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In vitro investigation of anti-inflammatory activity of propolis/saffron extract/curcumin-loaded ZIF8 nanoparticles and their potential application for treating osteoarthritis

Hongtao Zhang
Hongtao Zhang
, 
Kui Xu
Kui Xu
, 
Zhen Zhao
Zhen Zhao
, 
Chuan Dong
Chuan Dong
 und 
Yunfei Zhang
Yunfei Zhang
   | 11. Juli 2024
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Online veröffentlicht: 11. Juli 2024
Seitenbereich: 41 - 51
Eingereicht: 21. Apr. 2024
Akzeptiert: 19. Mai 2024
DOI: https://doi.org/10.2478/msp-2024-0016
Schlüsselwörter
© 2024 Hongtao Zhang et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1.

Representative SEM imaging results for (A) ZIF, (B) PROZIF, (C) SAFROZIF, and (D) CURCUZIF nanocarriers and their size distribution
Representative SEM imaging results for (A) ZIF, (B) PROZIF, (C) SAFROZIF, and (D) CURCUZIF nanocarriers and their size distribution

Fig. 2.

MTT assay with L929 cells cultured with different concentrations of (A) PROZIF, (B) SAFROZIF, (C) CURCUZIF, and (D) ZIF nanoparticles, a, b, and e show p-values < 0.05 relative to 1 μg/mL, 10 μg/mL, and control groups, respectively
MTT assay with L929 cells cultured with different concentrations of (A) PROZIF, (B) SAFROZIF, (C) CURCUZIF, and (D) ZIF nanoparticles, a, b, and e show p-values < 0.05 relative to 1 μg/mL, 10 μg/mL, and control groups, respectively

Fig. 3.

Histograms comparing the anti-inflammatory activity of (A) PROZIF, (B) SAFROZIF, (C) CURCUZIF, and (D) ZIF nanoparticles at different concentrations, a, b, c, and d show p-value < 0.05 relative to 1 μg/mL, 10 μg/mL, 100 μg/mL, and 1000 μg/mL concentrations, respectively
Histograms comparing the anti-inflammatory activity of (A) PROZIF, (B) SAFROZIF, (C) CURCUZIF, and (D) ZIF nanoparticles at different concentrations, a, b, c, and d show p-value < 0.05 relative to 1 μg/mL, 10 μg/mL, 100 μg/mL, and 1000 μg/mL concentrations, respectively

Fig. 4.

Histograms comparing the anti-inflammatory activity of ZIF, PROZIF, SAFROZIF, and CURCUZIF at (A) 1 μg/mL, (B) 10 μg/mL, (C) 100 μg/mL, and (D) 1000 μg/mL concentrations
Histograms comparing the anti-inflammatory activity of ZIF, PROZIF, SAFROZIF, and CURCUZIF at (A) 1 μg/mL, (B) 10 μg/mL, (C) 100 μg/mL, and (D) 1000 μg/mL concentrations

Fig. 5.

Cell migration assay with L929 cells cultured with different nanocarriers on day 0 (left panel), day 1 (middle panel), and day 2 (right panel), a shows p-value < 0.05 relative to PROZIF group
Cell migration assay with L929 cells cultured with different nanocarriers on day 0 (left panel), day 1 (middle panel), and day 2 (right panel), a shows p-value < 0.05 relative to PROZIF group

Fig. 6.

FTIR spectra of ZIF, PROZIF, SAFROZIF, and CURCUZIF nanoparticles
FTIR spectra of ZIF, PROZIF, SAFROZIF, and CURCUZIF nanoparticles

Fig. 7.

Cumulative release profile of propolis, saffron extract, and curcumin from PROZIF, SAFROZIF, and CURCUZIF during the course of 7 days in PBS
Cumulative release profile of propolis, saffron extract, and curcumin from PROZIF, SAFROZIF, and CURCUZIF during the course of 7 days in PBS
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Sprache:
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