and after cytoreductive surgery.

Microbiological monitoring in patients with advanced ovarian cancer before and after cytoreductive surgery – a preliminary report

Department of Microbiology, Professor Franciszek Lukaszczyk Oncology Center

Department of Oncology, Professor Franciszek Lukaszczyk Oncology Center

Department of Gynecologic Oncology, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology in Warsaw

Clinical Department of Gynecologic Oncology, Professor Franciszek Lukaszczyk Oncology Center

Department of Oncology, Radiotherapy and Oncological Gynecology, Ludwik Rydygier Collegium Medicum

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Multidrug-resistant organisms (MDROs) are becoming an increasing problem in hospitals. It is believed that screening patients for the incidence of MDROs prior...

Microbiological monitoring in patients with advanced ovarian cancer before and after cytoreductive surgery – a preliminary report

Data publikacji: 09 mar 2018

Zakres stron: 198 - 202

Otrzymano: 26 wrz 2017

Przyjęty: 29 gru 2017

DOI: https://doi.org/10.1515/cipms-2017-0038

Słowa kluczowe
microbiological monitoring, multidrug-resistant organisms, advanced ovarian cancer, cytoreductive surgery

© 2017 Maria Szymankiewicz et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Microbiological monitoring in patients with advanced ovarian cancer before and after cytoreductive surgery – a preliminary report

Data publikacji: 09 mar 2018

Zakres stron: 198 - 202

Otrzymano: 26 wrz 2017

Przyjęty: 29 gru 2017

DOI: https://doi.org/10.1515/cipms-2017-0038

Słowa kluczowemicrobiological monitoring, multidrug-resistant organisms, advanced ovarian cancer, cytoreductive surgery

© 2017 Maria Szymankiewicz et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Słowa kluczowe
microbiological monitoring, multidrug-resistant organisms, advanced ovarian cancer, cytoreductive surgery