Histopathological comparison of the salivary glands’ acini and striated ducts after experimental prolonged daily administration of oral ubiquinone doses in rats

1. Ferrante RJ, Andreassen OA, Dedeoglu A, Ferrante KL, Jenkins BG, Hersch SM, et al. Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington’s disease. J Neurosci. 2002;22(5):1592-9.10.1523/JNEUROSCI.22-05-01592.2002 Search in Google Scholar

2. Bhagavan HN, Chopra RK. Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic Res. 2006;40(5):445-53.10.1080/1071576060061784316551570 Search in Google Scholar

3. Langsjoen PH, Langsjoen AM. Supplemental ubiquinol in patients with advanced congestive heart failure. Biofactors. 2008;32(1-4):119-28.10.1002/biof.552032011419096107 Search in Google Scholar

4. Abdullah AG, Sedeeq BI, Azzubaidi MS. Histopathological nephrotoxic features of high oral doses of ubiquinone in rats. Curr Issues Pharm Med Sci. 2021;34(2):101-4.10.2478/cipms-2021-0014 Search in Google Scholar

5. Abdullah AG, Sedeeq BI, Azzubaidi MS. Histopathological changes in liver tissue after repeated administrations of an intermediate dose of co-enzyme Q10 to Wistar rats. Research J Pharm Tech. 2021;14(8):2025-8. Search in Google Scholar

6. Koufuchi R, Atsuko I, Rie TYT, Kazumune A, Taro S, Takashi Y, et al. Effects of coenzyme Q10 on salivary secretion. Clin Biochem. 2011;44:669-74.10.1016/j.clinbiochem.2011.03.02921406193 Search in Google Scholar

7. Sekine K, Ota N, Nishii M, Uetake T, Shimadzu M. Estimation of plasma and saliva levels of coenzyme Q10 and influence of oral supplementation. Biofactors. 2005;25(1-4):205-11.10.1002/biof.552025012516873948 Search in Google Scholar

8. Dawood GA, Taqa GA, Alnema MM. Histological effects of Co Q10 on liver and buccal mucosa in mice. J Appl Vet Sci. 2020;5(2) 1-5.10.21608/javs.2020.85543 Search in Google Scholar

9. Abdullah AG. Age related changes of submandibular salivary glands: An anatomical and histological study. Diyala J Med. 2011;1(1):53-61. Search in Google Scholar

10. Deshmukh G, Venkataramaiah SB, Doreswamy CM, Umesh MC, Subbanna RB, Pradhan BK, et al. Safety assessment of ubiquinol acetate: Subchronic toxicity and genotoxicity studies. J Toxicol. 2019;2019:3680757.10.1155/2019/3680757646356731057608 Search in Google Scholar

11. Kitano M, Watanabe D, Oda S, Kubo H, Kishida H, Fujii K, et al. Subchronic oral toxicity of ubiquinol in rats and dogs. Int J Toxicol. 2008;27(2):189-215.10.1080/1091581080197806018404543 Search in Google Scholar

12. Inoue K, Morikawa T, Matsuo S, Tamura K, Takahashi M, Yoshida M. Adaptive parotid gland hypertrophy induced by dietary treatment of GSE in rats. Toxicol Pathol. 2014;42(6):1016-23.10.1177/019262331351242924292390 Search in Google Scholar

13. Honda K, Tominaga S, Oshikata T, Kamiya K, Hamamura M, Kawasaki T, et al. Thirteen-week repeated dose oral toxicity study of coenzyme Q10 in rats. J Toxicol Sci. 2007;32(4):437-48.10.2131/jts.32.43717965558 Search in Google Scholar

14. Daskala ID, Tesseromatis CC. Morphological changes of parotid gland in experimental hyperlipidemia. Int J Dent. 2011;2011:928386. Search in Google Scholar

15. Veiga FF, Johann ACB, Kagy VS, Muniz LTB, Alanis LAR, Rosa EAR, et al. Action of lithium carbonate on parotid acini. Dent Oral Craniofac Res. 2016;2(3):287-91.10.15761/DOCR.1000164 Search in Google Scholar

16. Mieliauskaite D, Venalis A, Graziene V, Kirdaite G. Bilateral parotid enlargement due to malnutrition under the influence of the media in an adolescent in Lithuania. Appetite. 2007;49(1):260-2.10.1016/j.appet.2006.11.00617198741 Search in Google Scholar

17. Bertoldo BB, Bertoldo BB, Etchebehere RM, Furtado TCS, Faria JB, Silva CB, et al. Lingual salivary gland hypertrophy and decreased acinar density in chagasic patients without megaesophagus. Rev Inst Med Trop Sao Paulo. 2019;61:e67.10.1590/s1678-9946201961067690741631859844 Search in Google Scholar

18. Yeroshenko GA, Fedoniuk LY, Shevchenko KV, Kramarenko DR, Yachmin АІ, Vilkhova OV, et al. Structural reorganization of the rats’ submandibular glands acini after the influence of 1% methacrylate. Wiad Lek. 2020;73(7):1318-22.10.36740/WLek202007102 Search in Google Scholar

19. da Cunha Lima M, Sottovia-Filho D, Cestari TM, Taga R. Morphometric characterization of sexual differences in the rat sublingual gland. Braz Oral Res. 2004;18(1):53-8.10.1590/S1806-8324200400010001015273787 Search in Google Scholar

20. Raizner AE, Raizner AE. Coenzyme Q10. Methodist Debakey Cardiovasc J. 2019;15(3):185-91.10.14797/mdcj-15-3-185682264431687097 Search in Google Scholar