Association of SLC1A2 and SLC17A7 polymorphisms with major depressive disorder in a Thai population
, , , , oraz | 20 wrz 2019
O artykule
Article Category: Brief communication (original)
Data publikacji: 20 wrz 2019
Zakres stron: 131 - 138
DOI: https://doi.org/10.1515/abm-2019-0012
Słowa kluczowe
© 2018 B. Thaweethee et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Figure 1
Demographic data and clinical characteristics of the participants in the present study
| Variable (mean ± SD) or n (%) | Control | MDD | Nonsuicidal MDD | Suicidal MDD | ||
|---|---|---|---|---|---|---|
| (n = 100) | (n = 100) | (n = 50) | (n = 50) | |||
| Age (years), | 44.31 ± 14.77 | 43.74 ± 15.00 | 0.79† | 44.38 ± 15.32 | 44.24 ± 14.35 | 0.96† |
| Sex | ||||||
| Female | 74 (74) | 75 (75) | 0.94† | 39 (78) | 35 (70) | 0.36† |
| Male | 26 (26) | 25 (25) | 11 (22) | 15 (30) | ||
| Age of onset (years old) | 38.34 ± 16.28 | 33.66 ± 13.93 | 0.12† | |||
| Duration of illness (years) | 6.05 ± 8.44 | 10.58 ± 11.18 | 0.024†* | |||
| HDRS-17 (scores) | 11.66 ± 7.35 | 13.48 ± 7.44 | 0.22† | |||
| Female | 13.82 ± 7.75 | 0.004‡* | 12.33 ± 7.76 | 15.49 ± 7.50 | 0.08† | |
| Male | 9.00 ± 4.93 | 9.27 ± 5.26 | 8.80 ± 4.86 | 0.47† |
Genotype frequencies of SLC1A2 and SLC17A7 polymorphisms in the control and MDD groups
| n | Genotype (frequency) | † | ‡ | |||
|---|---|---|---|---|---|---|
| Control | 100 | 74 (0.74) | 26 (0.26) | 0 (0.00) | 0.25 | 0.23 |
| MDD | 100 | 81 (0.81) | 18 (0.18) | 1 (0.01) | ||
| Nonsuicidal | 50 | 45 (0.90) | 4 (0.08) | 1 (0.02) | 0.023* | 0.022* |
| Suicidal | 50 | 36 (0.72) | 14 (0.28) | 0 (0.00) | ||
| Control | 100 | 17 (0.17) | 51 (0.51) | 32 (0.32) | 0.16 | 0.65 |
| MDD | 100 | 26 (0.26) | 39 (0.39) | 35 (0.35) | ||
| Nonsuicidal | 50 | 14 (0.28) | 17 (0.34) | 19 (0.38) | 0.59 | 0.53 |
| Suicidal | 50 | 12 (0.24) | 22 (0.44) | 16 (0.32) | ||
| Control | 100 | 33 (0.33) | 45 (0.45) | 22 (0.22) | 0.89 | 0.65 |
| MDD | 100 | 30 (0.30) | 46 (0.46) | 24 (0.24) | ||
| Nonsuicidal | 50 | 12 (0.24) | 27 (0.54) | 11 (0.22) | 0.25 | 0.19 |
| Suicidal | 50 | 18 (0.36) | 19 (0.38) | 13 (0.26) | ||
| Control | 100 | 46 (0.46) | 47 (0.47) | 7 (0.07) | 0.52 | 0.32 |
| MDD | 100 | 53 (0.53) | 39 (0.39) | 8 (0.08) | ||
| Nonsuicidal | 50 | 27 (0.54) | 21 (0.42) | 2 (0.04) | 0.39 | 0.84 |
| Suicidal | 50 | 26 (0.52) | 18 (0.36) | 6 (0.12) | ||
| Control | 100 | 25 (0.25) | 55 (0.55) | 20 (0.20) | 0.85 | 0.74 |
| MDD | 100 | 23 (0.23) | 59 (0.59) | 18 (0.18) | ||
| Nonsuicidal | 50 | 9 (0.18) | 32 (0.64) | 9 (0.18) | 0.47 | 0.24 |
| Suicidal | 50 | 14 (0.28) | 27 (0.54) | 9 (0.18) | ||
| Control | 100 | 4 (0.04) | 36 (0.36) | 60 (0.60) | 0.047* | 0.016* |
| MDD | 100 | 8 (0.08) | 49 (0.49) | 43 (0.43) | ||
| Nonsuicidal | 50 | 3 (0.06) | 31 (0.62) | 16 (0.32) | 0.034* | 0.026* |
| Suicidal | 50 | 5 (0.10) | 18 (0.36) | 27 (0.54) | ||
| Control | 100 | 24 (0.24) | 49 (0.49) | 27 (0.27) | 0.69 | 0.87 |
| MDD | 100 | 19 (0.19) | 53 (0.53) | 28 (0.28) | ||
| Nonsuicidal | 50 | 14 (0.28) | 23 (0.46) | 13 (0.26) | 0.07 | 0.66 |
| Suicidal | 50 | 5 (0.10) | 30 (0.60) | 15 (0.30) | ||