Aging Impairs Endocytic Capacity Of Splenic Dendritic Cells From Dark Agouti Rats And Alters Their Response To TLR4 Stimulation

1. Banchereau J, Steinman RM: Dendritic cells and the control of immunity. Nature 1998,392: 245-252.10.1038/325889521319Search in Google Scholar

2. Munz C, Steinman RM, Fujii S: Dendritic cell maturation by innate lymphocytes: coordinated stimulation of innate and adaptive immunity. J Exp Med 2005, 202:203-207.10.1084/jem.20050810221301516027234Search in Google Scholar

3. Voisine C, Hubert FX, Trinite B, Heslan M, Josien R: Two phenotypically distinct subsets of spleen dendritic cells in rats exhibit different cytokine production and T cell stimulatory activity. J Immunol 2002, 169:2284-2291.10.4049/jimmunol.169.5.228412193693Search in Google Scholar

4. Hubert FX, Voisine C, Louvet C, Heslan M, Josien R: Rat plasmacytoid dendritic cells are an abundant subset of MHC class II+ CD4+CD11b-OX62- and type I IFN-producing cells that exhibit selective expression of Toll-like receptors 7 and 9 and strong responsiveness to CpG. J Immunol 2004, 172:7485-7494.10.4049/jimmunol.172.12.748515187127Search in Google Scholar

5. Burkle A, Caselli G, Franceschi C, Mariani E, Sansoni P, Santoni A, Vecchio G, Witkowski JM, Caruso C: Pathophysiology of ageing, longevity and age related diseases. Immun Ageing 2007, 4:4.10.1186/1742-4933-4-4197307517683521Search in Google Scholar

6. Gruver AL, Hudson LL, Sempowski GD: Immunosenescence of ageing. J Pathol 2007 211:144-156.10.1002/path.2104193183317200946Search in Google Scholar

7. Aspinall R, Goronzy JJ: Immune senescence. Curr Opin Immunol 2010, 22:497-499.10.1016/j.coi.2010.07.00220674319Search in Google Scholar

8. Nikolich-Zugich J: T cell aging: naive but not young. J Exp Med 2005, 201:837-840.10.1084/jem.20050341221309615781575Search in Google Scholar

9. Salam N, Rane S, Das R, Faulkner M, Gund R, Kandpal U, Lewis V, Mattoo H, Prabhu S, Ranganathan V, Durdik J, George A, Rath S, Bal V: T cell ageing: effects of age on development, survival & function. Indian J Med Res 2013, 138:595-608.Search in Google Scholar

10. Grolleau-Julius A, Garg MR, Mo R, Stoolman LL, Yung RL: Effect of aging on bone marrow-derived murine CD11c+CD4-CD8alpha- dendritic cell function. J Gerontol A Biol Sci Med Sci 2006, 61:1039-1047.10.1093/gerona/61.10.103917077196Search in Google Scholar

11. Agrawal A, Agrawal S, Cao JN, Su H, Osann K, Gupta S: Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway. J Immunol 2007, 178:6912-6922.10.4049/jimmunol.178.11.691217513740Search in Google Scholar

12. Agrawal A, Agrawal S, Tay J, Gupta S: Biology of dendritic cells in aging. J Clin Immunol 2008, 28:14-20.10.1007/s10875-007-9127-617828583Search in Google Scholar

13. Pereira LF, de Souza AP, Borges TJ, Bonorino C: Impaired in vivo CD4+ T cell expansion and differentiation in aged mice is not solely due to T cell defects: decreased stimulation by aged dendritic cells. Mech Ageing Dev 2011, 132:187-194.10.1016/j.mad.2011.03.00521453718Search in Google Scholar

14. Li G, Smithey MJ, Rudd BD, Nikolich-Zugich J: Age-associated alterations in CD8alpha+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium. Aging Cell 2012, 11:968-977.10.1111/j.1474-9726.2012.00867.x353376722862959Search in Google Scholar

15. Wong C, Goldstein DR: Impact of aging on antigen presentation cell function of dendritic cells. Curr Opin Immunol 2013, 25:535-541.10.1016/j.coi.2013.05.016377594423806201Search in Google Scholar

16. Gupta S: Role of dendritic cells in innate and adaptive immune response in human aging. Exp Gerontol 2013, 54:47-52.10.1016/j.exger.2013.12.00924370374Search in Google Scholar

17. Stojic-Vukanic Z, Bufan B, Arsenovic-Ranin N, Kosec D, Pilipovic I, Perisic Nanut M, Leposavic G: Aging affects AO rat splenic conventional dendritic cell subset composition, cytokine synthesis and T-helper polarizing capacity. Biogerontology 2013, 14:443-459.10.1007/s10522-013-9444-523873152Search in Google Scholar

18. Fournie GJ, Cautain B, Xystrakis E, Damoiseaux J, Mas M, Lagrange D Bernard I, Subra JF, Pelletier L, Druet P, Saoudi A: Cellular and genetic factors involved in the difference between Brown Norway and Lewis rats to develop respectively type-2 and type-1 immune-mediated diseases. Immunol Rev 2001, 184:145-160.10.1034/j.1600-065x.2001.1840114.x12086309Search in Google Scholar

19. Markovic M, Miljkovic D, Momcilovic M, Popadic D, Miljkovic Z, Savic E, Ramic Z, Mostarica Stojkovic M: Strain difference in susceptibility to experimental autoimmune encephalomyelitis in rats correlates with T(H)1 and T(H)17-inducing cytokine profiles. Mol Immunol 2009, 47:141-146.10.1016/j.molimm.2009.01.01219233473Search in Google Scholar

20. Hubert FX, Voisine C, Louvet C, Heslan JM, Ouabed A, Heslan M, Josien R: Differential pattern recognition receptor expression but stereotyped responsiveness in rat spleen dendritic cell subsets. J Immunol 2006, 177:1007-1016.10.4049/jimmunol.177.2.100716818757Search in Google Scholar

21. Pinchuk LM, Filipov NM: Differential effects of age on circulating and splenic leukocyte populations in C57BL/6 and BALB/c male mice. Immun Ageing 2008, 5:1. doi: 10.1186/1742-4933-5-1.10.1186/1742-4933-5-1226891518267021Search in Google Scholar

22. Lukic ML, Mensah-Brown E, Galadari S, Shahin A: Lack of apoptosis of infiltrating cells as the mechanism of high susceptibility to EAE in DA rats. Dev Immunol 2001, 8:193-200.10.1155/2001/32636Search in Google Scholar

23. Popov A, Mirkov I, Miljkovic D, Belij S, Zolotarevski L, Kataranovski D, Kataranovski M: Contact allergic response to dinitrochlorobenzene (DNCB) in rats: insight from sensitization phase. Immunobiology 2011, 216:763-770.10.1016/j.imbio.2010.12.007Search in Google Scholar

24. Pinto LA, Galvao Castro B, Soares MB, Grassi MF: An Evaluation of the Spontaneous Proliferation of Peripheral Blood Mononuclear Cells in HTLV-1-Infected Individuals Using Flow Cytometry. ISRN Oncol 2011, 2011:326719.10.5402/2011/326719Search in Google Scholar

25. Kamath AB, Nagarkatti PS, Nagarkatti M: Characterization of phenotypic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin on thymocytes in vivo and its effect on apoptosis. Toxicol Appl Pharmacol 1998, 150:117-124.10.1006/taap.1998.8390Search in Google Scholar

26. Eissler R, Schmaderer C, Rusai K, Kuhne L, Sollinger D, Lahmer T, Witzke O, Lutz J, Heemann U, Baumann M: Hypertension augments cardiac Toll-like receptor 4 expression and activity. Hypertens Res 2011, 34:551-558.10.1038/hr.2010.270Search in Google Scholar

27. Vremec D, O'Keeffe M, Wilson A, Ferrero I, Koch U, Radtke F, Scott B, Hertzog P, Villadangos J, Shortman K: Factors determining the spontaneous activation of splenic dendritic cells in culture. Innate Immun 2011, 17:338-352.10.1177/1753425910371396Search in Google Scholar

28. Popma SH, Krasinskas AM, McLean AD, Szeto WY, Kreisel D, Moore JS, Rosengard BR: Immune monitoring in xenotransplantation: the multiparameter flow cytometric mixed lymphocyte culture assay. Cytometry 2000, 42:277-283.10.1002/1097-0320(20001015)42:5<277::AID-CYTO4>3.0.CO;2-ASearch in Google Scholar

29. Wilke CM, Wang L, Wei S, Kryczek I, Huang E, Kao J, Lin Y, Fang J, Zou W: Endogenous interleukin-10 constrains Th17 cells in patients with inflammatory bowel disease. J Transl Med 2011, 9:217.10.1186/1479-5876-9-217Search in Google Scholar

30. Corsetti PP, de Almeida LA, Carvalho NB, Azevedo V, Silva TM, Teixeira HC, Faria AC, Oliveira SC: Lack of endogenous IL-10 enhances production of proinflammatory cytokines and leads to Brucella abortus clearance in mice. PLoS One 2013, 8:e74729.10.1371/journal.pone.0074729Search in Google Scholar

31. Niedbala W, Wei XQ, Campbell C, Thomson D, Komai-Koma M, Liew FY: Nitric oxide preferentially induces type 1 T cell differentiation by selectively up-regulating IL-12 receptor beta 2 expression via cGMP. Proc Natl Acad Sci USA 2002, 99:16186-16191.10.1073/pnas.252464599Search in Google Scholar

32. Agrawal A, Agrawal S, Gupta S: Dendritic cells in human aging. Exp Gerontol 2007, 42:421-426.10.1016/j.exger.2006.11.007Search in Google Scholar

33. Panda A, Qian F, Mohanty S, van Duin D, Newman FK, Zhang L Chen S, Towle V, Belshe RB, Fikrig E, Allore HG, Montgomery RR, Shaw AC: Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. J Immunol 2010, 184:2518-2527.10.4049/jimmunol.0901022Search in Google Scholar

34. Guha M, Mackman N: The PI3K-Akt pathway limits LPS activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J Biol Chem 2002, 277:32124-32132.10.1074/jbc.M203298200Search in Google Scholar

35. Shaw AC, Panda A, Joshi SR, Qian F, Allore HG, Montgomery RR: Dysregulation of human Toll-like receptor function in aging. Ageing Res Rev 2011, 10:346-353.10.1016/j.arr.2010.10.007Search in Google Scholar

36. Corinti S, Albanesi C, la Sala A, Pastore S, Girolomoni G: Regulatory activity of autocrine IL-10 on dendritic cell functions. J Immunol 2001, 166:4312-4318.10.4049/jimmunol.166.7.4312Search in Google Scholar

37. Morrison RS, 3rd, Cruse JM, Wang H, Lewis RE: Dendritic cell differentiation and proliferation: enhancement by tumor necrosis factor-alpha. Exp Mol Pathol 2003, 75:228-237.10.1016/S0014-4800(03)00087-XSearch in Google Scholar

38. Slobodin G, Kessel A, Peri R, Zaigraikin N, Rozenbaum M, Rosner I, Toubi E: Etanercept impairs maturation of human monocyte-derived dendritic cells by inhibiting the autocrine TNFalpha-mediated signaling. Inflammation 2009, 32:146-150.10.1007/s10753-009-9113-719301111Search in Google Scholar

39. You J, Dong H, Mann ER, Knight SC, Yaqoob P: Ageing impairs the T cell response to dendritic cells. Immunobiology 2013, 218:1077-1084.10.1016/j.imbio.2013.02.00223582781Search in Google Scholar

40. Haruna H, Inaba M, Inaba K, Taketani S, Sugiura K, Fukuba Y, Doi H, Toki J, Tokunaga R, Ikehara S. Abnormalities of B cells and dendritic cells in SAMP1 mice. Eur J Immunol, 1995, 25:1319–132510.1002/eji.18302505287539756Search in Google Scholar

41. Cannizzo ES, Clement CC, Morozova K, Valdor R, Kaushik S, Almeida L, Follo C, Sahu R, Cuervo AM, Macian F, Santambrogio L: Age-related oxidative stress compromises endosomal proteostasis. Cell Rep 2012, 2:136-149.10.1016/j.celrep.2012.06.005340859022840404Search in Google Scholar

42. Qi H, Denning TL, Soong L: Differential induction of interleukin-10 and interleukin-12 in dendritic cells by microbial toll-like receptor activators and skewing of T-cell cytokine profiles. Infect Immun 2003, 71:3337-3342.10.1128/IAI.71.6.3337-3342.2003Search in Google Scholar

43. de Waal Malefyt R, Yssel H, de Vries JE: Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation. J Immunol 1993, 150:4754-4765.10.4049/jimmunol.150.11.4754Search in Google Scholar

44. Mosmann TR, Sad S: The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 1996, 17:138-146.10.1016/0167-5699(96)80606-2Search in Google Scholar

45. Lalani I, Bhol K, Ahmed AR: Interleukin-10: biology, role in inflammation and autoimmunity. Ann Allergy Asthma Immunol 1997, 79:469-483.10.1016/S1081-1206(10)63052-9Search in Google Scholar

46. Diehl S, Rincon M: The two faces of IL-6 on Th1/Th2 differentiation. Mol Immunol 2002, 39: 531-536.10.1016/S0161-5890(02)00210-9Search in Google Scholar

47. Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B Hunte B, Vega F, Yu N, Wang J, Singh K, Zonin F, Vaisberg E, Churakova T, Liu M, Gorman D, Wagner J, Zurawski S, Liu Y, Abrams JS, Moore KW, Rennick D, de Waal-Malefyt R, Hannum C, Bazan JF, Kastelein RA: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000, 13:715-725.10.1016/S1074-7613(00)00070-4Search in Google Scholar

48. McGeachy MJ, Cua DJ: Th17 cell differentiation: the long and winding road. Immunity 2008, 28:445-453.10.1016/j.immuni.2008.03.001Search in Google Scholar

49. Torchinsky MB, Blander JM: T helper 17 cells: discovery, function, and physiological trigger. Cell Mol Life Sci 2010, 67:1407-1421.10.1007/s00018-009-0248-3Search in Google Scholar

50. Qu X, Liu X, Cheng K, Zhao RC: Mesenchymal stem cells inhibit Th17 cell differentiation by IL-10 secretion. Exp Hematol 2012, 40:761-770.10.1016/j.exphem.2012.05.006Search in Google Scholar

51. Kallen B, Nilsson O: Age as a factor determining susceptibility for experimental autoimmune encephalomyelitis in the rat. Int Arch Allergy Appl Immunol 1989, 90:16-19.10.1159/000234993Search in Google Scholar

52. Ludowyk PA, Hughes W, Hugh A, Willenborg DO, Rockett KA, Parish CR: Astrocytic hypertrophy: an important pathological feature of chronic experimental autoimmune encephalitis in aged rats. J Neuroimmunol 1993, 48:121-134.10.1016/0165-5728(93)90184-ZSearch in Google Scholar

53. Ditamo Y, Degano AL, Maccio DR, Pistoresi-Palencia MC, Roth GA: Age-related changes in the development of experimental autoimmune encephalomyelitis. Immunol Cell Biol 2005, 83:75-82.10.1111/j.1440-1711.2004.01294.x15661044Search in Google Scholar