[1. Stepien RL: Pulmonary arterial hypertension secondary to chronic left-sided cardiac dysfunction in dogs. J Small Anim Pract 2009, 50-SUPPL 1:34-43.10.1111/j.1748-5827.2009.00802.x19765218]Search in Google Scholar
[2. Hoeper MM, Bogaard HJ, Condliffe R, Frantz R, Khanna D, Kurzyna M, Langleben D, Manes A, Satoh T, Torres F, Wilkins MR, Badesch DB: Defi nitions and diagnosis of pulmonary hypertension. J Am Coll Cardiol 2013, 62(25 SUPPL):D42-D50.10.1016/j.jacc.2013.10.03224355641]Search in Google Scholar
[3. Galiè N, Hoeper MM, Humbert M, Torbicki A, Vachiery JL, Barbera JA, Beghetti M, Corris P, Gaine S, Gibbs JS, Gomez-Sanchez MA, Jondeau G, Klepetko W, Opitz C, Peacock A, Rubin L, Zellweger M, Simonneau G, Vahanian A, Auricchio A, Bax J, Ceconi C, Dean V, Filippatos G, Funck-Brentano C, Hobbs R, Kearney P, McDonagh T, McGregor K, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Vardas P, Widimsky P, Al Attar N, Andreotti F, Aschermann M, Asteggiano R, Benza R, Berger R, Bonnet D, Delcroix M, Howard L, Kitsiou AN, Lang I, Maggioni A, Nielsen-Kudsk JE, Park M, Perrone- Filardi P, Price S, Domenech MTS, Vonk-Noordegraaf A, Zamorano JL: Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J 2009, 30:2493-2537.10.1093/eurheartj/ehp29719713419]Search in Google Scholar
[4. Zamanian RT, Kudelko KT, Sung YK, De Jesus Perez V, Liu J, Spiekerkoetter E: Current clinical management of pulmonary arterial hypertension. Circ Res 2014, 115:131-147.10.1161/CIRCRESAHA.115.303827445201624951763]Search in Google Scholar
[5. Brown AJ, Davison E, Sleeper MM: Clinical effi cacy of sildenafi l in treatment of pulmonary arterial hypertension in dogs. J Vet Intern Med 2010, 24:850-854.10.1111/j.1939-1676.2010.0517.x20412435]Search in Google Scholar
[6. Hatano S, Strasser T: Primary pulmonary hypertension. WHO world Meet 1975, 1-43.]Search in Google Scholar
[7. Simonneau G, Galiè N, Rubin LJ, Langleben D, Seeger W, Domenighetti G, Gibbs S, Lebrec D, Speich R, Beghetti M, Rich S, Fishman A: Clinical classifi cation of pulmonary hypertension. J Am Coll Cardiol 2004, 43(SUPPL S):5-12.10.1016/j.jacc.2004.02.03715194173]Search in Google Scholar
[8. Simonneau G, Gatzoulis MA, Adatia I, Celermajer D, Denton C, Ghofrani A, Gomez Sanchez MA, Krishna Kumar R, Landzberg M, Machado RF, Olschewski H, Robbins IM, Souza R: Updated clinical classifi cation of pulmonary hypertension. J Am Coll Cardiol 2013, 62(SUPPL D):34-41.10.1016/j.jacc.2013.10.02924355639]Search in Google Scholar
[9. Pyle R, Abbott J, MacLean H: Pulmonary hypertension and cardiovascular sequelae in 54 dogs. J Appl Res Vet Med 2004, 2:99-109.]Search in Google Scholar
[10. Fleming E, Ettinger SJ: Pulmonary hypertension. Compendium 2006, October:720-731.]Search in Google Scholar
[11. Guglielmini C, Civitella C, Diana A, Di Tommaso M, Cipone M, Luciani A: Serum cardiac troponin I concentration in dogs with precapillary and postcapillary pulmonary hypertension. J Vet Intern Med 2010, 24:145-152.10.1111/j.1939-1676.2009.0430.x20002552]Search in Google Scholar
[12. Zabka TS, Campbell FE, Wilson DW: Pulmonary arteriopathy and idiopathic pulmonary arterial hypertension in six dogs. Vet Pathol 2006, 43:510-522.10.1354/vp.43-4-51016846993]Search in Google Scholar
[13. Glaus TM, Soldati G, Maurer R, Ehrensperger F: Clinical and pathological characterisation of primary pulmonary hypertension in a dog. Vet Rec 2004, 154:786-789.10.1136/vr.154.25.78615233456]Search in Google Scholar
[14. Johnson L, Boon J, Orton EC: Clinical characteristics of 53 dogs with Doppler-derived evidence of pulmonary hypertension: 1992-1996. J Vet Intern Med 1999, 13:440-447.10.1111/j.1939-1676.1999.tb01461.x]Search in Google Scholar
[15. Oyama MA, Sisson DD, Thomas WP, Bonagura JD: Congenital heart disease. In: Ettinger SJ, Feldman EC (eds), Textbook of veterinary internal medicine, 7th ed., St. Louis, Minnesota, US: Saunders Elsevier; 2010, 1256-1271.]Search in Google Scholar
[16. Kolm US, Amberger CN, Boujon CE, Lombard CW: Plexogenic pulmonary arteriopathy in a Pembroke Welsh corgi. J Small Anim Pract 2004, 45:461-466.10.1111/j.1748-5827.2004.tb00265.x]Search in Google Scholar
[17. Russel DS, Scansen BA, Himmel L: Plexogenic pulmonary arteriopathy in a dog with ventricular septal defect and pulmonary hypertension. J Small Anim Pract 2015, 56:524-529.10.1111/jsap.12341]Search in Google Scholar
[18. Van Israël N, French AT, Dukes-McEwan J, Welsh EM: Patent ductus arteriosus in the older dog. J Vet Cardiol 2003, 5:13-21.10.1016/S1760-2734(06)70040-6]Search in Google Scholar
[19. Kellihan HB, Stepien RL: Pulmonary hypertension in canine degenerative mitral valve disease. J Vet Cardiol 2012, 14:149-164.10.1016/j.jvc.2012.01.00122364721]Search in Google Scholar
[20. Kellum HB, Stepien RL: Sildenafi l citrate therapy in 22 dogs with pulmonary hypertension. J Vet Intern Med 2007, 21:1258-1264.10.1111/j.1939-1676.2007.tb01947.x]Search in Google Scholar
[21. Chiavegato D, Borgarelli M, D’Agnolo G, Santilli RA: Pulmonary hypertension in dogs with mitral regurgitation attributable to myxomatous valve disease. Vet Radiol Ultrasound 2009, 50:253-258.10.1111/j.1740-8261.2009.01529.x19507386]Search in Google Scholar
[22. Serres FJ, Chetboul V, Tissier R, Carlos Sampedrano C, Gouni V, Nicolle AP, Pouchelon JL: Doppler echocardiography-derived evidence of pulmonary arterial hypertension in dogs with degenerative mitral valve disease: 86 cases (2001-2005). J Am Vet Med Assoc 2006, 229:1772-1778.10.2460/javma.229.11.177217144824]Search in Google Scholar
[23. Borgarelli M, Abbott J, Braz-Ruivo L, Chiavegato D, Crosara S, Lamb K, Ljungvall I, Poggi M, Santilli RA, Haggstrom J: Prevalence and prognostic importance of pulmonary hypertension in dogs with myxomatous mitral valve disease. J Vet Intern Med 2015, 29:569-574.10.1111/jvim.12564489552225818210]Search in Google Scholar
[24. Glaus TM, Hässig M, Baumgartner C, Reusch CE: Pulmonary hypertension induced in dogs by hypoxia at different high-altitude levels. Vet Res Commun 2003, 27:661-670.10.1023/A:1027380614534]Search in Google Scholar
[25. Locatelli C, Stefanello D, Riscazzi G, Borgonovo S, Comazzi S: Pulmonary hypertension associated with Ehrlichia canis infection in a dog. Vet Rec 2012, 170, 26:676-676.10.1136/vr.10043622645155]Search in Google Scholar
[26. Johnson LR, Lappin MR, Baker DC. Pulmonary thromboembolism in 29 dogs: 1985-1995. J Vet Intern Med 1999, 13:338-345.10.1111/j.1939-1676.1999.tb02192.x]Search in Google Scholar
[27. Venco L, Mihaylova L, Boon JA: Right pulmonary artery distensibility index (RPAD Index). A field study of an echocardiographic method to detect early development of pulmonary hypertension and its severity even in the absence of regurgitant jets for Doppler evaluation in heartworm-infected dogs. Vet Parasitol 2014, 206:60-66.10.1016/j.vetpar.2014.08.01625218885]Search in Google Scholar
[28. Borgeat K, Sudunagunta S, Kaye B, Stern J, Luis Fuentes V, Connolly DJ: Retrospective evaluation of moderate-to-severe pulmonary hypertension in dogs naturally infected with Angiostrongylus vasorum. J Small Anim Pract 2015, 56:196-202.10.1111/jsap.1230925483150]Search in Google Scholar
[29. Matos JM, Schnyder M, Bektas R, Makara M, Kutter A, Jenni S, Deplazes P, Glaus T: Recruitment of arteriovenous pulmonary shunts may attenuate the development of pulmonary hypertension in dogs experimentally infected with Angiostrongylus vasorum. J Vet Cardiol 2012, 14:313-322.10.1016/j.jvc.2012.01.01422575676]Search in Google Scholar
[30. Kramer L, Grandi G, Passeri B, Gianelli P, Genchi M, Dzimianski MT, Supakorndej P, Mansour AM, Supakorndej N, McCall SD, McCall JW: Evaluation of lung pathology in Dirofi laria immitis-experimentally infected dogs treated with doxycycline or a combination of doxycycline and ivermectin before administration of melarsomine dihydrochloride. Vet Parasitol 2011, 176:357-360.10.1016/j.vetpar.2011.01.02121292403]Search in Google Scholar
[31. Mavropoulou A, Gnudi G, Grandi G, Volta A, Kramer LH, Quintavalla C: Clinical assessment of post-adulticide complications in Dirofi laria immitis-naturally infected dogs treated with doxycycline and ivermectin. Vet Parasitol 2014, 205:211-215. 10.1016/j.vetpar.2014.06.01424986465]Search in Google Scholar
[32. Venco L, McCall JW, Guerrero J, Genchi C: Effi cacy of long-term monthly administration of ivermectin on the progress of naturally acquired heartworm infections in dogs. Vet Parasitol 2004, 124:259-268.10.1016/j.vetpar.2004.06.02415381305]Search in Google Scholar
[33. Levick JR: Specialization in individual circulations. In Cardiovascular physiology, 5th ed. London, UK: Hodder Arnold; 2010, 300-306.]Search in Google Scholar
[34. Mercier E, Mathieu M, Charlotte F, Delvaux FH: Arterial pressure by use of right ventricular Doppler imaging in healthy Beagles. Am J Vet Res 2010, 71:891-897.10.2460/ajvr.71.8.89120673087]Search in Google Scholar
[35. Klodell CT: Secondary pulmonary hypertension a review of the cardiac causes. J Cardiovasc Nurs 2005, 20:119-123.10.1097/00005082-200503000-0000715855860]Search in Google Scholar
[36. Oswald GP, Orton EC: Patent ductus arteriosus and pulmonary hypertension in related Pembroke Welsh corgis. J Am Vet Med Assoc 1993, 202:761-764.]Search in Google Scholar
[37. Okubo S, Nakai M, Tomino T: Relevance of location of defect and pulmonary vascular resistance to the intracardiac pattern of left-to-right shunt fl ow in dogs with experimental ventricular septal defect. Circulation 1986, 76:775-783.10.1161/01.CIR.73.4.7753948374]Search in Google Scholar
[38. Campbell FE: Cardiac effects of pulmonary disease. Vet Clin North Am - Small Anim Pract 2007, 37:949-962.10.1016/j.cvsm.2007.05.00617693208]Search in Google Scholar
[39. West JB: Blood fl ow and metabolism. In: Respiratory physiology - the essentials, 9th ed. Philadelphia, US: Lippincott Williams and Wilkins, 2012, 36-54.]Search in Google Scholar
[40. Wauthy P, Pagnamenta A, Vassalli F, Naeije R, Brimioulle S: Right ventricular adaptation to pulmonary hypertension: an interspecies comparison. Am J Physiol Heart Circ Physiol 2004, 286:H1441-H1447.10.1152/ajpheart.00640.200314684368]Search in Google Scholar
[41. Vassalli F, Pierre S, Julien V, Bouckaert Y, Brimioulle S, Naeije R: Inhibition of hypoxic pulmonary vasoconstriction by carbon monoxide in dogs. Crit Care Med 2001, 29:359-366.10.1097/00003246-200102000-0002611246317]Search in Google Scholar
[42. Naeije R: Physiology of the pulmonary circulation and the right heart. Curr Hypertens Rep 2013, 15:623-631.10.1007/s11906-013-0396-624097187]Search in Google Scholar
[43. Helm JR, Morgan ER, Jackson MW, Wotton P, Bell R: Canine angiostrongylosis: An emerging disease in Europe. J Vet Emerg Crit Care 2010, 20:98-109.10.1111/j.1476-4431.2009.00494.x20230439]Search in Google Scholar
[44. Boyle KL, Leech E: A review of the pharmacology and clinical uses of pimobendan. J Vet Emerg Crit Care 2012, 22:398-408.10.1111/j.1476-4431.2012.00768.x22928748]Search in Google Scholar
[45. Budhiraja R, Tuder RM, Hassoun PM: Endothelial dysfunction in pulmonary hypertension. Circulation 2004, 109:159-165.10.1161/01.CIR.0000102381.57477.5014734504]Search in Google Scholar
[46. Voelkel NF, Gomez-Arroyo J, Abbate A, Bogaard HJ: Pathobiology of pulmonary arterial hypertension and right ventricular failure. Eur J Heart Fail 2012, 29:997-1003.]Search in Google Scholar
[47. Kim H, Yung GL, Marsh JJ, Konopka RG, Pedersen CA, Chiles PG, Morris TA, Channick RN: Endothelin mediates pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension. Eur Respir J 2000, 15:640-648.10.1034/j.1399-3003.2000.15d04.x10780753]Search in Google Scholar
[48. Moraes DL, Colucci WS: Secondary pulmonary hypertension in chronic heart failure. The role of the endothelium in pathophysiology and management. Circulation 2000, 102:1718-1723.10.1161/01.CIR.102.14.1718]Search in Google Scholar
[49. Gaynor SL, Maniar HS, Bloch JB, Steendijk P, Moon MR: Right atrial and ventricular adaptation to chronic right ventricular pressure overload. Circulation 2005, 112:212-218.10.1161/CIRCULATIONAHA.104.517789]Search in Google Scholar
[50. Chen EP, Akhter SA, Bittner HB, Koch WJ, Davis RD, Van Trigt P: Molecular and functional mechanisms of right ventricular adaptation in chronic pulmonary hypertension. Ann Thorac Surg 1999, 67:1053-1058.10.1016/S0003-4975(99)00142-3]Search in Google Scholar
[51. Bach JF, Rozanski EA, MacGregor J, Betkowski JM, Rush JE: Retrospective evaluation of sildenafil citrate as a therapy for pulmonary hypertension in dogs. J Vet Intern Med 2006, 20:1132-1135. 10.1111/j.1939-1676.2006.tb00711.x]Search in Google Scholar
[52. Ohad DG, Lenchner I, Bdolah-Abram T, Segev G: A loud right-apical systolic murmur is associated with the diagnosis of secondary pulmonary arterial hypertension: retrospective analysis of data from 201 consecutive client-owned dogs (2006-2007). Vet J 2013, 198:690-695.10.1016/j.tvjl.2013.09.067]Search in Google Scholar
[53. Johnson L: Diagnosis of pulmonary hypertension. Clin Tech Small Anim Pract 1999, 14:231-236.10.1016/S1096-2867(99)80016-4]Search in Google Scholar
[54. Mikawa S, Miyagawa Y, Toda N, Tominaga Y, Takemura N: Predictive model for the detection of pulmonary hypertension in dogs with myxomatous mitral valve disease. J Vet Med Sci 2015, 77:7-13.10.1292/jvms.14-0050434953225319513]Search in Google Scholar
[55. Le Roux A, Rademacher N, Saelinger C, Rodriguez D, Pariaut R, Gaschen L: Value of tracheal bifurcation angle measurement as a radiographic sign of left atrial enlargement in dogs. Vet Radio Ultrasound 2012, 53:28-33.10.1111/j.1740-8261.2011.01871.x22093147]Search in Google Scholar
[56. Diana A, Guglielmini C, Pivetta M, Sanacore A, Di Tommaso M, Lord PF, Cipone M: Radiographic features of cardiogenic pulmonary edema in dogs with mitral regurgitation: 61 cases (1998-2007). J Am Vet Med Assoc 2009, 235:1058-1063.10.2460/javma.235.9.105819878003]Search in Google Scholar
[57. Carlsson C, Häggström J, Eriksson A, Järvinen AK, Kvart C, Lord P: Size and shape of right heart chambers in mitral valve regurgitation in small-breed dogs. J Vet Intern Med 2009, 23:1007-1013.10.1111/j.1939-1676.2009.0359.x19674279]Search in Google Scholar
[58. Lewczuk J, Ajlan AW, Piszko P, Jagas J, Mikulewicz M, Wrabec K: Electrocardiographic signs of right ventricular overload in patients who underwent pulmonary embolism event(s). Are they useful in diagnosis of chronic thromboembolic pulmonary hypertension? J Electrocardiol 2004, 37:219-225.10.1016/j.jelectrocard.2004.04.00315286935]Search in Google Scholar
[59. Demerouti EA, Manginas AN, Athanassopoulos GD, Karatasakis GT: Complications leading to sudden cardiac death in pulmonary arterial hypertension. Respir Care 2013, 58:1246-1254.10.4187/respcare.02252]Search in Google Scholar
[60. Boon J: Pulmonary hypertension. In: Veterinary echocardiography, 2nd Ed. Chichester, West Sussex, UK: J. W. & Sons, Inc ; 2011, 436-456.]Search in Google Scholar
[61. D’Alto M, Romeo E, Argiento P, Pavelescu A, Mélot C, D’Andrea A, Correra A, Bossone E, Calabrò R, Russo MG, Naeije :. Echocardiographic prediction of pre- versus postcapillary pulmonary hypertension. J Am Soc Echocardiogr 2015, 28:108-115.10.1016/j.echo.2014.09.004]Search in Google Scholar
[62. Kaul S, Tei C, Hopkins JM, Shah PM: Assessment of right ventricular function using twodimensional echocardiography. Am Heart J 1984, 107:526-531.10.1016/0002-8703(84)90095-4]Search in Google Scholar
[63. Guazzi M, Bandiera F, Pelissero G, Castelvecchio S, Menicanti L, Temporelli PL, Arena R: Tricuspid annular plane systolic excursion and pulmonary arterial systolic pressure relationship in heart failure: an index of right ventricular contractile function and prognosis. Am J Physio Heart Circ Physiol 2013, 305:H1373-H1381.10.1152/ajpheart.00157.2013]Search in Google Scholar
[64. Pariaut R, Saelinger C, Strickland KN, Beaufrère H, Reynolds CA, Vila J: Tricuspid annular plane systolic excursion (TAPSE) in dogs: reference values and impact of pulmonary hypertension. J Vet Intern Med 2012, 26:1148-1154.10.1111/j.1939-1676.2012.00981.x]Search in Google Scholar
[65. Rudski LG, Lai WW, Afi lalo J, Hua L, Handschumacher MD, Chandrasekaran K, Solomon SD, Louie EK, Schiller NB: Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr 2010, 23:685-713.10.1016/j.echo.2010.05.010]Search in Google Scholar
[66. Berger M, Haimowitz A, Van Tosh A, Berdoff RL, Goldberg E: Quantitative assessment of pulmonary hypertension in patients with tricuspid regurgitation using continuous wave Doppler ultrasound. J Am Col Cardiol 1985, 6:359-365. 10.1016/S0735-1097(85)80172-8]Search in Google Scholar
[67. Soydan LC, Kellihan HB, Bates ML, Stepien RL, Consigny DW, Bellofi ore A, Francois CJ, Chesler NC: Accuracy of Doppler echocardiographic estimates of pulmonary artery pressures in a canine model of pulmonary hypertension. J Vet Cardiol 2015, 17:13-24.10.1016/j.jvc.2014.10.004455070225601540]Search in Google Scholar
[68. Uehara Y: An attempt to estimate the pulmonary artery pressure in dogs by means of pulsed Doppler echocardiography. J Vet Med Sci 1993, 55:307-312.10.1292/jvms.55.3078513015]Search in Google Scholar
[69. Schober KE, Baade H: Doppler echocardiographic prediction of pulmonary hypertension in West Highland white terriers with chronic pulmonary disease. J Vet Intern Med 2006, 20:912-920.10.1111/j.1939-1676.2006.tb01805.x]Search in Google Scholar
[70. Tei C, Dujardin KS, Hodge DO, Bailey KR, McGoon MD, Tajik AJ, Seward SB: Doppler echocardiographic index for assessment of global right ventricular function. J Am Soc Echocardiogr 1996, 9:838-847.10.1016/S0894-7317(96)90476-9]Search in Google Scholar
[71. Baumwart RD, Meurs KM, Bonagura JD: Tei index of myocardial performance applied to the right ventricle in normal dogs. J Vet Intern Med 2005, 19:828-832.10.1111/j.1939-1676.2005.tb02772.x]Search in Google Scholar
[72. Serres F, Chetboul V, Gouni V, Tissier R, Sampedrano CC, Pouchelon JL: Diagnostic value of echo-Doppler and tissue Doppler imaging in dogs with pulmonary arterial hypertension. J Vet Intern Med 2007, 21:1280-1289.10.1111/j.1939-1676.2007.tb01950.x]Search in Google Scholar
[73. Boissiere J, Gautier M, Machet MC, Hanton G, Bonnet P, Eder V: Doppler tissue imaging in assessment of pulmonary hypertension-induced right ventricle dysfunction. Am J Physiol Heart Circ Physiol 2005, 289:H2450-H2455.10.1152/ajpheart.00524.2005]Search in Google Scholar
[74. McLean AS, Ting I, Huang SJ, Wesley S: The use of the right ventricular diameter and tricuspid annular tissue Doppler velocity parameter to predict the presence of pulmonary hypertension. Eur J Echocardiogr 2007, 8:128-136.10.1016/j.euje.2006.02.005]Search in Google Scholar
[75. Smith KF, Quinn RL, Rahilly LJ: Biomarkers for differentiation of causes of respiratory distress in dogs and cats: Part 1 - Cardiac diseases and pulmonary hypertension. J Vet Emerg Crit Care 2015, 25:311-329.10.1111/vec.12318]Search in Google Scholar
[76. Kellihan HB, MacKie BA, Stepien RL: NT-proBNP, NT-proANP and cTnI concentrations in dogs with pre-capillary pulmonary hypertension. J Vet Cardiol 2011, 13:171-182.10.1016/j.jvc.2011.04.003]Search in Google Scholar
[77. Vélez-Martínez M, Ayers C, Mishkin JD, Bartolome SB, García CK, Torres F, Drazner MH, De Lemos JA, Turer AT, Chin KM: Association of cardiac troponin I with disease severity and outcomes in patients with pulmonary hypertension. Am J Cardiol 2013, 111:1812-1817.10.1016/j.amjcard.2013.02.036]Search in Google Scholar
[78. Mehta NJ, Jani K, Khan IA: Clinical usefulness and prognostic value of elevated cardiac troponin I levels in acute pulmonary embolism. Am Heart J 2003, 145:821-825.10.1016/S0002-8703(02)94704-6]Search in Google Scholar
[79. Hamacher L, Dorfelt R, Muller M, Wess G: Serum cardiac Troponin I concentrations in dogs with systemic infl ammatory response syndrome. J Vet Emerg Crit Care 2015, 29:164-170.10.1111/jvim.12474485808225619514]Search in Google Scholar
[80. Polizopoulou ZS, Koutinas CK, Dasopoulou A, Patsikas M, York M, Roman I, Gandhi M, Patel S, Koutinas AF, O’Brien PJ: Serial analysis of serum cardiac troponin I changes and correlation with clinical fi ndings in 46 dogs with mitral valve disease. Vet Clin Pathol 2014, 43:218-225.10.1111/vcp.1212424612252]Search in Google Scholar
[81. Carretón E, Morchón R, Simón F, Juste MC, Méndez JC, Montoya-Alonso JA: Cardiopulmonary and infl ammatory biomarkers in the assessment of the severity of canine dirofi lariosis. Vet Parasitol 2014, 206:43-47.10.1016/j.vetpar.2014.08.01925224789]Search in Google Scholar
[82. Boswood A, Dukes-McEwan J, Loureiro J, James RA, Martin M, Stafford-Johnson M, Smith P, Little C, Attree S: The diagnostic accuracy of different natriuretic peptides in the investigation of canine cardiac disease. J Small Anim Pract 2008, 49:26-32. ]Search in Google Scholar
[83. Oyama MA, Rush JE, Rozanski EA, Fox PR, Reynolds CA, Gordon SG, Bulmer BJ, Lefbom BK, Brown BA, Lehmkuhl LB, Prosek R, Lesser MB, Kraus MS, Bossbaly MJ, Rapoport GS, Boileau JS: Assessment of serum N-terminal pro-B-type natriuretic peptide concentration for differentiation of congestive heart failure from primary respiratory tract disease as the cause of respiratory signs in dogs. J Am Vet Med Assoc 2009, 235:1319-1325.10.2460/javma.235.11.131919951101]Search in Google Scholar
[84. Hori Y, Uchide T, Saitoh R, Thoei D, Uchida M, Yoshioka K, Chikazawa S, Hoshi F: Diagnostic utility of NT-proBNP and ANP in a canine model of chronic embolic pulmonary hypertension. Vet J 2012, 194:215-221.10.1016/j.tvjl.2012.03.02222578688]Search in Google Scholar
[85. Atkinson KJ, Fine DM, Thombs LA, Gorelick JJ, Durham HE: Evaluation of pimobendan and N-terminal probrain natriuretic peptide in the treatment of pulmonary hypertension secondary to degenerative mitral valve disease in dogs. J Vet Intern Med 2009, 23:1190-1196.10.1111/j.1939-1676.2009.0390.x19780931]Search in Google Scholar
[86. Hori Y, Tsubaki M, Katou A, Ono Y, Yonezawa T, Li X, Higuchi SI: Evaluation of NToro BNP and CT-ANP as markers of concentric hypertrophy in dogs with a model of compensated aortic stenosis. J Vet Intern Med 2008, 22:1118-1123.10.1111/j.1939-1676.2008.0161.x18681918]Search in Google Scholar
[87. Chen YF, Oparil S: Endothelin and pulmonary hypertension. J Cardiovasc Pharmacol 2000, 35:S49-S53.10.1097/00005344-200000002-0001210976782]Search in Google Scholar
[88. Cody RJ, Haas GJ, Binkley PF, Capers Q, Kelley R: Plasma endothelin correlates with the extent of pulmonary hypertension in patients with chronic congestive heart failure. Circulation 1992, 85:504-509.10.1161/01.CIR.85.2.504]Search in Google Scholar
[89. Uchide T, Saida K: Elevated Endothelin-1 expression in dogs with heartworm disease. J Vet Med Sci 2005, 67:1155-1161.10.1292/jvms.67.115516327228]Search in Google Scholar
[90. Fukumoto S, Hanazono K, Miyasho T, Endo Y, Kadosawa T, Iwano H, Uchide T: Serum big endothelin-1 as a clinical marker for cardiopulmonary and neoplastic diseases in dogs. Life Sci 2014, 118:329-32.10.1016/j.lfs.2014.01.00224447631]Search in Google Scholar
[91. Venco L, Bertazzolo W, Giordano G, Paltrinieri S: Evaluation of C-reactive protein as a clinical biomarker in naturally heartworm-infected dogs: A fi eld study. Vet Parasitol 2014, 206:48-54.10.1016/j.vetpar.2014.08.01825218887]Search in Google Scholar
[92. McLaughlin VV, Shah SJ, Souza R, Humbert M: Management of pulmonary arterial hypertension. J Am Coll Cardiol 2015, 65:1976-1997.10.1016/j.jacc.2015.03.54025953750]Search in Google Scholar
[93. Michelakis E, Tymchak W, Lien D, Webster L, Hashimoto K, Archer S: Oral sildenafi l is an effective and specifi c pulmonary vasodilator in patients with pulmonary arterial hypertension: Comparison with inhaled nitric oxide. Circulation 2002, 105:2398-2403.10.1161/01.CIR.0000016641.12984.DC12021227]Search in Google Scholar
[94. Hansdottir S, Groskreutz DJ, Gehlbach BK: WHO’s in second? A practical review of World Health Organization group 2 pulmonary hypertension. Chest 2013, 144:2638-650.10.1378/chest.12-2114373489223918108]Search in Google Scholar
[95. Brown AJ, Davison E, Sleeper MM: Clinical effi cacy of sildenafi l in treatment of pulmonary arterial hypertension in dogs. J Vet Intern Med 2010, 24:850-854.10.1111/j.1939-1676.2010.0517.x20412435]Search in Google Scholar
[96. Toyoshima Y, Kanemoto I, Arai S, Toyoshima: A case of long-term sildenafi l therapy in a young dog with pulmonary hypertension. J Vet Med Sci 2007, 69:1073-1075.10.1292/jvms.69.107317984597]Search in Google Scholar
[97. Nakamura K, Yamasaki M, Ohta H, Sasaki N, Murakami M, Bandula Kumara WR, Takiguchi M: Effects of sildenafi l citrate on fi ve dogs with Eisenmenger’s syndrome. J Small Anim Pract 2011, 52:595-598.10.1111/j.1748-5827.2011.01127.x21985577]Search in Google Scholar
[98. Hori Y, Kondo C, Matsui M, Yamagishi M, Okano S, Chikazawa S, Kanai K, Hoshi F, Itoh N: Effect of the phosphodiesterase type 5 inhibitor tadalafi l on pulmonary hemodynamics in a canine model of pulmonary hypertension. Vet J, 202:334-339. 10.1016/j.tvjl.2014.08.00925178687]Search in Google Scholar
[99. Serres F, Nicolle AP, Tissier R, Gouni V, Pouchelon JL, Chetboul V: Effi cacy of oral tadalafi l, a new long-acting phosphodiesterase-5 inhibitor, for the short-term treatment of pulmonary arterial hypertension in a dog. J Vet Med Ser A Physiol Pathol Clin Med 2006, 53:129-133.10.1111/j.1439-0442.2006.00800.x16533328]Search in Google Scholar
[100. Murray F, MacLean MR, Pyne NJ: Increased expression of the cGMP-inhibited cAMPspecifi c (PDE3) and cGMP binding cGMP-specifi c (PDE5) phosphodiesterases in models of pulmonary hypertension. Br J Pharmacol 2002, 137:1187-1194.10.1038/sj.bjp.0704984157360912466227]Search in Google Scholar
[101. Baliga RS, MacAllister RJ, Hobbs AJ: New perspectives for the treatment of pulmonary hypertension. Br J Pharmacol 2011, 63:125-140.10.1111/j.1476-5381.2010.01164.x]Search in Google Scholar
[102. Perros F, Montani D, Dorfmüller P, Durand-Gasselin I, Tcherakian C, Le Pavec J, Mazmanian M, Fadel E, Mussot S, Mercier O, Hervé P, Emilie D, Eddahibi S, Simonneau G, Souza R, Humbert M: Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med 2008, 178:81-88.10.1164/rccm.200707-1037OC]Search in Google Scholar
[103. Arita S, Arita N, Hikasa Y: Therapeutic effect of low-dose imatinib on pulmonary arterial hypertension in dogs. Can Vet J 2013, 54:255-61.]Search in Google Scholar
[104. Choussat R, Hittinger L, Barbe F, Maistre G, Carayon A, Crozatier B, Su J: Acute effects of an endothelin-1 receptor antagonist bosentan at different stages of heart failure in conscious dogs. Cardiovasc Res 1998, 39:580-588.10.1016/S0008-6363(98)00068-6]Search in Google Scholar