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Prognostic role of positron emission tomography and computed tomography parameters in stage I lung adenocarcinoma

Angelo Carretta
Angelo Carretta
, 
Alessandro Bandiera
Alessandro Bandiera
, 
Piergiorgio Muriana
Piergiorgio Muriana
, 
Stefano Viscardi
Stefano Viscardi
, 
Paola Ciriaco
Paola Ciriaco
, 
Ana Maria Samanes Gajate
Ana Maria Samanes Gajate
, 
Gianluigi Arrigoni
Gianluigi Arrigoni
, 
Chiara Lazzari
Chiara Lazzari
, 
Vanesa Gregorc
Vanesa Gregorc
 e 
Giampiero Negri
Giampiero Negri
   | 28 mag 2020
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Article Category: Research Article
Pubblicato online: 28 mag 2020
Pagine: 278 - 284
Ricevuto: 04 feb 2020
Accettato: 04 mag 2020
DOI: https://doi.org/10.2478/raon-2020-0034
© 2020 Angelo Carretta, Alessandro Bandiera, Piergiorgio Muriana, Stefano Viscardi, Paola Ciriaco, Ana Maria Samanes Gajate, Gianluigi Arrigoni, Chiara Lazzari, Vanesa Gregorc, Giampiero Negri, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Kaplan-Meier disease free survival (DFS) plot for non-invasive and invasive adenocarcinoma (Invasive adenocarcinoma). Five-year DFS (disease free survival) was 100% for non-invasive and 70% for invasive adenocarcinoma (p = 0.115).
Kaplan-Meier disease free survival (DFS) plot for non-invasive and invasive adenocarcinoma (Invasive adenocarcinoma). Five-year DFS (disease free survival) was 100% for non-invasive and 70% for invasive adenocarcinoma (p = 0.115).

Figure 2

Kaplan-Meier cancer specific survival (CSS) plot for non-invasive and invasive adenocarcinoma. Five-year CSS was 100% for non-invasive and 91% for invasive adenocarcinoma (p = 0.46).
Kaplan-Meier cancer specific survival (CSS) plot for non-invasive and invasive adenocarcinoma. Five-year CSS was 100% for non-invasive and 91% for invasive adenocarcinoma (p = 0.46).

Figure 3

Kaplan-Meier cancer specific survival curves according to SUVmax value. Five-year cancer specific survival (CSS) was 97% in patients with a SUVmax < 8.6 and 81% in patients with a SUVmax > 8.6 (p = 0.036).
Kaplan-Meier cancer specific survival curves according to SUVmax value. Five-year cancer specific survival (CSS) was 97% in patients with a SUVmax < 8.6 and 81% in patients with a SUVmax > 8.6 (p = 0.036).

Figure 4

Kaplan-Meier cancer specific survival curves (CSS) according to SUVindex value. Five-year CSS was 97% in patients with a SUVindex < 4.08 and 76% in patients with a SUVindex > 4.08 (p = 0.01).
Kaplan-Meier cancer specific survival curves (CSS) according to SUVindex value. Five-year CSS was 97% in patients with a SUVindex < 4.08 and 76% in patients with a SUVindex > 4.08 (p = 0.01).

Figure 5

Kaplan-Meier cancer specific survival curves (CSS) according to total lesion glycolysis (TLG) value. Five-year CSS was 100% in patients with a TLG < 9.38 and 82% in patients with a TLG > 9.38 (p = 0.02).
Kaplan-Meier cancer specific survival curves (CSS) according to total lesion glycolysis (TLG) value. Five-year CSS was 100% in patients with a TLG < 9.38 and 82% in patients with a TLG > 9.38 (p = 0.02).

Differences in CT and PET scan parameters according to histology

CT and PET scan parameterNon-invasive adenocarcinomaInvasive adenocarcinomap
GGO%42±7.0519±2.910.011
TDR%53±9.3124±2.89< 0.001
Consolidation diameter13±2.1921±1.440.07
SUVmax2.75±0.917.16±0.730.033
SUVindex0.98±0.253.12±0.360.037
MTV3.6±1.745.3±0.490.293
TLG12±7.3119.5±4.340.541

Characteristics of 58 surgically-treated patients with stage I adenocarcinoma

Non-invasive adenocarcinoma (7 patients)Invasive adenocarcinoma (51 patients)p
Gender
    Female4380.178
    Male313
Age (median;range)67 (46-75)65 (48-85)0.530
Type of surgery
    Wedge resection3100.188
    Lobectomy440
    Bilobectomy01
TNM
    Tis100.056
    T1aN039
    T1bN0117
    T1cN0216
    T2aN009

Characteristics of patient population grouped by standardized uptake value (SUV)max and SUVindex

SUVmaxSUVindex
< 2.6≥ 2.6p< 0.9≥ 0.9p
Total No. patients12461048
Histology
        NIA (7)32
        IA (51)430.028460.001
Gender
        male3235
        female141.00130.458
Smoke
        Yes10371.00400.381
        No298
T
        Tis–T1a77
        T1b1315
        T1c170.014170.011
        T2a99
Grading
        G111
        G2380.011400.004
        G377
eISSN:
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Lingua:
Inglese
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Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology
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