Stereological and Immunohistochemical Study of the Spleen in Hypothyroid Juvenile Rats

1. Miyake S: Mind over cytokines: Crosstalk and regulation between the neuroendocrine and immune systems. Clin Exp Neuroimmunol 2012, 3(1):1-15.10.1111/j.1759-1961.2011.00023.xSearch in Google Scholar

2. Pascual A, Aranda A: Thyroid hormone receptors, cell growth and differentiation. Biochim Biophys Acta 2013, 1830(7):3908-3916.10.1016/j.bbagen.2012.03.012Search in Google Scholar

3. Rooney AA, Fournier M, Bernier J, Cyr DG: Neonatal exposure to propylthiouracil induces a shift in lymphoid cell sub-populations in the developing postnatal male rat spleen and thymus. Cell Immunol 2003, 223:91-102.10.1016/S0008-8749(03)00153-9Search in Google Scholar

4. Pierpaoli W, Baroni C, Fabris N, Sorkin E: Hormones and the immunological capacity. II. Reconstitution of antibody production in hormonally deficient mice by somatotropic hormone, thyrotropic hormone and thyroxin. Immunology 1969, 16(2):217-230.Search in Google Scholar

5. Dorshkind K, Hoserman ND: The roles of prolactin, growth hormone, insulin-like growth factor-I, and thyroid hormones in lymphocyte development and function: insights from genetic models of hormone and hormone receptor deficiency. Endocr Rev 2000, 21(3):292-312.10.1210/er.21.3.292Search in Google Scholar

6. Nakamura R, Teshima R, Hachisuka A, Sato Y, Tagaki K, Nakamura R, Woo GH, Shibutani M, Sawada J: Effect of developmental hypothyroidism induced by maternal administration of methimazole or propylthiouracil on the immune system of the rats. Int Immunopharmacol 2007, 7(13):1630-1638.10.1016/j.intimp.2007.08.012Search in Google Scholar

7. Cano-Europa E, Blas-Valdivia V, Franco-Colin M, Gallardo-Casas CA, Ortiz-Butron R: Methimazole-induced hypothyroidism causes cellular damage in the spleen, heart, liver, lung and kidney. Acta Histochem 2011, 113(1):1-5.10.1016/j.acthis.2009.07.004Search in Google Scholar

8. Cesta MF: Normal structure, function, and histology of the spleen. Toxicol Patholog 2006, 34(5):455-465.10.1080/01926230600867743Search in Google Scholar

9. Garraud O, Borhis G, Badr G, Degrelle S, Pozzetto B, Cognasse F, Richard Y: Revisiting the B-cell compartment in mouse and humans: more than one B-cell subset exists in the marginal zone and beyond. BMC Immunol 2012, 13:63.10.1186/1471-2172-13-63Search in Google Scholar

10. Di Sabatino A, Carsetti R, Corazza GR: Post-splenectomy and hyposplenic states. Lancet 2011, 378(9785):86-97.10.1016/S0140-6736(10)61493-6Search in Google Scholar

11. Bronte V, Pittet MJ: The spleen in local and systemic regulation of immunity. Immunity 2013, 39(5):806-818.10.1016/j.immuni.2013.10.010391274224238338Search in Google Scholar

12. Thvilum M, Brandt F, Brix TH, Hegedüs L: A review of the evidence for and against increased mortality in hypothyroidism. Nat Rev Endocrinol 2012, 8(7):417-424.10.1038/nrendo.2012.2922392154Search in Google Scholar

13. Chang DL, Pearce EN: Screening for maternal thyroid dysfunction in pregnancy: a review of the clinical evidence and current guidelines. J Thyroid Res 2013, Article ID 851326, 8 pages, 2013. doi:10.1155/2013/85132610.1155/2013/851326367167423762776Search in Google Scholar

14. Weibel ER: Practical methods for biological morphometry. In: Stereological methods. London, United Kingdom: Academic Press; 1979, 40-116.Search in Google Scholar

15. Beckstead J: A Simple Technique for Preservation of Fixation-sensitive Antigens in Paraffin-embedded Tissues. J Histochem Cytochem 1994, 42:1127-1134.10.1177/42.8.80275318027531Search in Google Scholar

16. Cooper DS: Antithyroid drugs. N Engl J Med 2005, 352(9):905-917.10.1056/NEJMra04297215745981Search in Google Scholar

17. Hood A, Liu YP, Gattone VH, Klaassen CD: Sensitivity of thyroid gland growth to TSH in rats treated with antithyroid drugs. Toxicolog Sci 1999, 49:263-271.10.1093/toxsci/49.2.26310416271Search in Google Scholar

18. Montecino-Rodrigez E, Clark RG, Johnson A, Collins L, Dorshkind K: Defective B cell development in Snell dwarf (dw/dw) mice can be corrected by thyroxine treatment. J Immunol 1996, 157:3334-3340.10.4049/jimmunol.157.8.3334Search in Google Scholar

19. Arpin C, Pihlgren M, Fraichard A, Aubert D, Samarut J, Chassande O, Marvel J: Effect of T3α1 and T3α2 gene deletion on T and B lymphocyte development. J Immunol 2000, 164:152-160.10.4049/jimmunol.164.1.15210605006Search in Google Scholar

20. Kiecha AJ, Genaro AM, Gorelik G, Arcos ALB, Silberman DM, Schuman M, Garcia SI, Pirola C, Cremaschi GA: Integrative study of hypothalamus-pituitary-thyroid-immune system interaction: thyroid hormone-mediated modulation of lymphocyte activity through the protein kinase C signaling pathway. J Endocrinol 2006, 189:45-55.10.1677/joe.1.0613716614380Search in Google Scholar

21. Malhotra D, Fletcher AL, Turley SJ: Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity. Immunol Rev 2013, 251(1):160-176.10.1111/imr.12023353922923278748Search in Google Scholar

22. Mihara S, Suzuki N, Wakisaka S, Suzuki S, Sekita N, Yamamoto S, Saito N, Hoshino T, Sakane T: Effects of thyroid hormones on apoptotic cell death of human lymphocytes. J Clin Endocrinol Metab1999, 84(4):1378-1385.10.1210/jcem.84.4.559810199782Search in Google Scholar

23. Dammers PM, Lodewijk ME, Zandvoort A and Kroese FGM: Marginal zone B cells in neonatal rats express intermediate levels of CD90 (Thy-1). Dev Immunol 2003, 5:1-9.10.1080/10446670310001593488227610915144015Search in Google Scholar

24. Shulz C, Gomez Perdiguero E, Chorro L, Shabo-Rogers H, Cagnard N, Kierdorf K, Prinz M, Wu B, Jacobsen SE, Pollard JW, Frampton J, Liu KJ, Geissmann F: A lineage of myeloid cells independent of Myb and hematopoetic stem cells. Science 2012, 336(6077):86-90.10.1126/science.121917922442384Search in Google Scholar

25. Sieweke MH, Allen JE: Beyond stem cells: self-renewal of differentiated macrophages. Science 2013, 342(6161):1242974.10.1126/science.124297424264994Search in Google Scholar

26. Perrotta C, Bludorini M, Assi E, Cazzato D, De Palma C, Clementi E, Cervia D: The thyroid hormone triiodothyronine, controls macrophage maturation and functions: protective role during inflammation. Am J Pathol 2014, 184(1):230-247.10.1016/j.ajpath.2013.10.00624215914Search in Google Scholar

27. Kovačević Filipović M: The blood is rich in different types of mesoderm stem and progenitor cells. Acta Vet-Beograd 2014, 64(2):156-178.10.2478/acve-2014-0016Search in Google Scholar

28. Kukolj V: Myofibroblasts in normal and fibrotic liver in different animal species. Acta Vet- Beograd 2014, 64(4):397-412.10.2478/acve-2014-0038Search in Google Scholar

29. Safer JD: Thyroid hormone action on skin. Dermatoendocrinol 2011, 3(3):211-215.10.4161/derm.17027Search in Google Scholar

30. Roksandić D, Šimić M, Radovanović A, Gledić D: Body mass, spleen mass and level of thyroid hormones in juvenile hypothyroid rats. Vet. glasnik 2006, 60(3-4): 153-162. 10.2298/VETGL0604153RSearch in Google Scholar