The LRP1 gene polymorphism is associated with increased risk of metabolic syndrome prevalence in the Serbian population
, , , , , oraz | 30 cze 2017
O artykule
Article Category: Original Article
Data publikacji: 30 cze 2017
Zakres stron: 51 - 58
DOI: https://doi.org/10.1515/bjmg-2017-0004
Słowa kluczowe
© 2017 Vučinić N, Stokić E, Djan I, Obreht D, Veličković N, Stankov K, Djan M
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
One-way analysis of variance between the exon 3 LRP1 gene and tested relevant anthropometric and biochemical parameters.
| ANOVA | Exon 3 |
|
|---|---|---|
| Parameter | F = VA/VR | |
| BMI (kg/m2) | 4.47 | 0.010 |
| WC (cm) | 6.59 | 0.000 |
| Systolic BP (mmHg) | 4.67 | 0.012 |
| LDL cholesterol (mmol/L) | 40.54 | 0.000 |
| Index of atherosclerosis LDL/HDL | 11.52 | 0.000 |
Odds ratio for the exon 3 LRP1 gene allele and measured anthropometric and biochemical parameters.
| Parameters | Allele | C | T |
|---|---|---|---|
| BMI (<30 kg/m2) | OR | 0.23 | 4.24 |
| 95% CI | 0.07-0.70 | 1.42-12.65 | |
| >0.05 | <0.05 | ||
| LDL cholesteror (>3 mmol/L) | OR | 0.04 | 20.26 |
| 95% CI | 0.00-0.37 | 2.70-152.04 | |
| >0.05 | <0.05 | ||
The Student’s t-test results between the metabolic syndrome and control groups.
| Parameters | Arithmetic Mean | |||
|---|---|---|---|---|
| Control Group | MetS Group | |||
| Age (years) | 38.70 | 42.10 | −1.29 | 0.20 |
| BM (kg) Student’s |
87.33 | 123.30 | −4.98 | 0.00 |
| BH (cm) | 170.13 | 170.86 | −0.16 | 0.87 |
| BMI (kg/m2) Student’s |
25.99 | 41.50 | −8.97 | 0.00 |
| WC (cm) Student’s |
88.90 | 125.67 | −9.77 | 0.00 |
| Systolic BP (mmHg) Student’s |
120.50 | 139.37 | −4.91 | 0.00 |
| Diastolic BP (mmHg) Student’s |
77.33 | 89.60 | −4.20 | 0.00 |
| TC (mmol/L) | 5.18 | 5.48 | 1.01 | 0.31 |
| Triglycerides (mmol/L) |
3.57 | 2.12 | 2.33 | 0.02 |
| HDL cholesterol (mmol/L) Student’s |
1.45 | 0.97 | 5.47 | 0.00 |
| LDL cholesterol (mmol/L) Student’s |
2.29 | 3.68 | −5.19 | 0.00 |
| Non-HDL cholesterol (mmol/L) | 4.03 | 4.51 | −1.87 | 0.06 |
| LDL/HDL cholesterol (mmol/L) |
3.27 | 3.86 | −2.79 | 0.01 |
| Glycemia (mmol/L) | 4.67 | 5.18 | −1.93 | 0.06 |
| IRI (μU/mL) | 8.44 | 15.32 | −3.97 | 0.00 |
| HOMA IR (μU/mL) Student’s |
1.80 | 3.65 | −3.76 | 0.00 |
| C-reactive protein (mg/L) | 1.88 | 12.62 | −4.58 | 0.00 |
Frequencies of the LRP1 exon 3 alleles.
| Group | Allele | Total | |
|---|---|---|---|
| C (%) | T (%) | ||
| MetS group | 74.60 | 25.40 | 100.00 |
| Control group | 93.33 | 6.67 | 100.00 |
| Total | 80.65 | 19.35 | 100.00 |