<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Objective: Development of new electronic devices with applications in computer science as well as new medical devices pushed the researcher to find new technologies. Based on those new techniques we have designed and synthesized compounds with possible application in the field of advanced materials. Material and method: Compounds were analyzed by TLC and NMR. Routine 1H NMR (250 MHz) spectra were recorded at room temperature in deuterated acetone, unless stated otherwise. Thin-layer chromatography (TLC) was carried out on aluminum sheets coated with silicagel 60 F254 Merck TLC plates. Results: Starting from commercial available compounds intermediates were obtained in a good yield. 4,4′-(2,4,8,10-tetraoxaspiro[5.5]undecane-3,9-diyl)diphenol was obtained starting from pentaerythritol and p-hydroxy-benzaldehyde in the presence of catalytic amounts of APTS (p-toluensulfonic acid). The product was purified by recrystallization and characterized by NMR spectroscopy. The structure exhibit 2 different signals for equatorial and axial position. Furthermore di, tri and tetra ethylene glycol were obtained by microwave assisted synthesis in a matter of minutes. Compounds were separated by recrystallization. Conclusions: In conclusion, several intermediates were synthesized and characterized from spectroscopic point of view. Further analyses should be carried out and the compounds should be tested as advanced materials.</p></abstract>

Objective: Development of new electronic devices with applications in computer science as well as new medical devices pushed the researcher to find new technologies. Based on those new techniques we have designed and synthesized compounds with possible application in the field of advanced materials. Material and method: Compounds were analyzed by TLC and NMR. Routine 1H NMR (250 MHz) spectra were recorded at room temperature in deuterated acetone, unless stated otherwise. Thin-layer chromatography (TLC) was carried out on aluminum sheets coated with silicagel 60 F254 Merck TLC plates. Results: Starting from commercial available compounds intermediates were obtained in a good yield. 4,4′-(2,4,8,10-tetraoxaspiro[5.5]undecane-3,9-diyl)diphenol was obtained starting from pentaerythritol and p-hydroxy-benzaldehyde in the presence of catalytic amounts of APTS (p-toluensulfonic acid). The product was purified by recrystallization and characterized by NMR spectroscopy. The structure exhibit 2 different signals for equatorial and axial position. Furthermore di, tri and tetra ethylene glycol were obtained by microwave assisted synthesis in a matter of minutes. Compounds were separated by recrystallization. Conclusions: In conclusion, several intermediates were synthesized and characterized from spectroscopic point of view. Further analyses should be carried out and the compounds should be tested as advanced materials.

Research Article. Precursor Synthesis of Some New Macrocyclic Compounds

Organic Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy Tîrgu Mureş,

Drugs Industry and Pharmaceutical Management Department, Faculty of Pharmacy, University of Medicine and Pharmacy Tîrgu Mureş,

General and Inorganic Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy Tîrgu Mureş,

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Research Article. Precursor Synthesis of Some New Macrocyclic Compounds"}

Objective: Development of new electronic devices with applications in computer science as well as new medical devices pushed the researcher to find new...

Research Article. Precursor Synthesis of Some New Macrocyclic Compounds

Data publikacji: 20 kwi 2017

Zakres stron: 27 - 30

Otrzymano: 23 gru 2016

Przyjęty: 16 sty 2017

DOI: https://doi.org/10.1515/amma-2017-0005

Słowa kluczowe
spiran, 1,3-dioxan, polyethylene glycol, inside&outside methylene group

© by Șerban Andrei Gâz-Florea

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Research Article. Precursor Synthesis of Some New Macrocyclic Compounds

Data publikacji: 20 kwi 2017

Zakres stron: 27 - 30

Otrzymano: 23 gru 2016

Przyjęty: 16 sty 2017

DOI: https://doi.org/10.1515/amma-2017-0005

Słowa kluczowespiran, 1,3-dioxan, polyethylene glycol, inside&outside methylene group

© by Șerban Andrei Gâz-Florea

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Słowa kluczowe
spiran, 1,3-dioxan, polyethylene glycol, inside&outside methylene group