[1. Borgarelli, M., Buchanan, J.W. (2012). Historical review, epidemiology and natural history of degenerative mitral valve disease. J. Vet. Cardiol. 14, 93-101. http://dx.doi.org/10.1016/j.jvc.2012.01.01110.1016/j.jvc.2012.01.01122386588]Search in Google Scholar
[2. Buchanan, J. W. (1999). Prevalence of cardiovascular disorders: Prevalence of cardiovascular diseases. In: P. Fox, D. Sisson and S. Moise (Eds). Textbook of Canine and Feline Cardiology. 2nd ed. (pp 457-470). WB Saunders, Philadelphia]Search in Google Scholar
[3. Olsen, L.H., Fredholm, M., Pedersen, H.D. (1999). Epidemiology and inheritance of mitral valve prolapse in Dachshunds. J. Vet. Intern. Med. 13(5):448-456. http://dx.doi.org/10.1111/j.1939-1676.1999.tb01462.x10.1111/j.1939-1676.1999.tb01462.x]Search in Google Scholar
[4. Domanjko Petrič, A., Hozjan, E., Blejec, A. (2007). Predisposition and survival of different breeds with chronic valvular disease. Proceedings of 17th European College Veterinary Internal Medicine - Companion Animals Congress, pp. 239, 13th -15th September, Budapest, Hungary.]Search in Google Scholar
[5. Borgarelli, M., Savarino, P., Crosara, S., Santilli, R.A., Chiavegato, D., Poggi, M., Bellino, C., La Rosa, G., Zanatta, R., Haggstrom, J., Tarducci, A. (2008). Survival characteristics and prognostic variables of dogs with mitral regurgitation attributable to myxomatous valve disease. J. Vet. Intern. Med. 22, 120-128. http://dx.doi.org/10.1111/j.1939-1676.2007.0008.x10.1111/j.1939-1676.2007.0008.x18289298]Search in Google Scholar
[6. Garncarz, M., Parzeniecka-Jaworska, M., Jank, M., Łój, M. (2013). A retrospective study of clinical signs and epidemiology of chronic valve disease in a group of 207 Dachshunds in Poland. Acta Vet. Scand. Jul 11, 55:52.]Search in Google Scholar
[7. Pedersen, H.D, Lorentzen, K.A., Kristensen, B.Ø. (1999). Echocardiographic mitral valve prolapse in Cavalier King Charles Spaniels: epidemiology and prognostic significance for regurgitation. Vet. Rec. 144, 315-320. http://dx.doi.org/10.1136/vr.144.12.31510.1136/vr.144.12.31510212505]Search in Google Scholar
[8. Serfass, P., Chetboul, V., Sampedrano, C.C., Nicolle, A., Benalloul, T., Laforge, H., Gau, C. Hébert, C., Pouchelon, J.L., Tissier, R. (2006). Retrospective study of 942 small-sized dogs: Prevalence of left apical systolic heart murmur and left-sided heart failure, critical effects of breed and sex. J. Vet. Cardiol., 8(1): 11-18. http://dx.doi.org/10.1016/j.jvc.2005.10.00110.1016/j.jvc.2005.10.00119083332]Search in Google Scholar
[9. Hägström, J., Kvart, C., Hansson, K. (1995). Heart sounds and Murmurs: Changes related to severity of chronic valvular disease in the Cavalier King Charles Spaniel. J. Vet. Intern. Med. 9, 75-85. http://dx.doi.org/10.1111/j.1939-1676.1995.tb03276.x10.1111/j.1939-1676.1995.tb03276.x7760313]Search in Google Scholar
[10. Ohad, D.G. Lenchner, I. Bdolah-Abram, T., Segev, G. (2013). A loud right-apical systolic murmur is associated with the diagnosis of secondary pulmonary arterial hypertension: Retrospective analysis of data from 201 consecutive client-owned dogs (2006-2007). Vet. J. 198, 690-695. http://dx.doi.org/10.1016/j.tvjl.2013.09.06710.1016/j.tvjl.2013.09.06724215779]Search in Google Scholar
[11. Pedersen, H.D. (2000). Mitral valve prolapse in the dog. Pathogenesis, pathophysiology and comparative aspects or early myxomatous mitral valve disease. PhD thesis, Copenhagen]Search in Google Scholar
[12. Ljungvall, I., Höglund, K., Lilliehöök, I., Oyama, M.A., Tidholm, A., Tvedten, H., Hägström, J. (2013). Serum serotonin concentration is associated with severity of myxomatous mitral valve disease in dogs. J. Vet. Intern. Med. 27, 1105-1112. http://dx.doi.org/10.1111/jvim.1213710.1111/jvim.1213723865457]Search in Google Scholar
[13. Detweiler, DK., Patterson, DF. (1965). The prevalence and types of cardiovascular disease in dogs. Ann N Y Acad Sci. Sep 8; 127(1): 481-516.]Search in Google Scholar
[14. Swenson, L., Hägström, J., Kvart, C., Juneja, R.K. (1996). Relationship between parental cardiac status in Cavalier King Charles Spaniels and prevalence and severity of chronic valvular disease in offspring. J. Amer. Vet. Med. Assoc. 208, 2009-2012.]Search in Google Scholar
[15. Domanjko Petrič, A., Blagus, R., Mlakar, N. (2013). Survival characteristics in the myxomatous mitral valve disease. Proceedings of the 23rd European College Veterinary Internal Medicine - Companion Animals Congress, September 12-15th, Liverpool]Search in Google Scholar
[16. Häggström, J., Boswood, A., O’Grady, M., et al. (2008). Effect of pimobendan or benazepril hydrochloride on survival times in dogs with congestive heart failure caused by naturally occurring myxomatous mitral valve disease: the QUEST study. J Vet. Intern. Med. 22(5):1124-1135. http://dx.doi.org/10.1111/j.1939-1676.2008.0150.x10.1111/j.1939-1676.2008.0150.x18638016]Search in Google Scholar
[17. Häggström, J., Boswood, A., O’Grady, M., Jöns, O., et al. (2013). Longitudinal analysis of quality of life, clinical, radiographic, echocardiographic, and laboratory variables in dogs with myxomatous mitral valve disease receiving pimobendan or benazepril: the QUEST study. J Vet. Intern. Med. Nov-Dec; 27(6):1441-1451.]Search in Google Scholar
[18. Rasmussen, C.E., Falk, T., Domanjko Petrič, A., et al. (2014). Holter monitoring of small breed dogs with advanced myxomatous mitral valve disease with and without a history of syncope. J. Vet. Intern. Med. 28(2): 363-370. http://dx.doi.org/10.1111/jvim.1229010.1111/jvim.12290485799724417236]Search in Google Scholar
[19. Dillon, R., Dell’Italia, L. J., Tillson, M., Killingsworth, C., Denney, T., Hathcock, J., Botzman, L. (2012). Left ventricular remodeling in preclinical experimental mitral regurgitation of dogs. J Vet. Cardiol. 14, 1, 73-92. http://dx.doi.org/10.1016/j.jvc.2012.01.01210.1016/j.jvc.2012.01.01222386719]Search in Google Scholar
[20. Lord, P., Hansson, K., Kvart, C., Häggström, J. (2010). Rate of change of heart size before congestive heart failure in dogs with mitral regurgitation. J. Small Anim. Pract. 51(4):210-218. http://dx.doi.org/10.1111/j.1748-5827.2010.00910.x10.1111/j.1748-5827.2010.00910.x20406369]Search in Google Scholar
[21. Kittleson, M.D. (2005). Myxomatous mitral valve disease. In: Kittleson, M.D. and Kienle R.D. Small Animal Cardiovascular Medicine. http://www.vin.com/members/cms/project/ defaultadv1.aspx?pid=5928&catId=8440&perlredir=1]Search in Google Scholar
[22. Reynolds, C.A., Brown, D.C., Rush, J.E., Fox, P.R., Nguyenba, T.P., Lehmkuhl, L.B., Gordon, S.G., Kellihan, H.B., Stepien, R.L, Lefbom, B.K., Meier, C.K.,Oyama, M.A. (2012). Prediction of first onset of congestive heart failure in dogs with degenerative mitral valve disease: The PREDICT cohort study. J. Vet. Cardiol. 14, 1, 193-202. http://dx.doi.org/10.1016/j.jvc.2012.01.00810.1016/j.jvc.2012.01.00822366568]Search in Google Scholar
[23. Rishniw, M., Ljungvall, I., Porciello, F., Häggström, J., Ohad, D.G. (2012). Sleeping respiratory rates in apparently healthy adult dogs.Res. Vet. Sci. 93(2):965-9. http://dx.doi.org/10.1016/j.rvsc.2011.12.01410.1016/j.rvsc.2011.12.01422240295]Search in Google Scholar
[24. Bonagura, JD, Schober, KE. (2009). Can ventricular function be assessed by echocardiography in chronic canine mitral valve disease? J Small Anim. Pract. Sep; 50 Suppl. 1, 12-24.]Search in Google Scholar
[25. Atkins, C., Bonagura, J., Ettinger, S., Fox, P., Gordon, S., Haggstrom, J., Hamlin, R., Keene, B., Luis- Fuentes, V., Stepien, R. (2009). Guidelines for the diagnosis and treatment of canine chronic valvular heart disease. J Vet. Intern. Med. 23(6):1142-50. http://dx.doi.org/10.1111/j.1939-1676.2009.0392.x10.1111/j.1939-1676.2009.0392.x19780929]Search in Google Scholar
[26. Atkins, C. E., Häggström, J. (2012). Pharmacologic management of myxomatous mitral valve disease in dogs. J Vet. Cardiol., 14, 1, 165-184. http://dx.doi.org/10.1016/j.jvc.2012.02.002 10.1016/j.jvc.2012.02.00222386553]Search in Google Scholar
[27. Kvart, C., Häggström, J., Pedersen, HD., Hansson, K., et al. (2002). Efficacy of enalapril for prevention of congestive heart failure in dogs with myxomatous valve disease and asymptomatic mitral regurgitation. J Vet Intern Med. Jan-Feb; 16(1): 80-88.]Search in Google Scholar
[28. Atkins, C., Keene, B., Brown, W., Coats, J., Crawford, M., et al. (2007). Results of the veterinary enalapril trial to prove reduction in onset of heart failure in dogs chronically treated with enalapril alone for compensated, naturally occurring mitral valve insufficiency. J. Am. Vet. Med. Assoc. 23, 1061-1069. http://dx.doi.org/10.2460/javma.231.7.106110.2460/javma.231.7.106117916031]Search in Google Scholar
[29. The SOLVD Investigators. (1992). Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. New Eng. J. Med. 327, 725-727.]Search in Google Scholar
[30. Tarnow, I., Olsen L.H., Kvart, C., Höglund, K., Moesgaard, S.G., Kamstrup, T.S., Pedersen, H.D., Häggström, J. (2009). Predictive value of natriuretic peptides in dogs with mitral valve disease. Vet. J. 180, 195-201. http://dx.doi.org/10.1016/j.tvjl.2007.12.02610.1016/j.tvjl.2007.12.02618675567]Search in Google Scholar
[31. Ljungvall, I., Höglund, K., Carnabuci, C., Tidholm, A., Häggström, J. (2011). Assessment of global and regional left ventricular volume and shape by realtime 3-dimensional echocardiography in dogs with myxomatous mitral valve disease. J. Vet. Intern. Med. 25, 1036-1043. http://dx.doi.org/10.1111/j.1939-1676.2011.0774.x10.1111/j.1939-1676.2011.0774.x21848946]Search in Google Scholar
[32. Atkins, J., Bonagura, S., Ettinger, P., Fox, S., Gordon, J., Häggström, R., Hamlin, B., Keene (Chair), V., Luis-Fuentes, Stepien, R. (2009). Guidelines for the diagnosis and treatment of canine chronic valvular heart disease. J. Vet. Intern. Med. 23: 1142-1150. http://dx.doi.org/10.1111/j.1939-1676.2009.0392.x10.1111/j.1939-1676.2009.0392.x]Search in Google Scholar
[33. Hezzell, M.J, Boswood, A., Chang, Y.M., Moonarmart, W., Souttar, K., Elliott, J. (2012). The combined prognostic potential of serum highsensitivity cardiac troponin I and N-terminal pro-Btype natriuretic peptide concentrations in dogs with degenerative mitral valve disease. J Vet Intern Med. Mar-Apr; 26(2):302-311.]Search in Google Scholar
[34. Kanemoto, D., Taguchi, S., Yokoyama, M., Mizuno, H., Suzuki, T Kanamoto (2010). Open heart surgery with deep hypothermia and cardiopulmonary bypass in small and toy dogs. Vet. Surg. 39, 674-679.10.1111/j.1532-950X.2010.00687.x20459489]Search in Google Scholar
[35. Yamano, S., Uechi, M., Tanaka, K., Hori, Y., Ebisawa, T., Harada, K., Mizukoshi, T. (2011). Surgical repair of a complete endocardial cushion defect in a dog. Vet. Surg. 40, 408-412. http://dx.doi.org/10.1111/j.1532-950X.2011.00797.x10.1111/j.1532-950X.2011.00797.x21395617]Search in Google Scholar
[36. Orton, E.C., Hackett, T.B., Mama, K., Boon, J.A. (2005). Technique and outcome of mitral valve replacement in dogs. J. Am. Vet. Med. Assoc. 226, 1508-1511. http://dx.doi.org/10.2460/javma.2005.226.150810.2460/javma.2005.226.150815882001]Search in Google Scholar
[37. Masami Uechi. (2012). Mitral valve repair in dogs. J. Vet. Cardiol. 14, 185-192. http://dx.doi.org/10.1016/j.jvc.2012.01.00410.1016/j.jvc.2012.01.00422366571]Search in Google Scholar
[38. Orton, C.E. (2012). Mitral valve degenerations: still more questions than answers. J. Vet. Cardiol. 14, 3-5. http://dx.doi.org/10.1016/j.jvc.2012.02.003 10.1016/j.jvc.2012.02.00322366567]Search in Google Scholar