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Materials Science-Poland
Volume 42 (2024): Numero 2 (June 2024)
Accesso libero
In vitro investigation of anti-inflammatory activity of propolis/saffron extract/curcumin-loaded ZIF8 nanoparticles and their potential application for treating osteoarthritis
Hongtao Zhang
Hongtao Zhang
,
Kui Xu
Kui Xu
,
Zhen Zhao
Zhen Zhao
,
Chuan Dong
Chuan Dong
e
Yunfei Zhang
Yunfei Zhang
| 11 lug 2024
Materials Science-Poland
Volume 42 (2024): Numero 2 (June 2024)
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CONDIVIDI
Pubblicato online:
11 lug 2024
Pagine:
41 - 51
Ricevuto:
21 apr 2024
Accettato:
19 mag 2024
DOI:
https://doi.org/10.2478/msp-2024-0016
Parole chiave
osteoarthritis
,
zeolitic imidazolate framework
,
nanoparticles
,
drug delivery
,
propolis
,
saffron extract
,
curcumin
© 2024 Hongtao Zhang et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Fig. 1.
Representative SEM imaging results for (A) ZIF, (B) PROZIF, (C) SAFROZIF, and (D) CURCUZIF nanocarriers and their size distribution
Fig. 2.
MTT assay with L929 cells cultured with different concentrations of (A) PROZIF, (B) SAFROZIF, (C) CURCUZIF, and (D) ZIF nanoparticles, a, b, and e show p-values < 0.05 relative to 1 μg/mL, 10 μg/mL, and control groups, respectively
Fig. 3.
Histograms comparing the anti-inflammatory activity of (A) PROZIF, (B) SAFROZIF, (C) CURCUZIF, and (D) ZIF nanoparticles at different concentrations, a, b, c, and d show p-value < 0.05 relative to 1 μg/mL, 10 μg/mL, 100 μg/mL, and 1000 μg/mL concentrations, respectively
Fig. 4.
Histograms comparing the anti-inflammatory activity of ZIF, PROZIF, SAFROZIF, and CURCUZIF at (A) 1 μg/mL, (B) 10 μg/mL, (C) 100 μg/mL, and (D) 1000 μg/mL concentrations
Fig. 5.
Cell migration assay with L929 cells cultured with different nanocarriers on day 0 (left panel), day 1 (middle panel), and day 2 (right panel), a shows p-value < 0.05 relative to PROZIF group
Fig. 6.
FTIR spectra of ZIF, PROZIF, SAFROZIF, and CURCUZIF nanoparticles
Fig. 7.
Cumulative release profile of propolis, saffron extract, and curcumin from PROZIF, SAFROZIF, and CURCUZIF during the course of 7 days in PBS