Prognostic role of positron emission tomography and computed tomography parameters in stage I lung adenocarcinoma
Article Category: Research Article
Pubblicato online: 28 mag 2020
Pagine: 278 - 284
Ricevuto: 04 feb 2020
Accettato: 04 mag 2020
DOI: https://doi.org/10.2478/raon-2020-0034
© 2020 Angelo Carretta, Alessandro Bandiera, Piergiorgio Muriana, Stefano Viscardi, Paola Ciriaco, Ana Maria Samanes Gajate, Gianluigi Arrigoni, Chiara Lazzari, Vanesa Gregorc, Giampiero Negri, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Background
According to the current pathological classification, lung adenocarcinoma includes histological subtypes with significantly different prognoses, which may require specific surgical approaches. The aim of the study was to assess the role of CT and PET parameters in stratifying patients with stage I adenocarcinoma according to prognosis.
Patients and methods
Fifty-eight patients with pathological stage I lung adenocarcinoma who underwent surgical treatment were retrospectively reviewed. Adenocarcinoma
Results
Seven patients had a non-invasive adenocarcinoma and 51 an invasive adenocarcinoma. Five-year disease-free survival (DFS) and cancer-specific survival (CSS) for non-invasive and invasive adenocarcinoma were 100% and 100%, 70% and 91%, respectively. Univariate analysis showed a significant difference in SUVmax, SUVindex, GGO ratio and TDR ratio values between non-invasive and invasive adenocarcinoma groups. Optimal SUVmax, SUVindex, GGO ratio and TDR cut-off ratios to predict invasive tumours were 2.6, 0.9, 40% and 56%, respectively. TLG, SUVmax, SUVindex significantly correlated with cancer specific survival.
Conclusions
CT and PET scan parameters may differentiate between non-invasive and invasive stage I adenocarcinomas. If these data are confirmed in larger series, surgical strategy may be selected on the basis of preoperative imaging.