Factors affecting levels of endogenous hormones (menarche, menopause, first birth age). |
Exogenous hormone intake (menopause hormone replacement therapy). |
Anthropometric characteristics (height, weight). |
Breast biopsy (done, not done, presence of atypia, atypical hyperplasia). |
Family history of breast and ovarium cancer (mother, sisters, half-sisters, daughters, grandmothers, aunts, male relatives). |
Ovarian cancer of the participants. |
Low risk | – | – | 11,860 | 4,744 |
Population risk | 34,130 | 34,130 | 21,720 | 15,204 |
Moderately increased risk | 770 | 1,540 | 1,190 | 1,190 |
High risk | 10 | 20 | 140 | 280 |
Total | 34,910 | 35,690 | 34,910 | 21,418 |
10-year breast cancer risk | ||
low | 1,186 | 34.0 |
population | 2,172 | 62.2 |
moderately increased | 119 | 3.4 |
high | 14 | 0.4 |
Lifetime breast cancer risk | ||
population | 3,413 | 97.8 |
moderately increased | 77 | 2.2 |
high | 1 | 0.03 |
Family history: first-degree relatives with breast/ovarian cancer (mother, father, sisters, daughters) | ||
positive (1 relative) | 326 | 9.3 |
positive (2 or more relatives) | 28 | 0.8 |
negative | 2,854 | 81.8 |
unknown | 283 | 8.1 |
Family history: second-degree relatives with breast/ovarian cancer (aunts, uncles, grandmothers, half-sisters) | ||
positive (1 relative) | 437 | 12.5 |
positive (2 or more relatives) | 148 | 4.2 |
negative | 2,552 | 73.1 |
unknown | 354 | 10.1 |
Age (years) at menarche | ||
< 13 | 1,138 | 32.6 |
13 | 940 | 26.9 |
> 13 | 1,339 | 38.4 |
unknown | 74 | 2.1 |
Age (years) at first birth | ||
< 25 | 1,570 | 45.0 |
25–28 | 736 | 21.1 |
29–34 | 659 | 18.9 |
35 | 191 | 5.5 |
nulliparous | 335 | 9.6 |
unknown | 0 | 0.0 |
Menopausal status | ||
premenopausal | 1,392 | 39.9 |
perimenopausal | 632 | 18.1 |
postmenopausal | 631 | 18.1 |
unknown | 836 | 23.9 |
HRT usage | ||
yes | 286 | 8.2 |
no | 3,123 | 89.5 |
unknown | 82 | 2.3 |
Breast biopsy | ||
no biopsy | 3,123 | 89.5 |
biopsy (hyperplasia, atypical hyperplasia, LCIS) | 21 | 0.6 |
biopsy (else) | 44 | 1.3 |
biopsy (unknown result) | 256 | 7.3 |
unknown if biopsy done | 47 | 1.3 |
Breast density | ||
BI-RADS a | 215 | 6.2 |
BI-RADS b | 1,802 | 51.6 |
BI-RADS c | 1,410 | 40.4 |
BI-RADS d | 34 | 1.0 |
unknown (no screening mammography) | 30 | 0.9 |
BMI | ||
< 19 | 48 | 1.4 |
19–25 | 1,165 | 33.4 |
> 25 | 1,336 | 38.3 |
unknown | 942 | 27.0 |
Low risk (%) | < 1.3 | 5-year mammography screening interval | ||
Population risk (%) | < 16 | 1.3–3.9 | 2-year mammography screening interval | 3-year mammography screening interval |
Moderately increased risk (%) | 16–30 | 4.0–6.5 | 1-year mammography screening interval | 2-year mammography screening interval |
High risk (%) | > 30 | > 6.5 | 1-year mammography screening interval | 1-year mammography screening interval |