Accesso libero

Faecal microbiota transplantation associated adverse events

, , , , ,  e   
07 set 2024
INFORMAZIONI SU QUESTO ARTICOLO

Cita
Scarica la copertina

Zhang F, Luo W, Shi Y, Fan Z, Ji G. Should we standardize the 1,700-year-old fecal microbiota transplantation? Am J Gastroenterol. 2012;107:1755. Search in Google Scholar

Brandt LJ. Fecal microbiota transplant: respice, adspice, prospice. J Clin Gastroenterol. 2015;49:65-8. Search in Google Scholar

Eiseman B, Silen W, Bascom GS, Kuavar AJ. Fecal enema as an adjunct in the treatment of pseudomembranous enterocolitis. Surgery. 1958;44:854-9. Search in Google Scholar

Schwan A, Sjölin S, Trottestam U, Aronsson B. Relapsing Clostridium difficile enterocolitis cured by rectal infusion of normal faeces. Sca J Infectious Diseases. 1984;16:211-5. Search in Google Scholar

Borody TJ, George L, Andrews P Brandl S, Noonan S, Cole P, et al. Bowel-flora alteration: a potential cure for inflammatory bowel disease and irritable bowel syndrome? Med J Aust. 1989;150:604. Search in Google Scholar

Bennet JD, Brinkman M. Treatment of ulcerative colitis by implantation of normal colonic flora. Lancet. 1989;1,8630:164. Search in Google Scholar

Philips CA, Pande A, Shasthry SM, Jamwal KD, Khillan V, Chandel SS, et al. Healthy donor fecal microbiota transplantation in steroid-ineligible severe alcoholic hepatitis: a pilot study. Clin Gastroenterol Hepatol. 2017;15:600-2. Search in Google Scholar

Philips CA, Phadke N, Ganesan K, Ranade S, Augustine P. Corticosteroids, nutrition, pentoxifylline, or fecal microbiota transplantation for severe alcoholic hepatitis. Indian J Gastroenterol. 2018;37(3):215-25. Search in Google Scholar

Smits WK, Lyras D, Lacy DB, Wilcox MH, Kuijper EJ. Clostridium difficile infection. Nat Rev Dis Primers. 2016;2:16020. Search in Google Scholar

Van Nood E, Vrieze A. Nieuwdorp M, Fuentes S, Zoetendal EG, de Vos WM, et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med. 2013;368:407-15. Search in Google Scholar

Marotz CA, Zarrinpar A. Treating obesity and metabolic syndrome with fecal microbiota transplantation. Yale J Biol Med. 2016;89:383-8. Search in Google Scholar

Cheng F, Huang Z, Wei W, Li Z. Fecal microbiota transplantation for Crohn’s disease: a systematic review and meta-analysis. Tech Coloproctol. 2021;25:495-504. Search in Google Scholar

Wei Y, Li N, Xing H, Guo T, Gong H, Chen D. Effectiveness of fecal microbiota transplantation for severe diarrhea after drug-induced hypersensitivity syndrome. Med Baltimore. 2019;98(52):e18476. Search in Google Scholar

Preidis G.A, Versalovic J. Targeting the human microbiome with antibiotics, probiotics, and prebiotics: gastroenterology enters the metagenomics era. Gastroenterology. 2009;136:2015-31. Search in Google Scholar

El-Matary W, Simpson R, Ricketts-Burns N. Fecal microbiota transplantation: are we opening a can of worms ? Gastroenterology. 2012;143:e19-e20. Search in Google Scholar

Costello SP, Hughes PA, Waters O. Bryant RV, Vincent AD, Blatchford P, et al. Effect of fecal microbiota transplantation on 8-week remission in patients with ulcerative colitis: a randomized clinical trial. JAMA. 2019;321:156-64. Search in Google Scholar

Palmer R, Dimairo M, Latimer N, Cross E, Brady M, Enderby P, et al. Definitions of adverse events and serious adverse events and categories of serious adverse event results. W: Computerised speech and language therapy or attention control added to usual care for people with long-term post-stroke aphasia: the Big CACTUS three-arm RCT. NIHR Journals Library; 2020. https://www.ncbi.nlm.nih.gov/books/NBK556726/. Search in Google Scholar

Bajaj JS, Shamsaddini A, Fagan A, Sterling RK, Gavis E, Khoruts A, et al. Fecal microbiota transplant in cirrhosis reduces gut microbial antibiotic resistance genes: Analysis of two trials. Hepatol Commun. 2020;5(2):258-71. Search in Google Scholar

Shasthry SM. Fecal microbiota transplantation in alcohol related liver diseases. Clin Mol Hepatol. 2020;26(3):294-301. Search in Google Scholar

Li J, Wang D, Sun J. Application of fecal microbial transplantation in hepatic encephalopathy after transjugular intrahepatic portosystemic shunt. Medicine (Baltimore). 2022;101(3):e28584. Search in Google Scholar

Chauhan A, Kumar R, Sharma S, Mahanta M, Vayuuru SK, Nayak B, et al. Fecal microbiota transplantation in hepatitis B e antigen-positive chronic hepatitis B patients: A pilot study. Dig Dis Sci. 2021;66:873-80. Search in Google Scholar

Sun L, Li J, Lan LL, Li XA. The effect of fecal microbiota transplantation on Hepatic myelopathy: A case report. Medicine (Baltimore). 2019;98(28):e16430. Search in Google Scholar

Jiang ZD, Ajami NH, Petrosino JF, Jun G, Hanis CL, Shah M, et al. Randomised clinical trial: faecal microbiota transplantation for recurrent Clostridum difficile infection – fresh, or frozen, or lyophilised microbiota from a small pool of healthy donors delivered by colonoscopy. Alimentary Pharmacol Ther. 2017;45(7):899-908. Search in Google Scholar

Grehan MJ, Borody TJ, Leis SM, Campbell J, Mitchell H, Wettstein A. Durable alteration of the colonic microbiota by the administration of donor fecal flora. J Clin Gastroenterol. 2010;44:551-61. Search in Google Scholar

Kump PK, Grochenig HP, Lackner S, Trajanoski S, Reicht G, Hoffmann KM, et al. Alteration of intestinal dysbiosis by fecal microbiota transplantation does not induce remission in patients with chronic active ulcerative colitis. Inflamm Bowel Dis. 2013;19: 2155-65. Search in Google Scholar

Kunde S, Pham A, Bonczyk S, Crumb T, Duba M, Conrad H Jr, et al. Safety, tolerability, and clinical response after fecal transplantation in children and young adults with ulcerative colitis. J Pediatr Gastroenterol Nutr. 2013;56(6):597-601. Search in Google Scholar

Baxter M, Colville A. Adverse events in faecal microbiota transplant: a review of the literature. J Hosp Infect. 2016;92(2):117-27. Search in Google Scholar

Suskind DL, Brittnacher MJ, Wahbeh G, Shaffer ML, Hayden HS, Qin X, et al. Fecal microbial transplant effect on clinical outcomes and fecal microbiome in active Crohn’s disease. Inflammatory Bowel Diseases. 2015;21(3):556-63. Search in Google Scholar

Wang S, Xu M, Wang W, Cao X, Piao M, Khan S, et al. Systematic review: Adverse events of fecal microbiota transplantation. PLoS One. 2016;11(8):e0161174. Search in Google Scholar

Li N, Tian H, Ma C, Ding C, Ge X, Gu L, et al. Efficacy analysis of fecal microbiota transplantation in the treatment of 406 cases with gastrointestinal disorders. Zhonghua Wei Chang Wai Ke Za Zhi. 2017;20(1):40-6. Search in Google Scholar

Zhang XY, Wang YZ, Li XL, Hu H, Liu HF, Li D, et al. Safety of fecal microbiota transplantation in Chinese children: A single-center retrospective study. World J Clin Cases. 2018;6(16):1121-7. Search in Google Scholar

Wang W, Cui B, Li Q, Ding X, Li P, Zhang T, et al. The safety of fecal microbiota transplantation for crohn’s disease: findings from a long-term study. Adv Ther. 2018;35(11):1935-44. Search in Google Scholar

DeFilipp Z, Bloom PP, Soto MT, Mansour MK, Sater MRA, Huntley MH, et al. Drug-resistant E. coli bacteremia transmitted by fecal microbiota transplant. N Engl J Med. 2019;381:2043-50. Search in Google Scholar

Marcella C, Cui B, Kelly CR, Ianiro G, Cammarota G, Zhang F. Systematic review: the global incidence of faecal microbiota transplantation-related adverse events from 2000 to 2020. Aliment Pharmacol Ther. 2021;53(1):33-42. Search in Google Scholar

Michailidis L, Currier AC, Le M, Flomenhoft DR. Adverse events of fecal microbiota transplantation: a meta-analysis of high-quality studies. Ann Gastroenterol. 2021;34(6):802-14. Search in Google Scholar

Saha S, Mara K, Pardi DS, Khanna S. Long-term safety of fecal microbiota transplantation for recurrent clostridioides difficile infection. Gastroenterology. 2021;160(6):1961-69.e3. Search in Google Scholar

Yadav D, Khanna S. Safety of fecal microbiota transplantation for Clostridioides difficile infection focusing on pathobionts and SARSCoV-2. Therap Adv Gastroenterol. 2021;21:14. Search in Google Scholar

Kang Y, Cai Y. Altered Gut Microbiota in HIV Infection: Future Perspective of Fecal Microbiota Transplantation Therapy. Mary Ann Liebert, Inc; 2019. Search in Google Scholar

Bakken JS, Borody T, Brandt LJ, Brill JV, Demarco DC, Franzos MA, et al. Fecal Microbiota Transplantation Workgroup. Treating Clostridium difficile infection with fecal microbiota transplantation. Clin Gastroenterol Hepatol. 2011;9(12):1044-9. Search in Google Scholar

Li XX, Hu XM, Zhang DW. Advance in research on fecal microbiota transplantation and therapy in inflammatory bowel disease. Chin J Gastroenterol Hepatol. 2018;27:220-3. Search in Google Scholar

Fang H, Fu L, Wang J. Protocol for fecal microbiota transplantation in inflammatory bowel disease: a systematic review and meta-analysis. Biomed Res Int. 2018;13(2018):8941340. Search in Google Scholar

Aas J, Gessert CE, Bakken JS. Recurrent Clostridium Difficile Colitis: Case Series Involving 18 Patients Treated with Donor Stool Administered via a Nasogastric Tube. Cli Inf Diseases. 2003;36:580-5. Search in Google Scholar

Borody TJ, Warren EF, Leis S. Surace R, Ashman O. Treatment of ulcerative colitis using fecal bacteriotherapy. J Clin Gastroenterol. 2003;37:42-7. Search in Google Scholar

Choi HH, Cho YS. Fecal microbiota transplantation: Current applications, effectiveness, and future perspectives. Clin Endosc. 2016;49(3):257-65. Search in Google Scholar

Kao D, Roach B, Silva M, Beck P, Rioux K, Kaplan GG, et al. Effect of oral capsule- vs colonoscopy-delivered fecal microbiota transplantation on recurrent Clostridium difficile infection: a randomized clinical trial. JAMA. 2017;318:1985-93. Search in Google Scholar

Wilson BC, Vatanen T, Cutfield WS, O’Sullivan JM. The super -donor phenomenon in fecal microbiota transplantation. Front Cell Infect Microbiol. 2019;9:2. Search in Google Scholar

McCune V L, Quraishi MN, Manzoor S, Moran CE, Banavathi K, Steed H, et al. Results from the first English stool bank using faecal microbiota transplant as a medicinal product for the treatment of Clostridioides difficile infection. E Clin Med. 2020;20:100301. Search in Google Scholar

Borody TJ, Brandt LJ, Paramsothy S. Therapeutic faecal microbiota transplantation: current status and future developments. Curr Opin Gastroenterol. 2014;30:97-105. Search in Google Scholar

He Z, Cui BT, Zhang T, Li P, Long CY, Ji GZ, et al. Fecal microbiota transplantation cured epilepsy in a case with Crohn’s disease: the first report. World J Gastroenterol. 2017;23:3565-8. Search in Google Scholar

Rossen NG, Fuentes S, Van der Spek MJ, Tijssen JG, Hartman JH, Duflou A, et al. Findings from a randomized controlled trial of fecal transplantation for patients with ulcerative colitis. Gastroenterology. 2015;149:110-8.e4 Search in Google Scholar

Mullish BH, Quraishi MN, Segal JP, McCune VL, Baxter M, Marsden GL, et al. The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines. J Hosp Infect. 2018;100(1):1-31. Search in Google Scholar

Burke KE, Lamont JT. Fecal transplantation for recurrent Clostridium difficile infection in older adults: A review. J Am Geriatr Soc. 2013;61(8):1394-8. Search in Google Scholar

Coskunpinar E, Islamzade F, Yilmaz EP, Ors CH, Adak H, Yesiltepe A. The importance of fecal transplantation in personalized medicine. Bezmialem Science. 2018;6(4):305-11. Search in Google Scholar

Kelly CR, de Leon L, Jasutkar N. Fecal microbiota transplantation for relapsing Clostridium difficile infection in 26 patients: methodology and results. J Clin Gastroenterol. 2012;46(2):145-9. Search in Google Scholar

Kelly CR, Khoruts A, Staley C, Sadowsky MJ, Abd M, Alani M, et al. Effect of fecal microbiota transplantation on recurrence in multiply recurrent Clostridium difficile infection: a randomized trial. Ann Intern Med. 2016;165:609-16. Search in Google Scholar

Wen W, Zhang H, Shen J, Wei L, Shen S. Fecal microbiota transplantation for patients with irritable bowel syndrome: a meta-analysis protocol. Medicine Baltimore. 2018;97:e12661. Search in Google Scholar

Ianiro G, Bibbo S, Scaldaferri F, Gasbarrini A, Cammarota G. Fecal microbiota transplantation in inflammatory bowel disease: beyond the excitement. Medicine Baltimore. 2014;93:e97. Search in Google Scholar

Ding C, Fan W, Gu L, Tian H, Ge X, Gong J, et al. Outcomes and prognostic factors of fecal microbiota transplantation in patients with slow transit constipation: results from a prospective study with long-term follow-up. Gastroenterol Rep (Oxf). 2018;6:101-7. Search in Google Scholar

Li N, Tian HL, Chen QY, Yang B, Ma CL, Lin ZL, et al. Efficacy analysis of fecal microbiota transplantation in the treatment of 2010 patients with intestinal disorders. Chin J Gastrointestinal Surgery. 2019;22(9):861-8. Search in Google Scholar

Cammarota G, Masucci L, Ianiro G, Bibbò S, Dinoi G, Costamagna G, et al. Randomised clinical trial: faecal microbiota transplantation by colonoscopy vs. vancomycin for the treatment of recurrent Clostridium difficile infection. Aliment Pharmacol Ther. 2015; 41:835-43. Search in Google Scholar

Antushevich H. Fecal microbiota transplantation in disease therapy. Clinica Chimica Acta. 2020:503:90-8. Search in Google Scholar

Bajaj JS, Khoruts A. Microbiota changes and intestinal microbiota transplantation in liver diseases and cirrhosis. J Hepatology. 2020;72(5):1003-27. Search in Google Scholar

Philips CA, Phadke N, Ganesan K, Ranade S, Augustine P. Corticosteroids, nutrition, pentoxifylline, or fecal microbiota transplantation for severe alcoholic hepatitis. Indian J Gastroenterol. 2018;37(3):215-25. Search in Google Scholar

Bajaj JS, Kassam Z, Fagan A, Gavis EA, Liu E, Cox IJ, et al. Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial. Hepatology. 2017;66: 1727-38. Search in Google Scholar

Mullish BH, McDonald J, Thursz MR, Marchesi JR. Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: a randomized clinical trial. Hepatology. 2017;66: 1354-5. Search in Google Scholar

Ren YD, Ye ZS, Yang LZ, Jin LX, Wei WJ, Deng YY, et al. Fecal microbiota transplantation induces hepatitis B virus e-antigen (HBeAg) clearance in patients with positive HBeAg after long-term antiviral therapy. Hepatology. 2017;65:1765-8. Search in Google Scholar

Kao D, Roach B, Park H, Hotte N, Madsen K, Bain V, et al. Fecal microbiota transplantation in the management of hepatic encephalopathy. Hepatology. 2016;63:339-40. Search in Google Scholar

Rebello D, Wang E, Yen E, Lio PA, Kelly CR. Hair growth in two alopecia patients after fecal microbiota transplant. ACG Case Rep J. 2017;4:e107. Search in Google Scholar

Zhao H, Yichao S, Luo X, Peng L, Yang Y, Zou L. The Effect of Fecal Microbiota Transplantation on a Child with Tourette Syndrome. Case Reports in Medicine. 2017;2017:6165239. Search in Google Scholar

Kang Y, Cai V. Future prospect of faecal microbiota transplantation as a potential therapy in asthma. Allergologia et Immunopathologia. 2018;46,(3):307-9. Search in Google Scholar

Sampson, TR, Mazmanian SK. Control of brain development, function, and behavior by the microbiome. Cell Host Microbe. 2015; 17:565-76. Search in Google Scholar

Xu MQ, Cao H, Wang WQ, Wang S, Cao XC, Yan F, et al. Fecal microbiota transplantation broadening its application beyond intestinal disorders. World J Gastroenterol. 2015;21(1):102-11. Search in Google Scholar

Quaranta G, Sanguinetti M, Masucci L. Fecal microbiota transplantation: a potential tool for treatment of human female reproductive tract diseases. Frontiers in Immunology. 2019;10:2653. Search in Google Scholar

Aroniadis O, Brandt L. Fecal microbiota transplantation: past, present and future. Curr Opin Gastroenterol. 2013;29:79-84. Search in Google Scholar

Zheng YM, He XX, Xia HH, Yuan Y, Xie WR, Cai JY, et al. Multi-donor multi-course faecal microbiota transplantation relieves the symptoms of chronic hemorrhagic radiation proctitis: A case report. Medicine (Baltimore). 2020;99(39):e22298. Search in Google Scholar

Zhou G, Zeng J, Peng L, Wang L, Zheng W, Di Wu, et al. Fecal microbiota transplantation for membranous nephropathy. CEN Case Rep. 2021;10:261-4. Search in Google Scholar

Cheng F, Huang Z, Wei W, Li Z. Fecal microbiota transplantation for Crohn’s disease: a systematic review and meta-analysis. Tech Coloproctol. 2021;25:495-504. Search in Google Scholar

Saha S, Tariq R, Tosh PK, Pardi DS, Khanna S. Faecal microbiota transplantation for eradicating carriage of multidrug-resistant organisms: a systematic review. Clin Microbiol Infect. 2019;25(8): 958-63. Search in Google Scholar

Crum-Cianflone NF, Sullivan E, Ballon-Landa G. Fecal microbiota transplantation and successful resolution of multidrug-resistant-organism colonization. J Cl Microbiol. 2015;53(6):1986-9. Search in Google Scholar

Act of September 6, 2001 Pharmaceutical law. Journal of Laws 2023, item 605 with later Amended. Search in Google Scholar

Wiela-Hojeńska A, Łapiński Ł. Undesirable effects of drugs – types, division, causes and economic effects. Farm Pol. 2010;66(4): 275-88. Search in Google Scholar

Li N, Tian H. Current research progress and thinking of fecal microbiota transplantation for the treatment of gastrointestinal disorders. Zhonghua Wei Chang Wai Ke Za Zhi. 2017;20(10):1104-8. Search in Google Scholar

Kassam Z, Lee CH, Yuan Y, Hunt RH. Fecal microbiota transplantation for Clostridium difficile infection: systematic review and meta-analysis. Am J Gastroenterol. 2013;108:500-8. Search in Google Scholar

Bakken JS, Polgreen PM, Beekmann SE, Riedo FX, Streit JA. Treatment approaches including fecal microbiota transplantation for recurrent Clostridium difficile infection (RCDI) among infectious disease physicians. Anaerobe. 2013;24:20-4. Search in Google Scholar

Zipursky JS, Sidorsky TI, Freedman CA, Sidorsky MN, Kirkland KB. Physician attitudes toward the use of fecal microbiota transplantation for the tre.atment of recurrent Clostridium difficile infection. Can J Gastroenterol Hepatol. 2014;28(6):319-24. Search in Google Scholar

Rao K, Safdar N. Fecal microbiota transplantation for the treatment of Clostridium difficile infection. Journal of Hospital Medicine. 2016;11(1):56-61. Search in Google Scholar

Goyal A, Yeh A, Bush BR, Firek BA, Siebold LM, Rogers MB, et al. Safety, clinical response, and microbiome findings following fecal microbiota transplant in children with inflammatory bowel disease. Inflamm Bowel Dis. 2018;24(2):410-21. Search in Google Scholar

McLeod C, Nerlich B, Jaspal P. Fecal microbiota transplants: emerging social representations in the English-language print media. New Genetics and Society. 2019;38(3):331-51. Search in Google Scholar

Dennis M, Salpeter MJ, Hota S. Low awareness but positive attitudes toward fecal transplantation in Ontario physicians. Can J Infect Dis Med Microbiol. 2015;26(1):30-2. Search in Google Scholar

Xu D, Chen VL, Steiner CA, Berinstein JA, Eswaran S, Waljee AK, et al. Efficacy of fecal microbiota transplantation in irritable bowel syndrome: a systematic review and meta-analysis. Am JGastroenterol. 2019;114(7):1043-50. Search in Google Scholar

Zhou Y, Xu H, Huang H, Li Y, Chen H, He J, et al. Are There Potential Applications of Fecal Microbiota Transplantation beyond Intestinal Disorders? Biomed Res Int. 2019;2019:3469754. Search in Google Scholar

Gutin L, Piceno Y, Fadrosh D, Lynch K, Zydek M, Kassam Z, et al. Fecal microbiota transplant for Crohn disease: a study evaluating safety, efficacy, and microbiome profile. United Eur Gastroenterol. 2019;7:807-14. Search in Google Scholar

Ooijevaar RE, Terveer EM, Verspaget HW, Kuijper EJ, Keller JJ. Clinical application and potential of fecal microbiota transplantation. Ann Rev Med. 2019;70(1):335-51. Search in Google Scholar

US Food and Drug Administration. Enforcement policy regarding investigational new drug requirements for use of fecal microbiota for transplantation to treat Clostridium difficile infection not responsive to standard therapies draft guidance for industry. Food and Drug Administration (FDA): Silver Spring; 2013. (access: 25.09.2022). Search in Google Scholar

Tian HL, Chen QY, Yang B Ma CL, Lin ZL, Zhang XY, et al. Effects of fecal microbiota transplantation in different routes on the clinical efficacy of slow transit constipation. Zhonghua wei Chang wai ke za zhi. 2020;23:63-8. Search in Google Scholar

Nicco C, Paule A, Konturek P, Edeas M. From donor to patient: collection, preparation and cryopreservation of fecal samples for fecal microbiota transplantation. Diseases. 2020;8(2):9. Search in Google Scholar

Park SY, Seo GS. Fecal Microbiota Transplantation: Is It Safe? Clin Endosc. 2021;54(2):157-60. Search in Google Scholar

Ianiro G, Bibbò S, Masucci L, Quaranta G, Porcari S, Settanni CR, et al. Maintaining standard volumes, efficacy and safety, of fecal microbiota transplantation for C. difficile infection during the COVID-19 pandemic: A prospective cohort study. Dig Liver Dis. 2020;52(12):1390-5. Search in Google Scholar

Ianiro G, Mullish BH, Kelly CR, Kassam Z, Kuijper EJ, Ng SC, et al. Reorganisation of faecal microbiota transplant services during the COVID-19 pandemic. Gut. 2020;69:1555-63. Search in Google Scholar

Bibbò S, Settanni CR, Porcari S, Bocchino E, Ianiro G, Cammarota G, et al. Fecal microbiota transplantation: screening and selection to choose the optimal donor. J Clin Med. 2020;9(6):1757. Search in Google Scholar

Benard MV, de Bruijn CMA, Fenneman AC, Wortelboer K, Zeevenhoven J, Rethans B, et al. Challenges and costs of donor screening for fecal microbiota transplantations. PLoS One. 2022; 17(10):e0276323. Search in Google Scholar

Ng RW, Dharmaratne P, Wong S, Hawkey P, Chan P, Ip M. Revisiting the donor screening protocol of faecal microbiota transplantation (FMT): a systematic review. Gut. 2024;73:1029-31. Search in Google Scholar

Lingua:
Inglese
Frequenza di pubblicazione:
4 volte all'anno
Argomenti della rivista:
Medicina, Medicina clinica, Medicina clinica, altro, Farmacologia, Tossicologia, Farmacia, Farmacia, altro