<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_raon-2020-0040_s_006_w2aab3b7ab1b6b1aab1c16b1Aa"><h3>Background</h3><p>The aim of the study was to assess the proportion of women that would be classified as at above-average risk of breast cancer based on the 10 year-risk prediction of the Slovenian breast cancer incidence rate (S-IBIS) program in two presumably above-average breast cancer risk populations in age group 40-49 years: (i) women referred for any reason to diagnostic breast centres and (ii) women who were diagnosed with breast cancer aged 40–49 years. Breast cancer is the commonest female cancer in Slovenia, with an incidence rate below European average. The Tyrer-Cuzick breast cancer risk assessment algorithm was recently adapted to S-IBIS. In Slovenia a tailored mammographic screening for women at above average risk in age group 40–49 years is considered in the future. S-IBIS is a possible tool to select population at above-average risk of breast cancer for tailored screening.</p></sec><sec id="j_raon-2020-0040_s_007_w2aab3b7ab1b6b1aab1c16b2Aa"><h3>Patients and methods</h3><p>In 357 healthy women aged 40–49 years referred for any reason to diagnostic breast centres and in 367 female breast cancer patients aged 40–49 years at time of diagnosis 10-years breast cancer risk was calculated using the S-IBIS software. The proportion of women classified as above-average risk of breast cancer was calculated for each subgroup of the study population.</p></sec><sec id="j_raon-2020-0040_s_008_w2aab3b7ab1b6b1aab1c16b3Aa"><h3>Results</h3><p>48.7% of women in the Breast centre group and 39.2% of patients in the breast cancer group had above-average 10-year breast cancer risk. Positive family history of breast cancer was more prevalent in the Breast centre group (p &lt; 0.05).</p></sec><sec id="j_raon-2020-0040_s_009_w2aab3b7ab1b6b1aab1c16b4Aa"><h3>Conclusions</h3><p>Inclusion of additional risk factors into the S-IBIS is warranted in the populations with breast cancer incidence below European average to reliably stratify women into breast cancer risk groups.</p></sec></abstract>

BackgroundThe aim of the study was to assess the proportion of women that would be classified as at above-average risk of breast cancer based on the 10 year-risk prediction of the Slovenian breast cancer incidence rate (S-IBIS) program in two presumably above-average breast cancer risk populations in age group 40-49 years: (i) women referred for any reason to diagnostic breast centres and (ii) women who were diagnosed with breast cancer aged 40–49 years. Breast cancer is the commonest female cancer in Slovenia, with an incidence rate below European average. The Tyrer-Cuzick breast cancer risk assessment algorithm was recently adapted to S-IBIS. In Slovenia a tailored mammographic screening for women at above average risk in age group 40–49 years is considered in the future. S-IBIS is a possible tool to select population at above-average risk of breast cancer for tailored screening.Patients and methodsIn 357 healthy women aged 40–49 years referred for any reason to diagnostic breast centres and in 367 female breast cancer patients aged 40–49 years at time of diagnosis 10-years breast cancer risk was calculated using the S-IBIS software. The proportion of women classified as above-average risk of breast cancer was calculated for each subgroup of the study population.Results48.7% of women in the Breast centre group and 39.2% of patients in the breast cancer group had above-average 10-year breast cancer risk. Positive family history of breast cancer was more prevalent in the Breast centre group (p < 0.05).ConclusionsInclusion of additional risk factors into the S-IBIS is warranted in the populations with breast cancer incidence below European average to reliably stratify women into breast cancer risk groups.

Breast cancer risk based on adapted IBIS prediction model in Slovenian women aged 40–49 years - could it be better?

Radiology and Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

BackgroundThe aim of the study was to assess the proportion of women that would be classified as at above-average risk of breast cancer based on the 10...

	Breast cancer	Breast Centre
	group	group
Age (yaars, mean)*	45.6	44.8
BMI, mean (kg/m2)*	24.3	24.8
Age at menarche (years, mean)	13.0	13.0
Nulliparity	10.5%	11.1%
Age at first childbirth (years, mean)	23.0	23.4
Positive family history for breast and/or ovarian cancer*	48.8%	56.6%

	Population risk (< 2 %)	Moderately increased risk (2–6.5 %)	High risk (> 6.5 %)
Breast cancer group - 10-year breast cancer risk (age 40–49)	60.8 %	37.8 %	1.4 %
Breast centre group - 10-year breast cancer risk (age 40–49)	51.3 %	47.6 %	1.1 %
Breast cancer group - 10-year breast cancer risk (age 40–44)	64.0 %	34.4 %	1.6%
Breast centre group - 10-year breast cancer risk (age 40–44)	58.2%	41.8 %	0.0%
Breast cancer group - 10-year breast cancer risk (age 45–49)	59.1 %	39.7 %	1.2 %
Breast centre group - 10-year breast cancer risk (age 45–49)	46.1 %	51.9%	2.0%

Breast cancer risk based on adapted IBIS prediction model in Slovenian women aged 40–49 years - could it be better?

Article Category: Research Article

Pubblicato online: 02 lug 2020

Pagine: 335 - 340

Ricevuto: 25 mar 2020

Accettato: 07 mag 2020

DOI: https://doi.org/10.2478/raon-2020-0040

© 2020 Tjasa Oblak, Vesna Zadnik, Mateja Krajc, Katarina Lokar, Janez Zgajnar, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Breast cancer risk factors used for 10-year breast cancer risk calculation with S-IBIS software

Baseline characteristics of participants

Risk stratification for all participants and for age subgroups 40–44 years and 45–49 years based on S-IBIS calculation for breast cancer patients and women screened in Breast centre; risk categories for women aged 40 to 49 as in 2018 Slovenian guidelines

Risk factor
Age (years)
Height
Weight
Age at menarche (years)
Age at first childbirth
Menopausal status
Hormone replacement therapy use
Benign breast disorder
Family history of breast cancer (breast cancer in first-and second-degree relatives and age at presentation)
Family history of ovarian cancer (ovarian cancer in first-degree relatives and age at presentation)