Otwarty dostęp

Effects of [Cu(2-MeSNic)2(MeNia)2(H2O)2]·H2O and [Cu(2-MeSNic)2(H2O)]2 on Candida albicans

Barbora Kaliňáková
Barbora Kaliňáková
, 
Daniela Hudecová
Daniela Hudecová
, 
Peter Segľa
Peter Segľa
, 
Martina Palicová
Martina Palicová
 oraz 
Jozef Švorec
Jozef Švorec
   | 15 cze 2015
Acta Chimica Slovaca's Cover Image
O artykule
Poprzedni artykuł
Następny artykuł
Zacytuj
Data publikacji: 15 cze 2015
Zakres stron: 39 - 43
DOI: https://doi.org/10.1515/acs-2015-0008
Słowa kluczowe
© Barbora Kaliňáková et al.
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Probable mode of action of new copper complexes of 2-methylthionicotinate (2-MeSNic) of composition [Cu(2-MeSNic)2(H2O)2] and [Cu(2-MeSNic)2(MeNia)2(H2O)2]·H2O (where MeNia is N-methylnicotinamide) is described. Both partial growth inhibition of Candida albicans (IC50 ≥ 1.78 mmol·L−1, MIC ≥ 2.5 mmol·L−1) and leak of proteins into the extracellular space (more than 80 %) were observed in the presence of these copper complexes. The membrane damage was detected by staining with Hoechst 33342, propidium iodide and methylene blue. Ascorbic acid potentiated antifungal activity of copper complexes approximately seven-fold and induced the oxidative stress, respectively. The production of intracellular reactive oxygen species was visualized by dichlorofluorescein. Thiobarbituric acid-reactive substances were formed as a by-product of lipid peroxidation.

eISSN:
1337-978X
Język:
Angielski
Częstotliwość wydawania:
2 razy w roku
Dziedziny czasopisma:
Chemistry, other
Kanał RSS czasopisma