Inflammatory Cytokine IFNγ, IL-6, and IL-10 Association with Childhood Obesity

Al-Shorman, A., Al-Domi, Faqih, A. H. (2017). Markers of subclinical atherosclerosis in schoolchildren with obesity and metabolic syndrome. Swiss Med. Wkly, 147, w14446.10.4414/smw.2017.1444628634974 Search in Google Scholar

Al-Shukaili, A., Al-Ghafri, S.,Al-Marhoobi, S., Al-Abri, S., Al-Lawati, J., Al-Maskari, M. (2013). Analysis of inflammatory mediators in type 2 diabetes patients. Int. J. Endocrinol., 2013, 976810.10.1155/2013/976810367168023762057 Search in Google Scholar

Amin, K., Qadr, S. H., Hassan Hussein, R., Ali, K. M., Rahman, H. S. (2019). Levels of cytokines and GADA in type I and II diabetic patients. Prim. Care Diabetes,14 (1), 61–67. Search in Google Scholar

Beberashvili, I., Azar, A., Abu Hamad, R., Sinuani, I., Feldman, L., Maliar, A., Stav, K., Efrati, S. (2019). Abdominal obesity in normal weight versus overweight and obese hemodialysis patients: Associations with nutrition, inflammation, muscle strength, and quality of life. Nutrition, 59, 7–13.10.1016/j.nut.2018.08.00230415161 Search in Google Scholar

Bing, C. (2015). Is interleukin-1beta a culprit in macrophage-adipocyte crosstalk in obesity? Adipocyte, 4 (2), 149–152.10.4161/21623945.2014.979661449696326167419 Search in Google Scholar

Buie, J. J., Watson, L. S., Smith, C. J., Sims-Robinson, C. (2019). Obesity-related cognitive impairment: The role of endothelial dysfunction. Neurobiol. Dis., 132, 104580.10.1016/j.nbd.2019.104580683491331454547 Search in Google Scholar

Carolan, E., Hogan, A. E., Corrigan, M., Gaotswe, G., O’Connell, J., Foley, N., O’Neill, L. A., Cody, D., O’Shea, D. (2014). The impact of childhood obesity on inflammation, innate immune cell frequency, and metabolic microRNA expression. J. Clin. Endocrinol. Metab., 99 (3), E474–E478.10.1210/jc.2013-352924423308 Search in Google Scholar

Esposito, K., Pontillo, A., Giugliano, F., Giugliano, G., Marfella, R., Nicoletti, G., Giugliano, D. (2003). Association of low interleukin-10 levels with the metabolic syndrome in obese women. J. Clin. Endocrinol. Metab., 88 (3), 1055–1058.10.1210/jc.2002-02143712629085 Search in Google Scholar

Fang, X., Henao-Mejia, J., Henrickson, S. E. (2020). Obesity and immune status in children. Curr. Opin. Pediatr., 32 (6), 805–815.10.1097/MOP.0000000000000953848926533105275 Search in Google Scholar

Fang, X., Zuo, J., Zhou, J., Cai, J., Chen, C., Xiang, E., Li, H., Cheng, X., Chen, P. (2019). Childhood obesity leads to adult type 2 diabetes and coronary artery diseases: A 2-sample mendelian randomization study. Medicine (Baltimore), 98 (32), e16825.10.1097/MD.0000000000016825670887331393416 Search in Google Scholar

Forsythe, L. K., Wallace, J. M., Livingstone, M. B. (2008). Obesity and inflammation: The effects of weight loss. Nutr. Res. Rev., 21 (2), 117–133.10.1017/S095442240813873219087366 Search in Google Scholar

Gallistl, S., Sudi, K. M., Aigner, R., Borkenstein, M. (2001). Changes in serum interleukin-6 concentrations in obese children and adolescents during a weight reduction program. Int. J. Obes Relat. Metab. Disord., 25 (11), 1640–1643.10.1038/sj.ijo.080180811753584 Search in Google Scholar

Glowinska, B., Urban, M. (2003). Selected cytokines (Il-6, Il-8, Il-10, MCP-1, TNF-alpha) in children and adolescents with atherosclerosis risk factors: Obesity, hypertension, diabetes. Wiad Lek., 56 (3–4), 109–116 (in Polish). Search in Google Scholar

Hasan, Z., Irfan, M., Masood, Q., Ahmed, O., Moosajee, U. S., Rao, S., Salahuddin, N. (2019). Raised levels of IFN-gamma and IL-13 are associated with pre-diabetes amongst newly diagnosed patients with tuberculosis. J. Pak. Med. Assoc., 69 (4), 468–473. Search in Google Scholar

Herder, C., Schneitler, S., Rathmann, W., Haastert, B., Schneitler, H., Winkler, H., Bredahl, R., Hahnloser, E., Martin, S. (2007). Low-grade inflammation, obesity, and insulin resistance in adolescents. J. Clin. Endocrinol. Metab., 92 (12), 4569–4574.10.1210/jc.2007-095517911172 Search in Google Scholar

Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., Spiegelman, B. M. (1995). Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J. Clin. Invest., 95 (5), 2409–2415.10.1172/JCI1179362958727738205 Search in Google Scholar

Illan-Gomez, F., Gonzalvez-Ortega, M., Orea-Soler, I., Alcaraz-Tafalla, M. S., Aragon-Alonso, A., Pascual-Diaz, M., Perez-Paredes, M., Lozano-Almela, M. L. (2012). Obesity and inflammation: Change in adiponectin, C-reactive protein, tumour necrosis factor-alpha and interleukin-6 after bariatric surgery. Obes. Surg., 22 (6), 950–955.10.1007/s11695-012-0643-y22527592 Search in Google Scholar

Inadera, H. (2008). The usefulness of circulating adipokine levels for the assessment of obesity-related health problems. Int. J. Med. Sci., 5 (5), 248–262.10.7150/ijms.5.248252807118773088 Search in Google Scholar

Karczewski, J., Sledzinska, E., Baturo, A., Jonczyk, I., Maleszko, A., Samborski, P., Begier-Krasinska, B., Dobrowolska, A. (2018). Obesity and inflammation. Eur. Cytokine Netw., 29 (3), 83–94.10.1684/ecn.2018.041530547890 Search in Google Scholar

Kern, L., Mittenbühler, M. J., Vesting, A. J., Ostermann, A. L., Wunderlich, C. M., Wunderlich, F. T. (2018). Obesity-induced TNFα and IL-6 signaling: The missing link between obesity and inflammation-driven liver and colorectal cancers. Cancers, 11 (1), 24.10.3390/cancers11010024635622630591653 Search in Google Scholar

Kern, P. A., Ranganathan, S., Li, C., Wood, L., Ranganathan, G. (2001). Adi-pose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Amer. J. Physiol. Endocrinol. Metab., 280 (5), E745–751. Search in Google Scholar

Krasteva, N., Shentov, B., Elkina, S. (2018). Cytokines in asthma and obesity in children. Eur. Respir. J., 52 (suppl 62), PA1303.10.1183/13993003.congress-2018.PA1303 Search in Google Scholar

Lund, M. A. V., Thostrup, A. H., Frithioff-Bøjsøe, C., Lausten-Thomsen, U., Hedley, P. L., Pedersen, O., Christiansen, M., Hansen, T., Holm, J. C. (2020). Low-grade inflammation independently associates with cardiometabolic risk in children with overweight/obesity. Nutr. Metab. Cardiovasc. Dis., 30 (9), 1544–1553.10.1016/j.numecd.2020.04.02432571613 Search in Google Scholar

Mărginean, C. O., Melit, L. E., Hutanu, A., Ghiga, D. V., Săsăran, M. O. (2020). The adipokines and inflammatory status in the era of pediatric obesity. Cytokine, 126, 154925.10.1016/j.cyto.2019.15492531759309 Search in Google Scholar

Marti, A., Morell-Azanza, L., Rendo-Urteaga, T., Garcia-Calzon, S., Ojeda-Rodriguez, A., Martin-Calvo, N., Moreno-Aliaga, M. J., Martinez, J. A., Azcona-San Julian, M. C. (2018). Serum and gene expression levels of CT-1, IL-6, and TNF-alpha after a lifestyle intervention in obese children. Pediatr. Diabetes, 19 (2), 217–222.10.1111/pedi.1256128749076 Search in Google Scholar

Nguyen, X. M., Lane, J., Smith, B. R., Nguyen, N. T. (2009). Changes in inflammatory biomarkers across weight classes in a representative US population: A link between obesity and inflammation. J. Gastrointest. Surg., 13 (7), 1205–1212.10.1007/s11605-009-0904-9269377119415399 Search in Google Scholar

Rocha, V. Z., Folco, E. J., Sukhova, G., Shimizu, K., Gotsman, I., Vernon, A. H., Libby, P. (2008). Interferon-gamma, a Th1 cytokine, regulates fat inflammation: A role for adaptive immunity in obesity. Circ. Res., 103 (5), 467–476.10.1161/CIRCRESAHA.108.177105274038418658050 Search in Google Scholar

Saltiel, A. R., Olefsky, J. M. (2017). Inflammatory mechanisms linking obesity and metabolic disease. J. Clin. Invest., 127 (1), 1–4.10.1172/JCI92035519970928045402 Search in Google Scholar

Schwarz, S., Mrosewski, I., Silawal, S., Schulze-Tanzil, G. (2018). The interrelation of osteoarthritis and diabetes mellitus: Considering the potential role of interleukin-10 and in vitro models for further analysis. Inflamm. Res., 67 (4), 285–300.10.1007/s00011-017-1121-829196771 Search in Google Scholar

Silawal, S., Willauschus, M., Schulze-Tanzil, G., Gögele, C., Geßlein, M., Schwarz, S. (2019). IL-10 could play a role in the interrelation between diabetes mellitus and osteoarthritis. Int. J. Mol. Sci., 20 (3), 768.10.3390/ijms20030768638726230759730 Search in Google Scholar

Singer, K., Lumeng, C. N. (2017). The initiation of metabolic inflammation in childhood obesity. J. Clin. Investig., 127 (1), 65–73.10.1172/JCI88882519968728045405 Search in Google Scholar

Stefanadi, E. C., Dimitrakakis, G., Antoniou, C.-K., Challoumas, D., Punjabi, N., Dimitrakaki, I. A., Punjabi, S., Stefanadis, C. I. (2018). Metabolic syndrome and the skin: A more than superficial association. Reviewing the association between skin diseases and metabolic syndrome and a clinical decision algorithm for high risk patients. Diab. Metabol. Syndr., 10 (1), 9. Search in Google Scholar

Suhett, L. G., Hermsdorff, H. H. M., Cota, B. C., Ribeiro, S. A. V., Shivappa, N., Hébert, J. R., Franceschini, S., de Novaes, J. F. (2021). Dietary inflammatory potential, cardiometabolic risk and inflammation in children and adolescents: A systematic review. Crit. Rev. Food Sci. Nutr., 61 (3), 407–416.10.1080/10408398.2020.173491132156146 Search in Google Scholar

Utsal, L., Tillmann, V., Zilmer, M., Maestu, J., Purge, P., Jurimae, J., Saar, M., Latt, E., Maasalu, K., Jurimae, T. (2012). Elevated serum IL-6, IL-8, MCP-1, CRP, and IFN-gamma levels in 10- to 11-year-old boys with increased BMI. Horm. Res. Paediatr., 78 (1), 31–39.10.1159/00033983122832157 Search in Google Scholar

Vendrell, J., Chacon, M. R. (2013). TWEAK: A new player in obesity and diabetes. Front Immunol., 4, 488.10.3389/fimmu.2013.00488387454924416031 Search in Google Scholar

Wang, T., He, C. (2018). Pro-inflammatory cytokines: The link between obesity and osteoarthritis. Cytokine Growth Factor Rev., 44, 38–50.10.1016/j.cytogfr.2018.10.00230340925 Search in Google Scholar

Wen, X., Pekkala, S., Wang, R., Wiklund, P., Feng, G., Mei Cheng, S., Tan, X., Liu, Y., Chen, P., Eriksson, J. G., Alen, M., Cheng, S. (2014). Does systemic low-grade inflammation associate with fat accumulation and distribution? A 7-year follow-up study with peripubertal girls. J. Clin. Endocrinol. Metab., 99 (4), 1411–1419.10.1210/jc.2013-326724423339 Search in Google Scholar

Yeste, D., Vendrell, J., Tomasini, R., Broch, M., Gussinyé, M., Megia, A., Carrascosa, A. (2007). Interleukin-6 in obese children and adolescents with and without glucose intolerance. Diabetes Care, 30 (7), 1892–1894.10.2337/dc06-228917416792 Search in Google Scholar