<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Acute respiratory distress syndrome (ARDS) is common and multi factorial, clinically described as an inflammatory lung disorder that is associated with major morbidity and high mortality in intensive care patients. Recently, investigators have revised the AECC criteria from 1994. To diagnose ARDS and discover its severity we presently use Berlin definition criteria. An important role in developing of ARDS may be through a disbalance between reactive oxygen species (ROS), which have both oxidant and antioxidant compartments. The pathogenesis of ARDS is very complex, and unfortunately, the dynamic development of ARDS in an individual patient is difficult to recognise. ROS can initiate cellular tissue damage by modifying lipids, proteins and DNA, which can seriously compromise cell life ability or induce a large number of cellular responses through generation of secondary reactive species, leading, at last, to cell death by necrosis or apoptosis. Studies have shown that many patients with organ malfunction at admission to the intensive care units (ICU) show decreased antioxidative properties, worsening the harmful effects of lipid peroxidation. That is the reason why predicting development of ARDS has great value for intensive care specialists.</p></abstract>

Acute respiratory distress syndrome (ARDS) is common and multi factorial, clinically described as an inflammatory lung disorder that is associated with major morbidity and high mortality in intensive care patients. Recently, investigators have revised the AECC criteria from 1994. To diagnose ARDS and discover its severity we presently use Berlin definition criteria. An important role in developing of ARDS may be through a disbalance between reactive oxygen species (ROS), which have both oxidant and antioxidant compartments. The pathogenesis of ARDS is very complex, and unfortunately, the dynamic development of ARDS in an individual patient is difficult to recognise. ROS can initiate cellular tissue damage by modifying lipids, proteins and DNA, which can seriously compromise cell life ability or induce a large number of cellular responses through generation of secondary reactive species, leading, at last, to cell death by necrosis or apoptosis. Studies have shown that many patients with organ malfunction at admission to the intensive care units (ICU) show decreased antioxidative properties, worsening the harmful effects of lipid peroxidation. That is the reason why predicting development of ARDS has great value for intensive care specialists.

The Role of Oxidative Stress Markers in Developing of Acute Respiratory Distress Syndrome / Oksidatîvâ Stresa Marķieru Loma Akûta Respiratora Distresa Sindroma Attîstîbâ

Department of Anaesthesiology and Reanimatology, Rîga Stradiòð University, Rîga Stradiòð University, Dzirciema iela 16, Rîga, LV-1007, LATVIA

Laboratory of Biochemistry, Rîga Stradiòð University, Râtsupîtes iela 5, Rîga, LV-1067, LATVIA

Pauls Stradiòð Clinical University Hospital, Pilsoòu iela 13, LV-1002, LATVIA

Department of Infectology and Dermatology, Rîga Stradiòð University, Linezera iela 3, LV-1006, LATVIA

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Acute respiratory distress syndrome (ARDS) is common and multi factorial, clinically described as an inflammatory lung disorder that is associated with major...

The Role of Oxidative Stress Markers in Developing of Acute Respiratory Distress Syndrome / Oksidatîvâ Stresa Marķieru Loma Akûta Respiratora Distresa Sindroma Attîstîbâ

Pubblicato online: 30 dic 2014

Pagine: 200 - 206

Ricevuto: 19 giu 2014

DOI: https://doi.org/10.2478/prolas-2014-0024

© by Marina Ðarkele

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.