<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Given the increase in global mortality rate due to various types of cancer, the present study aimed to develop optimal conditions for the synthesis of cellulose-magnesium oxide nanocomposite with favorable anticancer activity. For this purpose, the Taguchi method was used to design nine experiments with varied ratios of cellulose biopolymer, magnesium oxide nanoparticles and different stirring times. The scanning electron microscopy (SEM) images confirmed the formation of cellulose-magnesium oxide nanocomposite. The anticancer activity level of nine nanocomposites studied was evaluated using MTT assay on Michigan Cancer Foundation-7 (MCF-7) cell line. The nanocomposite synthesized in experiment 9 (8 mg/ml of magnesium oxide, 2 mg/ml of cellulose and stirring time of 60 min) showed the highest growth inhibitory activity on the cancer cells. Based on the attained results,e cellulose-magnesium oxide nanocomposite synthesized in optimal conditions can be used as an eligible anticancer agent.</p></abstract>

Given the increase in global mortality rate due to various types of cancer, the present study aimed to develop optimal conditions for the synthesis of cellulose-magnesium oxide nanocomposite with favorable anticancer activity. For this purpose, the Taguchi method was used to design nine experiments with varied ratios of cellulose biopolymer, magnesium oxide nanoparticles and different stirring times. The scanning electron microscopy (SEM) images confirmed the formation of cellulose-magnesium oxide nanocomposite. The anticancer activity level of nine nanocomposites studied was evaluated using MTT assay on Michigan Cancer Foundation-7 (MCF-7) cell line. The nanocomposite synthesized in experiment 9 (8 mg/ml of magnesium oxide, 2 mg/ml of cellulose and stirring time of 60 min) showed the highest growth inhibitory activity on the cancer cells. Based on the attained results,e cellulose-magnesium oxide nanocomposite synthesized in optimal conditions can be used as an eligible anticancer agent.

Synthesis and anticancer properties of bacterial cellulose-magnesium oxide bionanocomposite

Oral and Dental Sciences Research Laboratory

Kermanshah University of Medical Sciences

Department of Nanobiotechnology, Faculty of Science

Department of Oral and Maxillofacial Medicine

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Given the increase in global mortality rate due to various types of cancer, the present study aimed to develop optimal conditions for the synthesis of...

Synthesis and anticancer properties of bacterial cellulose-magnesium oxide bionanocomposite

Pubblicato online: 06 apr 2019

Pagine: 29 - 33

Ricevuto: 29 apr 2018

Accettato: 17 ago 2018

DOI: https://doi.org/10.2478/cipms-2019-0007

Parole chiave
Cytotoxicity, magnesium oxide, nanoparticles, bacterial cellulose, biopolymer, nanocomposite, Taguchi method

© 2019 Mohsen Safaei et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Synthesis and anticancer properties of bacterial cellulose-magnesium oxide bionanocomposite

Pubblicato online: 06 apr 2019

Pagine: 29 - 33

Ricevuto: 29 apr 2018

Accettato: 17 ago 2018

DOI: https://doi.org/10.2478/cipms-2019-0007

Parole chiaveCytotoxicity, magnesium oxide, nanoparticles, bacterial cellulose, biopolymer, nanocomposite, Taguchi method

© 2019 Mohsen Safaei et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Parole chiave
Cytotoxicity, magnesium oxide, nanoparticles, bacterial cellulose, biopolymer, nanocomposite, Taguchi method